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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2010, Volume 107, Issue 13, pp. 6076 - 6081
Spirolide and gymnodimine macrocyclic imine phycotoxins belong to an emerging class of chemical agents associated with marine algal blooms and shelfish... 
Receptors | Imines | Shellfish | Ligands | Agonists | Toxins | Pharmacology | Nicotinic receptors | Nitrogen | Oocytes | Pharmacological and structural analyses | Seafood poisoning | Acetylcholine binding protein | Nicotinic acetylcholine receptor | Marine phycotoxins | PLANKTON | acetylcholine binding protein | seafood poisoning | DINOFLAGELLATE ALEXANDRIUM-OSTENFELDII | SHELLFISH TOXINS | SPIROLIDE-C | PROTEIN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | marine phycotoxins | AGONISTS | ACETYLCHOLINE-RECEPTOR | GYMNODIMINE | pharmacological and structural analyses | nicotinic acetylcholine receptor | REVEALS | Heterocyclic Compounds, 3-Ring - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Nicotinic Antagonists - metabolism | Humans | Aplysia - metabolism | Crystallography, X-Ray | Acetylcholine - metabolism | Nicotinic Antagonists - pharmacology | Hydrocarbons, Cyclic - pharmacology | Imines - chemistry | Oocytes - drug effects | Carrier Proteins - chemistry | Female | Molecular Structure | Spiro Compounds - chemistry | Receptors, Nicotinic - metabolism | Marine Toxins - metabolism | Oocytes - metabolism | Imines - metabolism | Models, Molecular | Electric Organ - metabolism | Marine Toxins - pharmacology | Imines - pharmacology | Macromolecular Substances | Animals | Carrier Proteins - metabolism | Xenopus - metabolism | Marine Toxins - chemistry | Nicotinic Antagonists - chemistry | Heterocyclic Compounds, 3-Ring - chemistry | Torpedo - metabolism | Kinetics | In Vitro Techniques | Hydrocarbons, Cyclic - chemistry | Spiro Compounds - pharmacology | Hydrocarbons, Cyclic - metabolism | Spiro Compounds - metabolism | Marine toxins | Crystals | Physiological aspects | Acetylcholine | Structure | Properties | Protein binding | Index Medicus | Life Sciences | Neurons and Cognition | Biological Sciences
Journal Article
The Plant Cell, ISSN 1040-4651, 7/2014, Volume 26, Issue 7, pp. 3010 - 3022
RidA (for Reactive Intermediate Deaminase A) proteins are ubiquitous, yet their function in eukaryotes is unclear. It is known that deleting Salmonella... 
Proteins | Enzymes | Imines | Chloroplasts | Branched chain amino acids | RESEARCH ARTICLES | Root growth | Corn | Biosynthesis | Plants | Plant cells | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SACCHAROMYCES-CEREVISIAE | MEMBER | PLANT SCIENCES | CELL BIOLOGY | SALMONELLA-ENTERICA | IN-VITRO | YJGF/YER057C/UK114 FAMILY | METABOLISM | PATHWAY | ISOLEUCINE BIOSYNTHESIS | THREONINE DEHYDRATASE | L-Serine Dehydratase - genetics | Zea mays - chemistry | Metabolomics | Butyrates - metabolism | Amino Acids, Branched-Chain - metabolism | Molecular Sequence Data | Plant Roots - genetics | Aminohydrolases - genetics | Plant Shoots - chemistry | Arabidopsis Proteins - metabolism | Threonine Dehydratase - genetics | Transaminases - metabolism | Plant Proteins - metabolism | Plant Shoots - genetics | Zea mays - metabolism | Threonine Dehydratase - metabolism | Amino Acid Sequence | Zea mays - genetics | Arabidopsis Proteins - genetics | L-Serine Dehydratase - metabolism | Arabidopsis - chemistry | Plant Roots - metabolism | Transaminases - genetics | Arabidopsis - cytology | Imines - metabolism | Plant Roots - cytology | Plant Shoots - cytology | Arabidopsis - metabolism | Arabidopsis - genetics | Hydrolysis | Plant Proteins - genetics | Plastids - enzymology | Sequence Alignment | Animals | Plant Shoots - metabolism | Plant Roots - chemistry | Aminohydrolases - metabolism | Arabidopsis thaliana | Physiological aspects | Instrument industry | International economic relations
Journal Article
Science, ISSN 0036-8075, 10/2002, Volume 298, Issue 5592, pp. 422 - 424
We have identified the xenobiotic receptor CAR (constitutive androstane receptor) as a key regulator of acetaminophen metabolism and hepatotoxicity. Known CAR... 
Receptors | Animals | Liver | Agonists | Reports | Mice | Automobiles | Dosage | Xenobiotics | Hepatotoxicity | Necrosis | MEDIATED INCREASES | ACTIVATION | POTENTIATION | GLUTATHIONE | MULTIDISCIPLINARY SCIENCES | CYP2B GENE | MOUSE-LIVER | MICE | TOXICITY | INDUCTION | NUCLEAR TRANSLOCATION | Phenobarbital - pharmacology | Acetaminophen - metabolism | Liver - pathology | Oxidoreductases, N-Demethylating - genetics | Cytochrome P-450 CYP3A | Glutathione - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Alanine Transaminase - blood | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | RNA, Messenger - metabolism | Glutathione Transferase - genetics | Analgesics, Non-Narcotic - toxicity | Liver - drug effects | Time Factors | Isoenzymes - metabolism | Cytochrome P-450 CYP1A2 - genetics | Oxidoreductases, N-Demethylating - metabolism | Benzoquinones - metabolism | Acetaminophen - toxicity | Isoenzymes - genetics | Imines - metabolism | Liver - metabolism | RNA, Messenger - genetics | Glutathione Transferase - metabolism | Mice, Transgenic | Transcription Factors - antagonists & inhibitors | Androstanols - pharmacology | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Analgesics, Non-Narcotic - metabolism | Transcription Factors - genetics | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mice, Knockout | Transcription Factors - metabolism | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Acetylcysteine - pharmacology | Cytochrome P-450 Enzyme System - genetics | Glutathione S-Transferase pi | Pyridines - pharmacology | Transcription Factors - agonists | Receptors, Cytoplasmic and Nuclear - metabolism | Liver failure | Dosage and administration | Analgesics | Drug therapy | Acetaminophen | Drug overdose
Journal Article
Journal Article
Journal Article
Journal Article
Chemosphere, ISSN 0045-6535, 09/2017, Volume 183, pp. 80 - 88
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 04/2013, Volume 168, Issue 7, pp. 1687 - 1706
Journal Article
Analytical Chemistry, ISSN 0003-2700, 02/2013, Volume 85, Issue 4, pp. 2340 - 2347
Biologically active macrocycles containing a cyclic imine were isolated for the first time from aquaculture sites in Nova Scotia, Canada, during the 1990s.... 
MARINE DINOFLAGELLATE | CHEMISTRY, ANALYTICAL | DINOFLAGELLATE ALEXANDRIUM-OSTENFELDII | NEW-ZEALAND | FLUORESCENCE POLARIZATION | SHELLFISH TOXINS | STATE TRANSITIONS | BIVALVE PINNA-MURICATA | CHROMATOGRAPHY-MASS SPECTROMETRY | CHOLINERGIC RECEPTOR | ACETYLCHOLINE-BINDING-PROTEIN | Flow Cytometry - methods | Heterocyclic Compounds, 3-Ring - metabolism | Imines - analysis | Biotin - chemistry | Microspheres | Receptors, Nicotinic - chemistry | Biotin - metabolism | Carrier Proteins - chemistry | Spiro Compounds - analysis | Bungarotoxins - metabolism | Lymnaea - metabolism | Streptavidin - chemistry | Receptors, Nicotinic - metabolism | Immobilized Proteins - chemistry | Phycoerythrin - chemistry | Imines - metabolism | Bungarotoxins - analysis | Heterocyclic Compounds, 3-Ring - analysis | Animals | Carrier Proteins - metabolism | Streptavidin - metabolism | Hydrocarbons, Cyclic - analysis | Torpedo - metabolism | Immobilized Proteins - metabolism | Protein Binding | Shellfish - analysis | Hydrocarbons, Cyclic - metabolism | Spiro Compounds - metabolism | Flow cytometry | Schiff bases | Usage | Analysis | Research | Radioligand assay | Index Medicus | Life Sciences | Neurons and Cognition | spirolide | acetylcholine binding protein | gymnodimine | microsphere-based assay | α-bungarotoxin | marine phycotoxins | nicotinic acetylcholine receptor
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2015, Volume 97, Issue 1, pp. 111 - 121
Gefitinib (GEF), an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is widely used for the treatment of cancers, particularly non-small... 
Metabolomics | Iminium | Gefitinib | Aldehyde | Bioactivation | DNA-ADDUCTS | CYTOCHROME-P450 | DRUG-INTERACTIONS | TOXICITY | MECHANISMS | PREGNANE-X-RECEPTOR | CELL LUNG-CANCER | IN-VITRO | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Humans | Microsomes, Liver - metabolism | Aldehydes - metabolism | Antineoplastic Agents - metabolism | Protein Kinase Inhibitors - chemistry | Cytochrome P-450 CYP3A - genetics | Quinazolines - metabolism | Isoenzymes - metabolism | Microsomes, Liver - drug effects | Cytochrome P-450 CYP3A - chemistry | Imines - chemistry | Membrane Proteins - metabolism | Microsomes, Liver - enzymology | Molecular Structure | Quinazolines - chemistry | Recombinant Proteins - metabolism | Metabolic Detoxication, Phase II | Isoenzymes - genetics | Membrane Proteins - genetics | Imines - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Metabolomics - methods | Mice, Knockout | Animals | Membrane Proteins - antagonists & inhibitors | Cytochrome P-450 CYP3A - metabolism | Metabolic Detoxication, Phase I | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Isoenzymes - antagonists & inhibitors | Aldehydes - chemistry | Protein Kinase Inhibitors - metabolism | Antimitotic agents | Physiological aspects | Antineoplastic agents | Index Medicus
Journal Article
Advanced Materials, ISSN 0935-9648, 11/2013, Volume 25, Issue 42, pp. 6123 - 6127
Journal Article