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Biochemical journal, ISSN 0264-6021, 2000, Volume 351, Issue 1, pp. 95 - 105
Journal Article
Nature communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 5712
Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway... 
BRAF INHIBITION | TYROSINE KINASE AXL | RAF INHIBITION | CELLS | BREAST-CANCER METASTASIS | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | IMPROVED SURVIVAL | MEK INHIBITORS | UP-REGULATION | CONFERS RESISTANCE | Prognosis | Skin Neoplasms - drug therapy | Humans | Gene Expression Regulation, Neoplastic | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Melanoma - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Indoles - pharmacology | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Skin Neoplasms - pathology | Proto-Oncogene Proteins - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - metabolism | Signal Transduction | Proto-Oncogene Proteins - genetics | Imidazoles - pharmacology | Melanoma - pathology | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Skin Neoplasms - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Proto-Oncogene Proteins B-raf - genetics | Aminopyridines - pharmacology | Melanoma - drug therapy | Skin Neoplasms - genetics | Cell Line, Tumor | Oximes - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Microphthalmia-Associated Transcription Factor - genetics | Pyridones - pharmacology
Journal Article
American Journal of Physiology: Cell Physiology, ISSN 0363-6143, 09/2011, Volume 301, Issue 3, pp. C559 - C565
Deliu E, Tica AA, Motoc D, Brailoiu GC, Brailoiu E. Intracellular angiotensin II activates rat myometrium. Am J Physiol Cell Physiol 301: C559-C565, 2011.... 
Calcium imaging | Microinjection | Cytosolic calcium concentration | Endoplasmic reticulum | CYCLIC ADP-RIBOSE | PHYSIOLOGY | ANG-II | LIVER LYSOSOMES | RECEPTOR | microinjection | METABOLIC-CLEARANCE | BLOOD-PRESSURE | UTERINE | CELL BIOLOGY | SIGNAL-TRANSDUCTION | RENAL ENDOSOMES | SMOOTH-MUSCLE-CELLS | calcium imaging | cytosolic calcium concentration | endoplasmic reticulum | Myometrium - drug effects | Type C Phospholipases - metabolism | Brefeldin A - pharmacology | Angiotensin II Type 1 Receptor Blockers - pharmacology | Autophagy - drug effects | Endosomes - metabolism | Angiotensin II Type 2 Receptor Blockers - pharmacology | Macrocyclic Compounds - pharmacology | Saralasin - pharmacology | Endoplasmic Reticulum - drug effects | Estrenes - pharmacology | Myometrium - metabolism | Inositol 1,4,5-Trisphosphate Receptors - antagonists & inhibitors | Ryanodine - pharmacology | Angiotensin II - pharmacology | Pyridines - administration & dosage | Endocytosis - drug effects | Enzyme Inhibitors - pharmacology | Losartan - pharmacology | Saralasin - administration & dosage | Rats | Imidazoles - pharmacology | Piperazines - pharmacology | Rats, Sprague-Dawley | Receptor, Angiotensin, Type 2 - metabolism | Signal Transduction - drug effects | Calcium Signaling - drug effects | Models, Biological | Receptor, Angiotensin, Type 1 - metabolism | Oxazoles - pharmacology | Losartan - administration & dosage | Angiotensin II - administration & dosage | Calcium Signaling - physiology | Endoplasmic Reticulum - metabolism | Imidazoles - administration & dosage | Type C Phospholipases - antagonists & inhibitors | Lysosomes - metabolism | Inositol 1,4,5-Trisphosphate Receptors - metabolism | Pyrrolidinones - pharmacology | Macrolides - pharmacology | NADP - analogs & derivatives | Female | NADP - metabolism | Heparin - pharmacology | Angiotensin II - metabolism | Arsenicals - pharmacology | Cells, Cultured | Sirolimus - pharmacology | Myometrium - cytology | Animals | Egtazic Acid - pharmacology | Uterus - cytology | Signal Transduction - physiology | Pyridines - pharmacology | Carbolines - pharmacology | Myometrium | Cell receptors | Calcium channels | Genetic aspects | Properties | Angiotensin | Receptors and Signal Transduction
Journal Article
Journal Article
Free radical biology & medicine, ISSN 0891-5849, 08/2014, Volume 73, pp. 51 - 59
Microglia are the resident immune cells in the brain. Microglial activation is characteristic of several inflammatory and neurodegenerative diseases including... 
Peroxynitrite | Free radicals | Protein radical | Inducible nitric oxide synthase | Lipopolysaccharide | Nitrone adducts | Parkinson disease | Microglia | NADPH OXIDASE | OXIDATIVE STRESS | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INOS EXPRESSION | KAPPA-B | LIPOPOLYSACCHARIDE-ACTIVATED MICROGLIA | REACTIVE OXYGEN | ENDOCRINOLOGY & METABOLISM | GENERATION | TYROSINE NITRATION | PARKINSONS-DISEASE | Microglia - metabolism | Metalloporphyrins - pharmacology | Lipopolysaccharides | Thiocarbamates - pharmacology | RNA Interference | Nitric Oxide Synthase Type II - antagonists & inhibitors | Spin Trapping | Acetophenones - pharmacology | Free Radicals - metabolism | Proline - pharmacology | Microglia - cytology | NG-Nitroarginine Methyl Ester - pharmacology | NF-kappa B - antagonists & inhibitors | Proline - analogs & derivatives | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Antioxidants - pharmacology | Neurodegenerative Diseases - metabolism | Coumarins - pharmacology | Animals | Nitric Oxide Synthase Type II - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Peroxynitrous Acid - metabolism | Amidines - pharmacology | Mice | Pyridines - pharmacology | RNA, Small Interfering | Benzylamines - pharmacology | Cell Line, Transformed | Boronic Acids - pharmacology | Nitric Oxide Synthase Type II - metabolism | Nitration | Nervous system diseases | Multiple sclerosis | Analysis | Nitric oxide | Environmental health | Physiological aspects | Alzheimer's disease | Index Medicus | Inducible nitric | oxide synthase | LPS | Parkinson’s disease
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2006, Volume 26, Issue 11, pp. 2862 - 2870
Neuronal activity evokes localized changes in blood flow. Although this response, termed neurovascular coupling, is widely used to monitor human brain function... 
Arachidonic acid metabolites | Retina | Calcium | Glia | ATP | Blood flow | arachidonic acid metabolites | 20-HETE | calcium | RAT | ASTROCYTE-MEDIATED CONTROL | CALCIUM WAVES | EPOXYGENASE | ARACHIDONIC-ACID | RELEASE | glia | NEUROSCIENCES | HEMODYNAMIC-RESPONSE | retina | NITRIC-OXIDE | blood flow | BRAIN | Arterioles - physiology | Cytochrome P-450 Enzyme Inhibitors | Rats, Long-Evans | Arterioles - enzymology | Nitric Oxide Synthase - physiology | Male | Vasodilation - radiation effects | Retinal Vessels - enzymology | Retinal Vessels - physiology | Hydroxyeicosatetraenoic Acids - biosynthesis | Vasoconstriction - radiation effects | Photolysis | Cyclic N-Oxides - pharmacology | Inositol 1,4,5-Trisphosphate - analogs & derivatives | Eye Proteins - antagonists & inhibitors | Purinergic Antagonists | Signal Transduction - radiation effects | Cytochrome P-450 Enzyme System - physiology | Hydrazines - pharmacology | Rats | Imidazoles - pharmacology | Retinal Vessels - drug effects | Arterioles - drug effects | Vasoconstriction - drug effects | Cytochrome P-450 CYP4A - physiology | Signal Transduction - drug effects | Miconazole - pharmacology | Eye Proteins - physiology | Retinal Vessels - radiation effects | Vasodilation - drug effects | Arterioles - radiation effects | Nitric Oxide - pharmacology | Caproates - pharmacology | Vasomotor System - drug effects | Nitric Oxide Synthase - antagonists & inhibitors | Inositol 1,4,5-Trisphosphate - pharmacology | Adenosine Triphosphate - pharmacology | Vasoconstriction - physiology | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Proadifen - pharmacology | Nitric Oxide Donors - pharmacology | Vasodilation - physiology | 8,11,14-Eicosatrienoic Acid - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Calcium Signaling - radiation effects | Cytochrome P-450 CYP4A - antagonists & inhibitors | Neuroglia - physiology | Nitric Oxide - physiology | Vasomotor System - radiation effects | Animals | Vasomotor System - physiology | Amidines - pharmacology | In Vitro Techniques
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 15, pp. 11810 - 11819
gamma-Secretase-mediated cleavage of amyloid precursor protein (APP) results in the production of Alzheimer disease-related amyloid-beta (A beta) peptides. The... 
TARGET | PROTEIN | PATTERN | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSMEMBRANE DOMAIN | INHIBITORS | BINDING-SITES | EXPRESSION | FAILURE | PRESENILIN-1 | Pyridines - chemistry | Receptors, Notch - metabolism | Humans | Receptor, EphA4 - metabolism | Pyrimidines - chemistry | Brain - metabolism | Alanine - analogs & derivatives | Dibenzazepines - pharmacology | Drug Interactions | Azepines - chemistry | Piperidines - pharmacology | Protein Processing, Post-Translational - drug effects | Pyrans - chemistry | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Female | Pyrans - pharmacology | Alanine - pharmacology | Carbamates - pharmacology | Binding, Competitive | Guinea Pigs | Amyloid beta-Peptides - biosynthesis | Dipeptides - pharmacology | Mice, Inbred C57BL | Rats | Imidazoles - pharmacology | Pyrimidines - pharmacology | Receptor, EphB2 - metabolism | Sulfonamides - pharmacology | Azepines - pharmacology | Brain - drug effects | Sulindac - analogs & derivatives | Amyloid Precursor Protein Secretases - metabolism | Animals | Cell-Free System | Protein Binding | Mice | Pyridines - pharmacology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Flurbiprofen - pharmacology | Sulindac - pharmacology | Neurodegenerative Diseases | Secretases | Neurobiology | Intramembrane Proteolysis | Amyloid | Pharmacology | Alzheimer Disease
Journal Article
Planta, ISSN 1432-2048, 2008, Volume 229, Issue 4, pp. 757 - 765
The effects of chitosan (β-1,4 linked glucosamine, a fungal elicitor), on the patterns of stomatal movement and signaling components were studied. cPTIO (NO... 
Pathogens | Reactive oxygen species | Calcium | Sodium | Fluorescence | Guard cells | Oxides | Stomata | Plants | Tungstates | Life Sciences | Signal transduction | Nitric oxide | Forestry | ROS | Ecology | Agriculture | Chitosan | Plant Sciences | Pea | ARABIDOPSIS-THALIANA | FREE CALCIUM | CULTURED-CELLS | PROTEIN-KINASES | BLUE-LIGHT | PLANT SCIENCES | SIGNAL-TRANSDUCTION | STRESS RESPONSES | HYDROGEN-PEROXIDE | ABSCISIC-ACID | DISEASE RESISTANCE | Free Radical Scavengers - pharmacology | Oxidants - pharmacology | Reactive Oxygen Species - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Tungsten Compounds - pharmacology | Peas - cytology | Plant Epidermis - metabolism | Dose-Response Relationship, Drug | Time Factors | Cyclic N-Oxides - pharmacology | Egtazic Acid - analogs & derivatives | Chitosan - pharmacology | Plant Epidermis - cytology | Plant Stomata - drug effects | Peas - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Peas - drug effects | Imidazoles - pharmacology | Chelating Agents - pharmacology | Onium Compounds - pharmacology | Plant Epidermis - drug effects | Abscisic Acid - pharmacology | Microscopy, Confocal | Egtazic Acid - pharmacology | Kinetics | Nitric Oxide - metabolism | Plant Growth Regulators - pharmacology | Plant Stomata - physiology | Oxidases | Legumes | Beans | Mimosaceae | Tungsten compounds | Index Medicus
Journal Article
Journal Article
Immunology and Cell Biology, ISSN 0818-9641, 10/2007, Volume 85, Issue 7, pp. 558 - 566
It has been recognized that protease‐activated receptors (PARs), interleukin (IL)‐4 and IL‐6 are involved in the pathogenesis of allergic diseases, and that... 
mast cell | IL‐4 | IL‐12 | trypsin | protease‐activated receptor | tryptase | IL-4 | Trypsin | Mast cell | Protease-activated receptor | IL-12 | Tryptase | SERINE PROTEINASES | THROMBIN RECEPTORS | HISTAMINE-RELEASE | INDUCTION | IMMUNOLOGY | HUMAN AIRWAYS | CELL BIOLOGY | SMOOTH-MUSCLE | INTERFERON-GAMMA | IN-VIVO | protease-activated receptor | VASCULAR ENDOTHELIAL-CELLS | INFLAMMATORY MEDIATORS | Receptors, Proteinase-Activated - metabolism | Nitriles - pharmacology | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | RNA, Messenger - metabolism | Receptors, Proteinase-Activated - genetics | Trypsin - pharmacology | Mast Cells - metabolism | Flavonoids - pharmacology | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-12 - pharmacology | Butadienes - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Imidazoles - pharmacology | Tyrphostins - pharmacology | Mast Cells - drug effects | Gene Expression Regulation - drug effects | Interleukin-4 - secretion | Animals | Tryptases - pharmacology | Mice | Pyridines - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Tyrphostins, pharmacology | Up-Regulation | Chromones, pharmacology | Trypsin, pharmacology | Humans | Imidazoles, pharmacology | Tryptases, pharmacology | Oligopeptides, pharmacology | Interleukin-12, pharmacology | Flow Cytometry | Pyridines, pharmacology | Polymerase Chain Reaction | Receptor, PAR-1, drug effects | Morpholines, pharmacology | RNA, Messenger, metabolism | Flavonoids, pharmacology | Receptor, PAR-2, drug effects | Receptors, Thrombin, drug effects | Enzyme-Linked Immunosorbent Assay | Signal Transduction | Butadienes, pharmacology | Down-Regulation | Mast Cells, drug effects | Interleukin-6, secretion | Nitriles, pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Interleukin-4, secretion | Fluorescent Antibody Technique
Journal Article
by Zhou, S and Liu, L and Li, H and Eilers, G and Kuang, Y and Shi, S and Yan, Z and Li, X and Corson, J M and Meng, F and Zhou, H and Sheng, Q and Fletcher, J A and Ou, W-B
British journal of cancer, ISSN 1532-1827, 2014, Volume 110, Issue 10, pp. 2479 - 2488
Background: Mesothelioma is a notoriously chemotherapy-resistant neoplasm, as is evident in the dismal overall survival for patients with those of... 
ACTIVATION | GROWTH-FACTOR-RECEPTOR | FACTOR SCATTER FACTOR | MALIGNANT PLEURAL MESOTHELIOMA | PHASE-II | tyrosine kinases | ANTITUMOR-ACTIVITY | MET RECEPTOR | PI3K/AKT/MDM2 | PI3K/AKT/mTOR | INHIBITION | ONCOLOGY | C-MET | mesothelioma | Mesothelioma - pathology | Nitriles - pharmacology | Humans | Neoplasm Proteins - physiology | Receptor Protein-Tyrosine Kinases - physiology | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Quinolines - pharmacology | MAP Kinase Signaling System | TOR Serine-Threonine Kinases - antagonists & inhibitors | raf Kinases - physiology | RNA Interference | TOR Serine-Threonine Kinases - physiology | Antineoplastic Agents - pharmacology | Chromones - pharmacology | Everolimus | Butadienes - pharmacology | Sirolimus - analogs & derivatives | RNA, Small Interfering - pharmacology | Morpholines - pharmacology | Imidazoles - pharmacology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Sirolimus - pharmacology | Indazoles - pharmacology | Signal Transduction - drug effects | Mesothelioma - enzymology | Cell Line, Tumor | Phosphatidylinositol 3-Kinases - physiology | Protein Kinase Inhibitors - pharmacology | Cell Cycle - drug effects | Drug Screening Assays, Antitumor | Translational Therapeutics | PI3K | mTOR | MDM2 | AKT
Journal Article