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1. Full Text Arabidopsis and Maize RidA Proteins Preempt Reactive Enamine/Imine Damage to Branched-Chain Amino Acid Biosynthesis in Plastids
by Thomas D. Niehaus and Thuy N.D. Nguyen and Satinder K. Gidda and Mona ElBadawi-Sidhu and Jennifer A. Lambrecht and Donald R. McCarty and Diana M. Downs and Arthur J.L. Cooper and Oliver Fiehn and Robert T. Mullen and Andrew D. Hanson
The Plant cell, ISSN 1040-4651, 7/2014, Volume 26, Issue 7, pp. 3010 - 3022
Proteins | Enzymes | Imines | Chloroplasts | Branched chain amino acids | RESEARCH ARTICLES | Root growth | Corn | Biosynthesis | Plants | Plant cells | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Plant Sciences | Science & Technology | Cell Biology | L-Serine Dehydratase - genetics | Zea mays - chemistry | Metabolomics | Butyrates - metabolism | Amino Acids, Branched-Chain - metabolism | Molecular Sequence Data | Plant Roots - genetics | Aminohydrolases - genetics | Plant Shoots - chemistry | Arabidopsis Proteins - metabolism | Threonine Dehydratase - genetics | Transaminases - metabolism | Plant Proteins - metabolism | Plant Shoots - genetics | Zea mays - metabolism | Threonine Dehydratase - metabolism | Amino Acid Sequence | Zea mays - genetics | Arabidopsis Proteins - genetics | L-Serine Dehydratase - metabolism | Arabidopsis - chemistry | Plant Roots - metabolism | Transaminases - genetics | Arabidopsis - cytology | Imines - metabolism | Plant Roots - cytology | Plant Shoots - cytology | Arabidopsis - metabolism | Arabidopsis - genetics | Hydrolysis | Plant Proteins - genetics | Plastids - enzymology | Sequence Alignment | Animals | Plant Shoots - metabolism | Plant Roots - chemistry | Aminohydrolases - metabolism | Arabidopsis thaliana | Physiological aspects | Instrument industry | International economic relations | Index Medicus
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2. Full Text Modulation of Acetaminophen-Induced Hepatotoxicity by the Xenobiotic Receptor CAR
by Jun Zhang and Wendong Huang and Steven S. Chua and Ping Wei and David D. Moore
Science (American Association for the Advancement of Science), ISSN 0036-8075, 10/2002, Volume 298, Issue 5592, pp. 422 - 424
Receptors | Animals | Liver | Agonists | Reports | Mice | Automobiles | Dosage | Xenobiotics | Hepatotoxicity | Necrosis | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Toxicity: digestive system | Biological and medical sciences | Medical sciences | Drug toxicity and drugs side effects treatment | Pharmacology. Drug treatments | Phenobarbital - pharmacology | Acetaminophen - metabolism | Liver - pathology | Oxidoreductases, N-Demethylating - genetics | Cytochrome P-450 CYP3A | Glutathione - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Alanine Transaminase - blood | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | RNA, Messenger - metabolism | Glutathione Transferase - genetics | Analgesics, Non-Narcotic - toxicity | Liver - drug effects | Time Factors | Isoenzymes - metabolism | Cytochrome P-450 CYP1A2 - genetics | Oxidoreductases, N-Demethylating - metabolism | Benzoquinones - metabolism | Acetaminophen - toxicity | Isoenzymes - genetics | Imines - metabolism | Liver - metabolism | RNA, Messenger - genetics | Glutathione Transferase - metabolism | Mice, Transgenic | Transcription Factors - antagonists & inhibitors | Androstanols - pharmacology | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Analgesics, Non-Narcotic - metabolism | Transcription Factors - genetics | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mice, Knockout | Transcription Factors - metabolism | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Acetylcysteine - pharmacology | Cytochrome P-450 Enzyme System - genetics | Glutathione S-Transferase pi | Pyridines - pharmacology | Transcription Factors - agonists | Receptors, Cytoplasmic and Nuclear - metabolism | Liver failure | Dosage and administration | Analgesics | Drug therapy | Acetaminophen | Drug overdose | Index Medicus
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3. Full Text Neutral Cysteine Protease Bleomycin Hydrolase Is Essential for the Breakdown of Deiminated Filaggrin into Amino Acids
by Yayoi Kamata and Aya Taniguchi and Mami Yamamoto and Junko Nomura and Kazuhiko Ishihara and Hidenari Takahara and Toshihiko Hibino and Atsushi Takeda
The Journal of biological chemistry, ISSN 0021-9258, 05/2009, Volume 284, Issue 19, pp. 12829 - 12836
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Calpain - metabolism | Humans | Citrulline - metabolism | Immunoenzyme Techniques | Amino Acids - metabolism | Cysteine Endopeptidases - metabolism | Imines - chemistry | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Aminopeptidases - metabolism | Animals, Newborn | Hydrolases - metabolism | Recombinant Proteins - metabolism | Caspase 14 - metabolism | Peptide Fragments - metabolism | Imines - metabolism | Rats | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Skin - enzymology | Rats, Sprague-Dawley | Peptide Fragments - chemistry | Animals | Hydrolases - chemistry | Mice | Intermediate Filament Proteins - metabolism | Index Medicus
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4. Full Text The Genetic and Molecular Basis for Sunscreen Biosynthesis in Cyanobacteria
by Emily P. Balskus and Christopher T. Walsh
Science (American Association for the Advancement of Science), ISSN 0036-8075, 9/2010, Volume 329, Issue 5999, pp. 1653 - 1656
Fungi | Phosphates | Enzymes | Imines | REPORTS | Cyanobacteria | Amino acids | Multigene family | Biosynthesis | Biochemistry | Open reading frames | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Microbiology | Metabolism. Enzymes | Bacteriology | Glycine - analogs & derivatives | Multigene Family | Cyclohexanols | Ligases - genetics | Methyltransferases - metabolism | Open Reading Frames | Methyltransferases - genetics | Anabaena variabilis - genetics | Sunscreening Agents - metabolism | Anabaena variabilis - metabolism | Ultraviolet Rays | Glycine - chemistry | Adenosine Triphosphate - metabolism | Cloning, Molecular | Escherichia coli - metabolism | Nostoc - genetics | Genes, Bacterial | Nostoc - enzymology | Biocatalysis | Imines - metabolism | Anabaena variabilis - enzymology | Bacterial Proteins - genetics | Cyclohexylamines - chemistry | Glycine - biosynthesis | Ligases - metabolism | Escherichia coli - genetics | Nostoc - metabolism | Bacterial Proteins - metabolism | Physiological aspects | Research | Properties | Sunscreens (Cosmetics) | Bacteria | Sunscreen | Molecular biology | Gene expression | Index Medicus | Macromolecules | Clusters | Strategy | Dealing | Ultraviolet
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5. Full Text Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture
by McCall, A. Scott and Cummings, Christopher F and Bhave, Gautam and Vanacore, Roberto and Page-Mccaw, Andrea and Hudson, Billy G
Cell (Cambridge), ISSN 0092-8674, 06/2014, Volume 157, Issue 6, pp. 1380 - 1392
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Line | Trace Elements - metabolism | Basement Membrane - ultrastructure | Bromine - metabolism | Extracellular Matrix Proteins - genetics | Humans | Imines - metabolism | Basement Membrane - metabolism | Larva - ultrastructure | Collagen - metabolism | Animals | Peroxidase - genetics | Drosophila - growth & development | Mice | Drosophila - metabolism | Bromine - deficiency | Extracellular Matrix Proteins - metabolism | Peroxidase - metabolism | Post-translational modification | Medical colleges | Architecture | Collagen | Resveratrol | Hypertension | Developmental biology | Index Medicus
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6. Full Text Occurrence of marine algal toxins in oyster and phytoplankton samples in Daya Bay, South China Sea
by Jiang, Tao and Liu, Lei and Li, Yang and Zhang, Jing and Tan, Zhijun and Wu, Haiyan and Jiang, Tianjiu and Lu, Songhui
Chemosphere (Oxford), ISSN 0045-6535, 09/2017, Volume 183, pp. 80 - 88
Okadaic acid | Shellfish toxins | Dinophysis | Domoic acid | Pectenotoxin | Pseudo-nitzschia | Environmental Sciences & Ecology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Bays - chemistry | Heterocyclic Compounds, 3-Ring - metabolism | Ostreidae - chemistry | Kainic Acid - analogs & derivatives | Okadaic Acid - metabolism | Imines - analysis | Pyrans - analysis | Marine Toxins - analysis | Tandem Mass Spectrometry | Pyrans - metabolism | China | Dinoflagellida - metabolism | Phytoplankton - metabolism | Phytoplankton - chemistry | Marine Toxins - metabolism | Okadaic Acid - analysis | Imines - metabolism | Environmental Monitoring - methods | Heterocyclic Compounds, 3-Ring - analysis | Water Pollutants, Chemical - analysis | Kainic Acid - metabolism | Kainic Acid - analysis | Water Pollutants, Chemical - metabolism | Animals | Hydrocarbons, Cyclic - analysis | Ostreidae - metabolism | Chromatography, Liquid - methods | Hydrocarbons, Cyclic - metabolism | Marine biology | Liquid chromatography | Marine toxins | Mass spectrometry | Amphibians | Analysis | Index Medicus
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7. Full Text Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism
by Liu, Xing and Lu, Yuanfu and Guan, Xinfu and Dong, Bingning and Chavan, Hemantkumar and Wang, Jin and Zhang, Yiqing and Krishnamurthy, Partha and Li, Feng
Biochemical pharmacology, ISSN 0006-2952, 09/2015, Volume 97, Issue 1, pp. 111 - 121
Metabolomics | Iminium | Gefitinib | Aldehyde | Bioactivation | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Humans | Microsomes, Liver - metabolism | Aldehydes - metabolism | Antineoplastic Agents - metabolism | Protein Kinase Inhibitors - chemistry | Cytochrome P-450 CYP3A - genetics | Quinazolines - metabolism | Isoenzymes - metabolism | Microsomes, Liver - drug effects | Cytochrome P-450 CYP3A - chemistry | Imines - chemistry | Membrane Proteins - metabolism | Microsomes, Liver - enzymology | Molecular Structure | Quinazolines - chemistry | Recombinant Proteins - metabolism | Metabolic Detoxication, Phase II | Isoenzymes - genetics | Membrane Proteins - genetics | Imines - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Metabolomics - methods | Mice, Knockout | Animals | Membrane Proteins - antagonists & inhibitors | Cytochrome P-450 CYP3A - metabolism | Metabolic Detoxication, Phase I | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Isoenzymes - antagonists & inhibitors | Aldehydes - chemistry | Protein Kinase Inhibitors - metabolism | Antimitotic agents | Physiological aspects | Antineoplastic agents | Index Medicus
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8. Full Text Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients
by Xie, Cen and Zhou, Jialan and Guo, Zitao and Diao, Xingxing and Gao, Zhiwei and Zhong, Dafang and Jiang, Haoyuan and Zhang, Lijia and Chen, Xiaoyan
British journal of pharmacology, ISSN 0007-1188, 04/2013, Volume 168, Issue 7, pp. 1687 - 1706
quinone‐imine | metabolism | famitinib | hepatotoxicity | bioactivation | quinone-imine | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Neoplasms - metabolism | Pyrroles - metabolism | Pyrroles - pharmacokinetics | Oxidation-Reduction | Administration, Oral | Humans | Microsomes, Liver - metabolism | Middle Aged | Cytochrome P-450 Enzyme System - metabolism | Male | Hepatocytes - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Antineoplastic Agents - metabolism | Tissue Distribution | Indoles - metabolism | Isoenzymes - metabolism | Biotransformation | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Indoles - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Hepatocytes - drug effects | Tyrosine | Cysteine | Cancer patients | Care and treatment | Metabolites | Hydroxylation | Quinone | Physiological aspects | Phenols | Liquid chromatography | Mass spectrometry | Urine | Enzymes | Metabolism | Cancer | Index Medicus | Research Papers
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9. Full Text Cyclic Imines: Chemistry and Mechanism of Action: A Review
by Otero, Alberto and Chapela, María-José and Atanassova, Miroslava and Vieites, Juan M and Cabado, Ana G
Chemical research in toxicology, ISSN 0893-228X, 11/2011, Volume 24, Issue 11, pp. 1817 - 1829
Physical Sciences | Toxicology | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Heterocyclic Compounds, 3-Ring - metabolism | Marine Toxins - toxicity | Food Contamination | Nicotinic Antagonists - metabolism | Humans | Pyrans - toxicity | Receptors, Muscarinic - metabolism | Shellfish Poisoning - metabolism | Structure-Activity Relationship | Pyrans - chemistry | Pyrans - metabolism | Heterocyclic Compounds, 3-Ring - toxicity | Imines - chemistry | Biological Assay | Binding Sites | Microalgae - chemistry | Nicotinic Antagonists - toxicity | Spiro Compounds - chemistry | Muscarinic Antagonists - metabolism | Cell Survival - drug effects | Muscarinic Antagonists - toxicity | Receptors, Nicotinic - metabolism | Shellfish - toxicity | Marine Toxins - metabolism | Hydrocarbons, Cyclic - toxicity | Imines - metabolism | Injections, Intraperitoneal | Imines - toxicity | Muscarinic Antagonists - chemistry | Animals | Spiro Compounds - toxicity | Marine Toxins - chemistry | Nicotinic Antagonists - chemistry | Heterocyclic Compounds, 3-Ring - chemistry | Protein Binding | Mice | Hydrocarbons, Cyclic - chemistry | Shellfish Poisoning - physiopathology | Hydrocarbons, Cyclic - metabolism | Spiro Compounds - metabolism | Index Medicus
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10. Full Text Controlled Cell Adhesion on Poly(dopamine) Interfaces Photopatterned with Non‐Fouling Brushes
by Rodriguez‐Emmenegger, Cesar and Preuss, Corinna M and Yameen, Basit and Pop‐Georgievski, Ognen and Bachmann, Michael and Mueller, Jan O and Bruns, Michael and Goldmann, Anja S and Bastmeyer, Martin and Barner‐Kowollik, Christopher
Advanced materials (Weinheim), ISSN 0935-9648, 11/2013, Volume 25, Issue 42, pp. 6123 - 6127
nitrile imine‐mediated tetrazole‐ene cycloaddition (NITEC) | micropatterning | photoligation | poly(dopamine) | antifouling polymer brushes | nitrile imine-mediated tetrazole-ene cycloaddition (NITEC) | Materials Science | Materials Science, Multidisciplinary | Physics, Condensed Matter | Science & Technology - Other Topics | Chemistry, Physical | Physics | Science & Technology | Physics, Applied | Physical Sciences | Chemistry | Nanoscience & Nanotechnology | Technology | Chemistry, Multidisciplinary | Polyethylene Glycols - metabolism | Recombinant Fusion Proteins - biosynthesis | Cell Line | Green Fluorescent Proteins - metabolism | Cell Adhesion Molecules - genetics | Acrylates - chemistry | Rats | Polyethylene Glycols - chemistry | Green Fluorescent Proteins - genetics | Phosphoproteins - genetics | Phosphoproteins - metabolism | Cell Adhesion | Cell Adhesion Molecules - metabolism | Indoles - metabolism | Animals | Acrylates - metabolism | Recombinant Fusion Proteins - genetics | Polymers - chemistry | Microfilament Proteins - metabolism | Indoles - chemistry | Microfilament Proteins - genetics | Silicon - chemistry | Polymers - metabolism | Phenols | Polymers | Adhesion | Index Medicus
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