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Phytomedicine, ISSN 0944-7113, 02/2019, Volume 53, pp. 79 - 85
In recent years the number of natural products used as pharmaceuticals, components of dietary supplements and cosmetics has increased tremendously requiring... 
Gastrointestinal absorption | Flavonolignans | PAMPA | Silybum marianum | QSAR | DIETARY POLYPHENOLS | CHEMISTRY, MEDICINAL | PREDICTION | PLANT SCIENCES | ISOSILYBIN | INTEGRATIVE & COMPLEMENTARY MEDICINE | 2,3-DEHYDROSILYBIN | PHARMACOLOGY & PHARMACY | SILYMARIN
Journal Article
Journal of Natural Products, ISSN 0163-3864, 12/2018, Volume 81, Issue 12, pp. 2630 - 2637
1,4-Benzodioxane lignans are a class of bioactive compounds that have received much attention through the years. Herein research pertaining to both... 
ANTIOXIDANT ACTIVITY | CHEMISTRY, MEDICINAL | STEREOCHEMISTRY | COMPONENTS | FLAVONOIDS | PLANT SCIENCES | ISOSILYBIN | HEPATITIS-C VIRUS | PHARMACOLOGY & PHARMACY | SILYBUM-MARIANUM | SILYMARIN | INFECTION | CONSTITUENTS
Journal Article
by Zhou, J and Chao, G and Li, YL and Wu, M and Zhong, SZ and Feng, ZY
NEUROSCIENCE LETTERS, ISSN 0304-3940, 10/2016, Volume 632, pp. 92 - 97
A beta-mediated oxidative stress damage is considered a direct cause of Alzheimer's disease (AD). Therefore, drugs that have been developed to block oxidative... 
Oxidative stress | Reactive oxygen species | PROTEIN | Isosilybin | SILYBIN | INDUCTION | SILIBININ | HT-22 cell | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | IN-VITRO | PATHWAY | SILYMARIN | EXPRESSION | TOXIC AGGREGATION
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 06/2019, Volume 27, Issue 12, pp. 2499 - 2507
Anti-melanogenesis effects of silymarin from milk thistle have been reported recently, but detailed tyrosinase inhibition properties of individual components... 
Tyrosinase inhibition | Flavonolignans | Lag time | Binding affinity | Silybum marianum | OXIDATION | CHEMISTRY, MEDICINAL | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ISOSILYBIN | MUSHROOM TYROSINASE | FLUORESCENCE | Tyrosine | Flavonoids | Flavones | Metabolites | Bioflavonoids | Analysis | Milk
Journal Article
Process Biochemistry, ISSN 1359-5113, 01/2013, Volume 48, Issue 1, pp. 184 - 189
► Isosilybin is probably the most potent anticancer compound in silymarin. ► Preparatory method for isolation of optically pure isosilybin A and B was... 
Silybin | Isosilybin | Silymarin | Novozym 435 | Diastereomers | Enzymes | Methods | Universities and colleges
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 01/2013, Volume 54, Issue 4, pp. 315 - 317
The base-catalyzed oxidation of the flavonolignans, silybin, and isosilybin into the corresponding 2,3-dehydro derivatives has been studied and optimized.... 
Silybin | Isosilybin | Oxidation | 2,3-Dehydroisosilybin | 2,3-Dehydrosilybin | CELLS | CHEMISTRY, ORGANIC | KERATINOCYTES | P-GLYCOPROTEIN | MARIANUM | DNA | PROSTATE-CANCER | GROWTH | SILYMARIN | FLAVONOLIGNANS | Derivatives (Financial instruments) | Oxidation-reduction reaction | Organic chemistry | Chemical Sciences
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 11/2013, Volume 54, Issue 46, pp. 6279 - 6282
A new and preparative oxidation of silibinin has been developed to give access to two different silibinin derivatives known for their enhanced antioxidant... 
Silybin | Oxidation | Microwave assisted reactions | Silibinin | 2,3-Dehydrosilybin | ISOSILYBIN | CHEMISTRY, ORGANIC | SILYMARIN | DERIVATIVES | Scavengers | Purification | Heating | Scavenging | Derivatives | Microwaves | Radicals
Journal Article
Journal of Molecular Catalysis. B, Enzymatic, ISSN 1381-1177, 04/2014, Volume 102, pp. 167 - 173
Flavonolignan silybin is a major component of the silymarin complex isolated from seeds of the milk thistle ( ) having strong antioxidant and hepatoprotective... 
Silybin diastereomers | Glucuronidation | Silymarin | Silibinin | Glucuronyl transferase | Keywords | MARIANUM | ISOSILYBIN | CHEMISTRY, PHYSICAL | DIASTEREOMERS | SULFOTRANSFERASE | Metabolites
Journal Article
Journal of Chromatography A, ISSN 0021-9673, 2003, Volume 990, Issue 1, pp. 239 - 245
Journal Article
Chinese Journal of Chromatography (Se Pu), ISSN 1000-8713, 2017, Volume 35, Issue 1, pp. 70 - 74
Journal Article
Journal Article
Journal of Molecular Catalysis. B, Enzymatic, ISSN 1381-1177, 05/2013, Volume 89, pp. 24 - 27
► Optically pure stereomers of silybin and isosilybin were sulfated. ► Arylsulfotransferase from was applied as a biocatalyst. ► The respective 20- -sulfates... 
Silibinin | Biotransformation | Diastereoisomers | Silybin | Isosilybin | Arylsulfate sulfotransferase | Sulfation | HEPATOCYTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | CHEMISTRY, PHYSICAL | EXCRETION | PLASMA | GROWTH | SILYMARIN | Sulfates | Universities and colleges
Journal Article
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