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1. Full Text The regulation of IgA class switching
by Cerutti, Andrea
Nature Reviews Immunology, ISSN 1474-1733, 06/2008, Volume 8, Issue 6, pp. 421 - 434
IgA class switching is the process whereby B cells acquire the expression of IgA, the most abundant antibody isotype in mucosal secretions. IgA class switching... 
FC-ALPHA-RI | CONSTANT-REGION GENE | INDUCED CYTIDINE DEAMINASE | GUT LAMINA PROPRIA | TOLL-LIKE RECEPTORS | HUMAN B-CELLS | COMMON VARIABLE IMMUNODEFICIENCY | GERM-LINE TRANSCRIPTS | IMMUNOLOGY | AUTOSOMAL RECESSIVE FORM | INTESTINAL DENDRITIC CELLS | Animals | Gene Expression Regulation - immunology | Immunoglobulin A - biosynthesis | Humans | Immunoglobulin A - genetics | Immunoglobulin A - blood | Immunity, Mucosal - genetics | Immunoglobulin Class Switching - genetics | Research | Gene mutations | Gene expression | Immunoglobulin A | Health aspects
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2. Full Text Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching
by Michela Di Virgilio and Elsa Callen and Arito Yamane and Wenzhu Zhang and Mila Jankovic and Alexander D. Gitlin and Niklas Feldhahn and Wolfgang Resch and Thiago Y. Oliveira and Brian T. Chait and André Nussenzweig and Rafael Casellas and Davide F. Robbiani and Michel C. Nussenzweig
Science, ISSN 0036-8075, 2/2013, Volume 339, Issue 6120, pp. 711 - 715
DNA double-strand breaks (DSBs) represent a threat to the genome because they can lead to the loss of genetic information and chromosome rearrangements. The... 
Proteins | Phosphorylation | B lymphocytes | DNA damage | DNA | REPORTS | Cell cycle | Genomes | DNA repair | Chromosomes | Genotypes | B-LYMPHOCYTES | RECOMBINATION | REGULATOR | REPAIR | REPLICATION | 53BP1 | MULTIDISCIPLINARY SCIENCES | END RESECTION | AID | DAMAGE | TELOMERES | Genomic Instability | Tumor Suppressor Proteins - antagonists & inhibitors | DNA Breaks, Double-Stranded | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | S Phase | Protein-Serine-Threonine Kinases - antagonists & inhibitors | G2 Phase | Telomere-Binding Proteins - metabolism | Immunoglobulin Class Switching | B-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Ataxia Telangiectasia Mutated Proteins | DNA - metabolism | G1 Phase | Animals | B-Lymphocytes - immunology | DNA Repair | Mice | Tumor Suppressor p53-Binding Protein 1 | Immunoglobulins | Research | Properties | Genomics | Breaking | Deoxyribonucleic acid | Damage | Online | Repair | Switching
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3. Full Text DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
by Hilbert, David M and Schaffer, Andras and Casali, Paolo and Litinskiy, Mikhail B and Nardelli, Bernardetta and He, Bing and Cerutti, Andrea
Nature Immunology, ISSN 1529-2908, 09/2002, Volume 3, Issue 9, pp. 822 - 829
Immunoglobulin (Ig) class-switch DNA recombination (CSR) is thought to be highly dependent upon engagement of CD40 on B cells by CD40 ligand on T cells. We... 
TNF RECEPTOR | BAFF | HUMAN DENDRITIC CELLS | TACI | NECROSIS-FACTOR FAMILY | LYMPHOCYTE STIMULATOR | CD40 LIGAND | B-CELL MATURATION | IMMUNOLOGY | ANTIGEN | MEMBER | CD40 Antigens - physiology | Up-Regulation | Immunoglobulin A - biosynthesis | Humans | Dendritic Cells - physiology | NF-kappa B - metabolism | Neuropeptides - physiology | B-Cell Activating Factor | Immunoglobulin G - biosynthesis | Membrane Proteins - physiology | Recombination, Genetic | Lipopolysaccharides - pharmacology | Tumor Necrosis Factor-alpha - physiology | Receptors, Antigen, B-Cell - physiology | Nuclear Proteins - physiology | Immunoglobulin Class Switching - genetics | Immunoglobulin Heavy Chains - genetics
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4. Full Text The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88
by Marodi, László and Li, Xiaoxia and Vasconcelos, Julia and Cunningham-Rundles, Charlotte and Shan, Meimei and Xiong, Huabao and Chen, Kang and Davies, Graham and Puga, Irene and Krause, Jens and Plebani, Alessandro and Chiu, April and Xu, Weifeng and Cols, Montserrat and Meffre, Eric and Santamaria, Raul and He, Bing and Picard, Capucine and Puel, Anne and Bussel, James B and Reichenbach, Jeanine and Issekutz, Andrew and Cerutti, Andrea and Döffinger, Rainer and Grimbacher, Bodo and Casanova, Jean-Laurent
Nature Immunology, ISSN 1529-2908, 09/2010, Volume 11, Issue 9, pp. 836 - 845
BAFF and APRIL are innate immune mediators that trigger immunoglobulin G (IgG) and IgA class-switch recombination (CSR) in B cells by engaging the receptor... 
BAFF-R | EPITHELIAL-CELLS | DENDRITIC CELLS | PYOGENIC BACTERIAL-INFECTIONS | PLASMA-CELL | TOLL-LIKE RECEPTORS | COMMON VARIABLE IMMUNODEFICIENCY | IGA DEFICIENCY | IMMUNOLOGY | NF-KAPPA-B | APRIL | Lymphocyte Activation - immunology | Animals | B-Lymphocytes - immunology | Signal Transduction | Humans | Mice, Inbred C57BL | Cells, Cultured | Immunoglobulin Class Switching - immunology | Myeloid Differentiation Factor 88 - immunology | Mice | Transmembrane Activator and CAML Interactor Protein - immunology | Immunoglobulins | Immune response | Physiological aspects | Genetic aspects | Cellular signal transduction | B cells | Research
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5. Full Text IgH class switching and translocations use a robust non-classical end-joining pathway
by Yan, Catherine T and Boboila, Cristian and Souza, Ellen Kris and Franco, Sonia and Hickernell, Thomas R and Murphy, Michael and Gumaste, Sunil and Geyer, Mark and Zarrin, Ali A and Manis, John P and Rajewsky, Klaus and Alt, Frederick W
Nature, ISSN 0028-0836, 09/2007, Volume 449, Issue 7161, pp. 478 - 482
Immunoglobulin variable region exons are assembled in developing B cells by V(D)J recombination. Once mature, these cells undergo class-switch recombination... 
REPAIR | XRCC4 | MULTIDISCIPLINARY SCIENCES | REGIONS | V(D)J RECOMBINATION | MICE | PROTEINS | DOUBLE-STRAND BREAK | DNA-LIGASE-IV | MAMMALIAN-CELLS | LYMPHOCYTES | B-Lymphocytes - cytology | B-Lymphocytes - radiation effects | Cell Proliferation | Cells, Cultured | In Situ Hybridization, Fluorescence | DNA-Binding Proteins - genetics | DNA-Binding Proteins - deficiency | Animals | Immunoglobulin G - genetics | Base Sequence | Genes, Immunoglobulin Heavy Chain - genetics | Recombination, Genetic - genetics | Mice | Immunoglobulin Class Switching - genetics | B-Lymphocytes - metabolism | Chromosome Breakage | Immunoglobulin G - metabolism | Radiation, Ionizing | Telomere - genetics | Translocation, Genetic - genetics | Antibody diversity | Immunoglobulins | Genetic aspects | Chemical properties | Immunology | Cellular biology | Genetic recombination | Molecular biology
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6. Full Text mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition
by Jose J. Limon and Lomon So and Stefan Jellbauer and Honyin Chiu and Juana Corado and Stephen M. Sykes and Manuela Raffatellu and David A. Fruman
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2014, Volume 111, Issue 47, pp. E5076 - E5085
The mammalian target of rapamycin (mTOR) is a kinase that functions in two distinct complexes, mTORC1 and mTORC2. In peripheral B cells, complete deletion of... 
Rapamycin | Differentiation | Kinase | Blymphocyte | Class switching | AZD8055 | differentiation | MULTIDISCIPLINARY SCIENCES | B lymphocyte | ANTITUMOR-ACTIVITY | class switching | kinase | IMMUNE-RESPONSES | SALMONELLA-TYPHIMURIUM | CELL DIFFERENTIATION | RICTOR | MICE | INFECTION | T-CELLS | rapamycin | TOR Serine-Threonine Kinases - antagonists & inhibitors | Animals | Immunoglobulin G - biosynthesis | Allosteric Regulation | Mice, Inbred C57BL | Mice | Protein Kinase Inhibitors - pharmacology | Immunoglobulin Class Switching - drug effects | Mechanistic Target of Rapamycin Complex 2 | Sirolimus - pharmacology | Multiprotein Complexes - antagonists & inhibitors | Biological Sciences | PNAS Plus
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7. Full Text IL-4-Induced Transcription Factor NFIL3/E4BP4 Controls IgE Class Switching
by Masaki Kashiwada and Deborah M. Levy and Lisa McKeag and Keri Murray and Andreas J. Schröder and Stephen M. Canfield and Geri Traver and Paul B. Rothman and Robert L. Coffman
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2010, Volume 107, Issue 2, pp. 821 - 826
IL-4 signaling promotes IgE class switching through STAT6 activation and the induction of Ig germ-line ε (GLε) transcription. Previously, we and others... 
Beta cells | Myeloid cells | Transcription factors | Transcriptional regulatory elements | B lymphocytes | Lymphocytes | Genes | Gene expression regulation | Mast cells | Natural killer cells | Germ-line transcription | IL-4 signal | Immunoglobulin | B-LYMPHOCYTES | immunoglobulin | MULTIDISCIPLINARY SCIENCES | AIRWAY INFLAMMATION | IDENTIFICATION | germ-line transcription | EPSILON | CELL-DIVISION | MAMMALIAN CIRCADIAN CLOCKS | GENE-EXPRESSION | BZIP FAMILY | T-CELLS | IMMUNOGLOBULIN-E | Mice, Inbred BALB C - genetics | Mice, Inbred C57BL | Basic-Leucine Zipper Transcription Factors - genetics | Immunoglobulin Switch Region - immunology | Mice, Knockout | CD4-Positive T-Lymphocytes - immunology | Basic-Leucine Zipper Transcription Factors - physiology | Interleukin-4 - pharmacology | Animals | B-Lymphocytes - immunology | Immunoglobulin E - immunology | Immunoglobulin E - genetics | Basic-Leucine Zipper Transcription Factors - deficiency | Killer Cells, Natural - immunology | Immunoglobulin Switch Region - genetics | Mice | Interleukin-4 - physiology | Physiological aspects | Immunoglobulin E | Interleukin-4 | Research | Biological Sciences
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8. Full Text Sequential class switching is required for the generation of high affinity IgE antibodies
by Xiong, Huizhong and Dolpady, Jayashree and Wabl, Matthias and de Lafaille, Maria A. Curotto and Lafaille, Juan J
Journal of Experimental Medicine, ISSN 0022-1007, 02/2012, Volume 209, Issue 2, pp. 353 - 364
IgE antibodies with high affinity for their antigens can be stably cross-linked at low concentrations by trace amounts of antigen, whereas IgE antibodies with... 
B-CELL RECEPTOR | MATURATION PATHWAY | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | FC-EPSILON-RI | MAST-CELLS | DOCK8 MUTATIONS | GERMINAL-CENTERS | IMMUNOLOGY | NIPPOSTRONGYLUS-BRASILIENSIS | T-CELLS | IMMUNOGLOBULIN-E | Enzyme-Linked Immunosorbent Assay | Immunoglobulin E - biosynthesis | Antibody Affinity - immunology | DNA Primers - genetics | Sequence Analysis, DNA | Animals | Flow Cytometry | Immunoglobulin G - genetics | Immunoglobulin G - immunology | Immunoglobulin Class Switching - physiology | Polymerase Chain Reaction | Anaphylaxis - immunology | Receptors, IgE - immunology | Mice | Mice, Inbred BALB C
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9. Full Text Impaired IgA Class Switching in APRIL-Deficient Mice
by Emanuela Castigli and Sumi Scott and Fatma Dedeoglu and Paul Bryce and Haifa Jabara and Atul K. Bhan and Emiko Mizoguchi and Raif S. Geha and Frederick W. Alt
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2004, Volume 101, Issue 11, pp. 3903 - 3908
The tumor necrosis factor (TNF) family member APRIL binds to the receptors BCMA on B cells and TACI on B and T cells. To investigate the role of APRIL in... 
T lymphocytes | Spleen | Antigens | Biological Sciences | Immunization | Receptors | Isotypes | B lymphocytes | Antibodies | Plasma cells | Mice | TNF RECEPTOR | BCMA GENE | MEMBERS BAFF | MULTIDISCIPLINARY SCIENCES | NECROSIS-FACTOR FAMILY | CD40-DEFICIENT MICE | INTESTINAL IGA | FACTOR RECEPTOR SUPERFAMILY | LYMPHOCYTE STIMULATOR | B-CELL MATURATION | AUTOIMMUNE-DISEASE | Neuropeptides - deficiency | Humans | Immunoglobulin Class Switching - immunology | Mice, Transgenic | Neuropeptides - physiology | Reverse Transcriptase Polymerase Chain Reaction | Lymphoid Tissue | Cell Division - physiology | Lymphocytes - physiology | Animals | Lymphocytes - immunology | Immunoglobulin A - physiology | Cell Division - immunology | Immunoglobulin A - immunology | Immunoglobulin Class Switching - physiology | Nuclear Proteins - deficiency | Immunoglobulin A - blood | Antigens - immunology | Nuclear Proteins - physiology | Mutation | Neuropeptides - genetics | Nuclear Proteins - genetics | Tumor necrosis factor | Research | CD44 antigen | APRIL protein | CD4 antigen
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10. Full Text Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL
by He, B and Xu, W and Santini, PA and Polydorides, AD and Chiu, A and Estrella, J and Shan, M and Chadburn, A and Villanacci, V and Plebani, A and Knowles, DM and Rescigno, M and Cerutti, A
IMMUNITY, ISSN 1074-7613, 06/2007, Volume 26, Issue 6, pp. 812 - 826
Bacteria colonize the intestine shortly after birth and thereafter exert several beneficial functions, including induction of protective immunoglobulin A (IgA)... 
HOMEOSTASIS | ACTIVATION | DENDRITIC CELLS | SOMATIC HYPERMUTATION | COMMENSAL BACTERIA | GUT LAMINA PROPRIA | DIFFERENTIATION | IMMUNOLOGY | NAIVE B-CELLS | IGA-PRODUCING CELLS | DNA RECOMBINATION | CD40 Antigens - analysis | B-Lymphocytes - microbiology | Cytokines - metabolism | Dendritic Cells - immunology | Humans | Toll-Like Receptors - immunology | Immunoglobulin A - genetics | Molecular Sequence Data | Intestinal Mucosa - microbiology | Tumor Necrosis Factor Ligand Superfamily Member 13 - metabolism | Intestines - immunology | CD4-Positive T-Lymphocytes - immunology | Bacteria - immunology | B-Lymphocytes - immunology | Intestines - microbiology | Bacterial Vaccines - immunology | Mucous Membrane - immunology | Intestinal Mucosa - immunology | Base Sequence | Immunoglobulin Class Switching | Intestines - cytology
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