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Nature (London), ISSN 1476-4687, 2011, Volume 471, Issue 7336, pp. 119 - 123
Misrepair of DNA double-strand breaks produced by the V(D)J recombinase (the RAG1/RAG2 proteins) at immunoglobulin (Ig) and T cell receptor (Tcr) loci has been... 
THYMIC LYMPHOMA | REPAIR | LYMPHOCYTE DEVELOPMENT | B-CELL | ROLES | TRANSLOCATIONS | MULTIDISCIPLINARY SCIENCES | V(D)J RECOMBINATION | DOUBLE-STRAND BREAKS | GENE AMPLIFICATION | ATM-DEFICIENT MICE | Genomic Instability | Protein-Serine-Threonine Kinases - deficiency | Gene Rearrangement, T-Lymphocyte - genetics | Chromosomes, Mammalian - genetics | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Recombination, Genetic - genetics | Lymphoma - pathology | Chromosome Deletion | Tumor Suppressor Proteins - metabolism | Kaplan-Meier Estimate | Protein-Serine-Threonine Kinases - genetics | Thymus Gland - cytology | Lymphoma - genetics | In Situ Hybridization, Fluorescence | Ataxia Telangiectasia Mutated Proteins | Genes, p53 - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Disease Progression | Animals | Genes, Immunoglobulin Heavy Chain - genetics | Mice | Receptors, Antigen, T-Cell - genetics | Translocation, Genetic - genetics | Causes of | Tumor suppressor genes | Lymphomas | Genetic aspects | Abnormalities | Software | Chromosomes | Deoxyribonucleic acid--DNA | Cell cycle | Apoptosis | Tumors | Thymus Gland | Translocation, Genetic | Protein-Serine-Threonine Kinases | Gene Rearrangement, T-Lymphocyte | Receptors, Antigen, T-Cell | Lymphoma | Chromosomes, Mammalian | Genes, Immunoglobulin Heavy Chain | Life Sciences | Genes, p53 | Immunology | Recombination, Genetic | Cell Cycle Proteins | Tumor Suppressor Proteins | DNA-Binding Proteins
Journal Article
The American journal of pathology, ISSN 0002-9440, 2016, Volume 186, Issue 12, pp. 3273 - 3284
Journal Article
PLoS genetics, ISSN 1553-7404, 2019, Volume 15, Issue 2, p. e1007930
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 4/2013, Volume 110, Issue 16, pp. 6470 - 6475
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2011, Volume 333, Issue 6049, pp. 1593 - 1602
.... A functional genomics analysis of expressed heavy and light chains revealed common pathways of antibody-heavy chain maturation, confined to the IGHV1-2... 
Germ cells | Neutralizing antibodies | B lymphocytes | RESEARCH ARTICLES | Genomics | Alleles | Antibodies | Phylogenetics | Epitopes | HIV 1 | High throughput nucleotide sequencing | DESIGN | DOMAIN | EPITOPE | MULTIDISCIPLINARY SCIENCES | BROAD | DIVERSITY | GLYCOPROTEIN | GP120 | MONOCLONAL-ANTIBODIES | SELECTION | BREADTH | Antibody Specificity | Complementarity Determining Regions - genetics | Humans | Immunoglobulin Heavy Chains - chemistry | Molecular Sequence Data | Crystallography, X-Ray | HIV Antibodies - isolation & purification | HIV Envelope Protein gp120 - metabolism | Genes, Immunoglobulin Heavy Chain | HIV Envelope Protein gp120 - immunology | Immunoglobulin Light Chains - chemistry | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV Antibodies - immunology | HIV-1 - chemistry | Immunoglobulin J-Chains - genetics | Base Sequence | HIV Envelope Protein gp120 - chemistry | Binding Sites | Immunoglobulin Heavy Chains - immunology | Immunoglobulin Light Chains - immunology | Amino Acid Sequence | Models, Molecular | Antibody Affinity | Antibodies, Neutralizing - genetics | HIV Antibodies - chemistry | Sequence Analysis, DNA | Antibodies, Neutralizing - isolation & purification | HIV-1 - immunology | Antibodies, Neutralizing - chemistry | Immunoglobulin Fab Fragments - chemistry | AIDS Vaccines | High-Throughput Nucleotide Sequencing | HIV Antibodies - genetics | Immunoglobulin Fab Fragments - immunology | Mutation | Binding Sites, Antibody | CD4 Antigens - metabolism | Evolution, Molecular | Viral antibodies | X-ray crystallography | Immunoglobulins | Physiological aspects | Genetic aspects | HIV (Viruses) | Health aspects | Methods | ANTIBODIES | IMMUNITY | BASIC BIOLOGICAL SCIENCES | GENETICS | IMMUNOGLOBULINS | CRYSTAL STRUCTURE | CRYSTALLOGRAPHY | CHAINS | 60 APPLIED LIFE SCIENCES | FUNCTIONALS
Journal Article
Nature (London), ISSN 1476-4687, 2011, Volume 477, Issue 7365, pp. 424 - 430
Journal Article
The Journal of Immunology, ISSN 0022-1767, 11/2003, Volume 171, Issue 10, pp. 5215 - 5224
By substituting the H chain C region of IgM with that of IgG, IgA, or IgE, class switching enables Abs to acquire new effector functions that are crucial for the neutralization of invading pathogens... 
LYMPHOMA CELLS | INTERFERON-ALPHA | DENDRITIC CELLS | MEMBRANE-PROTEIN 1 | NECROSIS-FACTOR FAMILY | ACTIVATES TRANSCRIPTION | GERMINAL-CENTERS | IMMUNOLOGY | NF-KAPPA-B | FACTOR RECEPTOR | EPSTEIN-BARR-VIRUS | T-Lymphocyte Subsets - immunology | Immunoglobulin Heavy Chains - biosynthesis | Viral Matrix Proteins - genetics | Herpesvirus 4, Human - genetics | Immunoglobulin alpha-Chains - genetics | Humans | Tumor Necrosis Factor-alpha - genetics | Molecular Sequence Data | Immunoglobulin alpha-Chains - biosynthesis | Tumor Necrosis Factor Ligand Superfamily Member 13 | Neuropeptides - physiology | Viral Matrix Proteins - physiology | Cytidine Deaminase - biosynthesis | Membrane Proteins - physiology | Recombination, Genetic | Base Sequence | Neuropeptides - biosynthesis | B-Lymphocyte Subsets - immunology | Immunoglobulin epsilon-Chains - biosynthesis | Adjuvants, Immunologic - physiology | Gene Expression Regulation - immunology | Lymphocyte Activation | Membrane Proteins - genetics | Cells, Cultured | Herpesvirus 4, Human - immunology | Up-Regulation - genetics | Adjuvants, Immunologic - biosynthesis | B-Lymphocyte Subsets - enzymology | Immunoglobulin epsilon-Chains - genetics | Nuclear Proteins | Immunoglobulin mu-Chains - genetics | Membrane Proteins - biosynthesis | B-Cell Activating Factor | B-Lymphocyte Subsets - metabolism | Up-Regulation - immunology | Immunoglobulin mu-Chains - biosynthesis | NF-kappa B - physiology | Tumor Necrosis Factor-alpha - physiology | HL-60 Cells | Transcription, Genetic - immunology | Promoter Regions, Genetic - immunology | Immunoglobulin Class Switching - genetics | Tumor Necrosis Factor-alpha - biosynthesis | Immunoglobulin Heavy Chains - genetics
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2009, Volume 107, Issue 1, pp. 181 - 186
Journal Article
Journal Article