X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (1645) 1645
animals (1449) 1449
mice (1042) 1042
index medicus (909) 909
abatacept (863) 863
immunoconjugates (728) 728
female (715) 715
ctla-4 antigen (605) 605
immunology (489) 489
antigens, cd (470) 470
immunoconjugates - chemistry (460) 460
immunoconjugates - therapeutic use (454) 454
male (445) 445
immunoconjugates - pharmacology (406) 406
oncology (398) 398
cell line, tumor (382) 382
immunoconjugates - metabolism (362) 362
immunoconjugates - pharmacokinetics (345) 345
expression (308) 308
cancer (307) 307
mice, inbred balb c (275) 275
antigens, differentiation - metabolism (265) 265
t-lymphocytes - immunology (264) 264
immunoconjugates - immunology (254) 254
in-vivo (236) 236
biochemistry & molecular biology (235) 235
immunoconjugates - administration & dosage (235) 235
mice, nude (224) 224
pharmacology & pharmacy (212) 212
antibodies (203) 203
tissue distribution (200) 200
mice, inbred c57bl (199) 199
lymphocyte activation (198) 198
antibodies, monoclonal - chemistry (196) 196
antibodies, monoclonal - pharmacology (193) 193
antigens, differentiation - genetics (191) 191
antibodies, monoclonal - immunology (190) 190
monoclonal-antibody (190) 190
activation (185) 185
adult (182) 182
antibodies, monoclonal - therapeutic use (181) 181
middle aged (179) 179
medicine, research & experimental (178) 178
therapy (175) 175
rats (171) 171
cells, cultured (170) 170
antibodies, monoclonal - pharmacokinetics (165) 165
ctla-4 (165) 165
antibodies, monoclonal - metabolism (161) 161
xenograft model antitumor assays (160) 160
cd28 antigens - metabolism (155) 155
cd28 (153) 153
molecular sequence data (152) 152
b7-1 antigen - metabolism (150) 150
flow cytometry (149) 149
article (146) 146
tumor cells, cultured (146) 146
antineoplastic agents - pharmacology (142) 142
cells (142) 142
antineoplastic agents - therapeutic use (135) 135
monoclonal-antibodies (135) 135
b7-2 antigen (133) 133
amino acid sequence (132) 132
antigen (132) 132
antigens, differentiation - immunology (132) 132
chemistry, multidisciplinary (132) 132
monoclonal antibodies (132) 132
t cells (132) 132
immunotherapy (130) 130
biochemical research methods (129) 129
tumors (129) 129
receptor (127) 127
transplantation (126) 126
proteins (125) 125
research (121) 121
cell line (120) 120
time factors (119) 119
radioimmunotherapy (118) 118
aged (114) 114
immunoconjugates - genetics (114) 114
drug delivery systems (113) 113
neoplasms - drug therapy (113) 113
disease models, animal (112) 112
treatment outcome (111) 111
analysis (110) 110
antibody (109) 109
gene expression (107) 107
ligands (106) 106
cd4-positive t-lymphocytes - immunology (105) 105
t-lymphocytes - metabolism (105) 105
costimulation (103) 103
immunoconjugate (102) 102
immunosuppressive agents - pharmacology (102) 102
antigens, cd - metabolism (100) 100
chemistry, organic (99) 99
hematology (99) 99
signal transduction (98) 98
protein binding (95) 95
dendritic cells (93) 93
induction (93) 93
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (2248) 2248
Chinese (14) 14
Japanese (5) 5
Russian (3) 3
German (2) 2
Spanish (2) 2
Hungarian (1) 1
Italian (1) 1
Portuguese (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Clinical Oncology, ISSN 0732-183X, 11/2015, Volume 33, Issue 32, pp. 3750 - 3758
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 12/2016, Volume 44, Issue 12, pp. 1958 - 1962
Pyrrolobenzodiazepine (PBD)-dimer is a DNA minor groove alkylator, and its CD22 THIOMAB antibody drug conjugate (ADC) demonstrated, through a disulfide linker,... 
AGENT | CELLS | REPAIR | POTENT | RNA | DIMER | CROSS-LINKING | PHARMACOLOGY & PHARMACY | CYTOTOXICITY | SJG-136 | DAMAGE | Neoplasms - metabolism | Pyrroles - metabolism | Antibodies - metabolism | Immunoconjugates - metabolism | Liver - metabolism | Heterografts - metabolism | DNA - metabolism | DNA Adducts - metabolism | Animals | Alkylation - physiology | Lung - metabolism | Mice | Benzodiazepines - metabolism
Journal Article
2012, Methods in Enzymology, ISBN 0124160395, Volume 502, 16
Many methods have been described for the conjugation of drugs to monoclonal antibodies. The presence of a discrete number of readily reducible disulfides in... 
Conjugation strategies | Drug loading | Unconjugated drug content | Maleimido drug-linker | Antibody reduction | Antibody-drug conjugates | THERAPEUTIC INDEX | BREAST-CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | CYTOTOXIC DRUG | CANCER-THERAPY | DELIVERY | Disulfides - metabolism | Neoplasms - metabolism | Hybridomas - metabolism | Humans | Chromatography, High Pressure Liquid | Drug Carriers - chemistry | Antineoplastic Agents - metabolism | Immunoconjugates - pharmacology | Disulfides - chemistry | Ethylmaleimide - chemistry | Antineoplastic Agents - pharmacology | Cysteine - metabolism | Molecular Structure | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Drug Carriers - metabolism | Cross-Linking Reagents - chemistry | Immobilized Proteins - chemistry | Oxidation-Reduction | Antineoplastic Agents - immunology | Immunoconjugates - metabolism | Antibodies, Monoclonal - pharmacology | Antigens - metabolism | Cysteine - chemistry | Antineoplastic Agents - chemistry | Immunoconjugates - chemistry | Drug Carriers - pharmacology | Sulfhydryl Reagents - chemistry | Neoplasms - drug therapy | Animals | Neoplasms - immunology | Hybridomas - immunology | Immobilized Proteins - metabolism | Cell Line, Tumor | Antigens - immunology | Mice | Antibodies, Monoclonal - metabolism | Neoplasms - pathology
Book Chapter
Journal Article
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 05/2015, Volume 205, pp. 58 - 69
Traditionally, any drug intended for combating the tumor would distribute profoundly to other organs and tissues as lack of targeting specificity, thus... 
Antibody targeting | ATTEMPTS | Prodrug | CPP-mediated intracellular drug delivery | Immunoconjugates - toxicity | Prodrugs - administration & dosage | Heparin - metabolism | Ribosome Inactivating Proteins, Type 1 - chemistry | Antibodies - metabolism | History, 21st Century | Antibodies - chemistry | Humans | Prodrugs - chemistry | Antineoplastic Agents - administration & dosage | Drug Delivery Systems - history | Immunoconjugates - administration & dosage | Prodrugs - metabolism | Antineoplastic Agents - toxicity | Drug Carriers | tat Gene Products, Human Immunodeficiency Virus - chemistry | Antineoplastic Agents - metabolism | Cell-Penetrating Peptides - chemistry | Peptide Fragments - metabolism | Immunoconjugates - metabolism | Technology, Pharmaceutical - methods | Antineoplastic Agents - chemistry | Immunoconjugates - chemistry | Chemistry, Pharmaceutical | Xenograft Model Antitumor Assays | Peptide Fragments - chemistry | Ribosome Inactivating Proteins, Type 1 - toxicity | Animals | Ribosome Inactivating Proteins, Type 1 - metabolism | Prodrugs - toxicity | Drug Delivery Systems - trends | Heparin - chemistry | Ribosome Inactivating Proteins, Type 1 - administration & dosage | Cell-Penetrating Peptides - metabolism | tat Gene Products, Human Immunodeficiency Virus - metabolism | Drugs | Viral antibodies | Drug delivery systems | Glycosaminoglycans | Antibodies | Anticoagulants (Medicine) | Biopharmaceutics | Vehicles | Index Medicus
Journal Article
The Journal of Immunology, ISSN 0022-1767, 09/2002, Volume 169, Issue 5, pp. 2756 - 2761
Regulatory T cells (T,,g) that prevent autoimmune diseases by suppression of self-reactive T cells may also suppress the immune response against cancer. In... 
IMMUNOTHERAPY | TOLERANCE | CONSEQUENCE | GENERATION | MICE | THYMECTOMY | IMMUNOLOGY | SUPPRESSION | ANTITUMOR IMMUNE-RESPONSE | PROGRESSIVE FIBRO-SARCOMA | IMMUNOLOGICALLY MEDIATED REGRESSION | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Breast Neoplasms - immunology | Coculture Techniques | Humans | Middle Aged | Male | Interferon-gamma - metabolism | T-Lymphocytes, Regulatory - pathology | Lymphocyte Activation - immunology | Adenocarcinoma - metabolism | Carcinoma, Ductal, Breast - pathology | Carcinoma, Ductal, Breast - metabolism | Receptors, Interleukin-2 - biosynthesis | Adenocarcinoma - blood | Adenocarcinoma - immunology | Pancreatic Neoplasms - pathology | Lymph Nodes - metabolism | Lymph Nodes - immunology | CTLA-4 Antigen | Antigens, Differentiation - biosynthesis | T-Lymphocyte Subsets - pathology | Immunoconjugates | Pancreatic Neoplasms - immunology | CD8-Positive T-Lymphocytes - immunology | Antigens, CD | T-Lymphocytes, Regulatory - metabolism | Lymph Nodes - pathology | T-Lymphocyte Subsets - cytology | Carcinoma, Ductal, Breast - immunology | Leukocyte Common Antigens - biosynthesis | Carcinoma, Ductal, Breast - blood | Breast Neoplasms - metabolism | Abatacept | Cell Division - immunology | T-Lymphocytes, Helper-Inducer - immunology | Interferon-gamma - antagonists & inhibitors | T-Lymphocytes, Regulatory - cytology | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Pancreatic Neoplasms - blood | Cytokines - metabolism | Cells, Cultured | Immunophenotyping | Lymphocytes, Tumor-Infiltrating - pathology | Breast Neoplasms - pathology | Down-Regulation - immunology | Breast Neoplasms - blood | Lymphocyte Count | Aged | Cytokines - biosynthesis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 4, pp. 1428 - 1433
A monodonal antibody against the C-type lectin DEC205 (αDEC205) is an effective vehicle for delivery of antigens to dendritic cells through creation of... 
T lymphocytes | Proteins | Antigens | Immunization | Dendritic cells | Antibodies | T lymphocyte epitopes | Epitopes | Cytoplasm | Adducts | TCR | vaccine development | DENDRITIC CELLS | vaccines | RECEPTOR DEC-205 | MULTIDISCIPLINARY SCIENCES | MOUSE | MODEL | TRANSNUCLEAR | antibody conjugates | protein engineering | IN-VIVO | MURINE GAMMAHERPESVIRUS 68 | MICE | T-CELLS | Vaccines, Subunit - genetics | Epitopes, T-Lymphocyte - genetics | Antigens, CD - genetics | Antigens, CD - metabolism | Histocompatibility Antigens Class I - metabolism | Lectins, C-Type - metabolism | Protein Engineering | Tumor Virus Infections - immunology | Amino Acid Sequence | Immunoconjugates - metabolism | Mice, Transgenic | Receptors, Cell Surface - immunology | Mice, Knockout | Epitopes, T-Lymphocyte - chemistry | Antigens, Viral - immunology | Immunoconjugates - genetics | Mice | Mice, Inbred BALB C | Proteasome Endopeptidase Complex - metabolism | CD8-Positive T-Lymphocytes - immunology | Herpesviridae Infections - immunology | Receptors, Cell Surface - genetics | Antigens, CD - immunology | Minor Histocompatibility Antigens | Viral Vaccines - genetics | Lectins, C-Type - immunology | Molecular Sequence Data | Antigens, Viral - genetics | Rhadinovirus - immunology | Lectins, C-Type - genetics | Lectins, C-Type - chemistry | Herpesviridae Infections - prevention & control | Immunoconjugates - immunology | Cysteine Endopeptidases - metabolism | Antigen Presentation | Receptors, Cell Surface - chemistry | Antigens, CD - chemistry | Epitopes, T-Lymphocyte - immunology | Rhadinovirus - genetics | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Antigens, Viral - chemistry | Vaccines, Subunit - immunology | Tumor Virus Infections - prevention & control | Animals | Aminoacyltransferases - metabolism | Bacterial Proteins - metabolism | Viral Vaccines - immunology | Biological Sciences
Journal Article