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The EMBO Journal, ISSN 0261-4189, 06/1999, Volume 18, Issue 12, pp. 3484 - 3490
During maturation of the immune response, IgM+ B cells switch to expression of one of the downstream isotypes (IgG, A or E). This class switching occurs by... 
mismatch repair | somatic hypermutation | Msh2 | immunoglobulin class switching | heavy chain switch recombination | Immunoglobulin class switching | Somatic hypermutation | Mismatch repair | Heavy chain switch recombination | PROTEIN | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | SACCHAROMYCES-CEREVISIAE MSH2 | DNA-MISMATCH | BREAKPOINTS | REGION | CELL BIOLOGY | B-CELLS | GENE DISRUPTION | MICE | MISMATCH REPAIR DEFICIENCY | Antigens, T-Independent - immunology | Ficoll - pharmacology | Immunoglobulin G - blood | Peyer's Patches - metabolism | Immunoglobulin A - genetics | Immunoglobulin Class Switching - immunology | Molecular Sequence Data | DNA Repair - genetics | Antigens, T-Independent - pharmacology | Base Pair Mismatch - genetics | Mutagenesis - drug effects | Base Sequence | Recombination, Genetic - genetics | Ficoll - analogs & derivatives | Immunoglobulin Class Switching - drug effects | B-Lymphocytes - metabolism | DNA-Binding Proteins | Immunoglobulin M - genetics | Proto-Oncogene Proteins - metabolism | B-Lymphocytes - cytology | Cells, Cultured | Proto-Oncogene Proteins - genetics | MutS Homolog 2 Protein | Proto-Oncogene Proteins - deficiency | Mutation - genetics | Mice, Knockout | B-Lymphocytes - drug effects | Peyer's Patches - cytology | Animals | B-Lymphocytes - immunology | Immunoglobulin G - genetics | Immunoglobulin M - blood | Lymphocyte Activation - drug effects | Lipopolysaccharides - pharmacology | Mice | Peyer's Patches - immunology | Immunoglobulin Class Switching - genetics | Recombination, Genetic - drug effects
Journal Article
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Journal of Immunology, ISSN 0022-1767, 01/2017, Volume 198, Issue 1, pp. 279 - 291
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Molecular and Cellular Biology, ISSN 0270-7306, 02/2011, Volume 31, Issue 3, pp. 442 - 449
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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2009, Volume 106, Issue 52, pp. 22375 - 22380
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Allergy, ISSN 0105-4538, 05/2013, Volume 68, Issue 5, pp. 593 - 603
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International Immunology, ISSN 0953-8178, 08/2003, Volume 15, Issue 8, pp. 937 - 944
The IgG2a Ig subclass plays a critical role in the pathogenesis of humoral autoimmunity and protection against pathogens. The T-box transcription factor T-bet... 
B lymphocyte | Rodent | Antibody | Cellular activation | ANTIBODIES | CELLS | antibody | IFN-GAMMA | CD40 LIGAND | IMMUNOLOGY | LINEAGE COMMITMENT | cellular activation | INTERFERON-GAMMA | IMMUNE-RESPONSES | rodent | DEFICIENT | MICE | EXPRESSION | Enzyme-Linked Immunosorbent Assay - methods | Antigens, T-Independent - immunology | Ficoll - pharmacology | Flow Cytometry - methods | Trinitrobenzenes - pharmacology | Immunoglobulin Class Switching - immunology | RNA, Messenger - analysis | Ficoll - immunology | Antigens, Differentiation, B-Lymphocyte - analysis | Haptens - immunology | Lipopolysaccharides - immunology | Lymphocyte Subsets - chemistry | Immunoglobulin G - immunology | Reverse Transcriptase Polymerase Chain Reaction - methods | Ficoll - analogs & derivatives | Trinitrobenzenes - immunology | Immunoglobulin Class Switching - drug effects | Transcription Factors - immunology | CD40 Antigens - pharmacology | Transcription Factors - physiology | Immunization - methods | Mice, Inbred C57BL | Gene Expression Regulation | Spleen - cytology | Transcription Factors - genetics | Mice, Knockout | Immunoglobulin Isotypes - blood | Animals | Immunoglobulin G - genetics | Interferon-gamma - immunology | Lipopolysaccharides - pharmacology | Immunoglobulin Isotypes - immunology | Mice | Mice, Inbred BALB C | Haptens - pharmacology | T-Box Domain Proteins | CD40 Antigens - immunology | Interferon-gamma - pharmacology
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Journal of Clinical Immunology, ISSN 0271-9142, 9/2010, Volume 30, Issue 5, pp. 746 - 755
Journal Article