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Cell reports (Cambridge), ISSN 2211-1247, 2016, Volume 16, Issue 10, pp. 2576 - 2592
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2014, Volume 146, Issue 7, pp. 1763 - 1774
Background & Aims The NACHT, LRR, and pyrin domain–containing protein 3 (NLRP3) inflammasome induces inflammation in response to organ injury, but little is... 
Gastroenterology and Hepatology | Innate Immune Response | Immune Regulation | Pancreas | Mouse Model | ACTIVATION | NLRP3 INFLAMMASOME | GPR81 | AGONISTS | GENE | TLR9 | MICE | HEPATOTOXICITY | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | SEVERITY | Liver - pathology | Inflammasomes - metabolism | Receptors, G-Protein-Coupled - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Male | NF-kappa B - metabolism | Monocytes - immunology | Lipopolysaccharides | Liver - immunology | Liver - drug effects | RNA Interference | Interleukin-1beta - metabolism | Toll-Like Receptors - drug effects | Anti-Inflammatory Agents - administration & dosage | Toll-Like Receptors - metabolism | Cytoprotection | Disease Models, Animal | Galactosamine | Chemical and Drug Induced Liver Injury - prevention & control | Anti-Inflammatory Agents - pharmacology | Down-Regulation | Liver - metabolism | Injections, Intraperitoneal | Pancreas - pathology | Pancreas - metabolism | Pancreas - immunology | Toll-Like Receptor 4 - metabolism | Chemical and Drug Induced Liver Injury - immunology | Monocytes - drug effects | Macrophages - metabolism | Signal Transduction - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Sodium Lactate - pharmacology | beta-Arrestins | Mice | Receptors, G-Protein-Coupled - genetics | RNA, Small Interfering - metabolism | Monocytes - metabolism | Pancreatitis - prevention & control | Arrestins - metabolism | Dose-Response Relationship, Drug | Pancreatitis - genetics | Transfection | Inflammasomes - drug effects | Sodium Lactate - administration & dosage | Pancreatitis - immunology | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Macrophages - immunology | Cell Line | Immunity, Innate - drug effects | Toll-Like Receptor 4 - drug effects | Mice, Inbred C57BL | Pancreas - drug effects | Chemical and Drug Induced Liver Injury - genetics | Pancreatitis - chemically induced | Animals | Carrier Proteins - metabolism | beta-Arrestin 2 | Inflammasomes - immunology | Macrophages - drug effects | Pancreatitis - pathology | Pancreatitis - metabolism | Ceruletide | Lactates | Gastrointestinal diseases | Inflammation
Journal Article
Cell metabolism, ISSN 1550-4131, 2017, Volume 26, Issue 3, pp. 493 - 508.e4
Type 2 cytokines are important signals triggering biogenesis of thermogenic beige adipocytes in white adipose tissue (WAT) during cold acclimation. However,... 
adipose remodeling | macrophages | adipocyte precursor cells | beiging | adaptive thermogenesis | eotaxin | eosinophils | type 2 immunity | ANTIDIABETIC ACTIONS | CELLS | ENERGY-EXPENDITURE | ADIPOCYTES | ADIPONECTIN | EOSINOPHILS | ENDOCRINOLOGY & METABOLISM | INSULIN SENSITIVITY | EOTAXIN | GROWTH-FACTOR 21 | FGF21 | CELL BIOLOGY | Eosinophils - metabolism | Eosinophils - drug effects | Sympathetic Nervous System - drug effects | Adaptation, Physiological - drug effects | Glucuronidase - metabolism | Adipose Tissue, White - metabolism | Adipocytes - cytology | Male | Autocrine Communication - drug effects | Stem Cells - cytology | Adipocytes - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | Stem Cells - metabolism | Sympathetic Nervous System - metabolism | Immunity - drug effects | Fibroblast Growth Factors - metabolism | Cold Temperature | Chemokine CCL11 - metabolism | Mice, Inbred C57BL | Fibroblast Growth Factors - deficiency | Recombinant Proteins - pharmacology | Mice, Knockout | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Adipocytes - metabolism | Stem Cells - drug effects | Adipose Tissue, Beige - drug effects | Macrophages - drug effects | Cell Proliferation - drug effects | Thermogenesis - drug effects | Adipose Tissue, Beige - metabolism | Adipose Tissue, White - drug effects | Adipose tissues | Fibroblast growth factors | Immune response | Macrophages | Pharmaceutical biotechnology
Journal Article
The Journal of clinical investigation, ISSN 1558-8238, 2015, Volume 125, Issue 11, pp. 4223 - 4238
.... We have recently shown that salt has a proinflammatory effect and boosts the activation of Th17 cells and the activation of classical, LPS-induced macrophages (M1... 
MEDICINE, RESEARCH & EXPERIMENTAL | M2 MACROPHAGES | NA+ STORAGE | TISSUE | GENE-EXPRESSION | URINARY SODIUM | TRANSCRIPTION FACTOR | POTASSIUM EXCRETION | ALTERNATIVE ACTIVATION | BLOOD-PRESSURE | T-CELLS | Sodium Chloride, Dietary - pharmacology | Sodium Chloride - pharmacology | Male | Glycolysis - drug effects | Proto-Oncogene Proteins c-akt - genetics | Oxidative Phosphorylation - drug effects | Interleukin-4 - pharmacology | Histone Code - drug effects | Bone Marrow Cells - drug effects | TOR Serine-Threonine Kinases - physiology | Wound Healing - drug effects | Macrophages - immunology | Macrophages - classification | Immunity, Innate - drug effects | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Inflammation | Proto-Oncogene Proteins c-akt - physiology | Mitochondria - drug effects | Random Allocation | Interleukin-13 - pharmacology | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | Sodium Chloride, Dietary - toxicity | Chitin - toxicity | Macrophages - drug effects | Mice | Macrophage Activation - drug effects | Salt | Medical research | Immune response | Medicine, Experimental | Research | Macrophages | Properties | Observations | Biological control systems | Health aspects | Hypertension | Wound healing | Sodium | Cytokines | Kinases | Metabolism | Gene expression | Experiments | Acquisitions & mergers
Journal Article
The Journal of experimental medicine, ISSN 0022-1007, 2014, Volume 211, Issue 13, pp. 2549 - 2566
DOCK8 mutations result in an inherited combined immunodeficiency characterized by increased susceptibility to skin and other infections. We show that when... 
MEDICINE, RESEARCH & EXPERIMENTAL | HERPES-SIMPLEX-VIRUS | IN-VITRO | DENDRITIC CELLS | LEUKOCYTE MIGRATION | VARICELLA-ZOSTER-VIRUS | RM CELLS | TISSUE | IMMUNOLOGY | ALDRICH-SYNDROME PROTEIN | MEMORY T-CELLS | IMMUNOLOGICAL SYNAPSES
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2008, Volume 205, Issue 4, pp. 869 - 882
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 50, pp. 15408 - 15413
Spontaneous CD8 T-cell responses occur in growing tumors but are usually poorly effective. Understanding the molecular and cellular mechanisms that drive these... 
Antitumor immunity | STING | Type I IFNs | Tumor endothelial cells | CD8 T cells | type I IFNs | DENDRITIC CELLS | RECOGNITION | MULTIDISCIPLINARY SCIENCES | SENSOR | antitumor immunity | I INTERFERON | 2ND-MESSENGER | tumor endothelial cells | RESPONSES | INTRACELLULAR DNA | MELANOMA | IMMUNOGENIC TUMORS | IPILIMUMAB | Dose-Response Relationship, Immunologic | Dendritic Cells - immunology | Immunity | Neoplasms - therapy | Melanoma, Experimental - immunology | Injections, Intralesional | Interferon Type I - metabolism | Dendritic Cells - drug effects | Membrane Proteins - metabolism | Disease Models, Animal | Receptor, Interferon alpha-beta - metabolism | Nucleotides, Cyclic - pharmacology | Antigens, Neoplasm - immunology | Endothelial Cells - metabolism | Mice, Inbred C57BL | Melanoma, Experimental - pathology | Lymphocytes, Tumor-Infiltrating - drug effects | Melanoma - pathology | CTLA-4 Antigen - immunology | Animals | Signal Transduction - drug effects | Melanoma - immunology | Neoplasms - immunology | Cell Proliferation - drug effects | Nucleotides, Cyclic - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | Endothelial Cells - drug effects | Lymphocytes, Tumor-Infiltrating - immunology | Growth | Cancer cells | Physiological aspects | Genetic aspects | T cells | Health aspects | Tumors | Endothelium | Biological Sciences
Journal Article
PLoS pathogens, ISSN 1553-7374, 2013, Volume 9, Issue 7, p. e1003471
In pathogenic HIV and SIV infections of humans and rhesus macaques (RMs), preferential depletion of CD4(+) Th17 cells correlates with mucosal immune... 
GASTROINTESTINAL-TRACT | SOOTY MANGABEYS | MICROBIOLOGY | ANTIRETROVIRAL THERAPY | CHRONIC VIRAL-INFECTION | VIRUS TYPE-1 INFECTION | CD8 T-CELLS | METASTATIC MELANOMA | HIV-INFECTION | VIROLOGY | LENTIVIRAL INFECTIONS | IMMUNE ACTIVATION | PARASITOLOGY | Simian Acquired Immunodeficiency Syndrome - metabolism | Perforin - genetics | Recombinant Fusion Proteins - adverse effects | Granzymes - metabolism | Recombinant Fusion Proteins - therapeutic use | Macaca mulatta | Granzymes - genetics | Bacterial Translocation - drug effects | Th17 Cells - virology | Intestinal Mucosa - drug effects | Immunity, Mucosal - drug effects | Simian Immunodeficiency Virus - isolation & purification | Interleukins - genetics | Simian Acquired Immunodeficiency Syndrome - virology | Th17 Cells - drug effects | Intestinal Mucosa - immunology | CD8-Positive T-Lymphocytes - metabolism | Female | Granzymes - biosynthesis | Immunoglobulin Fc Fragments - therapeutic use | Immunoglobulin Fc Fragments - adverse effects | Th17 Cells - pathology | Interleukins - therapeutic use | Intestinal Mucosa - virology | Random Allocation | Down-Regulation - drug effects | Interleukins - adverse effects | Simian Immunodeficiency Virus - physiology | Up-Regulation - drug effects | Animals | Simian Acquired Immunodeficiency Syndrome - drug therapy | Simian Acquired Immunodeficiency Syndrome - immunology | Cell Differentiation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Recombinant Fusion Proteins - genetics | Th17 Cells - immunology | Perforin - metabolism | CD8-Positive T-Lymphocytes - immunology | Viral Load - drug effects | Immunoglobulin Fc Fragments - genetics | Simian Immunodeficiency Virus - drug effects | Intestinal Mucosa - pathology | Perforin - biosynthesis | Rhesus monkey | Translocation (Genetics) | Interleukins | Physiological aspects | Host-parasite relationships | Genetic aspects | Research | Simian immunodeficiency virus | HIV (Viruses) | Health aspects | Antiretroviral drugs | HIV | Acquired immune deficiency syndrome | AIDS | Human immunodeficiency virus | Drug therapy | Immune system
Journal Article