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Analytical chemistry (Washington), ISSN 0003-2700, 12/2018, Volume 90, Issue 24, pp. 14287 - 14293
Physical Sciences | Chemistry | Chemistry, Analytical | Science & Technology | Thalidomide - metabolism | Peptide Hydrolases - genetics | Humans | Green Fluorescent Proteins - genetics | Small Molecule Libraries - metabolism | Time-Lapse Imaging | Protein Interaction Maps | Thalidomide - analogs & derivatives | Phenylurea Compounds - chemistry | HEK293 Cells | Plasmids - genetics | Fluorescence Resonance Energy Transfer | Phenylurea Compounds - metabolism | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Ikaros Transcription Factor - metabolism | Nuclear Proteins - genetics | Peptide Hydrolases - metabolism | Ikaros Transcription Factor - chemistry | Immunologic Factors - chemistry | Thalidomide - chemistry | Transcription Factors - genetics | Plasmids - metabolism | Peptide Hydrolases - chemistry | Microscopy, Confocal | Small Molecule Libraries - chemistry | Immunologic Factors - metabolism | Cell Cycle Proteins | Ubiquitin | Visualization | Ikaros protein | Immunomodulation | p53 Protein | Fluorescence | Phase transitions | Cells | Proteins | Molecules | Signal transduction | Genetic code | Coding | Cells (biology) | Green fluorescent protein | Transduction | Kinetics | Protein interaction | Ubiquitin-protein ligase | Index Medicus
Journal Article
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2024 - 11
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Proto-Oncogene Proteins c-mdm2 - genetics | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Depsipeptides - pharmacology | Tumor Suppressor Protein p53 - genetics | Lymphoma, T-Cell - metabolism | Ikaros Transcription Factor - genetics | Lymphoma, Extranodal NK-T-Cell - genetics | Lymphoma, Extranodal NK-T-Cell - drug therapy | Janus Kinase 2 - metabolism | Protein Binding - drug effects | Antineoplastic Agents - pharmacology | Ikaros Transcription Factor - metabolism | Drug Evaluation, Preclinical | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Janus Kinase 2 - antagonists & inhibitors | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Janus Kinase 2 - genetics | Tumor Suppressor Protein p53 - metabolism | Imidazolines - pharmacology | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Lymphoma, T-Cell - genetics | Remission Induction | Peptides - pharmacology | Whole Exome Sequencing | Xenograft Model Antitumor Assays | Lymphoma, T-Cell - drug therapy | Animals | Lymphoma, Extranodal NK-T-Cell - pathology | Nuclear Proteins - antagonists & inhibitors | Lymphoma, T-Cell - pathology | Ikaros Transcription Factor - antagonists & inhibitors | Mice | Lymphoma, Extranodal NK-T-Cell - metabolism | Cell culture | MDM2 protein | p53 Protein | Xenotransplantation | Lymphocytes T | Drug development | Lymphoma | Lymphocytes B | Janus kinase 2 | Xenografts | Biomarkers | Remission | T-cell lymphoma | Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 16, pp. 6187 - 6200
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Molecular Probes | Thalidomide - metabolism | Humans | Ubiquitin - metabolism | Thalidomide - pharmacology | Transcription Factors - drug effects | Thalidomide - analogs & derivatives | T-Lymphocytes - metabolism | Proteolysis | Conserved Sequence | Cullin Proteins - metabolism | Nuclear Proteins - drug effects | Peptide Hydrolases - metabolism | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Peptide Hydrolases - chemistry | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Adaptor Proteins, Signal Transducing | Animals | Lenalidomide - pharmacology | Cell Line, Tumor | Ligands | Mice | Proteasome Endopeptidase Complex - metabolism | Immunologic Factors - metabolism | Cell Cycle Proteins | Immunologic Factors - pharmacology | Index Medicus | Protein Structure and Folding | bromodomain-containing protein 4 (BRD4) | mouse | proteasome | multiple myeloma | E3 ubiquitin ligase | immunology | ubiquitin
Journal Article
Leukemia, ISSN 0887-6924, 2010, Volume 24, Issue 6, pp. 1128 - 1138
pathogenesis | polycythemia | myelofibrosis | isocitrate dehydrogenase | thrombocythemia | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Polycythemias | Diseases of red blood cells | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | Medical sciences | Platelet diseases and coagulopathies | Proto-Oncogene Proteins c-cbl - genetics | Prognosis | Humans | Janus Kinase 2 - genetics | Repressor Proteins - genetics | Isocitrate Dehydrogenase - genetics | Proto-Oncogene Proteins - genetics | Myeloproliferative Disorders - pathology | DNA-Binding Proteins - genetics | Mutation - genetics | Neoplasm Proteins - metabolism | Myeloproliferative Disorders - genetics | Ikaros Transcription Factor - genetics | Receptors, Thrombopoietin - genetics | Myeloproliferative Disorders - metabolism | Biomarkers, Tumor - metabolism | Biomarkers, Tumor - genetics | Neoplasm Proteins - genetics | Gene mutations | Physiological aspects | Development and progression | Genetic aspects | Research | Isocitrate dehydrogenase | Identification and classification | Protein kinases | Myeloproliferative disorders | Index Medicus | Review
Journal Article
Scientific reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 19654 - 14
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Jurkat Cells | Humans | Ubiquitin-Protein Ligases - metabolism | Recombinant Fusion Proteins - metabolism | Ikaros Transcription Factor - genetics | Proteolysis | Adaptor Proteins, Signal Transducing - genetics | HEK293 Cells | Protein Domains | Recombinant Fusion Proteins - genetics | Ikaros Transcription Factor - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Proteins | Ikaros protein | Immunomodulation | Degradability | VHL protein | Chimeras | Zinc finger proteins | Neoplasia | Index Medicus
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Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival
Nature immunology, ISSN 1529-2908, 2017, Volume 18, Issue 6, pp. 694 - 704
Life Sciences & Biomedicine | Immunology | Science & Technology | Prognosis | Humans | Gene Expression Regulation, Neoplastic | Protein Kinase C beta - genetics | B-Lymphocytes | Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality | NF-kappa B p50 Subunit - genetics | Ikaros Transcription Factor - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | STAT5 Transcription Factor - metabolism | Protein-Tyrosine Kinases - genetics | Flow Cytometry | Chromatin Immunoprecipitation | Trans-Activators - genetics | Pre-B Cell Receptors - genetics | Real-Time Polymerase Chain Reaction | Signal Transduction | PAX5 Transcription Factor - genetics | Interferon Regulatory Factors - genetics | Proto-Oncogene Proteins - genetics | Survival Rate | Multiplex Polymerase Chain Reaction | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Agammaglobulinaemia Tyrosine Kinase | Adaptor Proteins, Signal Transducing - genetics | Mice | Care and treatment | Immune response | Development and progression | STAT5 | Genetic aspects | Acute lymphocytic leukemia | Health aspects | Protein kinase C | Transcription factors | Ikaros protein | Acute lymphatic leukemia | Cell survival | Leukemia | Gene regulation | T cell receptors | Stat5 protein | Lymphatic leukemia | B-cell receptor | Gene expression | Pax5 protein | Defects | Enhancers | PU.1 protein | BLNK protein | Lymphocytes B | Interferon regulatory factor 4 | Index Medicus
Journal Article
Nature communications, 05/2018, Volume 9, Issue 1, p. 2024
Proto-Oncogene Proteins c-mdm2 - genetics | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Depsipeptides - pharmacology | Tumor Suppressor Protein p53 - genetics | Lymphoma, T-Cell - metabolism | Ikaros Transcription Factor - genetics | Lymphoma, Extranodal NK-T-Cell - genetics | Lymphoma, Extranodal NK-T-Cell - drug therapy | Janus Kinase 2 - metabolism | Protein Binding - drug effects | Antineoplastic Agents - pharmacology | Ikaros Transcription Factor - metabolism | Drug Evaluation, Preclinical | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Janus Kinase 2 - antagonists & inhibitors | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Janus Kinase 2 - genetics | Tumor Suppressor Protein p53 - metabolism | Imidazolines - pharmacology | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Lymphoma, T-Cell - genetics | Remission Induction | Peptides - pharmacology | Whole Exome Sequencing | Xenograft Model Antitumor Assays | Lymphoma, T-Cell - drug therapy | Animals | Lymphoma, Extranodal NK-T-Cell - pathology | Nuclear Proteins - antagonists & inhibitors | Lymphoma, T-Cell - pathology | Ikaros Transcription Factor - antagonists & inhibitors | Mice | Lymphoma, Extranodal NK-T-Cell - metabolism
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 05/2012, Volume 36, Issue 5, pp. 717 - 730
Life Sciences & Biomedicine | Immunology | Science & Technology | Forkhead Transcription Factors - immunology | T-Lymphocytes, Regulatory - metabolism | Epigenesis, Genetic | Autoimmunity - genetics | Diabetes Mellitus, Type 1 - metabolism | Histone Acetyltransferases - genetics | Histone Deacetylases - immunology | T-Lymphocytes, Regulatory - immunology | Interleukin-2 - immunology | Autoimmunity - immunology | Forkhead Transcription Factors - metabolism | Histone Acetyltransferases - metabolism | Trans-Activators - genetics | Acetylation | Diabetes Mellitus, Type 1 - immunology | Lysine Acetyltransferase 5 | Transcription Factors - immunology | Carrier Proteins - immunology | Trans-Activators - immunology | Interleukin-2 - metabolism | Transforming Growth Factor beta - immunology | Promoter Regions, Genetic | Histone Deacetylases - genetics | Nerve Tissue Proteins - immunology | Mice, Inbred C57BL | Diabetes Mellitus, Type 1 - genetics | Histone Deacetylases - metabolism | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | Interleukin-2 - genetics | Animals | Carrier Proteins - metabolism | Transforming Growth Factor beta - genetics | Histone Acetyltransferases - immunology | Mice, Inbred NOD | Trans-Activators - metabolism | Mice | Transforming Growth Factor beta - metabolism | Autoimmunity | Oncology, Experimental | Genes | Histones | Research | DNA binding proteins | Diabetes | Transforming growth factors | T cells | Cancer | Transcription factors | Statistical analysis | Rodents | DNA methylation | Epigenetics | T cell receptors | Gene expression | Age | Index Medicus | Histone deacetylase | Ikaros protein | Immunoregulation | Diabetes mellitus | Inflammation | Lymphocytes T | Histone acetyltransferase | Promoters | epigenetics | Gene silencing | Interleukin 2 | Development | Foxp3 protein | Zinc finger proteins | Autoimmune diseases | Fusion protein
Journal Article