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Protein Science, ISSN 0961-8368, 10/2018, Volume 27, Issue 10, pp. 1780 - 1796
Spleen tyrosine kinase (Syk) is an essential player in immune signaling through its ability to couple multiple classes of membrane immunoreceptors to... 
spleen tyrosine kinase (Syk) | tyrosine phosphorylation allostery | entropic allostery | multistate equilibrium with isomerization | regulation of protein–protein interaction | multi‐domain ensemble thermodynamics | NMR chemical shift difference analysis | tandem SH2 domain (tSH2) | doubly phosphorylated immunoreceptor tyrosine‐based activation motif (dp‐ITAM) | isothermal titration calorimetry model and data analysis | doubly phosphorylated immunoreceptor tyrosine-based activation motif (dp-ITAM) | multi-domain ensemble thermodynamics | LIGAND-BINDING | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | 3-KINASE SH2 DOMAIN | TANDEM SH2 | ISOTHERMAL TITRATION CALORIMETRY | PROTEIN INTERACTIONS | NMR | regulation of protein-protein interaction | STRUCTURAL BASIS | CELL ANTIGEN RECEPTOR | STRESS GRANULES | Phosphorylation | Syk Kinase - metabolism | Humans | Models, Molecular | Entropy | Immunoreceptor Tyrosine-Based Activation Motif | Syk Kinase - chemistry | Proteins | Tyrosine | Thermodynamics | Analysis | Isomerization | Phenols | Information management | Protein-protein interactions | Nuclear magnetic resonance--NMR | Enthalpy | Intracellular signalling | Kinases | Receptors | Allosteric properties | Protein-tyrosine kinase | Binding | Spleen | Titration calorimetry | Free energy | Domains | Organic chemistry | Chemical equilibrium | Calorimetry | Affinity | Syk protein | Titration | Immunoreceptor tyrosine-based activation motif | Protein interaction | Full‐Length Papers | Full‐Length Paper
Journal Article
Journal Article
Journal Article
Journal Article
Molecular Biology Reports, ISSN 0301-4851, 3/2012, Volume 39, Issue 3, pp. 3185 - 3196
Journal Article
Clinical Reviews in Allergy & Immunology, ISSN 1080-0549, 8/2016, Volume 51, Issue 1, pp. 48 - 58
Osteoclasts require coordinated co-stimulation by several signaling pathways to initiate and regulate their cellular differentiation. Receptor activator for... 
Allergology | Immunoreceptor | Immunology | Fc receptor | Medicine & Public Health | ITAM | Internal Medicine | Osteoimmunology | Osteoclast | RANK | HUMAN DENDRITIC CELLS | SIALIC-ACID | MEDIATED COSTIMULATION | IMMUNOLOGY | MYELOID CELLS | DAP12-ASSOCIATING LECTIN (MDL)-1 | DNAX-ACTIVATING PROTEIN | BONE LOSS | IMMUNE-SYSTEM | ALLERGY | FUNCTIONAL OSTEOCLASTS | FCR-GAMMA | Receptors, Immunologic - chemistry | RANK Ligand - metabolism | Signal Transduction | Immunomodulation | Humans | Receptors, Fc - metabolism | Bone Resorption - immunology | Osteoclasts - metabolism | Animals | Bone Resorption - genetics | Biomarkers | Bone Resorption - metabolism | Protein Binding | Protein Interaction Domains and Motifs | Receptor Activator of Nuclear Factor-kappa B - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Receptors, Immunologic - metabolism | Tyrosine | Cell differentiation | Tumor necrosis factor | Phosphoproteins | Immunity | Differentiation (biology) | Homeostasis | Stimulation | Proteins | Receptors | Tumor necrosis factor-TNF | Biocompatibility | TRANCE protein | Binding | Adaptor proteins | NF-κB protein | Myeloid cells | Immunoglobulins | Bone turnover | Adaptors | DAP12 protein | Osteoclastogenesis | Fc receptors | Signaling | Regulatory mechanisms (biology) | Ligands | Osteoclasts | Immunoreceptor tyrosine-based activation motif | Immunoreceptor tyrosine-based inhibition motif | Bone | Fc Receptor
Journal Article
International Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article