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Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2017, Volume 152, Issue 8, pp. 2052 - 2062.e2
...–induced cryoglobulinemia vasculitis (HCV-CV). We analyzed blood samples from patients with HCV-CV before and after DAA therapy to determine mechanisms of these drugs and their effects on cellular immunity... 
Gastroenterology and Hepatology | Immune Regulation | PDCD1 | Response To Treatment | Liver Disease | BAFF | ENVELOPE PROTEIN | RANDOMIZED CONTROLLED-TRIAL | MIXED CRYOGLOBULINEMIA | DEFICIENCY | AUTOIMMUNITY | RITUXIMAB | EXPANSION | REGULATORY T-CELL | GASTROENTEROLOGY & HEPATOLOGY | LYMPHOCYTES | T-Lymphocyte Subsets - immunology | Prospective Studies | Hepatitis C - drug therapy | Humans | Middle Aged | Cryoglobulinemia - diagnosis | Male | Vasculitis - virology | Cryoglobulinemia - virology | Hepatitis Viruses - drug effects | Simeprevir - therapeutic use | Case-Control Studies | Simeprevir - adverse effects | Viral Load | Vasculitis - immunology | Hepatitis C - immunology | Immunity, Cellular - drug effects | Time Factors | T-Lymphocyte Subsets - drug effects | B-Lymphocyte Subsets - immunology | Female | Hepatitis C - complications | Imidazoles - therapeutic use | Sofosbuvir - adverse effects | Drug Therapy, Combination | B-Lymphocyte Subsets - virology | Cytokines - blood | Immune Tolerance - drug effects | Sofosbuvir - therapeutic use | B-Lymphocyte Subsets - drug effects | Antiviral Agents - therapeutic use | Hepatitis Viruses - immunology | Cryoglobulinemia - drug therapy | Imidazoles - adverse effects | Ribavirin - therapeutic use | Treatment Outcome | Biomarkers - blood | T-Lymphocyte Subsets - virology | Cryoglobulinemia - immunology | Hepatitis C - diagnosis | Phenotype | B-Lymphocyte Subsets - metabolism | Vasculitis - diagnosis | Ribavirin - adverse effects | T-Lymphocyte Subsets - metabolism | Antiviral Agents - adverse effects | Vasculitis - drug therapy | Aged | Care and treatment | Vasculitis | Analysis | Gastrointestinal diseases | Interferon | Biological response modifiers | Hepatitis C virus | Antiviral agents | Medical research | Liver | Medicine, Experimental | Life Sciences | Immunology
Journal Article
Nature medicine, ISSN 1546-170X, 2009, Volume 15, Issue 11, pp. 1266 - 1272
Macrophages rapidly engulf apoptotic cells to limit the release of noxious cellular contents and to restrict autoimmune responses against self antigens.... 
GLOMERULONEPHRITIS | AUTOANTIBODIES | MEDICINE, RESEARCH & EXPERIMENTAL | SYSTEMIC-LUPUS-ERYTHEMATOSUS | PHAGOCYTOSIS | PHOSPHATIDYLSERINE RECEPTOR | NUCLEAR RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACTIVATED RECEPTOR-DELTA | DEFICIENCY | BALB/C MICE | CELL BIOLOGY | INSULIN-RESISTANCE | Enzyme-Linked Immunosorbent Assay - methods | Autoimmune Diseases - physiopathology | Autoantibodies - metabolism | Apoptosis - drug effects | Humans | Mitochondrial Proteins | Promoter Regions, Genetic - drug effects | RNA, Messenger - metabolism | Autoimmune Diseases - genetics | Opsonin Proteins - genetics | Time Factors | Immune Tolerance - immunology | Hyaluronan Receptors - metabolism | Female | Autoimmune Diseases - pathology | Macrophages - immunology | PPAR delta - genetics | Disease Models, Animal | Immune Tolerance - drug effects | PPAR delta - deficiency | Phagocytosis - drug effects | Cytokines - metabolism | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Cells, Cultured | Phagocytosis - immunology | Thymus Gland - cytology | Opsonin Proteins - metabolism | Fluoresceins | Mice, Knockout | Gene Expression Regulation - drug effects | Autoimmunity - physiology | Autoantibodies - immunology | Macrophages - metabolism | Animals | Promoter Regions, Genetic - physiology | PPAR delta - agonists | Macrophages - drug effects | Mice | Mice, Inbred BALB C | Thiazoles - pharmacology | Apoptosis - physiology | CD11b Antigen - metabolism | PPAR delta - metabolism | Autoimmunity - drug effects
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 497, Issue 7448, pp. 258 - 262
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2010, Volume 120, Issue 7, pp. 2486 - 2496
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 8, p. e44045
...) prolong allograft survival by inhibiting T-cell activation. However, this effect is limited and does not induce immunological tolerance when imDex are administered alone... 
GENERATION | ALLOANTIGEN | MULTIDISCIPLINARY SCIENCES | EXPOSURE | DISEASE | TRANSPLANTATION | Exosomes - drug effects | Graft Survival - immunology | Spleen - immunology | Dendritic Cells - immunology | Male | Transplantation, Homologous | CD4-Positive T-Lymphocytes - immunology | Dose-Response Relationship, Drug | Flow Cytometry | Exosomes - immunology | Dendritic Cells - drug effects | Models, Animal | Immunosuppressive Agents - pharmacology | Immune Tolerance - drug effects | Mice, Inbred C57BL | Heart Transplantation | Spleen - cytology | Sirolimus - pharmacology | Blotting, Western | Animals | Interleukin-2 Receptor alpha Subunit - metabolism | Cell Differentiation - drug effects | Lymphocyte Activation - drug effects | Antigens - immunology | Cell Proliferation - drug effects | Dendritic Cells - cytology | Mice | Mice, Inbred BALB C | Graft Rejection - immunology | Graft Survival - drug effects | CD4-Positive T-Lymphocytes - drug effects | Major histocompatibility complex | Dendritic cells | Physiological aspects | Rapamycin | Dosage and administration | Research | Properties | Health aspects | Cell culture | Transplants & implants | Xiao Li | Transplantation | Lymphocytes T | Exosomes | Cell activation | Immunology | Lymphocytes | Splenocytes | Rodents | Surgery | Bone marrow | CD25 antigen | Heart diseases | Spleen | Antigens | Cell survival | Cytokines | Immunoregulation | Heart transplantation | T cell receptors | Survival | Immunological tolerance | CD4 antigen | Immunosuppression | Hospitals | Combined treatment | Diabetes
Journal Article
PLoS biology, ISSN 1545-7885, 2014, Volume 12, Issue 1, p. e1001769
Journal Article
The Journal of clinical investigation, ISSN 1558-8238, 2018, Volume 128, Issue 7, pp. 2819 - 2832
Adverse drug reactions (ADRs) are a major obstacle to drug development, and some of these, including hypersensitivity reactions to the HIV reverse transcriptase inhibitor abacavir (ABC... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | TRANSCRIPTASE INHIBITOR ABACAVIR | DENDRITIC CELLS | LIVER-INJURY | IMMUNE-RESPONSES | REGULATORY T-CELLS | PEPTIDE REPERTOIRE | ANTIGEN-PRESENTING CELLS | HYPERSENSITIVITY REACTIONS | VIRAL-INFECTION | Drugs | Histocompatibility antigens | Abacavir | HLA histocompatibility antigens | Physiological aspects | Adverse and side effects | Models | Research | T cells | Health aspects
Journal Article
Oncogene, ISSN 1476-5594, 2011, Volume 30, Issue 49, pp. 4874 - 4886
.... High expression of antiapoptotic and/or drug transporter proteins induced by oncogenic signaling pathways has been implicated in the development of chemoresistance in cancer... 
hedgehog pathway | diffuse large B-cell lymphoma | ATP-binding cassettes | GLI | ABCG2 | SURVIVAL | TRANSPORTER | BIOCHEMISTRY & MOLECULAR BIOLOGY | P-GLYCOPROTEIN | CELL BIOLOGY | GENE | ONCOLOGY | PATHWAY | POOR RESPONSE | GENETICS & HEREDITY | MULTIDRUG-RESISTANCE | EXPRESSION | CANCER RESISTANCE PROTEIN | SONIC-HEDGEHOG | Transcription, Genetic - drug effects | Hedgehog Proteins - chemistry | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Drug Tolerance - genetics | Stromal Cells - pathology | Coculture Techniques | Humans | Hedgehog Proteins - metabolism | Peptide Fragments - pharmacology | Promoter Regions, Genetic - drug effects | RNA, Messenger - metabolism | Promoter Regions, Genetic - genetics | Tumor Microenvironment - genetics | ATP-Binding Cassette Transporters - genetics | Veratrum Alkaloids - pharmacology | ATP-Binding Cassette Transporters - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Binding Sites | Gene Expression Regulation, Neoplastic - genetics | Tumor Microenvironment - drug effects | Lymphoma, Large B-Cell, Diffuse - drug therapy | Lymphoma, Large B-Cell, Diffuse - pathology | RNA, Messenger - genetics | Stromal Cells - metabolism | Oncogene Proteins - metabolism | Treatment Outcome | Signal Transduction - genetics | Cinnamates - pharmacology | Signal Transduction - drug effects | Cell Line, Tumor | Trans-Activators - metabolism | Zinc Finger Protein GLI1 | Mutation | Lymphoma, Large B-Cell, Diffuse - genetics | Care and treatment | Carrier proteins | Physiological aspects | Drug targeting | Genetic aspects | Non-Hodgkin's lymphomas | Research | Drug resistance | Hedgehog proteins | Proteins | Signal transduction | Lymphomas | Cellular biology | Gene expression | Lymphocytes | Drugs | Transcription factors | double prime B-cell lymphoma | Chemoresistance | Paracrine signalling | Drug development | Doxorubicin | Lymph nodes | ABCG2 gene | Bcl-x protein | Drug tolerance | Methotrexate | Adenosine | Effusion | Tumor cells | Mortality | Survival | Promoters | Chemotherapy | Hedgehog protein | stromal cells | Site-directed mutagenesis | Microenvironments | Cancer | Peritoneum | Tumors | Index Medicus | ATP binding cassettes
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2009, Volume 106, Issue 29, pp. 12055 - 12060
Infectious tolerance describes the process of CD4⁺ regulatory T cells (Tregs) converting naïve T cells to become additional Tregs... 
T lymphocytes | Enzymes | Antigens | Transplantation tolerance | Dendritic cells | Immune tolerance | Amino acids | Exercise tolerance | Mast cells | Skin grafts | mTOR inhibitor | Rapamycin | Foxp3 | Regulatory T cells | Amino acid catabolism | FOXP3 EXPRESSION | foxp3 | DENDRITIC CELLS | amino acid catabolism | GCN2 KINASE | MULTIDISCIPLINARY SCIENCES | INDOLEAMINE 2,3-DIOXYGENASE | SUBSETS | INDUCTION | TRANSLATION | regulatory T cells | IDO | REJECTION | REGULATORY T-CELLS | rapamycin | Protein Kinases - metabolism | Skin Transplantation - immunology | Dendritic Cells - immunology | Adoptive Transfer | Amino Acids, Essential - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | T-Lymphocytes, Regulatory - immunology | Epitopes - immunology | Signal Transduction - immunology | Forkhead Transcription Factors - metabolism | Immune Tolerance - immunology | T-Lymphocytes, Regulatory - cytology | Dendritic Cells - drug effects | Protein-Serine-Threonine Kinases - metabolism | Immune Tolerance - drug effects | Cell Survival - drug effects | Sirolimus - pharmacology | Amino Acids, Essential - deficiency | Animals | Signal Transduction - drug effects | Lymphocyte Activation - drug effects | Cell Proliferation - drug effects | Dendritic Cells - cytology | Mice | TOR Serine-Threonine Kinases | Transforming Growth Factor beta - metabolism | T-Lymphocytes, Regulatory - enzymology | T cells | Amino acid metabolism | Research | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 1/2012, Volume 109, Issue 3, pp. 899 - 904
... in peripheral T-cell tolerance, bind to the sirt1 promoter to transcript sirt1 mRNA. In addition, the forkhead transcription factor, FoxO3a, interacts with early responsive genes 2/3 on the sirt1 promoter to synergistically regulate Sirt1 expression... 
T lymphocytes | Transcription factors | Transcriptional regulatory elements | Phosphorylation | Messenger RNA | HEK293 cells | Genes | Promoter regions | Western blotting | T cell antigen receptors | T-cell anergic gene | FoxO3a sequestration | TRANSCRIPTION FACTORS | SURVIVAL | ACTIVATION | DEACETYLASE | MULTIDISCIPLINARY SCIENCES | IL-2 | NFAT | UNRESPONSIVENESS | DIFFERENTIATION | PROMOTER | MODULATION | Sirtuin 1 - metabolism | Transcription, Genetic - drug effects | Molecular Sequence Data | Sirtuin 1 - genetics | Clonal Anergy - drug effects | Interleukin-2 - immunology | Forkhead Transcription Factors - metabolism | Immune Tolerance - immunology | T-Lymphocytes - drug effects | Base Sequence | Protein Binding - drug effects | Phosphorylation - drug effects | Immune Tolerance - drug effects | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Gene Expression Regulation - drug effects | Models, Immunological | Animals | Clonal Anergy - genetics | Clonal Anergy - immunology | Immune Tolerance - genetics | Interleukin-2 - pharmacology | Early Growth Response Protein 2 - metabolism | Early Growth Response Protein 3 - metabolism | T-Lymphocytes - immunology | Mice | Forkhead Box Protein O3 | Interleukin-2 | Molecular genetics | Genetic aspects | Research | Gene expression | Properties | T cells | Biological Sciences
Journal Article