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The FEBS Journal, ISSN 1742-464X, 02/2017, Volume 284, Issue 3, pp. 451 - 465
.... In cultured H4IIE hepatocytes, pioglitazone inhibited [2‐14C]‐pyruvate oxidation and pyruvate... 
pioglitazone | gluconeogenesis | pyruvate | mitochondria | MPCs | RESPIRATORY-CHAIN | GLYCEMIC CONTROL | ACTIVATED RECEPTOR-GAMMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE-LIVER | INSULIN SENSITIVITY | SKELETAL-MUSCLE | DEHYDROGENASE COMPLEX | TYPE-2 DIABETIC-PATIENTS | ISOLATED RAT | IN-VIVO | RNA, Small Interfering - genetics | Mitochondrial Membrane Transport Proteins - antagonists & inhibitors | Gluconeogenesis - drug effects | Glucose - biosynthesis | Hepatocytes - metabolism | Adenosine Triphosphate - biosynthesis | Glycolysis - drug effects | Mitochondrial Membrane Transport Proteins - genetics | Oxidative Phosphorylation - drug effects | Hepatocytes - cytology | Adenosine Triphosphate - antagonists & inhibitors | Anion Transport Proteins - antagonists & inhibitors | Pyruvic Acid - metabolism | Biological Transport - drug effects | Thiazolidinediones - pharmacology | Hepatocytes - drug effects | Cell Line | Mitochondrial Membrane Transport Proteins - metabolism | Oxidation-Reduction | Rats | Mitochondria - metabolism | Mitochondria - drug effects | Anion Transport Proteins - metabolism | Glucose - antagonists & inhibitors | Hypoglycemic Agents - pharmacology | Animals | Anion Transport Proteins - genetics | Carbon Radioisotopes | RNA, Small Interfering - metabolism | Type 2 diabetes | Physiological aspects | Glucose metabolism | Insulin resistance | Glucose | Dextrose | Mitochondria | Diabetes | Metabolism | Rodents | Regulators | Pathogenesis | Homeostasis | Pyruvic acid | Synthesis | Dependence | Oxidation | Inhibition | Diabetes mellitus (non-insulin dependent) | Pioglitazone | Diabetes mellitus | Muscles | Oxygen consumption | siRNA | Gene expression | Insulin | Skeletal muscle | Mode of action | Gene silencing | Hepatocytes | ATP
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2006, Volume 281, Issue 46, pp. 34870 - 34879
Journal Article
Drug metabolism and disposition, ISSN 1521-009X, 2018, Volume 46, Issue 5, pp. 680 - 691
.... As sandwich-cultured hepatocytes (SCHs) maintain metabolic activities and form a canalicular network, the whole interplay between uptake and efflux transporters and drug-metabolizing enzymes can be investigated simultaneously... 
SALT EXPORT PUMP | BILIARY-EXCRETION | CRYOPRESERVED HUMAN HEPATOCYTES | BETA-LACTAM ANTIBIOTICS | PHARMACOLOGY & PHARMACY | RESISTANCE-ASSOCIATED PROTEIN-2 | HUMAN LIVER-MICROSOMES | IN VIVO CORRELATION | ISOLATED RAT HEPATOCYTES | MYCOPHENOLIC-ACID | SINGLE NUCLEOTIDE POLYMORPHISMS
Journal Article
Drug metabolism and disposition, ISSN 1521-009X, 2007, Volume 35, Issue 6, pp. 859 - 865
Journal Article
Journal Article
Iranian journal of pharmaceutical research : IJPR, ISSN 1735-0328, 03/2018, Volume 17, Issue 2, pp. 553 - 562
Crocin, the main constituent of saffron (Crocus sativus L.), is a natural carotenoid which is known for its antioxidant activity. Liver as the organ that... 
Oxidative stress | Hepatoprotection | Isolated rat hepatocyte | Antioxidant | Crocin | GLUTATHIONE | STIGMA | SAFFRON | PHARMACOLOGY & PHARMACY | EXTRACT | CONSTITUENTS | Original
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 03/2005, Volume 33, Issue 3, pp. 419 - 425
The binding of 17 drugs to rat hepatocytes has been determined using equilibrium dialysis in combination with metabolic inhibitors and a kinetic model for the binding and dialysis processes... 
NONSPECIFIC-BINDING | IN-VITRO | TRANSPORT | METABOLISM | VIVO | PHARMACOLOGY & PHARMACY | LIVER-MICROSOMES | INTRINSIC CLEARANCE | ISOLATED RAT HEPATOCYTES | HEPATIC-CLEARANCE | PREDICTION | Pharmaceutical Preparations - metabolism | Animals | Models, Biological | Rats | Male | Dialysis | Hepatocytes - metabolism | Kinetics | In Vitro Techniques | Rats, Sprague-Dawley
Journal Article
Advanced pharmaceutical bulletin, ISSN 2228-5881, 2013, Volume 3, Issue 1, pp. 135 - 142
.... Hence, the capacity of organosulfur compounds to protect rat hepatocytes against cytotoxic effects of methimazole and its proposed toxic metabolite, N-methylthiourea was evaluated. Methods... 
Isolated hepatocytes | Methimazole | N-methylthiourea | Mitochondria | Protein carbonylation | Organosulfurs
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2010, Volume 55, Issue 1, pp. 133 - 144
Journal Article
Cytotechnology, ISSN 0920-9069, 8/2016, Volume 68, Issue 4, pp. 1577 - 1583
Journal Article
Research in pharmaceutical sciences, ISSN 1735-5362, 04/2015, Volume 10, Issue 2, pp. 143 - 151
.... This study was designed to evaluate the effect of L-carnitine on the cytotoxic effects of statins on the freshly-isolated rat hepatocytes... 
Isolated rat hepatocytes | Mitochondria | L-carnitine | Hepatotoxicity | Statins | Original
Journal Article
Toxicological sciences, ISSN 1096-6080, 2012, Volume 127, Issue 2, pp. 582 - 591
.... In mitochondria isolated from rat liver, sertraline uncoupled mitochondrial oxidative phosphorylation and inhibited the activities of oxidative phosphorylation complexes I and V... 
Mitochondrial dysfunction | Rat primary hepatocytes | Isolated liver mitochondria | Liver toxicity | Sertraline | OXIDATIVE-PHOSPHORYLATION | INNER MEMBRANE | rat primary hepatocytes | ADENINE-NUCLEOTIDE TRANSLOCATOR | isolated liver mitochondria | PRIMARY HEPATOCYTES | mitochondrial dysfunction | INDUCED LIVER-INJURY | CA-2&-INDUCED MEMBRANE TRANSITION | CEREBELLAR GRANULE CELLS | PERMEABILITY TRANSITION | liver toxicity | GENE-EXPRESSION | TOXICOLOGY | OF-THE-LITERATURE | sertraline | L-Lactate Dehydrogenase - metabolism | Mitochondrial Diseases - pathology | Cyclosporine - pharmacology | Mitochondria, Liver - metabolism | Mitochondrial Diseases - metabolism | Hepatocytes - pathology | Male | Hepatocytes - metabolism | Mitochondrial ADP, ATP Translocases - metabolism | Dose-Response Relationship, Drug | Oxidative Phosphorylation - drug effects | Time Factors | Adenosine Triphosphate - metabolism | Mitochondrial Diseases - chemically induced | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Hepatocytes - drug effects | Chemical and Drug Induced Liver Injury - prevention & control | Mitochondrial Diseases - prevention & control | Mitochondrial Membrane Transport Proteins - metabolism | Mitochondria, Liver - pathology | Risk Assessment | Serotonin Uptake Inhibitors - toxicity | Cells, Cultured | Rats | Mitochondrial Membrane Transport Proteins - drug effects | Bongkrekic Acid - pharmacology | Rats, Sprague-Dawley | Antidepressive Agents - toxicity | Mitochondria, Liver - drug effects | Animals | Chemical and Drug Induced Liver Injury - metabolism | Electron Transport Chain Complex Proteins - metabolism | Sertraline - toxicity | Energy Metabolism - drug effects | Mitochondrial ADP, ATP Translocases - drug effects | Index Medicus
Journal Article