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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2014, Volume 111, Issue 5, pp. 1766 - 1771
Journal Article
Nature Reviews Drug Discovery, ISSN 1474-1776, 05/2017, Volume 16, Issue 5, pp. 315 - 337
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 11/2015, Volume 527, Issue 7578, pp. 323 - 328
Journal Article
Journal Article
Investigational New Drugs, ISSN 0167-6997, 6/2012, Volume 30, Issue 3, pp. 1121 - 1131
The efficacy of anti-CD33 immunoconjugates had been previously demonstrated for gemtuzumab-ozogamicin. AVE9633 is an anti-CD33-maytansine conjugate created by... 
Medicine & Public Health | Pharmacodynamic | Oncology | Maytansine | Pharmacology/Toxicology | Acute myeloid leukemia | Pharmacokinetic | Antibody-drug conjugate | CELLS | ONCOLOGY | PHARMACOLOGY & PHARMACY | Antigens, CD - immunology | Humans | Leukemia, Myeloid, Acute - metabolism | Middle Aged | Immunoconjugates - pharmacokinetics | Male | Antineoplastic Agents - administration & dosage | Leukemia, Myeloid, Acute - immunology | Immunoconjugates - administration & dosage | Antibodies, Monoclonal, Humanized - administration & dosage | Antibodies, Monoclonal, Humanized - pharmacokinetics | Antineoplastic Agents - adverse effects | Aged, 80 and over | Leukemia, Myeloid, Acute - drug therapy | Adult | Female | Antineoplastic Agents - pharmacokinetics | Sialic Acid Binding Ig-like Lectin 3 | Antigens, Differentiation, Myelomonocytic - immunology | Immunoconjugates - adverse effects | Drug Hypersensitivity - etiology | Antibodies, Monoclonal, Humanized - adverse effects | Maytansine - adverse effects | Maytansine - analogs & derivatives | Maytansine - administration & dosage | Maytansine - pharmacokinetics | Aged | Bronchial Spasm - chemically induced | Infusions, Intravenous | Antimitotic agents | Monoclonal antibodies | Complications and side effects | Dosage and administration | Antineoplastic agents | Studies | Clinical trials | Cytotoxicity | Pharmacology | Leukemia | Index Medicus | Drug Hypersensitivity | Antineoplastic Agents | Leukemia, Myeloid, Acute | Life Sciences | Antibodies, Monoclonal, Humanized | Antigens, Differentiation, Myelomonocytic | Immunoconjugates | Bronchial Spasm | Antigens, CD | Cancer
Journal Article
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7549, pp. 697 - 701
TP53, a well-known tumour suppressor gene that encodes p53, is frequently inactivated by mutation or deletion in most human tumours'''. A tremendous effort has... 
INHIBITION | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | CRISPR-CAS9 SYSTEM | PHENOTYPE | P53 PATHWAY | AMANITIN | Tumor Suppressor Protein p53 - biosynthesis | Antibodies - chemistry | Colorectal Neoplasms - genetics | Humans | Databases, Genetic | Cell Adhesion Molecules - immunology | Tumor Suppressor Protein p53 - genetics | Epithelial Cell Adhesion Molecule | Immunoconjugates - immunology | Colorectal Neoplasms - drug therapy | Gene Deletion | Antibodies - immunology | Immunoconjugates - therapeutic use | Female | RNA Polymerase II - chemistry | Disease Models, Animal | Immunoconjugates - adverse effects | Protein Subunits - genetics | Gene Dosage - genetics | Catalytic Domain | Colorectal Neoplasms - enzymology | RNA Polymerase II - antagonists & inhibitors | Antigens, Neoplasm - immunology | Alpha-Amanitin - pharmacology | Genes, p53 - genetics | Tumor Suppressor Protein p53 - deficiency | Immunoconjugates - chemistry | Alpha-Amanitin - therapeutic use | Xenograft Model Antitumor Assays | Alpha-Amanitin - chemistry | Animals | Alpha-Amanitin - adverse effects | Protein Subunits - deficiency | Cell Line, Tumor | RNA Polymerase II - genetics | Cell Proliferation - drug effects | Mice | Protein Subunits - chemistry | Colorectal Neoplasms - pathology | RNA Polymerase II - deficiency | Care and treatment | Colorectal cancer | Tumor suppressor genes | Genetic aspects | Health aspects | Methods | Cancer | Cell growth | Toxicity | Genes | Cell cycle | RNA polymerase | Drug dosages | Cancer therapies | Tumors | Apoptosis | Index Medicus
Journal Article