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FEBS Letters, ISSN 0014-5793, 2004, Volume 574, Issue 1, pp. 37 - 41
Engagement of the immunoinhibitory receptor, programmed death‐1 (PD‐1) attenuates T‐cell receptor (TCR)‐mediated activation of IL‐2 production and T‐cell... 
TCR signaling | ZAP70 | Immunoinhibition | CD3ζ ITAM
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 9/2017, Volume 199, Issue 5, pp. 1555 - 1560
In order for the αβ or γδT cell receptor chains (TCR) to integrate extracellular stimuli into the appropriate intracellular cellular response, they must... 
development | TCR | CD3 | signaling | ITAM | thymocyte
Journal Article
Blood, ISSN 0006-4971, 03/2010, Volume 115, Issue 10, pp. 2008 - 2013
During platelet activation, phosphoinositide 3-kinases (PI3Ks) produce lipid second messengers participating in the regulation of functional responses. Here,... 
PHOSPHOLIPASE C-GAMMA-2 | STIMULATION | PATHWAY | ITAM | MEDIATED ACTIVATION | HEMATOLOGY | PEPTIDE
Journal Article
Journal of Hematology and Oncology, 10/2018, Volume 11, Issue 1
Journal Article
Bone, ISSN 8756-3282, 01/2020, Volume 130, p. 115140
Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by severe joint inflammation and bone destruction as the result of increased numbers... 
oxLDL | Osteoclasts | Bone destruction | ITAM co-stimulation pathway | High LDL levels
Journal Article
Cell Reports, ISSN 2211-1247, 04/2019, Volume 27, Issue 3, pp. 762 - 775.e5
Direct bacterial recognition by innate receptors is crucial for bacterial clearance. Here, we show that the IgA receptor CD89 is a major innate receptor that... 
Fc receptor | innate receptor | ITAM | sepsis | host defense | MICROORGANISMS | FC-ALPHA-RI | CELLS | IGA | ACTIVATION | IMMUNOGLOBULIN-A | NEGATIVE REGULATION | INHIBITORY ITAMS | IDENTIFICATION | EXPRESSION | CELL BIOLOGY
Journal Article
Thrombosis Research, ISSN 0049-3848, 04/2019, Volume 176, pp. 108 - 114
The main role of platelets is to control haemostasis when there is a blood vessel injury in order to minimise blood loss at the injury site. Under normal... 
Platelets | Haemostasis | ITAM | ITIM | Integrin αIIbβ3 | IMMUNOGLOBULIN SUPERFAMILY | PECAM-1 | COLLAGEN RECEPTOR | MEMBER | CELL-ADHESION MOLECULE-1 | RECEPTOR GLYCOPROTEIN VI | IN-VITRO | ACTIVATION MOTIF ITAM | SIGNALING PATHWAY | Integrin alpha IIb beta 3 | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | ASSOCIATION | Tyrosine | Thrombosis | Nitric oxide | Blood clot | Integrins | Endothelium
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue 18, pp. 1951 - 1962
RAP GTPases, important regulators of cellular adhesion, are abundant signaling molecules in the platelet/megakaryocytic lineage. However, mice lacking the... 
NADPH OXIDASE | INTEGRIN ACTIVATION | PROTEIN | ACTIVATION MOTIF ITAM | ALPHA-IIB-BETA-3 ACTIVATION | INFLAMMATION | KINASE | CALDAG-GEFI | SECRETION | HEMATOLOGY | HEMOSTASIS | Platelets and Thrombopoiesis
Journal Article
Protein Science, ISSN 0961-8368, 10/2018, Volume 27, Issue 10, pp. 1780 - 1796
Spleen tyrosine kinase (Syk) is an essential player in immune signaling through its ability to couple multiple classes of membrane immunoreceptors to... 
spleen tyrosine kinase (Syk) | tyrosine phosphorylation allostery | entropic allostery | multistate equilibrium with isomerization | regulation of protein–protein interaction | multi‐domain ensemble thermodynamics | NMR chemical shift difference analysis | tandem SH2 domain (tSH2) | doubly phosphorylated immunoreceptor tyrosine‐based activation motif (dp‐ITAM) | isothermal titration calorimetry model and data analysis | doubly phosphorylated immunoreceptor tyrosine-based activation motif (dp-ITAM) | multi-domain ensemble thermodynamics | LIGAND-BINDING | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | 3-KINASE SH2 DOMAIN | TANDEM SH2 | ISOTHERMAL TITRATION CALORIMETRY | PROTEIN INTERACTIONS | NMR | regulation of protein-protein interaction | STRUCTURAL BASIS | CELL ANTIGEN RECEPTOR | STRESS GRANULES | Phosphorylation | Syk Kinase - metabolism | Humans | Models, Molecular | Entropy | Immunoreceptor Tyrosine-Based Activation Motif | Syk Kinase - chemistry | Proteins | Tyrosine | Thermodynamics | Analysis | Isomerization | Phenols | Information management | Protein-protein interactions | Nuclear magnetic resonance--NMR | Enthalpy | Intracellular signalling | Kinases | Receptors | Allosteric properties | Protein-tyrosine kinase | Binding | Spleen | Titration calorimetry | Free energy | Domains | Organic chemistry | Chemical equilibrium | Calorimetry | Affinity | Syk protein | Titration | Immunoreceptor tyrosine-based activation motif | Protein interaction | Full‐Length Papers | Full‐Length Paper
Journal Article
Cellular Microbiology, ISSN 1462-5814, 11/2016, Volume 18, Issue 11, pp. 1570 - 1582
Journal Article
FEBS LETTERS, ISSN 0014-5793, 09/2004, Volume 574, Issue 1-3, pp. 37 - 41
Engagement of the immunoinhibitory receptor, programmed death-1 (PD-1) attenuates T-cell receptor (TCR)-mediated activation of IL-2 production and T-cell... 
ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | ZAP70 | B7 FAMILY-MEMBER | SHP-2 | BIOPHYSICS | immunoinhibition | ENDOTHELIAL-CELLS | TCR signaling | CD3 xi ITAM | MOUSE T | CTLA-4 | EXPRESSION | PROTEIN-TYROSINE-PHOSPHATASE | PD-1-DEFICIENT MICE | LYMPHOCYTES
Journal Article