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Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7642, pp. 479 - 483
B-lymphoid transcription factors, such as PAX5 and IKZF1, are critical for early B-cell development(1,2), yet lesions of the genes encoding these transcription... 
ENERGY STRESS | ACTIVATION | GENE | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | HEMATOPOIETIC STEM-CELLS | REGULATORY NETWORK | DIFFERENTIATION | MINIMAL RESIDUAL DISEASE | EXPRESSION | Glucocorticoids - therapeutic use | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Receptor, Cannabinoid, CB2 - agonists | Humans | Gene Expression Regulation, Neoplastic | Receptors, Glucocorticoid - metabolism | PAX5 Transcription Factor - deficiency | Carrier Proteins - agonists | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Chromatin Immunoprecipitation | Adenosine Triphosphate - metabolism | Cell Death | Pyruvic Acid - metabolism | Female | Ikaros Transcription Factor - metabolism | Energy Metabolism - genetics | B-Lymphocytes - metabolism | PAX5 Transcription Factor - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | AMP-Activated Protein Kinases - antagonists & inhibitors | Carcinogenesis - genetics | PAX5 Transcription Factor - genetics | Mice, Transgenic | Citric Acid Cycle | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Transcription Factors - metabolism | B-Lymphocytes - drug effects | Receptor, Cannabinoid, CB2 - metabolism | Animals | Carrier Proteins - metabolism | Sequence Analysis, RNA | Glucocorticoids - pharmacology | Glucose - metabolism | Mice | Physiological aspects | Transcription factors | B cells | Proteins | Metabolites | Rodents | Cloning | Leukemia | Glucose | Kinases | Metabolism | Gene expression | Apoptosis | Index Medicus
Journal Article
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 03/2014, Volume 15, Issue 3, pp. 283 - 293
Journal Article
Journal of Immunology, ISSN 0022-1767, 10/2017, Volume 199, Issue 7, pp. 2377 - 2387
Journal Article
Nature Immunology, ISSN 1529-2908, 10/2012, Volume 13, Issue 10, pp. 972 - 980
Journal Article
Nature, ISSN 0028-0836, 05/2008, Volume 453, Issue 7191, pp. 110 - 114
Journal Article
Cell, ISSN 0092-8674, 04/2018, Volume 173, Issue 2, pp. 470 - 484.e18
B cell activation during normal immune responses and oncogenic transformation impose increased metabolic demands on B cells and their ability to retain redox... 
B cell malignancies | G6PD | transcriptional repression | lineage-specific vulnerability | redox homeostasis | PP2A | glucose metabolism | TRANSCRIPTION FACTORS | GLYCOLYSIS | LUNG-CANCER | ACTIVATION | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | MECHANISMS | PROTEIN PHOSPHATASE 2A | TUMOR-GROWTH | CELL BIOLOGY | Oxidative Stress | Humans | Ikaros Transcription Factor - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Transcription, Genetic | Ikaros Transcription Factor - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | B-Lymphocytes - metabolism | PAX5 Transcription Factor - metabolism | Carbon - metabolism | B-Lymphocytes - cytology | Cell Survival | Mice, Inbred C57BL | PAX5 Transcription Factor - genetics | Protein Phosphatase 2 - genetics | Protein Phosphatase 2 - deficiency | Animals | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Glucose - metabolism | Glucosephosphate Dehydrogenase - metabolism | Glycolysis | Mice, Inbred NOD | Mice | Glucosephosphate Dehydrogenase - genetics | Pentose Phosphate Pathway | Phosphates | Enzymes | Pancreatic beta cells | Phosphatases | B cells | DNA binding proteins | Glucose | Drug resistance | Dextrose | Antioxidants | Glucose metabolism | Physiological aspects | Cancer | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 05/2012, Volume 36, Issue 5, pp. 717 - 730
Regulatory T (Treg) cells, driven by the Foxp3 transcription factor, are responsible for limiting autoimmunity and chronic inflammation. We showed that a... 
TARGET GENES | HOMEOSTASIS | AUTOIMMUNITY | INFLAMMATION | IN-VIVO | GENERATION | HISTONE-DEACETYLASE INHIBITORS | IMMUNOLOGY | INDEPENDENT REGULATION | RECEPTORS | EXPRESSION | Forkhead Transcription Factors - immunology | T-Lymphocytes, Regulatory - metabolism | Epigenesis, Genetic | Autoimmunity - genetics | Diabetes Mellitus, Type 1 - metabolism | Histone Acetyltransferases - genetics | Histone Deacetylases - immunology | T-Lymphocytes, Regulatory - immunology | Interleukin-2 - immunology | Autoimmunity - immunology | Forkhead Transcription Factors - metabolism | Histone Acetyltransferases - metabolism | Trans-Activators - genetics | Acetylation | Diabetes Mellitus, Type 1 - immunology | Lysine Acetyltransferase 5 | Transcription Factors - immunology | Carrier Proteins - immunology | Trans-Activators - immunology | Interleukin-2 - metabolism | Transforming Growth Factor beta - immunology | Promoter Regions, Genetic | Histone Deacetylases - genetics | Nerve Tissue Proteins - immunology | Mice, Inbred C57BL | Diabetes Mellitus, Type 1 - genetics | Histone Deacetylases - metabolism | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | Interleukin-2 - genetics | Animals | Carrier Proteins - metabolism | Transforming Growth Factor beta - genetics | Histone Acetyltransferases - immunology | Mice, Inbred NOD | Trans-Activators - metabolism | Mice | Transforming Growth Factor beta - metabolism | Autoimmunity | Oncology, Experimental | Genes | Histones | Research | DNA binding proteins | Diabetes | Transforming growth factors | T cells | Cancer | Transcription factors | Statistical analysis | Rodents | DNA methylation | Epigenetics | T cell receptors | Gene expression | Age | Index Medicus | Histone deacetylase | Ikaros protein | Immunoregulation | Diabetes mellitus | Inflammation | Lymphocytes T | Histone acetyltransferase | Promoters | epigenetics | Gene silencing | Interleukin 2 | Development | Foxp3 protein | Zinc finger proteins | Autoimmune diseases | Fusion protein
Journal Article