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1. Full Text Effects of Continuing or Stopping Alendronate After 5 Years of Treatment: The Fracture Intervention Trial Long-term Extension (FLEX): A Randomized Trial
by Black, Dennis M and Schwartz, Ann V and Ensrud, Kristine E and Cauley, Jane A and Levis, Silvina and Quandt, Sara A and Satterfield, Suzanne and Wallace, Robert B and Bauer, Douglas C and Palermo, Lisa and Wehren, Lois E and Lombardi, Antonio and Santora, Arthur C and Cummings, Steven R and FLEX Research Group, for the and FLEX Res Grp and FLEX Research Group
JAMA, ISSN 0098-7484, 12/2006, Volume 296, Issue 24, pp. 2927 - 2938
CONTEXT The optimal duration of treatment of women with postmenopausal osteoporosis is uncertain. OBJECTIVE To compare the effects of discontinuing alendronate... 
CORTICAL BONE | WOMEN | MEDICINE, GENERAL & INTERNAL | POSTMENOPAUSAL OSTEOPOROSIS | BONE-MINERAL DENSITY | EFFICACY | HIP-FRACTURES | RISK | RISEDRONATE | DISCONTINUATION | PREVALENT VERTEBRAL DEFORMITIES | Double-Blind Method | Follow-Up Studies | Humans | Spinal Fractures - epidemiology | Bone Density Conservation Agents - therapeutic use | Fractures, Bone - epidemiology | Risk | Bone Remodeling - physiology | Biomarkers - blood | Bone Density Conservation Agents - administration & dosage | Bone Remodeling - drug effects | Osteoporosis, Postmenopausal - drug therapy | Alendronate - therapeutic use | Bone Density - drug effects | Time Factors | Biopsy | Ilium - pathology | Postmenopause | Female | Aged | Fractures, Bone - prevention & control | Alendronate - administration & dosage | Care and treatment | Usage | Fractures | Alendronate | Postmenopausal women | Health aspects | Risk factors | Women | Osteoporosis | Risk assessment | Clinical trials | Bone density | Drug therapy | Long term
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2. Full Text Effects Of a One‐Month Treatment With PTH(1–34) on Bone Formation on Cancellous, Endocortical, and Periosteal Surfaces of the Human Ilium
by Lindsay, Robert and Zhou, Hua and Cosman, Felicia and Nieves, Jeri and Dempster, David W and Hodsman, Anthony B
Journal of Bone and Mineral Research, ISSN 0884-0431, 04/2007, Volume 22, Issue 4, pp. 495 - 502
Using bone histomorphometry, we found that a 1‐month treatment with PTH(1–34) [hPTH(1–34)] stimulated new bone formation on cancellous, endocortical, and... 
apoptosis | bone formation | bone histomorphometry | teriparatide | anabolic | Bone histomorphometry | Bone formation | Anabolic | Teriparatide | Apoptosis | CORTICAL BONE | TURNOVER | PARATHYROID-HORMONE 1-34 | MECHANICAL-PROPERTIES | OSTEOPOROSIS | THERAPY | OVARIECTOMIZED CYNOMOLGUS MONKEYS | ENDOCRINOLOGY & METABOLISM | OSTEOBLAST APOPTOSIS | POSTMENOPAUSAL WOMEN | Teriparatide - pharmacology | Calcification, Physiologic - drug effects | Drug Administration Schedule | Teriparatide - administration & dosage | Apoptosis - drug effects | Humans | Ilium - drug effects | Middle Aged | Osteoblasts - drug effects | Osteogenesis - drug effects | Osteoporosis, Postmenopausal - pathology | Periosteum - pathology | Haversian System - pathology | Osteoporosis, Postmenopausal - drug therapy | Osteoblasts - pathology | Injections, Subcutaneous | Ilium - pathology | Female | Aged | Haversian System - drug effects | Periosteum - drug effects
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3. Full Text Effects of Daily or Cyclic Teriparatide on Bone Formation in the Iliac Crest in Women on No Prior Therapy and in Women on Alendronate
by Dempster, David W and Cosman, Felicia and Zhou, Hua and Nieves, Jeri W and Bostrom, Mathias and Lindsay, Robert
Journal of Bone and Mineral Research, ISSN 0884-0431, 08/2016, Volume 31, Issue 8, pp. 1518 - 1526
ABSTRACT There is little information on the effects of combination therapy for osteoporosis at the tissue level. Using quadruple tetracycline‐labeled bone... 
BONE HISTOMORPHOMETRY | ANABOLICS | OSTEOPOROSIS | ANTIRESORPTIVES | ANTIRESORPTIVE THERAPY | COMBINATION THERAPY | DENOSUMAB | RANDOMIZED CONTROLLED-TRIAL | HORMONE PLUS ALENDRONATE | MINERAL DENSITY | HISTOMORPHOMETRY | ENDOCRINOLOGY & METABOLISM | PARATHYROID-HORMONE | POSTMENOPAUSAL WOMEN | Ilium - physiology | Demography | Teriparatide - pharmacology | Drug Administration Schedule | Humans | Ilium - drug effects | Middle Aged | Osteogenesis - drug effects | Cancellous Bone - drug effects | Case-Control Studies | Alendronate - pharmacology | Cortical Bone - drug effects | Female | Porosity | Osteoporosis | Alendronic acid | Envelopes | Bone growth | Parathyroid hormone | Biopsy | Iliac crest | Bisphosphonates | Osteogenesis | Bone (cancellous)
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4. Full Text The use of intravenous bisphosphonate therapy to treat vertebral fractures due to osteoporosis among boys with Duchenne muscular dystrophy
by Sbrocchi, A M and Rauch, F and Jacob, P and McCormick, A and McMillan, H J and Matzinger, M A and Ward, L M
Osteoporosis International, ISSN 0937-941X, 11/2012, Volume 23, Issue 11, pp. 2703 - 2711
The impact of intravenous bisphosphonate treatment to treat painful vertebral fractures in boys with DMD has not been documented. In this retrospective... 
Bone histomorphometry | Vertebral fractures | Corticosteroid osteoporosis | Medicine & Public Health | Gynecology | Orthopedics | Rheumatology | Clinical/pediatrics | Bone mineral density | Bisphosphonates | Endocrinology | PAMIDRONATE TREATMENT | TURNOVER | BONE-MINERAL DENSITY | SEVERE OSTEOGENESIS IMPERFECTA | PUBERTAL CHANGES | RHEUMATIC DISORDERS | PEDIATRIC POPULATION | CHILDREN | ACUTE LYMPHOBLASTIC-LEUKEMIA | ENDOCRINOLOGY & METABOLISM | DEFLAZACORT | Drug Evaluation - methods | Back Pain - physiopathology | Humans | Spinal Fractures - etiology | Male | Osteoporosis - drug therapy | Osteoporotic Fractures - drug therapy | Back Pain - drug therapy | Osteoporotic Fractures - etiology | Spinal Fractures - drug therapy | Diphosphonates - therapeutic use | Retrospective Studies | Osteoporotic Fractures - physiopathology | Child | Diphosphonates - adverse effects | Osteoporosis - physiopathology | Glucocorticoids - adverse effects | Back Pain - etiology | Bone Density Conservation Agents - adverse effects | Muscular Dystrophy, Duchenne - drug therapy | Bone Density Conservation Agents - therapeutic use | Treatment Outcome | Diphosphonates - administration & dosage | Bone Density Conservation Agents - administration & dosage | Muscular Dystrophy, Duchenne - complications | Spinal Fractures - physiopathology | Bone Density - drug effects | Osteoporosis - pathology | Biopsy | Adolescent | Ilium - pathology | Infusions, Intravenous | Pediatrics | Fractures | Drug therapy | Spine | Muscular dystrophy | Vertebrae | Intravenous administration | Fever | Osteoporosis | Side effects | Pain | Vomiting | Duchenne's muscular dystrophy | Risk assessment | Zoledronic acid | Standard deviation | Osteomalacia | Hypocalcemia | Osteogenesis
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5. Full Text Differential Effects of Teriparatide and Alendronate on Bone Remodeling in Postmenopausal Women Assessed by Histomorphometric Parameters
by Arlot, Monique and Meunier, Pierre J and Boivin, Georges and Haddock, Lillian and Tamayo, Juan and Correa‐Rotter, Ricardo and Jasqui, Salomón and Donley, David W and Dalsky, Gail P and Martin, Javier San and Eriksen, Erik Fink
Journal of Bone and Mineral Research, ISSN 0884-0431, 07/2005, Volume 20, Issue 7, pp. 1244 - 1253
An 18‐month randomized double‐blind study was conducted in postmenopausal women with osteoporosis to compare the effects of once‐daily teriparatide 20 μg with... 
histomorphometry | bone remodeling | bone formation | teriparatide | osteoporosis | Osteoporosis | Bone formation | Bone remodeling | Histomorphometry | Teriparatide | TURNOVER | RESORPTION | SKELETAL FRAGILITY | FRACTURE INTERVENTION TRIAL | TRABECULAR BONE | HIP FRACTURE | MINERAL DENSITY | VERTEBRAL FRACTURES | ENDOCRINOLOGY & METABOLISM | HUMAN PARATHYROID-HORMONE | Postmenopause - drug effects | Teriparatide - therapeutic use | Calcification, Physiologic - drug effects | Humans | Middle Aged | Biomarkers - analysis | Absorptiometry, Photon | Bone Remodeling - drug effects | Osteoporosis, Postmenopausal - drug therapy | Alendronate - therapeutic use | Bone Density - drug effects | Postmenopause - metabolism | Ilium - pathology | Female | Aged
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6. Full Text Effects of Daily Treatment with Parathyroid Hormone on Bone Microarchitecture and Turnover in Patients with Osteoporosis: A Paired Biopsy Study
by Dempster, David W and Cosman, Felicia and Kurland, Etah S and Zhou, Hua and Nieves, Jeri and Woelfert, Lillian and Shane, Elizabeth and Plavetić, Katarina and Müller, Ralph and Bilezikian, John and Lindsay, Robert
Journal of Bone and Mineral Research, ISSN 0884-0431, 10/2001, Volume 16, Issue 10, pp. 1846 - 1853
We examined paired iliac crest bone biopsy specimens from patients with osteoporosis before and after treatment with daily injections of 400 U of recombinant,... 
parathyroid hormone | osteoporosis | human | bone microarchitecture | Human | Osteoporosis | Parathyroid hormone | Bone microarchitecture | CORTICAL BONE | PRIMARY HYPERPARATHYROIDISM | ELASTIC PROPERTIES | IDIOPATHIC OSTEOPOROSIS | OVARIECTOMIZED RATS | MECHANICAL-PROPERTIES | TRABECULAR BONE | CANCELLOUS BONE | ENDOCRINOLOGY & METABOLISM | POSTMENOPAUSAL WOMEN | 3-DIMENSIONAL CONNECTIVITY | Bone and Bones - pathology | Bone Density | Drug Administration Schedule | Humans | Ilium - drug effects | Middle Aged | Peptide Fragments - administration & dosage | Parathyroid Hormone - therapeutic use | Tomography, X-Ray Computed - methods | Male | Osteoporosis - drug therapy | Osteoporosis, Postmenopausal - pathology | Osteoporosis, Postmenopausal - drug therapy | Bone and Bones - drug effects | Osteoporosis - pathology | Ilium - pathology | Female | Osteoporosis, Postmenopausal - physiopathology | Parathyroid Hormone - administration & dosage | Peptide Fragments - therapeutic use | Osteoporosis - physiopathology
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7. Full Text Daily parathyroid hormone 1‐34 replacement therapy for hypoparathyroidism induces marked changes in bone turnover and structure
by Gafni, Rachel I and Brahim, Jaime S and Andreopoulou, Panagiota and Bhattacharyya, Nisan and Kelly, Marilyn H and Brillante, Beth A and Reynolds, James C and Zhou, Hua and Dempster, David W and Collins, Michael T
Journal of Bone and Mineral Research, ISSN 0884-0431, 08/2012, Volume 27, Issue 8, pp. 1811 - 1820
Parathyroid hormone (PTH) has variable actions on bone. Chronically increased PTH is catabolic and leads to osteoporosis; yet intermittent administration is... 
PTH | HISTOMORPHOMETRY | HYPOPARATHYROIDISM | CORTICAL BONE | PTH(1-84) | OSTEOPOROSIS | MINERAL DENSITY | PARATHYROID-HORMONE-1-34 | ENDOCRINOLOGY & METABOLISM | ILIAC CREST | ARCHITECTURE | POSTMENOPAUSAL WOMEN | CALCITRIOL | Biomarkers - urine | Humans | Hypoparathyroidism - physiopathology | Ilium - drug effects | Middle Aged | Parathyroid Hormone - therapeutic use | Male | Parathyroid Hormone - pharmacology | Ilium - physiopathology | Bone Remodeling - drug effects | Hormone Replacement Therapy | Young Adult | Adult | Female | Densitometry | Porosity - drug effects | Hypoparathyroidism - drug therapy | Drug Administration Schedule | Osteogenesis - drug effects | Biomarkers - blood | Adolescent | Hypoparathyroidism - blood | Ilium - pathology | Parathyroid Hormone - administration & dosage | Hypoparathyroidism - urine | Osteoporosis | Medical colleges | Care and treatment | Parathyroid hormone | Hypoparathyroidism | Bones | Density | Bone density | Teenagers
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8. Full Text Effects of sevelamer hydrochloride and calcium carbonate on renal osteodystrophy in hemodialysis patients
by Ferreira, Aníbal and Frazão, João Miguel and Monier-Faugere, Marie-Claude and Gil, Célia and Galvao, José and Oliveira, Carlos and Baldaia, Jorge and Rodrigues, Ilidio and Santos, Carla and Ribeiro, Silvia and Hoenger, Regula Mueller and Duggal, Ajay and Malluche, Hartmut H and Sevelamer Study Grp and Sevelamer Study Group
Journal of the American Society of Nephrology, ISSN 1046-6673, 02/2008, Volume 19, Issue 2, pp. 405 - 412
Disturbances in mineral metabolism play a central role in the development of renal bone disease. In a 54-wk, randomized, open-label study, 119 hemodialysis... 
SURVIVAL | TURNOVER | DISEASE | UROLOGY & NEPHROLOGY | BONE HISTOMORPHOMETRY | ADYNAMIC BONE | ARTERIAL CALCIFICATIONS | CARDIOVASCULAR RISK | Polyamines - administration & dosage | Chronic Kidney Disease-Mineral and Bone Disorder - pathology | Calcification, Physiologic - drug effects | Chelating Agents - administration & dosage | Humans | Ilium - drug effects | Middle Aged | Male | Treatment Outcome | Parathyroid Hormone - blood | Chronic Kidney Disease-Mineral and Bone Disorder - drug therapy | Kidney Failure, Chronic - therapy | Calcium - blood | Biopsy | Phosphorus - blood | Kidney Failure, Chronic - complications | Ilium - pathology | Adult | Female | Aged | Calcium Carbonate - administration & dosage | Sevelamer | Antacids - administration & dosage | Renal Dialysis | Clinical Research
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9. Full Text Effect of intermittent PTH (1–34) on posterolateral spinal fusion with iliac crest bone graft in an ovariectomized rat model
by Qiu, Z and Wei, L and Liu, J and Sochacki, K R and Liu, X and Bishop, C and Ebraheim, M and Yang, H
Osteoporosis International, ISSN 0937-941X, 10/2013, Volume 24, Issue 10, pp. 2693 - 2700
Intermittent treatment with high-dose parathyroid hormone (PTH) enhances the quantity and quality of the fusion callus and reduces healing time of... 
Osteoporosis | Spine fusion | Medicine & Public Health | Ovariectomy | Rat | Parathyroid hormone | Orthopedics | Rheumatology | Endocrinology | QUALITY | HUMAN PARATHYROID-HORMONE-(1-34) | PARATHYROID-HORMONE 1-34 | ENHANCEMENT | MASS | ENDOCRINOLOGY & METABOLISM | Teriparatide - therapeutic use | Osteoporotic Fractures - drug therapy | Lumbar Vertebrae - surgery | Spinal Fractures - drug therapy | Ilium - transplantation | Injections, Subcutaneous | Female | Chemotherapy, Adjuvant | Osteoporotic Fractures - physiopathology | Wound Healing - drug effects | Lumbar Vertebrae - physiopathology | Disease Models, Animal | Bone Regeneration - drug effects | Drug Evaluation, Preclinical - methods | Spinal Fusion - methods | Teriparatide - pharmacology | Drug Administration Schedule | Teriparatide - administration & dosage | Spinal Fractures - surgery | Bone Density Conservation Agents - therapeutic use | Rats | Bone Density Conservation Agents - administration & dosage | Rats, Sprague-Dawley | Spinal Fractures - physiopathology | Bone Density Conservation Agents - pharmacology | Animals | Osteoporotic Fractures - surgery | Bone Transplantation - methods | Complications and side effects | Dosage and administration | Research | Drug therapy | Endocrine therapy | Back surgery | Spine | Rodents
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10. Full Text PTH(1–84) administration reverses abnormal bone‐remodeling dynamics and structure in hypoparathyroidism
by Rubin, Mishaela R and Dempster, David W and Sliney Jr, James and Zhou, Hua and Nickolas, Thomas L and Stein, Emily M and Dworakowski, Elzbieta and Dellabadia, Maryann and Ives, Rebecca and McMahon, Donald J and Zhang, Chiyuan and Silverberg, Shonni J and Shane, Elizabeth and Cremers, Serge and Bilezikian, John P
Journal of Bone and Mineral Research, ISSN 0884-0431, 11/2011, Volume 26, Issue 11, pp. 2727 - 2736
Hypoparathyroidism is associated with abnormal structural and dynamic skeletal properties. We hypothesized that parathyroid hormone(1–84) [PTH(1–84)] treatment... 
PTH(1–84) | Bone histomorphometry | Remodeling | Bone turnover markers | Hypoparathyroidism | PTH(1-84) | VITAMIN-D | PRIMARY HYPERPARATHYROIDISM | TURNOVER | ESTROGEN DEFICIENCY | SERUM | OSTEOPOROSIS | MINERAL DENSITY | REMODELING | INTACT PARATHYROID-HORMONE | HYPOPARATHYROIDISM | ENDOCRINOLOGY & METABOLISM | ILIAC CREST | BONE HISTOMORPHOMETRY | POSTMENOPAUSAL WOMEN | BONE TURNOVER MARKERS | Bone and Bones - pathology | Humans | Hypoparathyroidism - physiopathology | Ilium - drug effects | Middle Aged | Parathyroid Hormone - therapeutic use | Male | Parathyroid Hormone - pharmacology | Bone Remodeling - physiology | Ilium - physiopathology | Bone Remodeling - drug effects | Case-Control Studies | Bone and Bones - drug effects | Young Adult | Adult | Female | Biomarkers - metabolism | Hypoparathyroidism - drug therapy | Bone and Bones - physiopathology | Biopsy | Adolescent | Ilium - pathology | Parathyroid Hormone - administration & dosage | Aged | Longitudinal Studies | Cohort Studies
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11. Full Text Cancellous and cortical bone architecture and turnover at the iliac crest of postmenopausal osteoporotic women treated with parathyroid hormone 1–84
by Recker, R.R and Bare, S.P and Smith, S.Y and Varela, A and Miller, M.A and Morris, S.A and Fox, J
Bone, ISSN 8756-3282, 2008, Volume 44, Issue 1, pp. 113 - 119
Abstract Treatment with parathyroid hormone [PTH(1–84)] increases lumbar spine bone mineral density and decreases vertebral fractures, but its effects on bone... 
Orthopedics | Osteoporosis | Bone formation | Bone remodeling | Parathyroid hormone | Bone structure | POROSITY | OVARIECTOMIZED RHESUS-MONKEYS | VERTEBRAL FRACTURE | TERIPARATIDE | IMPROVES TRABECULAR ARCHITECTURE | MINERAL DENSITY | BIOMECHANICAL PROPERTIES | ENDOCRINOLOGY & METABOLISM | CYNOMOLGUS MONKEYS | PROXIMAL FEMUR | THICKNESS | Demography | Drug Administration Schedule | Humans | Ilium - drug effects | Middle Aged | Osteogenesis - drug effects | Osteoporosis, Postmenopausal - complications | Parathyroid Hormone - therapeutic use | Parathyroid Hormone - pharmacology | Tomography, X-Ray Computed | Bone Remodeling - physiology | Bone Resorption - complications | Periosteum - pathology | Bone Remodeling - drug effects | Osteoporosis, Postmenopausal - drug therapy | Bone Density - drug effects | Biopsy | Staining and Labeling | Ilium - pathology | Placebos | Female | Osteoporosis, Postmenopausal - physiopathology | Parathyroid Hormone - administration & dosage | Periosteum - drug effects | Postmenopausal women | Porosity | Peptide hormones | Analysis
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12. Full Text A Novel Tetracycline Labeling Schedule for Longitudinal Evaluation of the Short‐Term Effects of Anabolic Therapy With a Single Iliac Crest Bone Biopsy: Early Actions of Teriparatide
by Lindsay, Robert and Cosman, Felicia and Zhou, Hua and Bostrom, Mathias P and Shen, Victor W and Cruz, JoAnn D and Nieves, Jeri W and Dempster, David W
Journal of Bone and Mineral Research, ISSN 0884-0431, 03/2006, Volume 21, Issue 3, pp. 366 - 373
We describe a quadruple tetracycline labeling method that allows longitudinal assessment of short‐term changes in bone formation in a single biopsy. We show... 
histomorphometry | bone formation | bone biopsy | teriparatide | osteoporosis | Bone biopsy | Osteoporosis | Bone formation | Histomorphometry | Teriparatide | TURNOVER | BIOCHEMICAL MARKERS | ALENDRONATE | WOMEN | POSTMENOPAUSAL OSTEOPOROSIS | CANCELLOUS BONE | ENDOCRINOLOGY & METABOLISM | BMD | PARATHYROID-HORMONE | THICKNESS | Biopsy - methods | Anabolic Agents - therapeutic use | Teriparatide - pharmacology | Teriparatide - therapeutic use | Humans | Ilium - drug effects | Middle Aged | Bone Density Conservation Agents - therapeutic use | Osteoporosis, Postmenopausal - pathology | Osteoporosis, Postmenopausal - drug therapy | Bone Density Conservation Agents - pharmacology | Anabolic Agents - pharmacology | Ilium - pathology | Female | Longitudinal Studies | Tetracycline - administration & dosage | Osteogenesis | Tetracycline - analysis
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