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isthmic organizer (290) 290
animals (253) 253
developmental biology (163) 163
mice (129) 129
index medicus (119) 119
gene expression regulation, developmental (108) 108
mesencephalon - embryology (97) 97
neurosciences (85) 85
homeodomain proteins - genetics (77) 77
fgf8 (74) 74
midbrain (74) 74
mesencephalon - metabolism (68) 68
cell biology (67) 67
mid/hindbrain organizer (64) 64
homeodomain proteins - metabolism (62) 62
brain (61) 61
rhombencephalon - embryology (56) 56
gene-expression (55) 55
central-nervous-system (54) 54
humans (54) 54
cerebellum (52) 52
in situ hybridization (52) 52
midbrain-hindbrain boundary (52) 52
expression (51) 51
chick embryo (50) 50
neural plate (49) 49
gene expression (48) 48
transcription factors - genetics (48) 48
mouse (46) 46
hindbrain (45) 45
otx2 (45) 45
zebrafish (45) 45
nerve tissue proteins - genetics (44) 44
signal transduction (41) 41
fibroblast growth factor 8 (40) 40
fibroblast growth factors - metabolism (40) 40
female (39) 39
brain - embryology (38) 38
rhombencephalon - metabolism (38) 38
transcription factors - metabolism (38) 38
cerebellum - embryology (37) 37
chick-embryo (37) 37
mesencephalon - cytology (36) 36
morphogenesis (36) 36
body patterning (35) 35
fibroblast growth factors (35) 35
mesencephalon (35) 35
nervous system (35) 35
nervous-system (35) 35
body patterning - genetics (34) 34
otx2 expression (34) 34
transcription factors (34) 34
gbx2 (33) 33
molecular biology (33) 33
otx transcription factors (33) 33
gene expression regulation, developmental - physiology (32) 32
mice, transgenic (32) 32
neurogenesis (32) 32
neurons (32) 32
signal transduction - physiology (32) 32
fibroblast growth factors - genetics (30) 30
neurons - cytology (30) 30
sonic hedgehog (30) 30
zebrafish - embryology (30) 30
article (28) 28
neurons - metabolism (28) 28
embryonic structures (27) 27
homeobox gene (27) 27
int-1 protooncogene (27) 27
mice, knockout (27) 27
animal structures (26) 26
cell differentiation (25) 25
forebrain (25) 25
male (25) 25
nerve tissue proteins - metabolism (25) 25
trans-activators - genetics (25) 25
brain - metabolism (24) 24
chick (24) 24
differentiation (24) 24
molecular sequence data (24) 24
research (24) 24
zebrafish proteins (24) 24
anatomy & morphology (23) 23
body patterning - physiology (23) 23
fibroblast growth factor 8 - genetics (23) 23
gene expression regulation, developmental - genetics (23) 23
prosencephalon - embryology (23) 23
rhombencephalon - cytology (23) 23
fgf (22) 22
fibroblast growth factor 8 - metabolism (22) 22
gene (22) 22
sonic-hedgehog (22) 22
cerebellum - metabolism (21) 21
development (21) 21
embryonic development (21) 21
models, biological (21) 21
mutation (21) 21
analysis (20) 20
cell proliferation (20) 20
floor plate (20) 20
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Nature Neuroscience, ISSN 1097-6256, 06/2008, Volume 11, Issue 6, pp. 641 - 648
Journal Article
Trends in Genetics, ISSN 0168-9525, 2000, Volume 16, Issue 6, pp. 237 - 240
Regional diversity along the anterior-posterior axis of the central nervous system is established during gastrulation and is subsequently refined by local... 
Positioning | Otx2gBX2 | Midbrain–hindbrain boundary | Brain regionalization | fGF8 | Isthmic organiser | BRAIN MORPHOGENESIS | VISCERAL ENDODERM | FGF8 | MID/HINDBRAIN ORGANIZER | GENETICS & HEREDITY | ROSTRAL BRAIN | NEURAL PLATE | SPECIFICATION | MIDBRAIN-HINDBRAIN BOUNDARY | EXPRESSION | SEQUENTIAL ROLES | Otx2 gene | Gbx2 gene
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2003, Volume 23, Issue 10, pp. 4199 - 4207
Midbrain dopaminergic and hindbrain serotonergic neurons play an important role in the modulation of behavior and are involved in a series of neuropsychiatric... 
Development | Raphe nuclei | Isthmic organizer | Hyperactivity | Ventral tegmental area | Substantia nigra | isthmic organizer | development | substantia nigra | hyperactivity | DEFICIT HYPERACTIVITY DISORDER | DEVELOPMENTAL DEFECTS | NEURAL PLATE | NEUROSCIENCES | raphe nuclei | ATTENTION-DEFICIT/HYPERACTIVITY DISORDER | ventral tegmental area | GENE | GBX2 | NEURONS | OTX2 | EXPRESSION | Organizers, Embryonic - physiology | Serotonin - physiology | Mesencephalon - cytology | Nerve Tissue Proteins - deficiency | Gene Expression Regulation, Developmental - genetics | Organizers, Embryonic - cytology | Male | Neurons - cytology | Otx Transcription Factors | Trans-Activators - physiology | Rhombencephalon - cytology | Mesencephalon - anatomy & histology | Dopamine - physiology | Neurons - physiology | Trans-Activators - genetics | Female | Mice, Inbred DBA | Mesencephalon - physiology | Gene Expression Regulation, Developmental - physiology | Organizers, Embryonic - anatomy & histology | Nerve Tissue Proteins - physiology | Rhombencephalon - anatomy & histology | Mice, Inbred C57BL | Behavior, Animal - physiology | Mice, Transgenic | Brain Mapping - methods | Mice, Inbred Strains | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Rhombencephalon - physiology | Animals | Trans-Activators - deficiency | Mice | Mice, Congenic | Homeodomain Proteins - physiology | Plasticity | Repair
Journal Article
Development, ISSN 0950-1991, 06/2003, Volume 130, Issue 12, pp. 2633 - 2644
Journal Article
Molecules and cells, ISSN 1016-8478, 02/2018, Volume 41, Issue 2, pp. 110 - 118
The objective of this study was to induce the production of isthmic organizer (IsO)-like cells capable of secreting fibroblast growth factor (FGF) 8 and WNT1... 
isthmic organizer | human pluripotent stem cells | FGF | neural differentiation | Wnt | NERVOUS-SYSTEM | FOREBRAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | BRAIN-DEVELOPMENT | MODEL | OTX2 EXPRESSION | CELL BIOLOGY | FGF8 | ANTERIOR HINDBRAIN | NEURONS | MIDBRAIN | 생물학
Journal Article
Developmental Biology, ISSN 0012-1606, 04/2011, Volume 352, Issue 2, pp. 341 - 352
The midbrain–hindbrain boundary (MHB) acts as an organiser/signalling centre to pattern tectal and cerebellar compartments. Cells in adjacent compartments must... 
Lrrn1 | Capricious | Midbrain–hindbrain boundary organiser | Tartan | Boundary | Midbrain-hindbrain boundary organiser | MID/HINDBRAIN ORGANIZER | DEVELOPMENTAL BIOLOGY | MOUSE NERVOUS-SYSTEM | OTX2 EXPRESSION | EPH RECEPTORS | RICH REPEATS | ANTERIOR HINDBRAIN | GENE-EXPRESSION | WNT1 EXPRESSION | ISTHMIC ORGANIZER | TRANSMEMBRANE PROTEIN | Mesencephalon - cytology | Mesencephalon - metabolism | Receptors, Notch - metabolism | Fibroblast Growth Factors - genetics | Receptors, Notch - genetics | Organizers, Embryonic - embryology | Rhombencephalon - cytology | Fibroblast Growth Factors - metabolism | Transfection | Gene Expression Regulation, Developmental | Body Patterning | Rhombencephalon - embryology | Recombinant Proteins - metabolism | Avian Proteins - metabolism | Signal Transduction | Animals, Genetically Modified | Recombinant Proteins - genetics | Chick Embryo | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Mesencephalon - embryology | Organizers, Embryonic - metabolism | Cell Aggregation | Rhombencephalon - metabolism | Avian Proteins - genetics | Brain | Cerebellum | Mesencephalon | Glycosyltransferase | Fibroblast growth factor 8 | Boundaries | Neuromodulation | Leg | Eye | Wings | Cell fate | Hindbrain | Notch protein | Imaginal discs | Basic Medicine | Biological Sciences | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | Naturvetenskap | Biologiska vetenskaper | Medicinska och farmaceutiska grundvetenskaper | Natural Sciences | Developmental Biology | Utvecklingsbiologi | Neurovetenskaper
Journal Article
Journal Article
Neuroscience, ISSN 0306-4522, 2009, Volume 163, Issue 4, pp. 1012 - 1023
Journal Article
Journal Article
International Journal of Developmental Biology, ISSN 0214-6282, 2001, Volume 45, Issue 1, pp. 367 - 371
Journal Article