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index medicus (63) 63
humans (58) 58
female (25) 25
male (25) 25
animals (23) 23
ichthyosis - enzymology (21) 21
ichthyosis - genetics (21) 21
dermatology (19) 19
epidermis - enzymology (18) 18
steryl-sulfatase (17) 17
cell biology (15) 15
skin (13) 13
skin - enzymology (13) 13
ichthyosis (12) 12
mice (11) 11
epidermis (10) 10
integumentary system (10) 10
mutation (10) 10
adult (9) 9
child (9) 9
child, preschool (9) 9
intermediate filament proteins - metabolism (9) 9
keratinocytes (9) 9
skin - pathology (9) 9
x chromosome (9) 9
adolescent (8) 8
biochemistry (8) 8
dermatology & venereal diseases (8) 8
differentiation (8) 8
filaggrin (8) 8
gene deletion (8) 8
genetic aspects (8) 8
ichthyosis - pathology (8) 8
ichthyosis vulgaris (8) 8
keratinocytes - enzymology (8) 8
molecular biology (8) 8
proteins (8) 8
stratum-corneum (8) 8
x-linked ichthyosis (8) 8
arylsulfatases - deficiency (7) 7
arylsulfatases - genetics (7) 7
barrier function (7) 7
biochemistry & molecular biology (7) 7
genetic linkage (7) 7
lamellar ichthyosis (7) 7
research article (7) 7
sulfatases - deficiency (7) 7
abridged index medicus (6) 6
aged (6) 6
atopic-dermatitis (6) 6
gene (6) 6
genetics (6) 6
genetics & heredity (6) 6
heterozygote (6) 6
ichthyosis, x-linked - enzymology (6) 6
infant, newborn (6) 6
middle aged (6) 6
mutation, missense (6) 6
pedigree (6) 6
physiological aspects (6) 6
placenta - enzymology (6) 6
pregnancy (6) 6
proteases (6) 6
serine endopeptidases - genetics (6) 6
skin diseases (6) 6
transglutaminases - metabolism (6) 6
amino acid sequence (5) 5
analysis (5) 5
cell differentiation (5) 5
cells, cultured (5) 5
cholesterol sulfate (5) 5
endocrinology & metabolism (5) 5
epidermis - pathology (5) 5
gene expression regulation, enzymologic (5) 5
genes, recessive (5) 5
ichthyosis - diagnosis (5) 5
ichthyosis, x-linked - genetics (5) 5
identification (5) 5
infant (5) 5
intermediate filament proteins - genetics (5) 5
keratinocytes - pathology (5) 5
leukocytes - enzymology (5) 5
mutations (5) 5
netherton-syndrome (5) 5
research (5) 5
serine endopeptidases - metabolism (5) 5
skin - metabolism (5) 5
transglutaminases - genetics (5) 5
base sequence (4) 4
cell differentiation - physiology (4) 4
cell line (4) 4
dermatitis, atopic - enzymology (4) 4
dermatitis, atopic - genetics (4) 4
desquamation (4) 4
epidermis - cytology (4) 4
epidermis - metabolism (4) 4
expression (4) 4
fibroblasts - enzymology (4) 4
gene expression regulation (4) 4
genes (4) 4
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PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e75355 - e75355
Journal Article
Acta Dermato-Venereologica, ISSN 0001-5555, 1991, Volume 71, Issue 2, pp. 173 - 175
Journal Article
Nature Cell Biology, ISSN 1465-7392, 06/2007, Volume 9, Issue 6, pp. 666 - 674
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 11/2003, Volume 163, Issue 4, pp. 901 - 910
Profilaggrin is a large epidermal polyprotein that is proteolytically processed during keratinocyte differentiation to release multiple filaggrin monomer,... 
Newborns | Antibodies | Keratinocytes | Epidermis | Lipids | Skin diseases | Skin | Mice | Monomers | Ichthyosis | Membrane serine protease | Lipid lamellar bodies | Stratum corneum | Profilaggrin | Barrier function | ICHTHYOSIS VULGARIS | STRUCTURAL PROTEINS | CORNIFIED CELL ENVELOPES | HUMAN STRATUM-CORNEUM | LAMELLAR GRANULES | SERINE-PROTEASE | SKIN BARRIER FUNCTION | PERMEABILITY BARRIER | IDENTIFICATION | HARLEQUIN ICHTHYOSIS | CELL BIOLOGY | Peptide Hydrolases - genetics | Extracellular Matrix - metabolism | Peptide Hydrolases - deficiency | Epidermis - growth & development | Cell Differentiation - genetics | Extracellular Matrix - genetics | Ichthyosis - pathology | Ichthyosis - genetics | Serine Endopeptidases - genetics | Trypsin - genetics | Epidermis - enzymology | Skin Abnormalities - pathology | Keratinocytes - enzymology | Keratinocytes - ultrastructure | Skin Abnormalities - enzymology | Epidermis - pathology | Serine Endopeptidases - deficiency | Dehydration - enzymology | Trypsin - deficiency | Intermediate Filament Proteins - biosynthesis | Lipid Metabolism | S100 Proteins - metabolism | Permeability | Microscopy, Electron | Mice, Knockout | Protein Precursors - metabolism | Membrane Proteins | Keratinocytes - pathology | Animals | Intermediate Filament Proteins - deficiency | Skin Abnormalities - genetics | Ichthyosis - enzymology | Extracellular Matrix - pathology | Intermediate Filament Proteins - metabolism | Cell research | Serine | Calcium compounds | Cell differentiation | Genetic regulation | Proteases | Analysis | Physiological aspects | Genetic aspects | Binding proteins | Proteins | Cellular biology | Matriptase | filaggrin | MT-SP1 protein | Index Medicus | barrier function; lipid lamellar bodies; membrane serine protease; profilaggrin; stratum corneum
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2011, Volume 286, Issue 10, pp. 8204 - 8212
Loss-of-function mutation in the profilaggrin gene is a major risk factor for atopic dermatitis (AD). Previously, we showed that a neutral cysteine protease,... 
TRANSCRIPTION FACTORS | ICHTHYOSIS VULGARIS | FILAGGRIN | HUMAN-CHROMOSOME 1Q21 | AMINO-ACIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | STRATUM-CORNEUM | GENE-EXPRESSION | HOST-DEFENSE | SKIN-BARRIER FUNCTION | HUMAN KERATINOCYTES | Sequence Deletion | Dermatitis, Atopic - genetics | Dermatitis, Atopic - enzymology | Humans | Sp1 Transcription Factor - metabolism | Antiviral Agents - metabolism | Interferon-gamma - metabolism | Interleukin-4 - pharmacology | Kruppel-Like Transcription Factors - metabolism | Base Sequence | Intermediate Filament Proteins - genetics | Cell Differentiation | Keratinocytes - enzymology | Antiviral Agents - pharmacology | Response Elements | Interleukin-4 - metabolism | Cells, Cultured | Dermatitis, Atopic - pathology | Cysteine Endopeptidases - biosynthesis | Gene Expression Regulation, Enzymologic | Keratinocytes - pathology | Sp1 Transcription Factor - genetics | Cysteine Endopeptidases - genetics | Intermediate Filament Proteins - metabolism | Kruppel-Like Transcription Factors - genetics | Interferon-gamma - pharmacology | Index Medicus | Transcription | Cysteine proteinase | Helper cells | Interferon regulatory factor 1 | Lymphocytes T | Filaggrin | Gene deletion | Risk factors | Interleukin 4 | Bleomycin | Atopic dermatitis | Skin diseases | RNA-mediated interference | Keratinocytes | Calpain | Data processing | Inflammation | siRNA | Promoters | Electrophoretic mobility | Site-directed mutagenesis | hydrolase | gamma -Interferon | Mutation | Differentiation | Cysteine Protease | Bleomycin Hydrolase | Natural Moisturizing Factor | Protease | Epidermis | Keratinocyte | Skin | Protein Degradation | Cell Biology
Journal Article
Experimental Dermatology, ISSN 0906-6705, 06/2001, Volume 10, Issue 3, pp. 193 - 203
Journal Article
British Journal of Dermatology, ISSN 0007-0963, 1985, Volume 112, Issue 4, pp. 431 - 433
Twenty-one patients with ichthyosis were classified as either ichthyosis vulgaris (IV) (five cases) or recessive X-linked ichthyosis (RXLI) (sixteen cases) by... 
Diagnosis, Differential | Humans | Male | Sulfatases - deficiency | Genes, Recessive | Leukocytes - enzymology | Ichthyosis - genetics | X Chromosome | Epidermis - enzymology | Female | Steryl-Sulfatase | Ichthyosis - enzymology | Genetic Linkage | Ichthyosis - diagnosis | Index Medicus
Journal Article