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amino acid sequence (73) 73
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ikaros transcription factor - immunology (52) 52
precursor b-cell lymphoblastic leukemia-lymphoma - genetics (52) 52
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1. Full Text Dynamic Imaging of Small Molecule Induced Protein-Protein Interactions in Living Cells with a Fluorophore Phase Transition Based Approach
by Chung, Chan-I and Zhang, Qiang and Shu, Xiaokun
Analytical Chemistry, ISSN 0003-2700, 12/2018, Volume 90, Issue 24, pp. 14287 - 14293
Protein-protein interactions (PPIs) mediate signal transduction in cells. Small molecules that regulate PPIs are important tools for biology and biomedicine.... 
TARGET | CHEMISTRY, ANALYTICAL | COMPUTATIONAL DESIGN | IN-VIVO | DEGRADATION | P53 PATHWAY | CEREBLON | GREEN | E3 UBIQUITIN LIGASE | Thalidomide - metabolism | Peptide Hydrolases - genetics | Humans | Green Fluorescent Proteins - genetics | Small Molecule Libraries - metabolism | Time-Lapse Imaging | Protein Interaction Maps | Thalidomide - analogs & derivatives | Phenylurea Compounds - chemistry | HEK293 Cells | Plasmids - genetics | Fluorescence Resonance Energy Transfer | Phenylurea Compounds - metabolism | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Ikaros Transcription Factor - metabolism | Nuclear Proteins - genetics | Peptide Hydrolases - metabolism | Ikaros Transcription Factor - chemistry | Immunologic Factors - chemistry | Thalidomide - chemistry | Transcription Factors - genetics | Plasmids - metabolism | Peptide Hydrolases - chemistry | Microscopy, Confocal | Small Molecule Libraries - chemistry | Immunologic Factors - metabolism | Ubiquitin | Visualization | Ikaros protein | Phase transformations | Immunomodulation | p53 Protein | Fluorescence | Cells | Proteins | Molecules | Signal transduction | Genetic code | Coding | Cells (biology) | Green fluorescent protein | Transduction | Kinetics | Protein interaction | Ubiquitin-protein ligase | Phase transition | Index Medicus
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2. Full Text Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models
by Ng, Samuel Y and Yoshida, Noriaki and Christie, Amanda L and Ghandi, Mahmoud and Dharia, Neekesh V and Dempster, Joshua and Murakami, Mark and Shigemori, Kay and Morrow, Sara N and Van Scoyk, Alexandria and Cordero, Nicolas A and Stevenson, Kristen E and Puligandla, Maneka and Haas, Brian and Lo, Christopher and Meyers, Robin and Gao, Galen and Cherniack, Andrew and Louissaint, Abner and Nardi, Valentina and Thorner, Aaron R and Long, Henry and Qiu, Xintao and Morgan, Elizabeth A and Dorfman, David M and Fiore, Danilo and Jang, Julie and Epstein, Alan L and Dogan, Ahmet and Zhang, Yanming and Horwitz, Steven M and Jacobsen, Eric D and Santiago, Solimar and Ren, Jian-Guo and Guerlavais, Vincent and Annis, D. Allen and Aivado, Manuel and Saleh, Mansoor N and Mehta, Amitkumar and Tsherniak, Aviad and Root, David and Vazquez, Francisca and Hahn, William C and Inghirami, Giorgio and Aster, Jon C and Weinstock, David M and Koch, Raphael
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 11
T- and NK-cell lymphomas (TCL) are a heterogenous group of lymphoid malignancies with poor prognosis. In contrast to B-cell and myeloid malignancies, there are... 
Cell culture | MDM2 protein | p53 Protein | Xenotransplantation | Lymphocytes T | Drug development | Lymphoma | Lymphocytes B | Janus kinase 2 | Xenografts | Biomarkers | Remission | Bioindicators | Lymphomas | T-cell lymphoma | Index Medicus
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3. Full Text Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival
by Katerndahl, C.D.S and Heltemes-Harris, L.M and Willette, M.J.L and Henzler, C.M and Frietze, S and Yang, R and Schjerven, H and Silverstein, K.A.T and Ramsey, L.B and Hubbard, G and Wells, A.D and Kuiper, R.P and Scheijen, B and Leeuwen, F.N. van and Muschen, M and Kornblau, S.M and Farrar, M.A
Nature Immunology, ISSN 1529-2908, 2017, Volume 18, Issue 6, pp. 694 - 704
The transcription factor STAT5 has a critical role in B cell acute lymphoblastic leukemia (B-ALL). How STAT5 mediates this effect is unclear. Here we found... 
MAINTENANCE | ACTIVATION | PROTEIN | DISRUPTION | SUPER-ENHANCERS | IKAROS | ACUTE LYMPHOBLASTIC-LEUKEMIA | RECEPTOR | IMMUNOLOGY | NF-KAPPA-B | EXPRESSION | Prognosis | Humans | Gene Expression Regulation, Neoplastic | Protein Kinase C beta - genetics | B-Lymphocytes | Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality | NF-kappa B p50 Subunit - genetics | Ikaros Transcription Factor - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | STAT5 Transcription Factor - metabolism | Protein-Tyrosine Kinases - genetics | Flow Cytometry | Chromatin Immunoprecipitation | Trans-Activators - genetics | Pre-B Cell Receptors - genetics | Real-Time Polymerase Chain Reaction | Signal Transduction | PAX5 Transcription Factor - genetics | Interferon Regulatory Factors - genetics | Proto-Oncogene Proteins - genetics | Survival Rate | Multiplex Polymerase Chain Reaction | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Adaptor Proteins, Signal Transducing - genetics | Mice | Care and treatment | Immune response | Development and progression | STAT5 | Genetic aspects | Acute lymphocytic leukemia | Health aspects | Protein kinase C | Transcription factors | Ikaros protein | Acute lymphatic leukemia | Cell survival | Leukemia | Gene regulation | T cell receptors | Stat5 protein | Lymphatic leukemia | B-cell receptor | Gene expression | Pax5 protein | Bruton's tyrosine kinase | Defects | Enhancers | PU.1 protein | BLNK protein | Lymphocytes B | Interferon regulatory factor 4 | Index Medicus
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4. Full Text BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
by Shurtleff, Sheila A and Dalton, James and Pui, Ching-Hon and Radtke, Ina and Mullighan, Charles G and White, Deborah and Hughes, Timothy P and Relling, Mary V and Ma, Jing and Phillips, Letha A and Downing, James R and Miller, Christopher B and Le Beau, Michelle M
Nature, ISSN 0028-0836, 05/2008, Volume 453, Issue 7191, pp. 110 - 114
The Philadelphia chromosome, a chromosomal abnormality that encodes BCR-ABL1, is the defining lesion of chronic myelogenous leukaemia (CML) and a subset of... 
CELLS | POLYMERASE-CHAIN-REACTION | ISOFORMS | MULTIDISCIPLINARY SCIENCES | MUTATION | DNA-BINDING PROTEINS | PHENOTYPE | GENE ENCODES | EXPRESSION | CHRONIC MYELOID-LEUKEMIA | FAMILY | Ikaros Transcription Factor - chemistry | Ikaros Transcription Factor - deficiency | Protein Structure, Tertiary | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Ikaros Transcription Factor - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Fusion Proteins, bcr-abl - genetics | Protein Isoforms - metabolism | Protein Isoforms - chemistry | Gene Deletion | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Polymorphism, Single Nucleotide - genetics | Adult | Ikaros Transcription Factor - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Child | Protein Isoforms - genetics | Genomics | Analysis | Genomes | Proteins | Leukemia | Fluorescence in situ hybridization | Mutation | Kinases | Arrays | Mass spectrometry | Index Medicus
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5. Full Text Loss of Epigenetic Modification Driven by the Foxp3 Transcription Factor Leads to Regulatory T Cell Insufficiency
by Bettini, Maria and Bettini, Matthew L and Pan, Fan and Finkelstein, David and Rehg, Jerold E and Floess, Stefan and Bell, Bryan D and Ziegler, Steven F and Huehn, Jochen and Pardoll, Drew M and Vignali, Dario A.A
Immunity, ISSN 1074-7613, 05/2012, Volume 36, Issue 5, pp. 717 - 730
Regulatory T (Treg) cells, driven by the Foxp3 transcription factor, are responsible for limiting autoimmunity and chronic inflammation. We showed that a... 
TARGET GENES | HOMEOSTASIS | AUTOIMMUNITY | INFLAMMATION | IN-VIVO | GENERATION | HISTONE-DEACETYLASE INHIBITORS | IMMUNOLOGY | INDEPENDENT REGULATION | RECEPTORS | EXPRESSION | Forkhead Transcription Factors - immunology | T-Lymphocytes, Regulatory - metabolism | Epigenesis, Genetic | Autoimmunity - genetics | Diabetes Mellitus, Type 1 - metabolism | Histone Acetyltransferases - genetics | Histone Deacetylases - immunology | T-Lymphocytes, Regulatory - immunology | Interleukin-2 - immunology | Autoimmunity - immunology | Forkhead Transcription Factors - metabolism | Histone Acetyltransferases - metabolism | Trans-Activators - genetics | Acetylation | Diabetes Mellitus, Type 1 - immunology | Lysine Acetyltransferase 5 | Transcription Factors - immunology | Carrier Proteins - immunology | Trans-Activators - immunology | Interleukin-2 - metabolism | Transforming Growth Factor beta - immunology | Promoter Regions, Genetic | Histone Deacetylases - genetics | Nerve Tissue Proteins - immunology | Mice, Inbred C57BL | Diabetes Mellitus, Type 1 - genetics | Histone Deacetylases - metabolism | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | Interleukin-2 - genetics | Animals | Carrier Proteins - metabolism | Transforming Growth Factor beta - genetics | Histone Acetyltransferases - immunology | Mice, Inbred NOD | Trans-Activators - metabolism | Mice | Transforming Growth Factor beta - metabolism | Autoimmunity | Oncology, Experimental | Genes | Histones | Research | DNA binding proteins | Diabetes | Transforming growth factors | T cells | Cancer | Transcription factors | Statistical analysis | Rodents | DNA methylation | Epigenetics | T cell receptors | Gene expression | Age | Index Medicus | Histone deacetylase | Ikaros protein | Immunoregulation | Diabetes mellitus | Inflammation | Lymphocytes T | Histone acetyltransferase | Promoters | epigenetics | Gene silencing | Interleukin 2 | Development | Foxp3 protein | Zinc finger proteins | Autoimmune diseases | Fusion protein
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6. Full Text Transcription factors E2A, FOXO1 and FOXP1 regulate recombination activating gene expression in cancer cells
by Chen, Zhengshan and Xiao, Yanna and Zhang, Junjun and Li, Jing and Liu, Yuxuan and Zhao, Yingying and Ma, Changchun and Luo, Jin and Qiu, Yamei and Huang, Guowei and Korteweg, Christine and Gu, Jiang
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 5, pp. e20475 - e20475
It has long been accepted that immunoglobulins (Igs) were produced by B lymphoid cells only. Recently Igs have been found to be expressed in various human... 
B-CELLS | REARRANGEMENT | LYMPHOCYTE DEVELOPMENT | MULTIDISCIPLINARY SCIENCES | V(D)J RECOMBINATION | CARCINOMAS | NONLYMPHOID CELLS | PROTEINS | ALPHA HEAVY-CHAIN | IMMUNOGLOBULIN-G | RAG-2 PROMOTER | Homeodomain Proteins - metabolism | Humans | NF-kappa B - metabolism | DNA-Binding Proteins - metabolism | Ikaros Transcription Factor - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Chromatin Immunoprecipitation | RNA Interference | Forkhead Transcription Factors - metabolism | Recombination, Genetic - genetics | Ikaros Transcription Factor - metabolism | Nuclear Proteins - genetics | Gene Expression Regulation, Neoplastic - physiology | Gene Expression Regulation, Neoplastic - genetics | Repressor Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Electrophoresis, Polyacrylamide Gel | Repressor Proteins - genetics | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Forkhead Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Homeodomain Proteins - genetics | NF-kappa B - genetics | Fluorescent Antibody Technique | Cell Line, Tumor | Forkhead Box Protein O1 | Enzymes | RNA | Analysis | Genes | Cancer cells | Genetic aspects | B cells | DNA binding proteins | Gene expression | Cancer | Chromatin | Transcription factors | Recombination | Immunoprecipitation | Colorectal cancer | Nuclei | Foxp1 protein | Proteins | Cell activation | FOXO1 protein | Lymphocytes | Acetylation | Deoxyribonucleic acid--DNA | Immunoglobulins | Lymphoid cells | RNA-mediated interference | RNA polymerase | Tumor cell lines | Polymerase chain reaction | Pathology | Overexpression | RAG2 protein | Ribonucleic acids | Lymphocytes B | RAG1 protein | Gene rearrangement | Cell lines | Regulatory mechanisms (biology) | Nuclei (cytology) | Immunofluorescence | Index Medicus | Deoxyribonucleic acid | DNA
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7. Full Text The myeloma drug lenalidomide promotes the cereblon-dependent destruction of ikaros proteins
by Lu, Gang and Middleton, Richard E and Sun, Huahang and Naniong, MarkVic and Ott, Christopher J and Mitsiades, Constantine S and Wong, Kwok-Kin and Bradner, James E and Kaelin Jr, William G
Science, ISSN 0036-8075, 2014, Volume 343, Issue 6168, pp. 305 - 309
Thalidomide-like drugs such as lenalidomide are clinically important treatments for multiple myeloma and show promise for other B cell malignancies. The... 
MULTIPLE-MYELOMA | SURVIVAL | TARGET | B-CELL LYMPHOMA | MULTIDISCIPLINARY SCIENCES | DIFFERENTIATION | THALIDOMIDE | IDENTIFICATION | MAMMALIAN-CELLS | EXPRESSION | POMALIDOMIDE | Peptide Hydrolases - genetics | Humans | Thalidomide - pharmacology | Multiple Myeloma - metabolism | Ikaros Transcription Factor - genetics | Thalidomide - analogs & derivatives | Teratogens - pharmacology | Proteolysis | HEK293 Cells | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Ikaros Transcription Factor - metabolism | Peptide Hydrolases - metabolism | Proteins | Drug interactions | Multiple myeloma | Physiological aspects | Research | Drug therapy | Health aspects | Biochemistry | Index Medicus
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8. Identification of proteins associated with transcription factors HOXA9 and E2A-PBX1 by tandem affinity purification
by Shestakova, E A and Boutin, M and Bourassa, S and Bonneil, E and Bijl, J J
Molekuliarnaia biologiia, ISSN 0026-8984, 05/2017, Volume 51, Issue 3, p. 490
Chimeric transcription factor E2A-PBX1 induces the development of acute lymphoblastic B-cell leukemia in children. Using a transgenic mouse model, we... 
Chromosomal Proteins, Non-Histone - isolation & purification | Oncogene Proteins, Fusion - metabolism | Homeodomain Proteins - metabolism | Humans | Ikaros Transcription Factor - isolation & purification | Protein Interaction Maps | DNA-Binding Proteins - metabolism | Ikaros Transcription Factor - genetics | Tandem Mass Spectrometry | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplasm Proteins - genetics | Pre-B-Cell Leukemia Transcription Factor 1 | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Proto-Oncogene Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Leukemia, B-Cell - pathology | Proto-Oncogene Proteins - genetics | Gene Expression Regulation, Leukemic | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Leukemia, B-Cell - genetics | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Protein Binding | Transcription Factors - isolation & purification | Ubiquitin-Protein Ligases - isolation & purification | Myeloid Ecotropic Viral Integration Site 1 Protein | Ubiquitin-Protein Ligases - genetics
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9. Full Text Cloning and Characterization of a Promoter Flanking the Early B Cell Factor (EBF) Gene Indicates Roles for E-Proteins and Autoregulation in the Control of EBF Expression
by Smith, Emma M. K and Gisler, Ramiro and Sigvardsson, Mikael and Medicinska fakulteten and Faculty of Medicine and Lund University and Institutionen för laboratoriemedicin and Department of Laboratory Medicine and Stem Cell Center and Stamcellscentrum (SCC) and Lunds universitet
The Journal of Immunology, ISSN 0022-1767, 07/2002, Volume 169, Issue 1, pp. 261 - 270
The early B cell factor (EBF) is a transcription factor shown crucial for the development of B lymphocytes. The protein is expressed from the earliest stages... 
E2A PROTEINS | IKAROS GENE | LOOP-HELIX PROTEINS | TARGET GENES | HEAVY-CHAIN | LYMPHOCYTE DEVELOPMENT | DNA-BINDING PROTEINS | IMMUNOGLOBULIN ENHANCER | IMMUNOLOGY | MOUSE BONE-MARROW | TRANSCRIPTIONAL REGULATION | Protein Binding - genetics | Humans | Molecular Sequence Data | 5' Untranslated Regions - genetics | Helix-Loop-Helix Motifs - immunology | Trans-Activators - chemistry | E-Box Elements - immunology | 5' Untranslated Regions - immunology | Organ Specificity - immunology | Trans-Activators - physiology | Organ Specificity - genetics | Base Sequence | Cloning, Molecular | Trans-Activators - genetics | TCF Transcription Factors | Trans-Activators - biosynthesis | Nuclear Proteins - genetics | B-Lymphocytes - metabolism | Amino Acid Sequence | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Mice, Inbred C57BL | Cells, Cultured | Transcription Factor 7-Like 1 Protein | Exons - genetics | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | E-Box Elements - genetics | Protein Binding - immunology | DNA-Binding Proteins - chemistry | Helix-Loop-Helix Motifs - genetics | Animals | B-Lymphocytes - immunology | Base Composition | Mice | Mice, Inbred BALB C | Nuclear Proteins - physiology | HeLa Cells | Promoter Regions, Genetic - immunology | DNA-Binding Proteins - biosynthesis | Exons - immunology | Index Medicus | Abridged Index Medicus | Support | Medical and Health Sciences | Trans-Activators : genetics | Nuclear Proteins : genetics | Organ Specificity : immunology | Cultured | Nuclear Proteins : physiology | Organ Specificity : genetics | Human | Basic Medicine | Trans-Activators : biosynthesis | Trans-Activators : physiology | Transcription Factors : physiology | DNA-Binding Proteins : physiology | B-Lymphocytes : metabolism | Animal | 5' Untranslated Regions : immunology | Non-U.S. Gov't | Hela Cells | Exons : genetics | Inbred BALB C | DNA-Binding Proteins : chemistry | DNA-Binding Proteins : genetics | E-Box Elements : immunology | Medicin och hälsovetenskap | Protein Binding : immunology | Immunologi inom det medicinska området | Helix-Loop-Helix Motifs : immunology | Molecular | Trans-Activators : chemistry | Exons : immunology | DNA-Binding Proteins : biosynthesis | Helix-Loop-Helix Motifs : genetics | Protein Binding : genetics | E-Box Elements : genetics | Immunology in the medical area | B-Lymphocytes : immunology | Nuclear Proteins : metabolism | Cloning | Promoter Regions (Genetics) : immunology | Cells | Inbred C57BL | 5' Untranslated Regions : genetics | Medicinska och farmaceutiska grundvetenskaper
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10. Full Text Sumoylation Inhibits the Growth Suppressive Properties of Ikaros
by Apostolov, Apostol and Litim-Mecheri, Isma and Oravecz, Attila and Goepp, Marie and Kirstetter, Peggy and Marcha, Patricia and Ittel, Antoine and Mauvieux, Laurent and Chan, Susan and Kastner, Philippe
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, pp. e0157767 - e0157767
The Ikaros transcription factor is a tumor suppressor that is also important for lymphocyte development. How post-translational modifications influence Ikaros... 
TRANSITION | LOCALIZATION | TRANSCRIPTIONAL ACTIVITY | ACTIVATION | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | DNA-BINDING PROTEINS | SUMO-1 MODIFICATION | CELL-LINE | T-CELLS | Sumoylation - genetics | Humans | Protein Processing, Post-Translational - genetics | Gene Expression Regulation, Neoplastic | Ikaros Transcription Factor - biosynthesis | DNA-Binding Proteins - genetics | Ikaros Transcription Factor - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Lymphocytes - pathology | Animals | SUMO-1 Protein - genetics | Cell Line, Tumor | Transcription, Genetic | Mice | B-Lymphocytes - pathology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | DNA-Binding Proteins - biosynthesis | Tumor Suppressor Proteins | Immunoglobulins | Transcription factors | Ikaros protein | Leukemia | Genes | Lymphocytes T | Leukocytes | Phosphatase | Nuclei | Proteins | White blood cells | SUMO protein | Cell growth | Lymphocytes B | Lysine | Lymphocytes | Peripheral blood | Post-translation | Tumor suppressor genes | Localization | Deoxyribonucleic acid--DNA | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
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11. Full Text Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos
by Yeung, Fan and Chung, Eunhee and Guess, Martin G and Bell, Matthew L and Leinwand, Leslie A
Nucleic Acids Research, ISSN 0305-1048, 08/2012, Volume 40, Issue 15, pp. 7303 - 7318
The sarcomeric myosin gene, Myh7b, encodes an intronic microRNA, miR-499, which regulates cardiac and skeletal muscle biology, yet little is known about its... 
IKAROS GENE | SKELETAL-MUSCLE | MYOD | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCINEURIN | PROTEINS | FAMILY | Humans | Molecular Sequence Data | Myosin Heavy Chains - genetics | Muscle, Skeletal - metabolism | Myosin Heavy Chains - biosynthesis | Nerve Tissue Proteins - chemistry | Base Sequence | Myocardium - metabolism | Carrier Proteins - chemistry | Transcription, Genetic | Protein Interaction Domains and Motifs | Ikaros Transcription Factor - metabolism | Myosin Type II - genetics | Carrier Proteins - physiology | Promoter Regions, Genetic | Nerve Tissue Proteins - physiology | Myosin Type II - biosynthesis | Ikaros Transcription Factor - physiology | Cells, Cultured | Gene Expression Regulation | Myogenic Regulatory Factors - metabolism | MicroRNAs - biosynthesis | MyoD Protein - metabolism | Myogenic Regulatory Factors - physiology | E-Box Elements | Nerve Tissue Proteins - metabolism | Animals | Carrier Proteins - metabolism | Transcription Initiation Site | Mice | MicroRNAs - genetics | Index Medicus | Chromatin | Transcription factors | Ikaros protein | MyoD protein | Cardiac muscle | myogenin | Gene regulation | Gene deletion | Gene expression | Promoters | Skeletal muscle | Myosin | miRNA | Gene Regulation, Chromatin and Epigenetics
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12. Full Text Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon
by Akuffo, Afua A and Alontaga, Aileen Y and Metcalf, Rainer and Beatty, Matthew S and Becker, Andreas and McDaniel, Jessica M and Hesterberg, Rebecca S and Goodheart, William E and Gunawan, Steven and Ayaz, Muhammad and Yang, Yan and Rezaul Karim, M and Orobello, Morgan E and Daniel, Kenyon and Guida, Wayne and Yoder, Jeffrey A and Rajadhyaksha, Anjali M and Schönbrunn, Ernst and Lawrence, Harshani R and Lawrence, Nicholas J and Epling-Burnette, Pearlie K
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 16, pp. 6187 - 6200
Upon binding to thalidomide and other immunomodulatory drugs, the E3 ligase substrate receptor cereblon (CRBN) promotes proteosomal destruction by engaging the... 
TARGET | UBIQUITIN LIGASE | DATA-BANK | BIOCHEMISTRY & MOLECULAR BIOLOGY | LENALIDOMIDE | THALIDOMIDE ANALOGS | ANTITUMOR-ACTIVITY | MULTIPLE-MYELOMA CELLS | POMALIDOMIDE | MYELODYSPLASTIC SYNDROMES | T-CELLS | Index Medicus | Protein Structure and Folding | bromodomain-containing protein 4 (BRD4) | mouse | proteasome | multiple myeloma | E3 ubiquitin ligase | immunology | ubiquitin
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13. Full Text Preclinical activity of CPI-0610, a novel small-molecule bromodomain and extra-terminal protein inhibitor in the therapy of multiple myeloma
by Siu, K.T and Ramachandran, J and Yee, A.J and Eda, H and Santo, L and Panaroni, C and Mertz, J.A and Sims, R.J and Cooper, M.R and Raje, N
Leukemia, ISSN 0887-6924, 08/2017, Volume 31, Issue 8, pp. 1760 - 1769
Inhibition of the bromodomain and extra-terminal (BET) proteins is a promising therapeutic strategy for various hematologic cancers. Previous studies suggest... 
TARGET | ACTIVATION | ANTIMYELOMA ACTIVITY | ONCOLOGY | MULTITARGETED KINASE INHIBITOR | TRANSCRIPTION | C-MYC | LENALIDOMIDE | LEUKEMIA | COMBINATION | HEMATOLOGY | BET BROMODOMAINS | Proto-Oncogene Proteins c-myc - analysis | Humans | Interferon Regulatory Factors - genetics | Transcription Factors - antagonists & inhibitors | Benzazepines - pharmacology | Ikaros Transcription Factor - genetics | Isoxazoles - pharmacology | Multiple Myeloma - drug therapy | Multiple Myeloma - pathology | Animals | Nuclear Proteins - antagonists & inhibitors | Ikaros Transcription Factor - analysis | Protein-Serine-Threonine Kinases - antagonists & inhibitors | G1 Phase Cell Cycle Checkpoints | Mice | Proto-Oncogene Proteins c-myc - genetics | Interferon Regulatory Factors - analysis | Cell proliferation | Drugs | Biotechnology | Ikaros protein | Transcription | Toxicity | Multiple myeloma | Cytotoxicity | In vitro testing | Myc protein | Synergism | Anticancer properties | Degradation | Proteins | Rodents | Cell cycle | Xenografts | Bone marrow | Biocompatibility | Inhibition | Cell survival | Cytokines | Immunomodulation | Caspase | Inhibitors | Terminal protein | Interferon regulatory factor 4 | Stromal cells | Cell lines | Antitumor activity | In vivo methods and tests | Apoptosis | Index Medicus
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