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Psychopharmacology, ISSN 0033-3158, 8/2016, Volume 233, Issue 15, pp. 2955 - 2971
Fas-associated death domain (FADD) is an adaptor of death receptors that can also induce anti-apoptotic actions through its phosphorylated form (p-FADD).... 
Neuroplasticity | Neuroprotection | Neurosciences | Biomedicine | FADD and p-FADD | Forced swim test | Anti-depressant drugs | Pharmacology/Toxicology | Psychiatry | Electroconvulsive shock | PRESYNAPTIC AUTORECEPTORS | NEUROTRANSMITTER RELEASE | PSYCHIATRY | ANTIDEPRESSANT TREATMENT | ADRENERGIC-RECEPTOR | MAJOR DEPRESSION | SUICIDE VICTIMS | NEUROSCIENCES | PREFRONTAL CORTEX | MONOAMINE-OXIDASE INHIBITORS | PHARMACOLOGY & PHARMACY | GAMMA-AMINOBUTYRIC-ACID | DEATH DOMAIN PROTEIN | Phosphoproteins - drug effects | Phenelzine - pharmacology | Autoreceptors - metabolism | Clorgyline - pharmacology | Male | Adrenergic alpha-Antagonists - pharmacology | Phosphoproteins - metabolism | Cerebral Cortex - metabolism | Idazoxan - pharmacology | Mianserin - analogs & derivatives | Mianserin - pharmacology | Desipramine - pharmacology | Fluoxetine - analogs & derivatives | Mirtazapine | Antidepressive Agents - pharmacology | Cerebral Cortex - drug effects | Phosphorylation - drug effects | RNA-Binding Proteins - antagonists & inhibitors | Fluoxetine - pharmacology | Idazoxan - analogs & derivatives | Monoamine Oxidase Inhibitors - pharmacology | Fas-Associated Death Domain Protein - drug effects | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Fas-Associated Death Domain Protein - metabolism | Rats | Excitatory Amino Acid Antagonists - pharmacology | Blotting, Western | Brain - drug effects | Animals | CASP8 and FADD-Like Apoptosis Regulating Protein | Thiazoles - pharmacology | Ketamine - pharmacology | Electroshock | Apoptosis | Indans - pharmacology | Pharmacology, Experimental | Antidepressants | Desipramine | Fluoxetine | Psychopharmacology | Dosage and administration | Research
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 01/2006, Volume 26, Issue 2, pp. 467 - 478
In Alzheimer's disease ( AD), there is a significant loss of locus ceruleus (LC) noradrenergic neurons. However, functional and anatomical evidence indicates... 
Norepinephrine | In situ hybridization | Alzheimer's disease | Hippocampus | Adrenoreceptors | Locus ceruleus | norepinephrine | SENILE DEMENTIA | HUMAN ALPHA-2-ADRENERGIC RECEPTOR | locus ceruleus | hippocampus | adrenoreceptors | TYROSINE-HYDROXYLASE | CEREBROSPINAL-FLUID | NEURONAL LOSS | NEUROSCIENCES | DUAL-PROBE MICRODIALYSIS | ADRENERGIC PROJECTION | TRANSPORTER MESSENGER-RNA | HUMAN-BRAIN | RAT-BRAIN | in situ hybridization | Receptors, Adrenergic, alpha-1 - metabolism | Receptors, Adrenergic, alpha-2 - genetics | Locus Coeruleus - chemistry | Hippocampus - chemistry | Norepinephrine - physiology | Humans | Middle Aged | Nerve Tissue Proteins - analysis | Receptors, Adrenergic, alpha-2 - metabolism | Prazosin - metabolism | RNA, Messenger - analysis | Male | Dendrites - ultrastructure | Alzheimer Disease - pathology | RNA, Messenger - biosynthesis | Receptors, Adrenergic, alpha-1 - analysis | In Situ Hybridization | Fluoxetine - analogs & derivatives | Aged, 80 and over | Adult | Female | Idazoxan - analogs & derivatives | Locus Coeruleus - pathology | Lewy Body Disease - pathology | Hippocampus - pathology | Tyrosine 3-Monooxygenase - analysis | Receptors, Adrenergic, alpha-2 - analysis | Nerve Tissue Proteins - genetics | Adrenergic alpha-Antagonists - metabolism | Lewy Body Disease - metabolism | Nerve Tissue Proteins - metabolism | Tyrosine 3-Monooxygenase - biosynthesis | Tyrosine 3-Monooxygenase - genetics | Idazoxan - metabolism | Norepinephrine - chemistry | Receptors, Adrenergic, alpha-1 - genetics | Alzheimer Disease - metabolism | Fluoxetine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - analysis | Aged | Tetralones - metabolism | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Neurobiology of Disease
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 2016, Volume 41, Issue 3, pp. 858 - 868
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 10/2016, Volume 788, pp. 113 - 121
Kinetic on and off rate constants for many receptor ligands are difficult to determine with regular radioligand binding technique since only few of the ligands... 
Off-rate | [3H]-RX821002 | Kinetics | Residence time | Spiroxatrine | MK912 | Idazoxan - analogs & derivatives | Idazoxan - metabolism | Humans | HEK293 Cells | Radioligand Assay - methods | Receptors, Adrenergic, alpha-2 - metabolism | Protein Binding | Ligands | Recombinant Fusion Proteins - metabolism
Journal Article
Brain Structure and Function, ISSN 1863-2653, 6/2016, Volume 221, Issue 5, pp. 2703 - 2715
Journal Article
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 10/2010, Volume 53, Issue 19, pp. 6986 - 6995
We report the discovery of a new family of alpha(2) adrenergic receptor antagonists derived from atipamezole. Affinities of the compounds at human alpha(2) in... 
CHEMISTRY, MEDICINAL | 2-AMINOIMIDAZOLINE AROMATIC DERIVATIVES | LEVODOPA-INDUCED DYSKINESIA | NORADRENALINE RELEASE | SUBTYPES | ALPHA-ADRENOCEPTOR ANTAGONISTS | IDAZOXAN | NOREPINEPHRINE RELEASE | ADRENERGIC-RECEPTORS | PREFRONTAL CORTEX | PARKINSONS-DISEASE
Journal Article
Journal of Immunology, ISSN 0022-1767, 09/2014, Volume 193, Issue 6, pp. 3023 - 3035
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/1999, Volume 42, Issue 9, pp. 1587 - 1603
Journal Article
Psychopharmacology, ISSN 0033-3158, 2014, Volume 231, Issue 8, pp. 1503 - 1515
Rationale Social play behavior is a characteristic form of social behavior displayed by juvenile and adolescent mammals. This social play behavior is highly... 
Adolescence | Taverne | International (English) | Amphetamine | Dopamine | Serotonin | Alpha-2 adrenoceptor | Social play | Cocaine | Noradrenaline | Neurosciences | Biomedicine | Pharmacology/Toxicology | Psychiatry | SUBSTANCE USE | DOPAMINE RELEASE | PSYCHIATRY | ADOLESCENT RATS | LOCOMOTOR-ACTIVITY | ADULT-RATS | JUVENILE RATS | PSYCHOMOTOR STIMULANTS | NEUROSCIENCES | PHARMACOLOGY & PHARMACY | RATTUS-NORVEGICUS | MODULATION | BRAIN | Motor Activity - physiology | Rats, Wistar | Motor Activity - drug effects | Male | Behavior, Animal | Dose-Response Relationship, Drug | Idazoxan - pharmacology | Exploratory Behavior - physiology | Social Behavior | Atomoxetine Hydrochloride | Exploratory Behavior - drug effects | Flupenthixol - pharmacology | Fluoxetine - pharmacology | Idazoxan - analogs & derivatives | Dopamine Uptake Inhibitors - pharmacology | Play and Playthings | Amphetamine - pharmacology | Serotonin Antagonists - pharmacology | Adrenergic Agents - pharmacology | Adrenergic alpha-2 Receptor Antagonists - pharmacology | Piperazines - pharmacology | Cocaine - pharmacology | Animals | Dopamine Antagonists - pharmacology | Adrenergic Uptake Inhibitors - pharmacology | Propylamines - pharmacology | Serotonin Uptake Inhibitors - pharmacology | Complications and side effects | Amphetamines | Physiological aspects | Dosage and administration | Research | Social behavior in animals | Animal behavior | Rodents | Psychopharmacology
Journal Article