Articles

UofT Libraries is getting a new library services platform in January 2021.
Learn more about the change.

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
science & technology (772) 772
life sciences & biomedicine (693) 693
humans (598) 598
animals (420) 420
ikaros transcription factor - genetics (420) 420
mice (329) 329
ikaros transcription factor - metabolism (255) 255
female (229) 229
hematology (214) 214
ikaros (213) 213
immunology (206) 206
male (204) 204
oncology (197) 197
ikaros transcription factor (195) 195
transcription factors - genetics (180) 180
gene expression (176) 176
ikaros protein (171) 171
transcription factors (158) 158
leukemia (138) 138
genetic aspects (124) 124
biochemistry & molecular biology (121) 121
child (121) 121
cell biology (119) 119
mutation (118) 118
research (117) 117
dna-binding proteins (111) 111
dna-binding proteins - genetics (110) 110
abridged index medicus (108) 108
precursor cell lymphoblastic leukemia-lymphoma - genetics (108) 108
adult (105) 105
adolescent (99) 99
transcription factors - metabolism (97) 97
middle aged (92) 92
molecular sequence data (92) 92
cell differentiation (89) 89
base sequence (88) 88
proteins (86) 86
cell line, tumor (85) 85
biological and medical sciences (84) 84
lymphocytes (82) 82
mice, inbred c57bl (82) 82
cancer (80) 80
signal transduction (80) 80
protein binding (79) 79
genes (78) 78
multidisciplinary sciences (78) 78
science & technology - other topics (78) 78
child, preschool (76) 76
analysis (74) 74
genetics & heredity (73) 73
mice, knockout (73) 73
prognosis (71) 71
cell line (70) 70
medical sciences (68) 68
acute lymphocytic leukemia (67) 67
cell proliferation (67) 67
gene deletion (67) 67
t cells (66) 66
flow cytometry (65) 65
promoter regions, genetic (65) 65
aged (64) 64
gene expression regulation (63) 63
research article (62) 62
cells, cultured (61) 61
ikaros transcription factor - physiology (60) 60
transcription, genetic (60) 60
dna-binding proteins - metabolism (59) 59
genetic predisposition to disease (59) 59
binding sites (58) 58
physiological aspects (58) 58
reverse transcriptase polymerase chain reaction (58) 58
infant (57) 57
polymorphism, single nucleotide (57) 57
deoxyribonucleic acid--dna (56) 56
health aspects (56) 56
ikaros transcription factor - immunology (55) 55
lymphocytes b (55) 55
risk factors (54) 54
amino acid sequence (53) 53
hematologic and hematopoietic diseases (53) 53
ikzf1 (53) 53
mice, transgenic (53) 53
lymphocytes t (52) 52
protein isoforms - genetics (52) 52
acute lymphatic leukemia (50) 50
precursor b-cell lymphoblastic leukemia-lymphoma - genetics (50) 50
transcription factors - physiology (50) 50
leukemias. malignant lymphomas. malignant reticulosis. myelofibrosis (48) 48
medicine (48) 48
acute lymphoblastic leukemia (47) 47
young adult (47) 47
zinc finger proteins (46) 46
kinases (45) 45
science (45) 45
dna binding proteins (44) 44
hemic and lymphatic diseases (44) 44
gene expression regulation, neoplastic (43) 43
apoptosis (42) 42
dna (42) 42
gene expression profiling (42) 42
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (922) 922
Chinese (15) 15
Japanese (7) 7
French (3) 3
Russian (2) 2
Czech (1) 1
Norwegian (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Dynamic Imaging of Small Molecule Induced Protein–Protein Interactions in Living Cells with a Fluorophore Phase Transition Based Approach
by Chung, Chan-I and Zhang, Qiang and Shu, Xiaokun
Analytical chemistry (Washington), ISSN 0003-2700, 12/2018, Volume 90, Issue 24, pp. 14287 - 14293
Physical Sciences | Chemistry | Chemistry, Analytical | Science & Technology | Thalidomide - metabolism | Peptide Hydrolases - genetics | Humans | Green Fluorescent Proteins - genetics | Small Molecule Libraries - metabolism | Time-Lapse Imaging | Protein Interaction Maps | Thalidomide - analogs & derivatives | Phenylurea Compounds - chemistry | HEK293 Cells | Plasmids - genetics | Fluorescence Resonance Energy Transfer | Phenylurea Compounds - metabolism | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Ikaros Transcription Factor - metabolism | Nuclear Proteins - genetics | Peptide Hydrolases - metabolism | Ikaros Transcription Factor - chemistry | Immunologic Factors - chemistry | Thalidomide - chemistry | Transcription Factors - genetics | Plasmids - metabolism | Peptide Hydrolases - chemistry | Microscopy, Confocal | Small Molecule Libraries - chemistry | Immunologic Factors - metabolism | Cell Cycle Proteins | Ubiquitin | Visualization | Ikaros protein | Immunomodulation | p53 Protein | Fluorescence | Phase transitions | Cells | Proteins | Molecules | Signal transduction | Genetic code | Coding | Cells (biology) | Green fluorescent protein | Transduction | Kinetics | Protein interaction | Ubiquitin-protein ligase | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models
by Ng, Samuel Y and Yoshida, Noriaki and Christie, Amanda L and Ghandi, Mahmoud and Dharia, Neekesh V and Dempster, Joshua and Murakami, Mark and Shigemori, Kay and Morrow, Sara N and Van Scoyk, Alexandria and Cordero, Nicolas A and Stevenson, Kristen E and Puligandla, Maneka and Haas, Brian and Lo, Christopher and Meyers, Robin and Gao, Galen and Cherniack, Andrew and Louissaint, Abner and Nardi, Valentina and Thorner, Aaron R and Long, Henry and Qiu, Xintao and Morgan, Elizabeth A and Dorfman, David M and Fiore, Danilo and Jang, Julie and Epstein, Alan L and Dogan, Ahmet and Zhang, Yanming and Horwitz, Steven M and Jacobsen, Eric D and Santiago, Solimar and Ren, Jian-Guo and Guerlavais, Vincent and Annis, D. Allen and Aivado, Manuel and Saleh, Mansoor N and Mehta, Amitkumar and Tsherniak, Aviad and Root, David and Vazquez, Francisca and Hahn, William C and Inghirami, Giorgio and Aster, Jon C and Weinstock, David M and Koch, Raphael
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2024 - 11
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Proto-Oncogene Proteins c-mdm2 - genetics | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Depsipeptides - pharmacology | Tumor Suppressor Protein p53 - genetics | Lymphoma, T-Cell - metabolism | Ikaros Transcription Factor - genetics | Lymphoma, Extranodal NK-T-Cell - genetics | Lymphoma, Extranodal NK-T-Cell - drug therapy | Janus Kinase 2 - metabolism | Protein Binding - drug effects | Antineoplastic Agents - pharmacology | Ikaros Transcription Factor - metabolism | Drug Evaluation, Preclinical | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Janus Kinase 2 - antagonists & inhibitors | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Janus Kinase 2 - genetics | Tumor Suppressor Protein p53 - metabolism | Imidazolines - pharmacology | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Lymphoma, T-Cell - genetics | Remission Induction | Peptides - pharmacology | Whole Exome Sequencing | Xenograft Model Antitumor Assays | Lymphoma, T-Cell - drug therapy | Animals | Lymphoma, Extranodal NK-T-Cell - pathology | Nuclear Proteins - antagonists & inhibitors | Lymphoma, T-Cell - pathology | Ikaros Transcription Factor - antagonists & inhibitors | Mice | Lymphoma, Extranodal NK-T-Cell - metabolism | Cell culture | MDM2 protein | p53 Protein | Xenotransplantation | Lymphocytes T | Drug development | Lymphoma | Lymphocytes B | Janus kinase 2 | Xenografts | Biomarkers | Remission | T-cell lymphoma | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon
by Akuffo, Afua A and Alontaga, Aileen Y and Metcalf, Rainer and Beatty, Matthew S and Becker, Andreas and McDaniel, Jessica M and Hesterberg, Rebecca S and Goodheart, William E and Gunawan, Steven and Ayaz, Muhammad and Yang, Yan and Rezaul Karim, M and Orobello, Morgan E and Daniel, Kenyon and Guida, Wayne and Yoder, Jeffrey A and Rajadhyaksha, Anjali M and Schönbrunn, Ernst and Lawrence, Harshani R and Lawrence, Nicholas J and Epling-Burnette, Pearlie K
The Journal of biological chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 16, pp. 6187 - 6200
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Molecular Probes | Thalidomide - metabolism | Humans | Ubiquitin - metabolism | Thalidomide - pharmacology | Transcription Factors - drug effects | Thalidomide - analogs & derivatives | T-Lymphocytes - metabolism | Proteolysis | Conserved Sequence | Cullin Proteins - metabolism | Nuclear Proteins - drug effects | Peptide Hydrolases - metabolism | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Peptide Hydrolases - chemistry | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Adaptor Proteins, Signal Transducing | Animals | Lenalidomide - pharmacology | Cell Line, Tumor | Ligands | Mice | Proteasome Endopeptidase Complex - metabolism | Immunologic Factors - metabolism | Cell Cycle Proteins | Immunologic Factors - pharmacology | Index Medicus | Protein Structure and Folding | bromodomain-containing protein 4 (BRD4) | mouse | proteasome | multiple myeloma | E3 ubiquitin ligase | immunology | ubiquitin
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1
by Tefferi, A
Leukemia, ISSN 0887-6924, 2010, Volume 24, Issue 6, pp. 1128 - 1138
pathogenesis | polycythemia | myelofibrosis | isocitrate dehydrogenase | thrombocythemia | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Polycythemias | Diseases of red blood cells | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | Medical sciences | Platelet diseases and coagulopathies | Proto-Oncogene Proteins c-cbl - genetics | Prognosis | Humans | Janus Kinase 2 - genetics | Repressor Proteins - genetics | Isocitrate Dehydrogenase - genetics | Proto-Oncogene Proteins - genetics | Myeloproliferative Disorders - pathology | DNA-Binding Proteins - genetics | Mutation - genetics | Neoplasm Proteins - metabolism | Myeloproliferative Disorders - genetics | Ikaros Transcription Factor - genetics | Receptors, Thrombopoietin - genetics | Myeloproliferative Disorders - metabolism | Biomarkers, Tumor - metabolism | Biomarkers, Tumor - genetics | Neoplasm Proteins - genetics | Gene mutations | Physiological aspects | Development and progression | Genetic aspects | Research | Isocitrate dehydrogenase | Identification and classification | Protein kinases | Myeloproliferative disorders | Index Medicus | Review
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera
by Kim, Kidae and Lee, Dong Ho and Park, Sungryul and Jo, Seung-Hyun and Ku, Bonsu and Park, Sung Goo and Park, Byoung Chul and Jeon, Yeong Uk and Ahn, Sunjoo and Kang, Chung Hyo and Hwang, Daehee and Chae, Sehyun and Ha, Jae Du and Kim, Sunhong and Hwang, Jong Yeon and Kim, Jeong-Hoon
Scientific reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 19654 - 14
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Jurkat Cells | Humans | Ubiquitin-Protein Ligases - metabolism | Recombinant Fusion Proteins - metabolism | Ikaros Transcription Factor - genetics | Proteolysis | Adaptor Proteins, Signal Transducing - genetics | HEK293 Cells | Protein Domains | Recombinant Fusion Proteins - genetics | Ikaros Transcription Factor - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Proteins | Ikaros protein | Immunomodulation | Degradability | VHL protein | Chimeras | Zinc finger proteins | Neoplasia | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival
by Katerndahl, C.D.S and Heltemes-Harris, L.M and Willette, M.J.L and Henzler, C.M and Frietze, S and Yang, R and Schjerven, H and Silverstein, K.A.T and Ramsey, L.B and Hubbard, G and Wells, A.D and Kuiper, R.P and Scheijen, B and Leeuwen, F.N. van and Muschen, M and Kornblau, S.M and Farrar, M.A
Nature immunology, ISSN 1529-2908, 2017, Volume 18, Issue 6, pp. 694 - 704
Life Sciences & Biomedicine | Immunology | Science & Technology | Prognosis | Humans | Gene Expression Regulation, Neoplastic | Protein Kinase C beta - genetics | B-Lymphocytes | Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality | NF-kappa B p50 Subunit - genetics | Ikaros Transcription Factor - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | STAT5 Transcription Factor - metabolism | Protein-Tyrosine Kinases - genetics | Flow Cytometry | Chromatin Immunoprecipitation | Trans-Activators - genetics | Pre-B Cell Receptors - genetics | Real-Time Polymerase Chain Reaction | Signal Transduction | PAX5 Transcription Factor - genetics | Interferon Regulatory Factors - genetics | Proto-Oncogene Proteins - genetics | Survival Rate | Multiplex Polymerase Chain Reaction | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Agammaglobulinaemia Tyrosine Kinase | Adaptor Proteins, Signal Transducing - genetics | Mice | Care and treatment | Immune response | Development and progression | STAT5 | Genetic aspects | Acute lymphocytic leukemia | Health aspects | Protein kinase C | Transcription factors | Ikaros protein | Acute lymphatic leukemia | Cell survival | Leukemia | Gene regulation | T cell receptors | Stat5 protein | Lymphatic leukemia | B-cell receptor | Gene expression | Pax5 protein | Defects | Enhancers | PU.1 protein | BLNK protein | Lymphocytes B | Interferon regulatory factor 4 | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models
by Ng, Samuel Y and Yoshida, Noriaki and Christie, Amanda L and Ghandi, Mahmoud and Dharia, Neekesh V and Dempster, Joshua and Murakami, Mark and Shigemori, Kay and Morrow, Sara N and Van Scoyk, Alexandria and Cordero, Nicolas A and Stevenson, Kristen E and Puligandla, Maneka and Haas, Brian and Lo, Christopher and Meyers, Robin and Gao, Galen and Cherniack, Andrew and Louissaint, Jr, Abner and Nardi, Valentina and Thorner, Aaron R and Long, Henry and Qiu, Xintao and Morgan, Elizabeth A and Dorfman, David M and Fiore, Danilo and Jang, Julie and Epstein, Alan L and Dogan, Ahmet and Zhang, Yanming and Horwitz, Steven M and Jacobsen, Eric D and Santiago, Solimar and Ren, Jian-Guo and Guerlavais, Vincent and Annis, D Allen and Aivado, Manuel and Saleh, Mansoor N and Mehta, Amitkumar and Tsherniak, Aviad and Root, David and Vazquez, Francisca and Hahn, William C and Inghirami, Giorgio and Aster, Jon C and Weinstock, David M and Koch, Raphael
Nature communications, 05/2018, Volume 9, Issue 1, p. 2024
Proto-Oncogene Proteins c-mdm2 - genetics | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Depsipeptides - pharmacology | Tumor Suppressor Protein p53 - genetics | Lymphoma, T-Cell - metabolism | Ikaros Transcription Factor - genetics | Lymphoma, Extranodal NK-T-Cell - genetics | Lymphoma, Extranodal NK-T-Cell - drug therapy | Janus Kinase 2 - metabolism | Protein Binding - drug effects | Antineoplastic Agents - pharmacology | Ikaros Transcription Factor - metabolism | Drug Evaluation, Preclinical | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Janus Kinase 2 - antagonists & inhibitors | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Janus Kinase 2 - genetics | Tumor Suppressor Protein p53 - metabolism | Imidazolines - pharmacology | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Lymphoma, T-Cell - genetics | Remission Induction | Peptides - pharmacology | Whole Exome Sequencing | Xenograft Model Antitumor Assays | Lymphoma, T-Cell - drug therapy | Animals | Lymphoma, Extranodal NK-T-Cell - pathology | Nuclear Proteins - antagonists & inhibitors | Lymphoma, T-Cell - pathology | Ikaros Transcription Factor - antagonists & inhibitors | Mice | Lymphoma, Extranodal NK-T-Cell - metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Loss of Epigenetic Modification Driven by the Foxp3 Transcription Factor Leads to Regulatory T Cell Insufficiency
by Bettini, Matthew L and Pan, Fan and Bettini, Maria and Finkelstein, David and Rehg, Jerold E and Floess, Stefan and Bell, Bryan D and Ziegler, Steven F and Huehn, Jochen and Pardoll, Drew M and Vignali, Dario A.A
Immunity (Cambridge, Mass.), ISSN 1074-7613, 05/2012, Volume 36, Issue 5, pp. 717 - 730
Life Sciences & Biomedicine | Immunology | Science & Technology | Forkhead Transcription Factors - immunology | T-Lymphocytes, Regulatory - metabolism | Epigenesis, Genetic | Autoimmunity - genetics | Diabetes Mellitus, Type 1 - metabolism | Histone Acetyltransferases - genetics | Histone Deacetylases - immunology | T-Lymphocytes, Regulatory - immunology | Interleukin-2 - immunology | Autoimmunity - immunology | Forkhead Transcription Factors - metabolism | Histone Acetyltransferases - metabolism | Trans-Activators - genetics | Acetylation | Diabetes Mellitus, Type 1 - immunology | Lysine Acetyltransferase 5 | Transcription Factors - immunology | Carrier Proteins - immunology | Trans-Activators - immunology | Interleukin-2 - metabolism | Transforming Growth Factor beta - immunology | Promoter Regions, Genetic | Histone Deacetylases - genetics | Nerve Tissue Proteins - immunology | Mice, Inbred C57BL | Diabetes Mellitus, Type 1 - genetics | Histone Deacetylases - metabolism | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | Interleukin-2 - genetics | Animals | Carrier Proteins - metabolism | Transforming Growth Factor beta - genetics | Histone Acetyltransferases - immunology | Mice, Inbred NOD | Trans-Activators - metabolism | Mice | Transforming Growth Factor beta - metabolism | Autoimmunity | Oncology, Experimental | Genes | Histones | Research | DNA binding proteins | Diabetes | Transforming growth factors | T cells | Cancer | Transcription factors | Statistical analysis | Rodents | DNA methylation | Epigenetics | T cell receptors | Gene expression | Age | Index Medicus | Histone deacetylase | Ikaros protein | Immunoregulation | Diabetes mellitus | Inflammation | Lymphocytes T | Histone acetyltransferase | Promoters | epigenetics | Gene silencing | Interleukin 2 | Development | Foxp3 protein | Zinc finger proteins | Autoimmune diseases | Fusion protein
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights