X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (22382) 22382
Publication (1184) 1184
Book Chapter (72) 72
Book Review (63) 63
Dissertation (47) 47
Conference Proceeding (23) 23
Magazine Article (21) 21
Book / eBook (12) 12
Newsletter (4) 4
Government Document (2) 2
Data Set (1) 1
Paper (1) 1
Web Resource (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (9180) 9180
isoquinolines - pharmacology (8340) 8340
humans (7113) 7113
male (5429) 5429
rats (4118) 4118
index medicus (3592) 3592
female (3520) 3520
isoquinolines (2967) 2967
isoquinoline derivatives (2660) 2660
pharmacology & pharmacy (2305) 2305
mice (2229) 2229
chemistry, organic (2070) 2070
isoquinolines - chemistry (1982) 1982
adult (1913) 1913
biochemistry & molecular biology (1847) 1847
isoquinolines - therapeutic use (1766) 1766
isoquinolines - metabolism (1730) 1730
neurosciences (1695) 1695
middle aged (1682) 1682
piperazines - pharmacology (1669) 1669
dose-response relationship, drug (1523) 1523
1--2-methylpiperazine (1474) 1474
tetrahydroisoquinolines (1447) 1447
in vitro techniques (1427) 1427
cells, cultured (1397) 1397
alkaloids (1384) 1384
isoquinolines - chemical synthesis (1331) 1331
chemistry, medicinal (1260) 1260
enzyme inhibitors - pharmacology (1197) 1197
protein kinase c - antagonists & inhibitors (1148) 1148
kinetics (1141) 1141
aged (1105) 1105
isoquinolines - administration & dosage (1097) 1097
time factors (1096) 1096
molecular structure (1044) 1044
phosphorylation (1044) 1044
sulfonamides - pharmacology (1034) 1034
isoquinoline alkaloids (1007) 1007
sulfonamides (997) 997
rats, sprague-dawley (986) 986
chemistry, multidisciplinary (984) 984
isoquinoline (982) 982
alkaloids - pharmacology (972) 972
structure-activity relationship (971) 971
derivatives (957) 957
cell line (851) 851
cyclic amp-dependent protein kinases - antagonists & inhibitors (839) 839
cell biology (819) 819
activation (817) 817
chemistry (808) 808
tetradecanoylphorbol acetate - pharmacology (801) 801
expression (790) 790
rats, wistar (777) 777
isoquinolines - pharmacokinetics (745) 745
fluorescent dyes (737) 737
oncology (735) 735
analysis (713) 713
cells (708) 708
ring closure reactions (695) 695
cyclic amp-dependent protein kinases - metabolism (689) 689
isoquinolines - adverse effects (686) 686
protein kinase c - metabolism (672) 672
stereoisomerism (671) 671
catalysis (666) 666
calcium - metabolism (604) 604
rats, inbred strains (600) 600
protein kinase inhibitors (596) 596
cell line, tumor (592) 592
cyclization (574) 574
ligands (571) 571
cyclic amp - metabolism (560) 560
research (555) 555
adolescent (550) 550
inhibition (549) 549
tumor cells, cultured (539) 539
antineoplastic agents - pharmacology (529) 529
physiology (520) 520
rabbits (514) 514
signal transduction (508) 508
apoptosis (504) 504
anesthesiology (501) 501
in-vitro (497) 497
blood pressure - drug effects (494) 494
brain (478) 478
rat (462) 462
brain - metabolism (455) 455
atracurium (446) 446
colforsin - pharmacology (446) 446
cancer (444) 444
models, molecular (436) 436
signal transduction - drug effects (432) 432
article (426) 426
dogs (424) 424
endocrinology & metabolism (423) 423
guinea pigs (420) 420
binding (414) 414
protein kinase inhibitors - pharmacology (405) 405
drug interactions (398) 398
research article (395) 395
binding sites (393) 393
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (21523) 21523
Japanese (477) 477
German (263) 263
Chinese (247) 247
French (137) 137
Russian (121) 121
Spanish (78) 78
Italian (34) 34
Portuguese (22) 22
Czech (16) 16
Danish (13) 13
Hungarian (13) 13
Polish (13) 13
Ukrainian (11) 11
Bulgarian (10) 10
Korean (9) 9
Slovak (4) 4
Afrikaans (1) 1
Finnish (1) 1
Hebrew (1) 1
Norwegian (1) 1
Swedish (1) 1
Welsh (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 06/2015, Volume 23, Issue 11, pp. 2699 - 2715
[Display omitted] Scaffold diversity is key in the ongoing exercise of discovery of novel bioactive compounds using high throughput screening (HTS). Based on... 
Synthesis | Tetrazol | Parallel | Isocyanide | Ugi | Pictet–Spengler | unclassified drug | n [[(4 chlorophenyl)[1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]methyl] 2 3,4 dimethoxyphenyl]ethanamine | 8 ethyl 2,3 dimethoxy 8 methyl 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | n [2 (1h indol 3 yl)ethyl] 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]propan 1 amine | tetracyclic tetrazole scaffold | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl)cyclohexanamine | n [[1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl](4 fluorophenyl)methyl] 2 (3,4 dimethoxy phenyl)ethanamine | 8 (4 chlorophenyl) 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 8 isopropyl 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazoleo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl) 2 phenylethanamine | high throughput screening | mass spectrometry | Pictet-Spengler | multicomponent reaction chemistry | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl)propan 1 amine | thin layer chromatography | 1 benzyl 4 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxy phenethyl)piperidin 4 amine | proton nuclear magnetic resonance | n [2 (1h indol 3 yl)ethyl] 1 benzyl 4 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]piperidin 4 amine | 2,3 dimethoxy 8 phenyl 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 7',12',12b',13' tetrahydro 6'h spiro[cyclohexane 1,4' tetrazolo[1'',5'' 4',5']pyrazino[1',2' 1,2]pyrido[3,4 b]indole] | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl) 2 phenylpropan 1 amine | 2,3 dimethoxy 8 phenethyl 6,8,13,13a tetrahydro 5h tetrazoleo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | chemical reaction | supercritical fluid chromatography | tetrazole derivative | n [2 (1h indol 3 yl)ethyl] 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]cyclohexanamine | article | carbon nuclear magnetic resonance | n [[1,1' biphenyl] 4 yl[1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]methyl] 2 (3,4 dimethoxyphenyl)ethanamine | controlled study | 8 (4 fluorophenyl) 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 8 benzyl 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazoleo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 8 ethyl 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazoleo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl) 2 methylpropan 1 amine | 8 [[1,1' biphenyl] 4 yl] 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 1 benzyl 2',3'dimethoxy 5',6',13',13a' tetrahydrospiro[piperidine 4,8' tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline] | 4 ethyl 4,6,7,12,12b,13 hexahydro tetrazolo[1'',5'' 4',5']pyrazino[1',2' 1,2]pyrido[3,4 b]indole | 2',3'dimethoxy 5',6',13',13a' tetrahydrospiro[cyclohexane 1,8' tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline] | unindexed drug | pharmacophore | n [[1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl](phenyl)methyl] 2 (3,4 dimethoxy phenyl)ethanamine | 2 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl)butan 2 amine | CHEMISTRY, MEDICINAL | ONE-POT | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | PRAZIQUANTEL | LIBRARIES | MULTICOMPONENT REACTIONS | CHEMISTRY | DIVERSITY | EFFICIENT | DERIVATIVES | Models, Molecular | Molecular Structure | Tetrazoles - chemical synthesis | Polycyclic Compounds - chemical synthesis | Drug Discovery | Pictet-spengler
Journal Article
1972, Organic chemistry; a series of monographs, ISBN 0126382506, Volume 25., xviii, 594
Book
1978, ISBN 9780306310591, xvii, 425 p. cm.
Book
CHEMISTRY-A EUROPEAN JOURNAL, ISSN 0947-6539, 10/2015, Volume 21, Issue 44, pp. 15529 - 15533
Efficient, scalable cobalt-catalyzed redox-neutral [4+2] annulation of readily available oximes and alkyne is reported. The developed synthetic methodology is... 
ORGANIC-SYNTHESIS | DIRECT FUNCTIONALIZATION | BETA-PHENYLETHYLAMINES | NATURAL-PRODUCTS | ISOQUINOLINE ALKALOIDS | AROMATIC IMINES | EFFICIENT SYNTHESIS | cobalt | CHEMISTRY, MULTIDISCIPLINARY | H BOND ACTIVATION | ORTHO ALKYLATION | annulation | CH activation | ARYLZINC REAGENTS | isoquinoline | heterocycles
Journal Article
Journal Article
Organic Letters, ISSN 1523-7060, 09/2011, Volume 13, Issue 17, pp. 4636 - 4639
Journal Article
Journal Article
1965, 1st ed., Commonwealth and international library of science, technology, engineering and liberal studies. A course in organic chemistry, advanced section, Volume 26, 264
Book
Journal Article
by Wang, B and Zhao, YJ and Zhao, YL and Liu, YP and Li, XN and Zhang, HB and Luo, XD
ORGANIC LETTERS, ISSN 1523-7060, 01/2020, Volume 22, Issue 1, pp. 257 - 260
Dactylicapnosines A (1) and B (2), two reconstructed aporphines with unprecedent five-membered carbon ring D, were isolated from Dactylicapnos scandens, in... 
CHEMISTRY, ORGANIC | ISOQUINOLINE | ALKALOIDS
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 06/2015, Volume 11, Issue 6, pp. 432 - 437
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 01/2020, Volume 61, Issue 5, p. 151454
[Display omitted] •The reaction worked smoothly without any catalyst and additives.•A renewable solvent, such as water was used.•High atom economy and no toxic... 
Isoquinoline | Green chemistry | Cyclization | Catalyst free
Journal Article
Organic Letters, ISSN 1523-7060, 12/2011, Volume 13, Issue 24, pp. 6548 - 6551
Ruthenium-catalyzed isoquinolone syntheses with ample scope were accomplished through carboxylate assistance in environmentally benign water as a reaction... 
ROOM-TEMPERATURE | PALLADIUM | HETEROCYCLES | ARENES | CHEMISTRY, ORGANIC | DIRECT ARYLATIONS | OXIDES | ALKYNES | DERIVATIVES | H ACTIVATION | Isoquinolines - chemistry | Carboxylic Acids - chemistry | Isoquinolines - chemical synthesis | Water - chemistry | Alkynes - chemistry | Colorimetry | Molecular Structure | Catalysis | Ruthenium - chemistry | Benzamides - chemistry
Journal Article
No results were found for your search.

Cannot display more than 1000 results, please narrow the terms of your search.