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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2012, Volume 20, Issue 9, pp. 2912 - 2922
In this study, eighteen new isoxazolo[4,5- ]pyridazin-4(5 )-one derivatives possessing either a 1,3,4-thiadiazole or a 1,2,4-triazole-5-thione moiety were... 
Docking | Cyclooxygenase | Isoxazolo[4,5-d]pyridazin-4-(5H)-one | Lipoxygenase | NSAID | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ACETIC-ACID | ASPIRIN | SELECTIVE COX-2 INHIBITORS | 1,3,4-THIADIAZOLE DERIVATIVES | MUCOSAL INTEGRITY | CYCLOOXYGENASE-2 INHIBITORS | IN-VIVO | DRUGS | DUAL INHIBITORS | PHARMACOLOGICAL EVALUATION | Humans | Pyridazines - pharmacology | Cyclooxygenase 2 Inhibitors - chemistry | Lipoxygenase Inhibitors - chemistry | Computer Simulation | Protein Binding - drug effects | Arachidonate 5-Lipoxygenase - chemistry | Cyclooxygenase 2 Inhibitors - therapeutic use | Anti-Inflammatory Agents - therapeutic use | Binding Sites | Pyridazines - therapeutic use | Catalytic Domain | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Lipoxygenase Inhibitors - therapeutic use | Rats | Edema - drug therapy | Isoxazoles - chemistry | Enzyme Activation - drug effects | Pyridazines - chemistry | Animals | Cyclooxygenase 2 - metabolism | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - pharmacology | Anti-inflammatory drugs | Heterocyclic compounds | Analysis | Index Medicus | Drugs | Edema | Enzymes | Antiinflammatory agents | Molecular modelling | scaffolds | Cyclooxygenase-1 | Ulcers | Ibuprofen | Inflammation | Cyclooxygenase-2
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2010, Volume 20, Issue 4, pp. 1324 - 1329
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 422 - 432
Phospho-nonsteroidal anti-inflammatory drugs (phospho-NSAIDs) are novel NSAID derivatives with improved anticancer activity and reduced side effects in... 
Organophosphates - metabolism | Indomethacin - analogs & derivatives | Naproxen - analogs & derivatives | Humans | Naproxen - pharmacology | Phenylglyoxal - analogs & derivatives | Indomethacin - metabolism | Valproic Acid - analogs & derivatives | Anti-Inflammatory Agents, Non-Steroidal - blood | Naproxen - metabolism | Organophosphorus Compounds - metabolism | Valproic Acid - pharmacology | Ibuprofen - analogs & derivatives | Aspirin - metabolism | Nitrophenols - therapeutic use | Organophosphorus Compounds - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Aspirin - pharmacology | Carboxylesterase - antagonists & inhibitors | Valproic Acid - metabolism | Cell Survival - drug effects | Organophosphates - blood | Enzyme Inhibitors - pharmacology | Organophosphorus Compounds - therapeutic use | Stomach Neoplasms - drug therapy | Ibuprofen - metabolism | Indomethacin - pharmacology | Aspirin - analogs & derivatives | Mice, Nude | Carboxylesterase - genetics | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Kinetics | Organophosphates - therapeutic use | Stomach Neoplasms - pathology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Sulindac - metabolism | Transfection | Nitrophenols - pharmacology | HEK293 Cells | Inhibitory Concentration 50 | Female | Sulindac - blood | Carboxylic Ester Hydrolases - genetics | Carboxylic Ester Hydrolases - antagonists & inhibitors | Ibuprofen - pharmacology | Phenylglyoxal - pharmacology | Sulindac - therapeutic use | Carboxylesterase - metabolism | Hydrolysis | Organophosphates - pharmacology | Xenograft Model Antitumor Assays | Sulindac - analogs & derivatives | Drug Therapy, Combination - methods | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Drug Interactions - physiology | Organophosphorus Compounds - blood | Sulindac - pharmacology | Carboxylic Ester Hydrolases - metabolism | Index Medicus | Metabolism, Transport, and Pharmacogenomics
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 04/2019, Volume 85, pp. 577 - 584
A series of novel naproxen analogues containing 3-aryl-1,2,4-oxadiazoles moiety and their reaction intermediates aryl carboximidamides moiety was synthesized... 
15- LOX | COX-2 | COX-1 | Naproxen | Aryl carboximidamides | Anti-inflammatory | 1, 2, 4-oxadiazoles | DRUG-THERAPY | CYCLOOXYGENASE-2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | LEUKOTRIENES | 15-LOX | IBUPROFEN | BIOLOGICAL EVALUATION | ROFECOXIB | OSTEOARTHRITIS | 5-LOX | INSIGHTS | Meclofenamate | COX-2 inhibitors | Analysis | Pharmacy | Crystals | Drugstores | Structure
Journal Article
Drug Design, Development and Therapy, ISSN 1177-8881, 10/2016, Volume 10, pp. 3529 - 3543
This article reports on the design, synthesis, and pharmacological activity of a new series of hybrid pyrazole analogues: 5a-5u. Among the series 5a-5u, the... 
Molecular docking studies | Anti-inflammatory activity | TNFα inhibition | Selective COX2 inhibition | Analgesic activity | Pyrazole | GASTROINTESTINAL TOXICITY | RHEUMATOID-ARTHRITIS | molecular docking studies | selective COX2 inhibition | CHEMISTRY, MEDICINAL | TNF alpha | CYCLOOXYGENASE-2 | pyrazole | inhibition | anti-inflammatory activity | ANTICANCER | DRUGS | BIOLOGICAL EVALUATION | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | analgesic activity | DERIVATIVES | STRUCTURE-BASED DESIGN | Cyclooxygenase 2 Inhibitors - chemical synthesis | Pyrazoles - therapeutic use | Ibuprofen - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Pyrazoles - chemical synthesis | Cyclooxygenase 2 - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Pyrazoles - chemistry | Ibuprofen - chemistry | Hydrogen Bonding | Analgesics - chemical synthesis | Analgesics - chemistry | Molecular Docking Simulation | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Drugs | Anti-inflammatory drugs | Pyrazoles | Structure-activity relationship (Pharmacology) | Comparative analysis | Structure-activity relationships | Health aspects | Testing | Nuclear magnetic resonance--NMR | Laboratories | Hydrocarbons | Cytotoxicity | Selectivity | Design | Analgesics | Ibuprofen | Toxicity testing | Docking | Biocompatibility | Physiology | Inhibition | Nonsteroidal anti-inflammatory drugs | Enzymes | Antiinflammatory agents | Ethanol | Pharmacology | Inflammation | Celecoxib | Tumor necrosis factor-α | Chromatography | Studies | Chemistry | Acids | Ligands | In vivo methods and tests | Cyclooxygenase-2 | Cancer | Index Medicus | Selective COX-II inhibition | TNF-α inhibition
Journal Article
Journal Article
Inorganic Chemistry Communications, ISSN 1387-7003, 08/2016, Volume 70, pp. 47 - 50
In order to improve the interaction of MIL-101(Cr) with ibuprofen (IBU) and nimesulide (NMS), its functionalization with NH groups was proposed. MIL-101(Cr)... 
Controlled drug release | Nimesulide | MIL-101(Cr) | Ibuprofen | CATALYSIS | DRUG-DELIVERY | SORPTION | SITES | CHEMISTRY, INORGANIC & NUCLEAR | Amines
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 2/2013, Volume 28, Issue 1, pp. 172 - 182
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2007, Volume 565, Issue 1, pp. 26 - 36
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2010, Volume 51, Issue 40, pp. 5246 - 5251
A novel approach for a one-pot, three-component reductive alkylation (TCRA) reaction of arylacetonitriles-containing electron-withdrawing groups with... 
Amino acids | Cascade reactions | Organocatalysis | Ibuprofen analogs | TCRA reactions | ELECTROPHILICITY PARAMETERS | ALDOL | ASYMMETRIC-SYNTHESIS | KNOEVENAGEL | MICHAEL | CHEMISTRY, ORGANIC | KETONE ANALOGS | HYDROTALCITE | ALCOHOLS | NITRILES | CONDENSATION | Ibuprofen | Analogs | Agricultural chemicals | Synthesis (chemistry) | Ketones | Cascades | Tetrahedrons | Reductive alkylation
Journal Article
Journal Article
Archiv der Pharmazie, ISSN 0365-6233, 01/2015, Volume 348, Issue 1, pp. 55 - 61
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 03/2012, Volume 83, Issue 6, pp. 715 - 722
Journal Article