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1991, Laboratory techniques in biochemistry and molecular biology, ISBN 9780444813022, Volume 21., xx, 460
Book
Journal of Hepatology, ISSN 0168-8278, 2015, Volume 63, Issue 4, pp. 934 - 942
Journal Article
The FEBS Journal, ISSN 1742-464X, 02/2017, Volume 284, Issue 3, pp. 451 - 465
Pioglitazone is used globally for the treatment of type 2 diabetes mellitus (T2DM) and is one of the most effective therapies for improving glucose homeostasis... 
pioglitazone | gluconeogenesis | pyruvate | mitochondria | MPCs | RESPIRATORY-CHAIN | GLYCEMIC CONTROL | ACTIVATED RECEPTOR-GAMMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE-LIVER | INSULIN SENSITIVITY | SKELETAL-MUSCLE | DEHYDROGENASE COMPLEX | TYPE-2 DIABETIC-PATIENTS | ISOLATED RAT | IN-VIVO | RNA, Small Interfering - genetics | Mitochondrial Membrane Transport Proteins - antagonists & inhibitors | Gluconeogenesis - drug effects | Glucose - biosynthesis | Hepatocytes - metabolism | Adenosine Triphosphate - biosynthesis | Glycolysis - drug effects | Mitochondrial Membrane Transport Proteins - genetics | Oxidative Phosphorylation - drug effects | Hepatocytes - cytology | Adenosine Triphosphate - antagonists & inhibitors | Anion Transport Proteins - antagonists & inhibitors | Pyruvic Acid - metabolism | Biological Transport - drug effects | Thiazolidinediones - pharmacology | Hepatocytes - drug effects | Cell Line | Mitochondrial Membrane Transport Proteins - metabolism | Oxidation-Reduction | Rats | Mitochondria - metabolism | Mitochondria - drug effects | Anion Transport Proteins - metabolism | Glucose - antagonists & inhibitors | Hypoglycemic Agents - pharmacology | Animals | Anion Transport Proteins - genetics | Carbon Radioisotopes | RNA, Small Interfering - metabolism | Type 2 diabetes | Physiological aspects | Glucose metabolism | Insulin resistance | Glucose | Dextrose | Mitochondria | Diabetes | Metabolism | Rodents | Regulators | Pathogenesis | Homeostasis | Pyruvic acid | Synthesis | Dependence | Oxidation | Inhibition | Diabetes mellitus (non-insulin dependent) | Pioglitazone | Diabetes mellitus | Muscles | Oxygen consumption | siRNA | Gene expression | Insulin | Skeletal muscle | Mode of action | Gene silencing | Hepatocytes | ATP | Index Medicus
Journal Article
Journal Article
Cytotechnology, ISSN 0920-9069, 8/2016, Volume 68, Issue 4, pp. 1577 - 1583
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2010, Volume 120, Issue 7, pp. 2355 - 2369
Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESPIRATORY-CHAIN | SKELETAL-MUSCLE | PHOSPHOENOLPYRUVATE CARBOXYKINASE | ACTIVATED PROTEIN-KINASE | GLUCOKINASE TRANSLOCATION | GLUCOSE-METABOLISM | COACTIVATOR TORC2 | AICA RIBOSIDE | UPSTREAM KINASE | ISOLATED RAT HEPATOCYTES | Glucose-6-Phosphatase - genetics | Hypoglycemic Agents - metabolism | Diabetes Mellitus, Type 2 - genetics | Gluconeogenesis - drug effects | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Metformin - metabolism | AMP-Activated Protein Kinases | Hyperglycemia - genetics | Liver - drug effects | Protein-Serine-Threonine Kinases - metabolism | Liver - metabolism | Metformin - pharmacology | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Glucose - genetics | Glucose - pharmacology | Glucose-6-Phosphatase - metabolism | Hypoglycemic Agents - pharmacology | Mice, Knockout | Hyperglycemia - metabolism | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Up-Regulation - drug effects | Animals | Gluconeogenesis - genetics | Glucose-6-Phosphatase - biosynthesis | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Glucose - metabolism | Mice | Protein-Serine-Threonine Kinases - pharmacology | Type 2 diabetes | Control | Usage | Genetic aspects | Research | Metformin | Gene expression | Drug therapy | Health aspects | Gluconeogenesis | Up-Regulation | Glucose-6-Phosphatase | gluconeogenesis, animal models | Liver | Protein-Serine-Threonine Kinases | Glucose | LKB1 | Life Sciences | Hypoglycemic Agents | Phosphoenolpyruvate Carboxykinase (ATP) | Human health and pathology | Hyperglycemia | Hepatocytes | AMPK | Endocrinology and metabolism | Diabetes Mellitus, Type 2
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 06/2007, Volume 35, Issue 6, pp. 859 - 865
The wealth of information that has emerged in recent years detailing the substrate specificity of hepatic transporters necessitates an investigation into their... 
VITRO | MICROSOMES | HUMANS | PHARMACOLOGY & PHARMACY | ANION TRANSPORTING POLYPEPTIDES | METABOLIC-CLEARANCE | INTRINSIC CLEARANCE | ISOLATED RAT HEPATOCYTES | BINDING | DRUG-METABOLISM | PREDICTION | Pharmaceutical Preparations - metabolism | Animals | Models, Biological | Humans | Liver - metabolism | Cells, Cultured | Rats | Hepatocytes - metabolism | Pharmacokinetics
Journal Article
Archives of Environmental Contamination and Toxicology, ISSN 0090-4341, 8/2018, Volume 75, Issue 2, pp. 295 - 305
Determining the biotransformation potential of commercial chemicals is critical for estimating their persistence in the aquatic environment. In vitro systems... 
Pollution, general | Environmental Health | Monitoring/Environmental Analysis | Ecotoxicology | Environment | Environmental Chemistry | Soil Science & Conservation | ENVIRONMENTAL SCIENCES | OPSANUS-BETA | POLYCHLORINATED BIPHENYL CONGENERS | ENVIRONMENTAL FATE | POLYCYCLIC AROMATIC-HYDROCARBONS | BIOACCUMULATION ASSESSMENTS | ONCORHYNCHUS-MYKISS | THERMAL MODULATION | IN-VITRO METABOLISM | FRESHLY ISOLATED HEPATOCYTES | TOXICOLOGY | XENOBIOTIC INTRINSIC CLEARANCE | Anthracenes | Organic Chemicals - chemistry | Water Pollutants, Chemical - chemistry | Water Pollutants, Chemical - pharmacokinetics | Male | Hepatocytes - metabolism | Oncorhynchus mykiss | Benzo(a)pyrene - pharmacokinetics | Animals | Organic Chemicals - pharmacokinetics | Biotransformation | Chrysenes - pharmacokinetics | Hydrophobic and Hydrophilic Interactions | Polychlorinated Biphenyls - pharmacokinetics | Hepatocytes - drug effects | Benzopyrene | Trout | Analysis | Fishes | Environmental protection | Rate constants | Octanol | Benzo(a)pyrene | Chrysene | Hydrophobicity | Cell density | PCB compounds | Aquatic environment | Mathematical analysis | Bioaccumulation | Fish | Organic compounds | Statistical analysis | Incubation | Estimation | Metabolism | PCB | Chemicals | Pyrene | Organic chemistry | Depletion | Hepatocytes | Biological magnification | Polychlorinated biphenyls | Organic chemicals
Journal Article