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Angewandte Chemie International Edition, ISSN 1433-7851, 10/2015, Volume 54, Issue 43, pp. 12584 - 12587
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2002, Volume 99, Issue 3, pp. 1158 - 1163
Isopentenyl diphosphate and dimethylallyl diphosphate serve as the universal precursors for the biosynthesis of terpenes. Although their biosynthesis by means... 
Enzymes | Chemical equilibrium | Biological Sciences | Metabolites | Plasmids | Terpenoids | Atoms | Biosynthesis | Biochemistry | Diphosphates | Terpenes | Biosynthesis of isoprenoids | Isopentenyl diphosphate | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate | Dimethylallyl diphosphate | PRECURSOR | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | THIAMIN | 4-(CYTIDINE 5'-DIPHOSPHO)-2-C-METHYL-D-ERYTHRITOL | biosynthesis of isoprenoids | ENZYME | GENE | ISOPRENOID BIOSYNTHESIS | 5-PHOSPHATE | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate isopentenyl diphosphate | dimethylallyl diphosphate | ISOPENTENYL-DIPHOSPHATE ISOMERASE | Recombinant Proteins - metabolism | Promoter Regions, Genetic | Magnetic Resonance Spectroscopy | Operon | Bacterial Proteins - genetics | Oligodeoxyribonucleotides - chemistry | Enterobacteriaceae - genetics | Molecular Sequence Data | Mevalonic Acid - metabolism | Escherichia coli Proteins | Terpenes - metabolism | Escherichia coli - genetics | Base Sequence | Escherichia coli - metabolism | Bacterial Proteins - metabolism | Oxidoreductases | Mycobacterium tuberculosis - genetics | Physiological aspects | Genetic research | Analysis | ispH gene | mevalonic acid | lytB gene | terpenes | isopentenyl diphosphate | biosynthesis of isoprenoids‖1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate‖isopentenyl diphosphate‖dimethylallyl diphosphate
Journal Article
Journal Article
Journal Article
ChemBioChem, ISSN 1439-4227, 11/2017, Volume 18, Issue 21, pp. 2137 - 2144
IspH, also called LytB, a protein involved in the biosynthesis of isoprenoids through the methylerythritol phosphate pathway, is an attractive target for the... 
X-ray crystallography | In silico docking | MEP pathway inhibitors | LytB/IspH | [4Fe-4S] cluster | CHEMISTRY, MEDICINAL | MECHANISM | METHYLERYTHRITOL PHOSPHATE-PATHWAY | PROTEIN ISPH | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIPHOSPHATE REDUCTASE | NON-MEVALONATE-PATHWAY | 4FE-4S CLUSTER | ENZYME | SPECTROSCOPY | ISOPRENOID BIOSYNTHESIS | Oxidoreductases - antagonists & inhibitors | Escherichia coli - enzymology | Erythritol - analogs & derivatives | Oxidoreductases - metabolism | Escherichia coli - drug effects | Enzyme Inhibitors - pharmacology | Crystallography, X-Ray | Escherichia coli Proteins - metabolism | Enzyme Inhibitors - chemical synthesis | Oxidoreductases - chemistry | Anti-Bacterial Agents - chemical synthesis | Sugar Phosphates - metabolism | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Drug Design | Anti-Bacterial Agents - pharmacology | Erythritol - metabolism | Molecular Docking Simulation | Molecular Structure | Escherichia coli Proteins - antagonists & inhibitors | Escherichia coli Proteins - chemistry | Phosphates | Anti-infective agents | Structure | Escherichia coli | Crystals | Drugs | Inhibitors | E coli | Antimicrobial agents | Protein biosynthesis | Biosynthesis | Terpenes | Drug development | Antiinfectives and antibacterials | Crystal structure | Life Sciences | Biomolecules | Biochemistry, Molecular Biology
Journal Article
Journal Article
Journal Article
Angewandte Chemie, ISSN 0044-8249, 02/2013, Volume 125, Issue 7, pp. 2172 - 2175
Das Eisen‐Schwefel‐Protein IspH katalysiert einen Schlüsselschritt in der Biosynthese von Isoprenoiden in Bakterien und Malariaparasiten. Kristallstrukturen... 
IspH | Bioanorganische Chemie | Metalloenzyme | Terpenoide | LytB | Beta lactamases
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2002, Volume 99, Issue 19, pp. 12108 - 12113
Earlier in vivo studies showed the involvement of IspH protein in the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate... 
Proteins | Enzymes | Biological Sciences | Sodium | Plasmids | Chromoplasts | Biosynthesis | Catalytic activity | Diphosphates | Experimental procedures | Cell extracts | IspH | lytB | Isopentenyl diphosphate | Deoxyxylulose | Isoprenoids | PROTEIN | isoprenoids | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE | MULTIDISCIPLINARY SCIENCES | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE | ESCHERICHIA-COLI | 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL | isopentenyl diphosphate | deoxyxylulose | 4-(CYTIDINE 5'-DIPHOSPHO)-2-C-METHYL-D-ERYTHRITOL | 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE | ispH | ENZYME | ISOPRENOID BIOSYNTHESIS | NONMEVALONATE PATHWAY | Recombinant Proteins - metabolism | Amino Acid Sequence | Capsicum - enzymology | Escherichia coli - enzymology | Oxidoreductases - metabolism | Oxidoreductases - genetics | Bacterial Proteins - genetics | Molecular Sequence Data | Recombinant Proteins - genetics | Organophosphorus Compounds - metabolism | Capsicum - genetics | Sequence Homology, Amino Acid | Terpenes - chemistry | Animals | DNA, Bacterial - genetics | Escherichia coli Proteins | Terpenes - metabolism | Escherichia coli - genetics | Base Sequence | Cloning, Molecular | Hemiterpenes | Bacterial Proteins - metabolism | Physiological aspects | Research | Cytochemistry | Molecular biology | Terpenes | Gene expression
Journal Article