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Immunity (Cambridge, Mass.), ISSN 1074-7613, 2019, Volume 50, Issue 1, pp. 181 - 194.e6
An improved understanding of the anti-tumor CD8+ T cell response after checkpoint blockade would enable more informed and effective therapeutic strategies... 
checkpoint blockade | memory | immunotherapy | single-cell | exhaustion | CD8+ T cell | cancer | PD-1 | dysfunction | Tim-3 | CD8 | T cell | METASTATIC MELANOMA | RESPONSES | DIFFERENTIAL EXPRESSION | BIOCONDUCTOR PACKAGE | THERAPY | SET ENRICHMENT ANALYSIS | IMMUNOLOGY | TIM-3 | EXHAUSTION | PD-1 EXPRESSION | T-Lymphocyte Subsets - immunology | Cell Proliferation | Hepatocyte Nuclear Factor 1-alpha - genetics | Antigens, Neoplasm - immunology | Humans | Mice, Inbred C57BL | Neoplasms, Experimental - therapy | Transcriptome | Antibodies, Monoclonal - therapeutic use | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Lymphocytes, Tumor-Infiltrating - drug effects | Hepatocyte Nuclear Factor 1-alpha - metabolism | Hepatitis A Virus Cellular Receptor 2 - antagonists & inhibitors | Animals | Melanoma, Experimental | CD8-Positive T-Lymphocytes - drug effects | Immunotherapy | Neoplasms, Experimental - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | Immunologic Memory - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Memory cells | Immunoglobulins | Immunological memory | Transcription factors | Tumor-infiltrating lymphocytes | Transcription | PD-1 protein | CD8 antigen | Effector cells | Principal components analysis | Lymphocytes T | Gene expression | Ribonucleic acid--RNA | Immune checkpoint | Lymphocytes | Precursors | Population | Software | Cancer | Tumors | CD8+ T cell
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2018, Volume 362, Issue 6411, pp. eaar3593 - 197
Programmed cell death protein–1 (PD-1) and programmed cell death ligand–1 (PD-L1) checkpoint blockade immunotherapy elicits durable antitumor effects in multiple cancers, yet not all patients respond... 
CELL LUNG-CANCER | MISMATCH-REPAIR DEFICIENCY | MUTATIONAL PROCESSES | METASTATIC MELANOMA | CTLA-4 BLOCKADE | MULTIDISCIPLINARY SCIENCES | COPY NUMBER | PROGRAMMED DEATH LIGAND-1 | SEQUENCING DATA | CLINICAL-RESPONSE | SOMATIC MUTATIONS | Antibodies, Monoclonal, Humanized - therapeutic use | Humans | Transcriptome | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Genetic Markers | Cell Cycle Checkpoints | Neoplasms - therapy | Neoplasms - genetics | Antineoplastic Agents, Immunological - therapeutic use | Immunotherapy | Inflammation - genetics | T-Lymphocytes - immunology | Tumor Burden - genetics | Biomarkers, Tumor - genetics | Mutation | Molecular Targeted Therapy - methods | Monoclonal antibodies | Genetic aspects | T cells | Biological markers | Gene expression | Cancer | Tumors | Apoptosis | Cell receptors | Physiological aspects | Diagnosis | Identification and classification | Methods | PD-1 protein | Genomics | Clinical trials | Genomes | Biology | Lymphocytes T | Microsatellite instability | Data bases | Subgroups | Anticancer properties | Proteins | Cell activation | Pembrolizumab | Databases | Antigenicity | Lymphocytes | Deoxyribonucleic acid--DNA | Medical research | Stability | Microsatellites | Mortality | Melanoma | Data processing | Inflammation | Patients | Immune checkpoint | Cell death | Correlation analysis | PD-L1 protein | Biomarkers | Ligands | Antitumor activity | Cutoffs | Solid tumors
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2016, Volume 375, Issue 18, pp. 1749 - 1755
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 539, Issue 7629, pp. 443 - 447
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2015, Volume 212, Issue 2, pp. 139 - 148
Journal Article
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2015, Volume 348, Issue 6230, pp. 56 - 61
Journal Article
Cancer Treatment Reviews, ISSN 0305-7372, 2016, Volume 44, pp. 51 - 60
Highlights • Role of immune checkpoint inhibition in the management of key malignancies... 
Hematology, Oncology and Palliative Medicine | Pembrolizumab | Immune-related adverse events | Renal cancer | Ipilimumab | Nivolumab | Lung cancer | Melanoma | Immune-checkpoint inhibitors | OPEN-LABEL | SINGLE-ARM | ANTI-CTLA-4 ANTIBODY | METASTATIC MELANOMA | ONCOLOGY | ADVANCED MELANOMA | LONG-TERM SAFETY | MALIGNANT MESOTHELIOMA | ENTERIC NEUROPATHY | ADVERSE EVENTS | IPILIMUMAB RETREATMENT | Lung Neoplasms - drug therapy | Skin Neoplasms - drug therapy | Humans | Immunosuppressive Agents - therapeutic use | Antibodies, Monoclonal - adverse effects | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Adrenal Cortex Hormones - therapeutic use | Diarrhea - chemically induced | Infliximab - therapeutic use | Drug Eruptions - drug therapy | Antineoplastic Agents - adverse effects | Colitis - chemically induced | Antilymphocyte Serum - therapeutic use | Colitis - drug therapy | Carcinoma, Renal Cell - drug therapy | Chemical and Drug Induced Liver Injury - etiology | Pituitary Diseases - chemically induced | Pituitary Diseases - drug therapy | Antibodies, Monoclonal, Humanized - adverse effects | Drug Eruptions - etiology | Neoplasms - drug therapy | Cyclosporine - therapeutic use | Tacrolimus - therapeutic use | Mycophenolic Acid - analogs & derivatives | Mycophenolic Acid - therapeutic use | Melanoma - drug therapy | Chemical and Drug Induced Liver Injury - drug therapy | Diarrhea - drug therapy | CTLA-4 Antigen - antagonists & inhibitors | Kidney Neoplasms - drug therapy | Thyroiditis - drug therapy | Thyroiditis - chemically induced | Index Medicus
Journal Article