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Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2010, Volume 207, Issue 8, pp. 1589 - 1597
Uncontrolled extracellular matrix production by fibroblasts in response to tissue injury contributes to fibrotic diseases, such as idiopathic pulmonary... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESPONSES | PHOSPHATASE | INJURY | TENSIN HOMOLOG | MECHANISMS | GROWTH-FACTOR | IMMUNOLOGY | MYOFIBROBLAST DIFFERENTIATION | EXPRESSION | CANCER | MICRORNA | Oligonucleotides - genetics | Pulmonary Fibrosis - therapy | Idiopathic Pulmonary Fibrosis - genetics | Gene Expression - drug effects | Gene Expression - genetics | Humans | Actins - metabolism | MicroRNAs - metabolism | Pulmonary Fibrosis - genetics | Idiopathic Pulmonary Fibrosis - metabolism | Actins - genetics | Antisense Elements (Genetics) - therapeutic use | Collagen - genetics | Lung - metabolism | Phosphorylation - drug effects | Smad7 Protein - genetics | Extracellular Matrix Proteins - metabolism | Transforming Growth Factor beta1 - pharmacology | Fibroblasts - metabolism | Smad7 Protein - metabolism | Cell Line | Lung - pathology | Extracellular Matrix Proteins - genetics | Mice, Inbred C57BL | Smad2 Protein - metabolism | Mice, Transgenic | Pulmonary Fibrosis - pathology | Transforming Growth Factor beta1 - genetics | Fibroblasts - pathology | Fibronectins - metabolism | Collagen - metabolism | Animals | Fibroblasts - drug effects | Antisense Elements (Genetics) - genetics | Idiopathic Pulmonary Fibrosis - pathology | Pulmonary Fibrosis - chemically induced | Bleomycin - pharmacology | Fibronectins - genetics | Mice | MicroRNAs - genetics | Index Medicus | Brief Definitive Report
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 2015, Volume 308, Issue 4, pp. L344 - L357
Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is both a cause and consequence of fibroblast activation.... 
Plasminogen activator inhibitor 1 | Extracellular matrix | Mechanotransduction | Hippo | Idiopathic pulmonary fibrosis | LUNG | DOMAIN | PHYSIOLOGY | mechanotransduction | HIPPO PATHWAY | idiopathic pulmonary fibrosis | TRANSCRIPTIONAL COACTIVATOR | plasminogen activator inhibitor 1 | GROWTH-FACTOR-BETA | MECHANICAL MEMORY | MATRIX STIFFNESS | INHIBITION | RESPIRATORY SYSTEM | DIFFERENTIATION | IDIOPATHIC PULMONARY-FIBROSIS | extracellular matrix | NIH 3T3 Cells | Humans | Male | Intracellular Signaling Peptides and Proteins - metabolism | Pulmonary Fibrosis - genetics | Phosphoproteins - metabolism | Serpin E2 - biosynthesis | Gene Knockdown Techniques | Female | Lung - metabolism | Pulmonary Fibrosis - metabolism | Plasminogen Activator Inhibitor 1 - genetics | Intracellular Signaling Peptides and Proteins - genetics | Mechanotransduction, Cellular - genetics | Fibroblasts - metabolism | Lung - pathology | Pulmonary Fibrosis - pathology | Phosphoproteins - genetics | Fibroblasts - pathology | Plasminogen Activator Inhibitor 1 - biosynthesis | Serpin E2 - genetics | Animals | Transforming Growth Factor beta - genetics | Adaptor Proteins, Signal Transducing - genetics | Mice, Inbred NOD | Mice | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Transforming Growth Factor beta - metabolism | Transcriptional coactivators | Fibroblasts | Genetic aspects | Pulmonary fibrosis | Health aspects | Oncogenes | Bone morphogenetic proteins | Fibrosis | Signal transduction | Pathology | Cellular biology | Protein expression | Biosynthesis | Physiology | Binding sites | Index Medicus | Call for Papers
Journal Article
American journal of respiratory and critical care medicine, ISSN 1073-449X, 04/2016, Volume 193, Issue 7, pp. 745 - 752
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2008, Volume 105, Issue 35, pp. 13051 - 13056
Idiopathic interstitial pneumonias (IIPs) have a progressive and often fatal course, and their enigmatic etiology has complicated approaches to effective... 
Telomeres | Pulmonary alveoli | Lungs | Interstitial lung diseases | Idiopathic pulmonary fibrosis | Liver | Fibrosis | Dyskeratosis congenita | Genetic mutation | Liver cirrhosis | Liver fibrosis | Interstitial lung disease | Telomerase | Aplastic anemia | RNA | MULTIDISCIPLINARY SCIENCES | DOMINANT DYSKERATOSIS-CONGENITA | REVERSE-TRANSCRIPTASE | LENGTH | IN-SITU HYBRIDIZATION | TERMINAL TRANSFERASE | liver fibrosis | dyskeratosis congenita | telomerase | GENE | interstitial lung disease | FAMILIES | aplastic anemia | MUTATIONS | APLASTIC-ANEMIA | Biomarkers - metabolism | Leukocytes, Mononuclear - metabolism | Epithelium - pathology | Pulmonary Alveoli - pathology | Pulmonary Fibrosis - complications | Fibrosis - complications | Humans | Risk Factors | In Situ Hybridization, Fluorescence | Tomography, X-Ray Computed | Pulmonary Fibrosis - genetics | Pulmonary Fibrosis - pathology | Case-Control Studies | RNA - genetics | Fibrosis - diagnostic imaging | Telomerase - genetics | Pulmonary Fibrosis - diagnostic imaging | Germ-Line Mutation | Family | Heterozygote | Telomere - metabolism | Fibrosis - pathology | Genetic aspects | Pulmonary fibrosis | Properties | Health aspects | Risk factors | Tissue | Leucocytes | Pneumonia | Mutation | Chromosomes | Deoxyribonucleic acid--DNA | Epithelial cells | Lung | Lung diseases | Heredity | Leukocytes | Cirrhosis | Etiology | telomerase reverse transcriptase | Alveoli | Age | Index Medicus | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, pp. e41394 - e41394
Background: Autophagy is a basic cellular homeostatic process important to cell fate decisions under conditions of stress. Dysregulation of autophagy impacts... 
RAPAMYCIN | TARGET | GROWTH-FACTOR-BETA | OXIDATIVE STRESS | EPITHELIAL-CELLS | INFLAMMATION | DISEASE | BIOLOGY | GENE-EXPRESSION | ENDOPLASMIC-RETICULUM STRESS | HYPOXIA | Fibronectins - biosynthesis | Sequestosome-1 Protein | Humans | Homeostasis | Autophagy | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - biosynthesis | Lung - metabolism | TOR Serine-Threonine Kinases - biosynthesis | Fibroblasts - metabolism | Apoptosis Regulatory Proteins - biosynthesis | Beclin-1 | Lung - pathology | Mice, Inbred C57BL | Gene Expression Regulation | Intracellular Signaling Peptides and Proteins - biosynthesis | Microtubule-Associated Proteins - biosynthesis | Cell Lineage | Membrane Proteins - biosynthesis | Animals | Microscopy, Fluorescence - methods | Idiopathic Pulmonary Fibrosis - pathology | Adaptor Proteins, Signal Transducing - biosynthesis | Mice | Transforming Growth Factor beta - metabolism | Animal experimentation | Fibronectins | Medical research | Pulmonary fibrosis | Analysis | Medicine, Experimental | Bone morphogenetic proteins | Transforming growth factors | Muscle proteins | Fluorescence microscopy | Regulators | Lung | Lung cancer | Phagosomes | Smooth muscle | Confocal | Fibronectin | Proteins | Bleomycin | Fibroblasts | Chronic obstructive pulmonary disease | Growth factors | Rapamycin | Surfactants | Electron microscopy | Patients | Studies | Hospitals | p62 Protein | Fibrosis | Hypoxia | Endoplasmic reticulum | Phagocytosis | Oxidative stress | Fluorescence | Critical care | Confocal microscopy | Arthritis | Activation | Tissues | Medical schools | Western blotting | Cell fate | Actin | Rodents | Lung diseases | Muscles | Cystic fibrosis | Medicine | Transmission electron microscopy | Microscopy | Lungs | Womens health | Collagen | Obstructive lung disease | Immunofluorescence | Cancer | Apoptosis | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 521 - 538
Journal Article
Journal of Immunology, ISSN 0022-1767, 10/2014, Volume 193, Issue 7, pp. 3755 - 3768
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2014, Volume 111, Issue 1, pp. 367 - 372
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 07/2011, Volume 208, Issue 7, pp. 1459 - 1471
Journal Article