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Respiratory Research, ISSN 1465-9921, 12/2011, Volume 12, Issue 1, pp. 1 - 8
The development of bronchial hyperreactivity (BHR) subsequent to precapillary pulmonary hypertension (PHT) was prevented by acting on the major signalling... 
Medicine & Public Health | Pneumology/Respiratory System | PARENCHYMAL MECHANICS | LUNG | METHACHOLINE-INDUCED BRONCHOCONSTRICTION | AIRWAY | THERAPY | VASOACTIVE-INTESTINAL-PEPTIDE | RESPIRATORY SYSTEM | ARTERIAL-HYPERTENSION | INHALATION | NITRIC-OXIDE | VIP | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Airway Resistance - drug effects | Iloprost - pharmacology | Bronchial Provocation Tests | Antihypertensive Agents - administration & dosage | Hypertension, Pulmonary - physiopathology | Male | Endothelins - metabolism | Sulfones - pharmacology | Lung Volume Measurements | Sildenafil Citrate | Time Factors | Vasoactive Intestinal Peptide - pharmacology | Bronchoconstriction - drug effects | Bronchial Hyperreactivity - physiopathology | Bronchial Hyperreactivity - metabolism | Blood Pressure - drug effects | Hypertension, Pulmonary - drug therapy | Lung - metabolism | Phosphodiesterase 5 Inhibitors - pharmacology | Endothelin Receptor Antagonists | Disease Models, Animal | Bronchial Hyperreactivity - etiology | Prostaglandins I - metabolism | Bronchial Hyperreactivity - therapy | Infusion Pumps, Implantable | Vasodilator Agents - pharmacology | Administration, Oral | Purines - pharmacology | Receptors, Endothelin - metabolism | Infusions, Parenteral | Rats | Hypertension, Pulmonary - metabolism | Lung - physiopathology | Piperazines - pharmacology | Rats, Sprague-Dawley | Animals | Analysis of Variance | Signal Transduction - drug effects | Lung - drug effects | Pyridines - pharmacology | Lung - blood supply | Nitric Oxide - metabolism | Vasodilator Agents - administration & dosage | Hypertension, Pulmonary - complications | Bronchi | Physiological aspects | Development and progression | Respiratory agents | Research | Drug therapy | Health aspects | Pulmonary hypertension | Prevention | Nitric oxide
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2012, Volume 302, Issue 3, pp. 553 - 559
Erythrocytes have been implicated as controllers of vascular caliber by virtue of their ability to release the vasodilator ATP in response to local... 
Carbenoxolone | UT-15C | Iloprost | Bcl-X | Red blood cell | Isoproterenol | Tro19622 | BH4 | TRO19622 | G-PROTEIN G(I) | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | iloprost | isoproterenol | RABBIT ERYTHROCYTES | PLASMA-MEMBRANE | red blood cell | carbenoxolone | Bcl-x(L) BH4(4-23) | ADENOSINE-TRIPHOSPHATE | PLASMODIUM-FALCIPARUM | MITOCHONDRIAL CHANNEL | PERIPHERAL VASCULAR DISEASE | RED-BLOOD-CELLS | CELLULAR ATP | INDUCED INCREASES | SIGNAL-TRANSDUCTION PATHWAY | Connexins - antagonists & inhibitors | Antihypertensive Agents - pharmacology | Receptors, Epoprostenol | Iloprost - pharmacology | Humans | Middle Aged | Male | Receptors, Prostaglandin - metabolism | Young Adult | bcl-X Protein - pharmacology | Adenosine Triphosphate - metabolism | Adult | Epoprostenol - pharmacology | Female | Cyclic AMP - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | Rabbits | Vasodilator Agents - pharmacology | Erythrocyte Membrane - metabolism | Voltage-Dependent Anion Channel 1 - metabolism | Adrenergic beta-Agonists - pharmacology | Erythrocyte Membrane - drug effects | Connexins - metabolism | Nerve Tissue Proteins - metabolism | Carbenoxolone - pharmacology | Epoprostenol - analogs & derivatives | Animals | Receptors, Prostaglandin - agonists | Signal Transduction - drug effects | Isoproterenol - pharmacology | Signal Transduction - physiology | Physiological aspects | Prostacyclin | Ion channels | Health aspects | Adenosine triphosphate | Erythrocytes | Vascular Biology and Microcirculation | Bcl-xL BH44–23
Journal Article
Circulation Research: Journal of The American Heart Association, ISSN 0009-7330, 03/2004, Volume 94, Issue 5, pp. 592 - 600
ABSTRACT—Hyaluronic acid (HA) is a prominent constituent of the extracellular matrix of atherosclerotic vascular lesions in humans known to modulate vascular... 
Extracellular matrix | Prostaglandins | Cyclooxygenase-2 | Hyaluronic acid | Atherosclerosis | atherosclerosis | MIGRATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PERICELLULAR MATRIX | SUBTYPES | cyclooxygenase-2 | EPIDERMAL-KERATINOCYTES | hyaluronic acid | CAROTID ARTERIES | GROWTH-FACTOR-BETA | PROSTANOID RECEPTORS | prostaglandins | PERIPHERAL VASCULAR DISEASE | MOLECULAR-CLONING | HEMATOLOGY | EXPRESSION | extracellular matrix | Iloprost - pharmacology | Cyclooxygenase 2 | Humans | Muscle Cells - drug effects | Maleimides - pharmacology | Extracellular Matrix - metabolism | Alprostadil - analogs & derivatives | Cyclic AMP - physiology | Glucuronosyltransferase - genetics | RNA, Messenger - biosynthesis | Macrophages - secretion | Isoquinolines - pharmacology | Carotid Artery Diseases - pathology | Hyaluronic Acid - biosynthesis | Acetophenones - pharmacology | Enzyme Induction - drug effects | Epoprostenol - pharmacology | Indoles - pharmacology | Hyaluronan Synthases | Benzopyrans - pharmacology | Carotid Artery, Internal - pathology | Isoenzymes - physiology | Muscle, Smooth, Vascular - drug effects | Pertussis Toxin - pharmacology | Cells, Cultured - drug effects | Vasodilator Agents - pharmacology | Colforsin - pharmacology | Proto-Oncogene Proteins c-sis | RNA, Small Interfering - pharmacology | Alprostadil - pharmacology | Receptors, Prostaglandin E - drug effects | 6-Ketoprostaglandin F1 alpha - biosynthesis | Platelet-Derived Growth Factor - pharmacology | Cells, Cultured - secretion | Membrane Proteins | Epoprostenol - analogs & derivatives | Hyaluronic Acid - secretion | Sulfonamides | Receptors, Prostaglandin E, EP2 Subtype | Arteriosclerosis - metabolism | Bucladesine - pharmacology | Muscle, Smooth, Vascular - secretion | Arteriosclerosis - pathology | Glucuronosyltransferase - biosynthesis | Muscle Cells - secretion | Prostaglandin-Endoperoxide Synthases - physiology
Journal Article
by Choi, S and Kim, MY and Joo, MY and Park, S and Kim, JA and Jung, JC and Oh, S and Suh, SH
PHARMACOLOGICAL RESEARCH, ISSN 1043-6618, 07/2012, Volume 66, Issue 1, pp. 51 - 59
Modafinil has been used as a psychostimulant for the treatment of narcolepsy. However, its primary mechanism of action remains elusive. Therefore, we examined... 
Phosphorylation | MARMOSET PARKINSON MODEL | ENDOTHELIAL DYSFUNCTION | PROTEIN-KINASE | Ca2+-activated K+ channel | cAMP | BLOOD-PRESSURE | Vascular smooth muscle contraction | CYCLIC-AMP | SMOOTH-MUSCLE | Modafinil | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | ACTIVATED POTASSIUM CHANNEL | INTERMEDIATE-CONDUCTANCE | Enzyme Activators - pharmacology | NIH 3T3 Cells | Up-Regulation | Iloprost - pharmacology | Muscle, Smooth, Vascular - metabolism | Humans | Male | Peptide Fragments - pharmacology | Intermediate-Conductance Calcium-Activated Potassium Channels - metabolism | Dose-Response Relationship, Drug | Isoquinolines - pharmacology | Time Factors | Carrier Proteins - pharmacology | Intermediate-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Cyclic AMP - metabolism | Myocytes, Smooth Muscle - metabolism | Potassium Channel Blockers - pharmacology | Muscle, Smooth, Vascular - drug effects | Cyclic AMP-Dependent Protein Kinases - metabolism | Second Messenger Systems - drug effects | Vasodilator Agents - pharmacology | Colforsin - pharmacology | Rats | Sulfonamides - pharmacology | Vasoconstriction - drug effects | Patch-Clamp Techniques | Animals | Membrane Potentials | Benzhydryl Compounds - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Enzyme Activation
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e45273
Although prostanoids are known to be involved in regulation of the spontaneous beating rate of cultured neonatal rat cardiomyocytes, the various subtypes of... 
HEART | ARRHYTHMIAS | SIGNALING PATHWAYS | INTERNATIONAL UNION | PROSTAGLANDINS | MYOCYTES | SUBTYPES | MULTIDISCIPLINARY SCIENCES | IN-VIVO | CLASSIFICATION | CALCIUM MOBILIZATION | Iloprost - pharmacology | Receptors, Prostaglandin - physiology | Receptors, Prostaglandin E, EP1 Subtype - physiology | Dose-Response Relationship, Drug | Cloprostenol - pharmacology | Epoprostenol - pharmacology | Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide - pharmacology | Receptors, Prostaglandin - antagonists & inhibitors | Animals, Newborn | Dinoprostone - pharmacology | Hydantoins - pharmacology | Cells, Cultured | Rats | Rats, Sprague-Dawley | Blotting, Western | Epoprostenol - analogs & derivatives | Animals | Myocytes, Cardiac - drug effects | Receptors, Prostaglandin - agonists | Myocytes, Cardiac - physiology | Receptors, Thromboxane - agonists | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Dinoprostone - analogs & derivatives | Myocytes, Cardiac - metabolism | Prostaglandins F, Synthetic - pharmacology | Receptors, Prostaglandin E, EP1 Subtype - agonists | Prostaglandin D2 - pharmacology | Receptors, Prostaglandin E, EP1 Subtype - antagonists & inhibitors | Receptors, Thromboxane - physiology | Prostaglandins | Heart cells | Heart | Neonates | Cell culture | Laboratories | Cardiomyocytes | Pharmacology | Prostaglandin receptors | Gene expression | Misoprostol | Experiments | Western blotting | Receptors | Ischemia | Rodents
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2017, Volume 363, Issue 3, pp. 348 - 357
This article describes the preclinical pharmacology and pharmacokinetics (PK) of hexadecyl-treprostinil (C16TR), a prodrug of treprostinil (TRE), formulated in... 
PROSTACYCLIN RECEPTOR | EP4 RECEPTOR | ANALOGS | ARTERIAL-HYPERTENSION | IP | PHARMACOLOGY & PHARMACY | BINDING | ILOPROST | Antihypertensive Agents - pharmacology | Nanoparticles - chemistry | Vasodilator Agents - pharmacokinetics | Phosphatidylethanolamines - adverse effects | Humans | Excipients - adverse effects | Male | Polyethylene Glycols - chemistry | Squalene - analogs & derivatives | Drug Compounding | Hypertension, Pulmonary - drug therapy | Epoprostenol - pharmacokinetics | Guinea Pigs | Squalene - adverse effects | Antihypertensive Agents - therapeutic use | Excipients - administration & dosage | Rats, Sprague-Dawley | Epoprostenol - analogs & derivatives | Lung - drug effects | Vasodilation - drug effects | Phosphatidylethanolamines - chemistry | Drug Delivery Systems - adverse effects | Epoprostenol - administration & dosage | Prodrugs - administration & dosage | Epoprostenol - metabolism | Vasodilator Agents - therapeutic use | Antihypertensive Agents - administration & dosage | Polyethylene Glycols - adverse effects | Hypertension, Pulmonary - blood | Nanoparticles - adverse effects | Dose-Response Relationship, Drug | Epoprostenol - therapeutic use | Excipients - chemistry | Epoprostenol - pharmacology | Female | Lung - metabolism | Platelet Aggregation - drug effects | Drug Evaluation, Preclinical | Squalene - chemistry | Vasodilator Agents - pharmacology | Administration, Inhalation | Phosphatidylethanolamines - administration & dosage | Squalene - administration & dosage | Antihypertensive Agents - pharmacokinetics | Polyethylene Glycols - administration & dosage | Animals | Prodrugs - pharmacokinetics | Dogs | Nanoparticles - administration & dosage | Prodrugs - therapeutic use | Lung - blood supply | Prodrugs - pharmacology | Vasodilator Agents - administration & dosage | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/2004, Volume 141, Issue 4, pp. 580 - 585
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2000, Volume 387, Issue 1, pp. 111 - 118
Journal Article
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 05/2002, Volume 90, Issue 9, pp. 1028 - 1036
Endothelium-dependent hyperpolarization and relaxation of vascular smooth muscle are mediated by endothelium-derived hyperpolarizing factors (EDHFs). EDHF... 
Epoxyeicosatrienoic acids | Endothelium-derived hyperpolarizing factors | Arachidonic acid | 20-Hydroxyeicosatetraenoic acid | Endothelium | arachidonic acid | endothelium | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | CYTOCHROME-P450 METABOLITES | endothelium-derived hyperpolarizing factors | ARACHIDONIC-ACID | MESENTERIC-ARTERY | RENAL ARCUATE ARTERIES | epoxyeicosatrienoic acids | SMOOTH-MUSCLE | 20-hydroxyeicosatetraenoic acid | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | BINDING | K+ CHANNELS | EETS | Kidney Cortex - drug effects | Microsomes - metabolism | Arachidonic Acid - metabolism | Iloprost - pharmacology | Kidney Cortex - metabolism | 8,11,14-Eicosatrienoic Acid - chemistry | Male | Structure-Activity Relationship | Nitroprusside - pharmacology | Endothelium, Vascular - physiology | Dose-Response Relationship, Drug | Microsomes - drug effects | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Cattle | 8,11,14-Eicosatrienoic Acid - antagonists & inhibitors | 8,11,14-Eicosatrienoic Acid - pharmacology | Benzopyrans - pharmacology | Bradykinin - pharmacology | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | Vasoconstrictor Agents - pharmacology | Coronary Vessels - drug effects | Coronary Vessels - physiology | Rats | Muscle, Smooth, Vascular - cytology | Rats, Sprague-Dawley | Vasoconstriction - drug effects | Animals | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Dihydropyridines - pharmacology | Benzimidazoles - pharmacology | Vasodilation - drug effects | In Vitro Techniques
Journal Article
Circulation Research, ISSN 0009-7330, 01/2005, Volume 96, Issue 1, pp. e1 - e6
There is concern that cyclooxygenase (COX)-2 inhibitors may promote atherothrombosis by inhibiting vascular formation of prostacyclin (PGI2) and an increased... 
CARDIAC & CARDIOVASCULAR SYSTEMS | CYCLOOXYGENASE-2 | PROSTACYCLIN | cyclooxygenase | RECEPTOR | ARTERIAL THROMBOSIS | smooth muscle cells | CYCLIC-AMP | thrombosis | INHIBITION | GENE | thrombomodulin | ENDOTHELIAL-CELLS | DISEASE | prostaglandins | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | CARDIOVASCULAR RISK | Oligonucleotide Array Sequence Analysis | Humans | Gene Expression Profiling | Cyclooxygenase Inhibitors - toxicity | Thrombomodulin - biosynthesis | RNA, Messenger - biosynthesis | Carotid Artery Diseases - pathology | Myocytes, Smooth Muscle - drug effects | Carotid Artery, Internal - chemistry | Dinoprostone - pharmacology | Cells, Cultured - drug effects | Second Messenger Systems - drug effects | Sulfones - toxicity | Thrombophilia - physiopathology | Colforsin - pharmacology | Myocytes, Smooth Muscle - enzymology | Alprostadil - pharmacology | Sulfonamides - pharmacology | Receptors, Prostaglandin E, EP3 Subtype | Carotid Artery, Internal - enzymology | Membrane Proteins | Epoprostenol - analogs & derivatives | Pyridines - toxicity | Thrombophilia - blood | Carotid Artery Diseases - enzymology | Mammary Arteries - cytology | Models, Biological | Prostaglandins - deficiency | Receptors, Prostaglandin E - antagonists & inhibitors | Thrombophilia - chemically induced | Cells, Cultured - metabolism | Diclofenac - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Iloprost - pharmacology | Cyclooxygenase 2 | Culture Media, Serum-Free | Alprostadil - analogs & derivatives | Isoquinolines - pharmacology | Epoprostenol - pharmacology | Thrombomodulin - genetics | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Receptors, Prostaglandin - antagonists & inhibitors | Saphenous Vein - cytology | Vasodilator Agents - pharmacology | RNA, Messenger - genetics | Gene Expression Regulation - physiology | Gene Expression Regulation - drug effects | Cyclooxygenase 2 Inhibitors | Coronary Vessels - cytology | Bucladesine - pharmacology | Blood Coagulation - physiology | Prostaglandin-Endoperoxide Synthases - physiology
Journal Article
Journal Article
Acta Pharmaceutica, ISSN 1330-0075, 09/2014, Volume 64, Issue 3, pp. 345 - 353
There is considerable interest in the pleiotropic effects of statins and their potential role in the treatment of pulmonary hypertension. Previous experimental... 
combination therapy | hemodynamic parameters | rosuvastatin | sildenafil | pulmonary hypertension | CHOLESTEROL | STATINS | ILOPROST | ATORVASTATIN | FASUDIL | VENTRICULAR HYPERTROPHY | THERAPY | ARTERIAL-HYPERTENSION | PHARMACOLOGY & PHARMACY | SIMVASTATIN | BOSENTAN | Antihypertensive Agents - pharmacology | Rats, Wistar | Monocrotaline | Hypertension, Pulmonary - physiopathology | Male | Hypertension, Pulmonary - blood | Hypertrophy, Right Ventricular - drug therapy | Fluorobenzenes - pharmacology | Sildenafil Citrate | Hypertrophy, Right Ventricular - physiopathology | Pulmonary Artery - metabolism | Time Factors | Arterial Pressure - drug effects | Hypertension, Pulmonary - drug therapy | Ventricular Function, Right - drug effects | Vascular Remodeling - drug effects | Drug Therapy, Combination | Phosphodiesterase 5 Inhibitors - pharmacology | Natriuretic Peptide, Brain - blood | Disease Models, Animal | Vasodilator Agents - pharmacology | Purines - pharmacology | Vascular Endothelial Growth Factor A - blood | Ventricular Pressure - drug effects | Rosuvastatin Calcium | Pulmonary Artery - physiopathology | Biomarkers - blood | Pulmonary Artery - drug effects | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Piperazines - pharmacology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Cholesterol, HDL - blood
Journal Article
Circulation Research, ISSN 0009-7330, 07/2008, Volume 103, Issue 1, pp. 80 - 88
The role of prostaglandin production in the control of regenerative function of endothelial progenitor cells (EPCs) has not been studied. We hypothesized that... 
Angiogenesis | Cyclooxygenase | Prostaglandins | Adult stem cells | Peroxisome proliferator-activated receptor | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | angiogenesis | PROLIFERATOR-ACTIVATED RECEPTORS | CA2+-ACTIVATED K+ CHANNELS | cyclooxygenase | adult stem cells | TRANSPLANTATION | IN-VIVO | ACUTE MYOCARDIAL-INFARCTION | NITRIC-OXIDE | prostaglandins | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | peroxisome proliferator-activated receptor | GROWTH-FACTOR | HEMATOLOGY | UP-REGULATION | Gene Expression Regulation, Enzymologic - drug effects | Neovascularization, Physiologic - drug effects | RNA, Small Interfering - genetics | Cell Proliferation | Iloprost - pharmacology | Epoprostenol - biosynthesis | Humans | Middle Aged | Culture Media, Conditioned - pharmacology | Male | Stem Cells - cytology | Gene Expression Regulation, Enzymologic - physiology | Stem Cells - enzymology | Adult | Cyclooxygenase 1 - genetics | Cyclooxygenase 1 - biosynthesis | Vasodilator Agents - pharmacology | Cells, Cultured | Enzyme Activation - drug effects | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Neovascularization, Physiologic - physiology | Regeneration | Tumor Necrosis Factor-alpha - pharmacology | Endothelial Cells - cytology | PPAR delta - agonists | Leukocytes, Mononuclear - cytology | Leukocytes, Mononuclear - enzymology | Thiazoles - pharmacology | Endothelial Cells - enzymology | Enzyme Activation - physiology | peroxisome-proliferator activated receptor
Journal Article