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Toxicology and Applied Pharmacology, ISSN 0041-008X, 2004, Volume 201, Issue 3, pp. 226 - 294
Experience with dose response and mechanisms of toxicity has shown that multiple mechanisms may exist for a single agent along the continuum of the full... 
Mechanisms of toxicity | Dose response | Formaldehyde | Zinc | Progesterone/hydroxyflutamide | Propylene oxide | Dose-dependent transitions | Peroxisome proliferator-activated receptor | Acetaminophen | Vinylidene chloride | Butadiene, ethylene glycol | Methylene chloride | Vinyl acetate | Vinyl chloride | Manganese | Progesterone/ hydroxyflutamide | ACETAMINOPHEN-INDUCED HEPATOTOXICITY | propylene oxide | ACTIVATED RECEPTOR-GAMMA | dose-dependent transitions | mechanisms of toxicity | vinylidene chloride | manganese | butadiene | INDUCED HEPATIC-NECROSIS | dose response | ethylene glycol | methylene chloride | PHARMACOLOGY & PHARMACY | TOXICOLOGY | peroxisome proliferator-activated receptor | vinyl acetate | zinc | SISTER-CHROMATID EXCHANGES | SPRAGUE-DAWLEY RATS | MANGANESE OXIDE AEROSOL | formaldehyde | CHRONIC INHALATION TOXICITY | PROTEIN CROSS-LINKS | acetaminophen | vinyl chloride | GLUTATHIONE-S-TRANSFERASE | PARA-BENZOQUINONE IMINE | progesterone/hydroxyflutamide | Analgesics, Non-Narcotic - pharmacokinetics | Progesterone - administration & dosage | Humans | Acetaminophen - administration & dosage | Epoxy Compounds - pharmacokinetics | Dichloroethylenes - toxicity | Manganese - pharmacokinetics | Methylene Chloride - administration & dosage | Analgesics, Non-Narcotic - toxicity | Manganese - administration & dosage | Dichloroethylenes - pharmacokinetics | Dichloroethylenes - administration & dosage | Formaldehyde - toxicity | Androgen Antagonists - toxicity | Ethylene Glycol - toxicity | Butadienes - toxicity | Androgen Antagonists - pharmacokinetics | Progesterone - pharmacokinetics | Oxidation-Reduction | Acetaminophen - toxicity | Vinyl Compounds - administration & dosage | Zinc - toxicity | Androgen Antagonists - administration & dosage | Flutamide - administration & dosage | Vinyl Compounds - toxicity | Zinc - administration & dosage | Peroxisome Proliferator-Activated Receptors - physiology | Drug-Related Side Effects and Adverse Reactions - chemically induced | Flutamide - toxicity | Drug-Related Side Effects and Adverse Reactions - metabolism | Vinyl Compounds - pharmacokinetics | Dose-Response Relationship, Drug | Methylene Chloride - toxicity | Zinc - pharmacokinetics | Epoxy Compounds - administration & dosage | Formaldehyde - administration & dosage | Ethylene Glycol - administration & dosage | Formaldehyde - pharmacokinetics | Ethylene Glycol - pharmacokinetics | Butadienes - pharmacokinetics | Flutamide - analogs & derivatives | Analgesics, Non-Narcotic - administration & dosage | Epoxy Compounds - toxicity | Animals | Butadienes - administration & dosage | Progesterone - toxicity | Methylene Chloride - pharmacokinetics | Acetaminophen - pharmacokinetics | Flutamide - pharmacokinetics | Manganese Poisoning - metabolism
Journal Article
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 05/2017, Volume 523, Issue 1, pp. 300 - 309
Metastasis impedes the successful chemotherapy for breast cancer. In this study, an Akt inhibitor (quercetin, Qu) was co-delivered with a chemotherapeutic... 
Metastasis docetaxel | Breast cancer | Akt/MMP-9 pathway | Hyaluronic acid | Quercetin | MMP-9 EXPRESSION | TARGETED DRUG-DELIVERY | POLYMERIC MICELLES | CELLULAR UPTAKE | COLON-CANCER | TUMOR XENOGRAFTS | IN-VIVO | COMBINATION CHEMOTHERAPY | PHARMACOLOGY & PHARMACY | ANTICANCER DRUGS | PI3K/AKT SIGNALING PATHWAY | Alct/MMP-9 pathway | Polyethylenes - administration & dosage | Antioxidants - chemistry | Nanoparticles - chemistry | Apoptosis - drug effects | Matrix Metalloproteinase Inhibitors - administration & dosage | Matrix Metalloproteinase Inhibitors - pharmacokinetics | Antineoplastic Agents - administration & dosage | Breast Neoplasms | Polyethylenes - pharmacokinetics | Lactic Acid - pharmacokinetics | Matrix Metalloproteinase 9 - metabolism | Quercetin - pharmacokinetics | Imines - chemistry | Quercetin - administration & dosage | Female | Antineoplastic Agents - pharmacokinetics | Proto-Oncogene Proteins c-akt - metabolism | Lactic Acid - administration & dosage | Polyethylenes - chemistry | Wound Healing - drug effects | Imines - administration & dosage | Polyglycolic Acid - administration & dosage | Taxoids - chemistry | Cell Survival - drug effects | Hyaluronic Acid - administration & dosage | Lactic Acid - chemistry | Quercetin - chemistry | Hyaluronic Acid - chemistry | Matrix Metalloproteinase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Hyaluronic Acid - pharmacokinetics | Imines - pharmacokinetics | Taxoids - pharmacokinetics | Cell Movement - drug effects | Taxoids - administration & dosage | Animals | Polyglycolic Acid - pharmacokinetics | Polyglycolic Acid - chemistry | Antioxidants - administration & dosage | Cell Line, Tumor | Mice, Inbred BALB C | Nanoparticles - administration & dosage | Antioxidants - pharmacokinetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Nanoparticles | Chemotherapy | Cancer cells | Metastasis | Cancer
Journal Article
Journal Article
Journal Article
Journal Article