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Journal Article
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7642, pp. 483 - 493
Activation-induced cytidine deaminase (AID) is a B-cell-specific enzyme that targets immunoglobulin genes to initiate class switch recombination and somatic... 
CHROMOSOMAL TRANSLOCATIONS | SUPER-ENHANCERS | INDUCED CYTIDINE DEAMINASE | DNA | MULTIDISCIPLINARY SCIENCES | CHRONIC LYMPHOCYTIC-LEUKEMIA | CLASS-SWITCH RECOMBINATION | TARGETING BTK | AID | HYPERMUTATION | SEQUENCING REVEALS | Isoquinolines - adverse effects | Class I Phosphatidylinositol 3-Kinases - metabolism | Humans | Lymphoma, Mantle-Cell - pathology | Phosphatidylinositol 3-Kinases - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Translocation, Genetic - drug effects | Isoquinolines - pharmacology | Antineoplastic Agents - adverse effects | Genomic Instability - drug effects | Female | Antineoplastic Agents - pharmacology | Purines - adverse effects | B-Lymphocytes - pathology | Immunoglobulin Class Switching - drug effects | Somatic Hypermutation, Immunoglobulin - drug effects | Lymphoma, Mantle-Cell - genetics | B-Lymphocytes - metabolism | Quinazolinones - pharmacology | Pyrazoles - adverse effects | Pyrazoles - pharmacology | Enzyme Inhibitors - adverse effects | B-Lymphocytes - enzymology | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | B-Lymphocytes - drug effects | Animals | Agammaglobulinaemia Tyrosine Kinase | Cytidine Deaminase - metabolism | Pyrimidines - adverse effects | Cell Line, Tumor | Mice | Immunoglobulin Heavy Chains - genetics | Quinazolinones - adverse effects | Recombination, Genetic - drug effects | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Cell, ISSN 0092-8674, 09/2000, Volume 102, Issue 5, pp. 553 - 563
Induced overexpression of AID in CH12F3-2 B lymphoma cells augmented class switching from IgM to IgA without cytokine stimulation. AID deficiency caused a... 
B-CELLS | SOMATIC HYPERMUTATION | HYPER-IGM SYNDROME | IMMUNOGLOBULIN GENES | CIRCULAR DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | X-LINKED IMMUNODEFICIENCY | CD40 LIGAND | HEAVY-CHAIN LOCUS | SACCHAROMYCES-CEREVISIAE | REGION RECOMBINATION | CELL BIOLOGY | Immunohistochemistry | Spleen - immunology | RNA Editing | Germinal Center - enzymology | Immunoglobulin A - genetics | Male | Spleen - drug effects | APOBEC-1 Deaminase | Gene Deletion | B-Lymphocytes - pathology | Immunoglobulin Class Switching - drug effects | Immunoglobulin M - genetics | Cytidine Deaminase - genetics | Enzyme Induction | Germinal Center - pathology | Mutation - genetics | Mice, Knockout | B-Lymphocytes - immunology | Mutation - drug effects | Cytidine Deaminase - metabolism | Immunoglobulin A - immunology | Lipopolysaccharides - pharmacology | Mice | Haptens - pharmacology | Recombination, Genetic - drug effects | Germinal Center - immunology | RNA, Messenger - analysis | Germinal Center - drug effects | Germ-Line Mutation - genetics | Immunoglobulin M - immunology | Flow Cytometry | Germ-Line Mutation - drug effects | Spleen - enzymology | Recombination, Genetic - genetics | Female | Cytidine Deaminase - drug effects | Tumor Cells, Cultured | Spleen - pathology | B-Lymphocytes - enzymology | RNA, Messenger - genetics | B-Lymphocytes - drug effects | Animals | Lymphocyte Activation - drug effects | Cytidine Deaminase - deficiency | Heterozygote | gamma-Globulins - pharmacology | Immunoglobulin Class Switching - genetics | Cytokines - pharmacology | Chimera | Immunogenetics | Immunoglobulins | Analysis | Physiological aspects | Genetic aspects | Research | Genetic recombination | Enzyme activation | DNA-ligand interactions
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2016, Volume 197, Issue 10, pp. 3792 - 3805
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2014, Volume 192, Issue 6, pp. 2651 - 2658
The TLR4 ligand LPS causes mouse B cells to undergo IgE and IgG1 isotype switching in the presence of IL-4. TLR4 activates two signaling pathways mediated by... 
CHAIN | SELECTIVE DEFECTS | CELLS | GERMLINE | INDUCED CYTIDINE DEAMINASE | GENE-EXPRESSION | IL-4 | IMMUNOLOGY | NF-KAPPA-B | C-H TRANSCRIPTION | EPSILON | Cytidine Deaminase - immunology | Phenylenediamines - immunology | Cell Survival - genetics | Immunoblotting | Mice, 129 Strain | Adaptor Proteins, Vesicular Transport - metabolism | Lipopolysaccharides - immunology | Receptors, Interleukin - metabolism | Interleukin-4 - pharmacology | Toll-Like Receptor 4 - agonists | Immunoglobulin Class Switching - drug effects | B-Lymphocytes - metabolism | Cell Survival - drug effects | Receptors, Interleukin - immunology | Cytidine Deaminase - genetics | Immunoglobulin E - metabolism | Myeloid Differentiation Factor 88 - genetics | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | Adaptor Proteins, Vesicular Transport - immunology | Immunoglobulin epsilon-Chains - genetics | Reverse Transcriptase Polymerase Chain Reaction | Receptors, Interleukin - genetics | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Interleukin-4 - immunology | B-Lymphocytes - immunology | Immunoglobulin G - genetics | Immunoglobulin gamma-Chains - immunology | Signal Transduction - drug effects | Cytidine Deaminase - metabolism | Lipopolysaccharides - pharmacology | Phenylenediamines - pharmacology | Mice | Mice, Inbred BALB C | Immunoglobulin G - metabolism | Immunoglobulin gamma-Chains - genetics | Transcription Factor RelA - antagonists & inhibitors | Adaptor Proteins, Vesicular Transport - genetics | Immunoglobulin Class Switching - immunology | Signal Transduction - immunology | Immunoglobulin E - immunology | Immunoglobulin E - genetics | Immunoglobulin G - immunology | Myeloid Differentiation Factor 88 - immunology | Immunoglobulin gamma-Chains - metabolism | Transcription Factor RelA - immunology | Mice, Inbred C57BL | Immunoglobulin epsilon-Chains - immunology | Cell Survival - immunology | B-Lymphocytes - drug effects | Animals | Transcription Factor RelA - metabolism | Immunoglobulin epsilon-Chains - metabolism | Myeloid Differentiation Factor 88 - metabolism | B cells | TRIF | TLR4 | TRAM | IgE | LPS
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2014, Volume 193, Issue 12, pp. 5933 - 5950
Class-switch DNA recombination (CSR) and somatic hypermutation (SHM), which require activation-induced cytidine deaminase (AID), and plasma cell... 
ACTIVATION-INDUCED DEAMINASE | SYSTEMIC-LUPUS-ERYTHEMATOSUS | GERMINAL CENTER B | SOMATIC HYPERMUTATION | AUTOIMMUNE INFLAMMATION | COLONIC INFLAMMATION | INDUCED CYTIDINE DEAMINASE | SWITCH DNA RECOMBINATION | VALPROIC ACID | IMMUNOLOGY | PLASMA-CELLS | Antibodies - metabolism | Epigenesis, Genetic | Humans | Cell Survival - genetics | Autoantibodies - biosynthesis | Dose-Response Relationship, Drug | Plasma Cells - drug effects | Lymphocyte Activation - immunology | Mice, Inbred MRL lpr | Antibodies - immunology | Female | Plasma Cells - metabolism | Immunoglobulin Class Switching - drug effects | Somatic Hypermutation, Immunoglobulin - drug effects | Cell Survival - drug effects | B-Lymphocytes - cytology | Cytidine Deaminase - genetics | Gene Silencing | B-Lymphocytes - physiology | Repressor Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Gene Knockout Techniques | Regulatory Factor X Transcription Factors | Gene Expression Regulation - drug effects | B-Lymphocytes - drug effects | Autoantibodies - immunology | Animals | Cell Differentiation - drug effects | Lymphocyte Activation - drug effects | Antibody Formation | Histone Deacetylase Inhibitors - pharmacology | Mice | MicroRNAs - genetics | DNA Methylation - drug effects | Plasma Cells - cytology | Plasma Cells - immunology | Positive Regulatory Domain I-Binding Factor 1
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 07/2010, Volume 207, Issue 7, pp. 1485 - 1500
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2009, Volume 206, Issue 1, pp. 99 - 111
Journal Article
Molecular Immunology, ISSN 0161-5890, 03/2015, Volume 64, Issue 1, pp. 144 - 151
Journal Article