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Journal of Hematology and Oncology, ISSN 1756-8722, 07/2017, Volume 10, Issue 1, pp. 133 - 17
The two murine double minute (MDM) family members MDM2 and MDMX are at the center of an intense clinical assessment as molecular target for the management of... 
MDM2 | Pediatric tumors | Clinical studies | Leukemia | MDMX | Pharmacological inhibitor | SUPPRESSOR TRANSACTIVATION DOMAIN | ADVANCED SOLID TUMORS | ACUTE MYELOGENOUS LEUKEMIA | POTENTIAL THERAPEUTIC TARGET | ACUTE MYELOID-LEUKEMIA | PRECLINICAL TESTING PROGRAM | B-CELL LYMPHOMA | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | CHRONIC LYMPHOCYTIC-LEUKEMIA | HEMATOLOGY | P53 ACTIVATOR NUTLIN-3 | Proto-Oncogene Proteins c-mdm2 - genetics | Protein Interaction Maps - drug effects | para-Aminobenzoates - pharmacology | Humans | Spiro Compounds - therapeutic use | Antineoplastic Agents - therapeutic use | Hematologic Neoplasms - pathology | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Imidazolines - therapeutic use | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Child | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Hematologic Neoplasms - metabolism | Molecular Targeted Therapy - methods | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Suppressor Protein p53 - metabolism | Imidazolines - pharmacology | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Animals | Signal Transduction - drug effects | Nuclear Proteins - antagonists & inhibitors | para-Aminobenzoates - therapeutic use | Hematologic Neoplasms - drug therapy | Indoles - therapeutic use | Hematologic Neoplasms - genetics | Spiro Compounds - pharmacology | Pediatrics | Medical research | Clinical trials | Medicine, Experimental | Development and progression | Tumor proteins | Cancer | Cell proliferation | MDM2 protein | Animal models | Hematology | Medical innovations | p53 Protein | Genomics | Multiple myeloma | Genomes | Proteins | Side effects | Chemotherapy | Cell cycle | Lymphomas | Mutation | Chromosomes | Regulatory proteins | Tumors
Journal Article
Nature, ISSN 0028-0836, 06/2016, Volume 534, Issue 7607, pp. 341 - 346
Chronic myeloid leukaemia (CML) arises after transformation of a haemopoietic stem cell (HSC) by the protein-tyrosine kinase BCR-ABL. Direct inhibition of... 
CD34(+) CELLS | INHIBITION | MICROARRAY | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | IMATINIB | TUMOR | COMBINATION | CANCER | EXPRESSION | CHRONIC MYELOID-LEUKEMIA | Antigens, CD34 - metabolism | Tumor Suppressor Protein p53 - antagonists & inhibitors | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Transcriptome | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Acetamides - pharmacology | Male | Neoplasm Proteins - metabolism | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Imatinib Mesylate - therapeutic use | Acetamides - therapeutic use | Neoplastic Stem Cells - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Imidazolines - therapeutic use | Neoplastic Stem Cells - pathology | Female | Cell Death - drug effects | Hematopoietic Stem Cells - drug effects | Reproducibility of Results | Imatinib Mesylate - pharmacology | Tumor Suppressor Protein p53 - metabolism | Imidazolines - pharmacology | Hematopoietic Stem Cells - metabolism | Tumor Suppressor Protein p53 - deficiency | Proto-Oncogene Proteins c-myc - metabolism | Neoplastic Stem Cells - transplantation | Azepines - therapeutic use | Azepines - pharmacology | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Hematopoietic Stem Cells - cytology | Proto-Oncogene Proteins c-myc - deficiency | Proteomics | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice | Proto-Oncogene Proteins c-myc - genetics | Fusion Proteins, bcr-abl - metabolism | Molecular targeted therapy | Cancer cells | Stem cells | Development and progression | Genetic aspects | Chronic myeloid leukemia | Tumor proteins | Properties | Health aspects | Methods | Proteins | Transcription factors | Leukemia | Cell cycle | Kinases | Cancer therapies | Apoptosis
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 02/2014, Volume 21, Issue 5, pp. 553 - 574
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2016, Volume 22, Issue 4, pp. 868 - 876
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2017, Volume 362, Issue 1, pp. 119 - 130
Journal Article
Journal Article
Progress in Neuropsychopharmacology & Biological Psychiatry, ISSN 0278-5846, 07/2013, Volume 44, pp. 136 - 142
Journal Article