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Journal Article
Science, ISSN 0036-8075, 9/2011, Volume 333, Issue 6049, pp. 1593 - 1602
Antibody VRC01 is a human immunoglobulin that neutralizes about 90% of HIV-1 isolates. To understand how such broadly neutralizing antibodies develop, we used... 
Germ cells | Neutralizing antibodies | B lymphocytes | RESEARCH ARTICLES | Genomics | Alleles | Antibodies | Phylogenetics | Epitopes | HIV 1 | High throughput nucleotide sequencing | DESIGN | DOMAIN | EPITOPE | MULTIDISCIPLINARY SCIENCES | BROAD | DIVERSITY | GLYCOPROTEIN | GP120 | MONOCLONAL-ANTIBODIES | SELECTION | BREADTH | Antibody Specificity | Complementarity Determining Regions - genetics | Humans | Immunoglobulin Heavy Chains - chemistry | Molecular Sequence Data | Crystallography, X-Ray | HIV Antibodies - isolation & purification | HIV Envelope Protein gp120 - metabolism | Genes, Immunoglobulin Heavy Chain | HIV Envelope Protein gp120 - immunology | Immunoglobulin Light Chains - chemistry | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV Antibodies - immunology | HIV-1 - chemistry | Immunoglobulin J-Chains - genetics | Base Sequence | HIV Envelope Protein gp120 - chemistry | Binding Sites | Immunoglobulin Heavy Chains - immunology | Immunoglobulin Light Chains - immunology | Amino Acid Sequence | Models, Molecular | Antibody Affinity | Antibodies, Neutralizing - genetics | HIV Antibodies - chemistry | Sequence Analysis, DNA | Antibodies, Neutralizing - isolation & purification | HIV-1 - immunology | Antibodies, Neutralizing - chemistry | Immunoglobulin Fab Fragments - chemistry | AIDS Vaccines | High-Throughput Nucleotide Sequencing | HIV Antibodies - genetics | Immunoglobulin Fab Fragments - immunology | Mutation | Binding Sites, Antibody | CD4 Antigens - metabolism | Evolution, Molecular | Viral antibodies | X-ray crystallography | Immunoglobulins | Physiological aspects | Genetic aspects | HIV (Viruses) | Health aspects | Methods | Index Medicus | ANTIBODIES | IMMUNITY | BASIC BIOLOGICAL SCIENCES | GENETICS | IMMUNOGLOBULINS | CRYSTAL STRUCTURE | CRYSTALLOGRAPHY | CHAINS | 60 APPLIED LIFE SCIENCES | FUNCTIONALS
Journal Article
Nature Immunology, ISSN 1529-2908, 07/2015, Volume 16, Issue 7, pp. 755 - 765
Acute systemic lupus erythematosus (SLE) courses with surges of antibody-secreting cells (ASCs) whose origin, diversity and contribution to serum... 
RESPONSES | ACTIVATION | MEMORY B-CELLS | AFFINITY MATURATION | AUTOIMMUNITY | PERIPHERAL-BLOOD | GERMINAL CENTER | IMMUNOLOGY | MONOCLONAL-ANTIBODIES | SLE | ANTIGEN | Autoantibodies - metabolism | Cell Proliferation | Immunoglobulin G - blood | Humans | Immunoglobulin Variable Region - metabolism | Lupus Erythematosus, Systemic - metabolism | Molecular Sequence Data | Immunoglobulin Variable Region - immunology | Tandem Mass Spectrometry | Antibody Diversity - genetics | Flow Cytometry | Antibody Diversity - immunology | Immunoglobulin G - immunology | Single-Cell Analysis - methods | Base Sequence | Proteome - immunology | Clone Cells - immunology | Lupus Erythematosus, Systemic - immunology | Proteomics - methods | Immunoglobulin Heavy Chains - immunology | B-Lymphocytes - metabolism | Amino Acid Sequence | Antibody-Producing Cells - metabolism | Acute Disease | Proteome - analysis | Clone Cells - metabolism | Sequence Homology, Amino Acid | Autoantibodies - immunology | Antibody-Producing Cells - immunology | B-Lymphocytes - immunology | Immunoglobulin G - genetics | Influenza Vaccines - immunology | Lupus Erythematosus, Systemic - genetics | Immunoglobulin Heavy Chains - metabolism | Immunoglobulin Variable Region - genetics | Autoantibodies - genetics | Tetanus Toxoid - immunology | Immunoglobulin Heavy Chains - genetics | Systemic lupus erythematosus | Immune response | Autoantibodies | Development and progression | Genetic aspects | Nucleotide sequencing | Identification and classification | Methods | DNA sequencing | Index Medicus
Journal Article
Journal of Virology, ISSN 0022-538X, 2014, Volume 88, Issue 8, pp. 4047 - 4057
Journal Article
Nature Immunology, ISSN 1529-2908, 02/2016, Volume 17, Issue 3, pp. 331 - 343
The transcription factor Blimp-1 is necessary for the generation of plasma cells. Here we studied its functions in plasmablast differentiation by identifying... 
RNA-POLYMERASE-II | MATURE B | GERMINAL CENTER B | LYMPHOPOIESIS | MESSENGER-RNA | REPRESSION | ER STRESS | GENE-EXPRESSION | IMMUNOLOGY | ELONGATION-FACTOR | T-CELLS | Humans | Cell Movement - genetics | Cell Migration Assays, Leukocyte | Cell Movement - immunology | Cell Differentiation - genetics | Flow Cytometry | Immunoglobulin kappa-Chains - immunology | Chromatin Immunoprecipitation | Mass Spectrometry | HEK293 Cells | Plasma Cells - metabolism | Electrophoretic Mobility Shift Assay | Transcription Factors - immunology | Immunoglobulin Heavy Chains - immunology | B-Lymphocytes - metabolism | Cell Adhesion - genetics | Enzyme-Linked Immunosorbent Assay | Gene Expression Regulation | Interferon Regulatory Factors - genetics | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Sequence Analysis, DNA | Cell Adhesion - immunology | Cell Differentiation - immunology | Immunoglobulin kappa-Chains - genetics | Interferon Regulatory Factors - immunology | Animals | B-Lymphocytes - immunology | Sequence Analysis, RNA | High-Throughput Nucleotide Sequencing | Mice | Immunoglobulin Heavy Chains - genetics | Plasma Cells - immunology | Positive Regulatory Domain I-Binding Factor 1 | Transcription factors | Plasma cells | Genetic research | Genetic aspects | Genetic transcription | Research | Cell differentiation | Health aspects | Index Medicus
Journal Article
PLoS pathogens, ISSN 1553-7366, 2013, Volume 9, Issue 5, pp. e1003342 - e1003342
New broad and potent neutralizing HIV-1 antibodies have recently been described that are largely dependent on the gp120 N332 glycan for Env recognition.... 
SYSTEM | COMPLEX | POTENT NEUTRALIZATION | PROTEIN | SOLUBLE CD4 | ENVELOPE GLYCOPROTEIN | ELECTRON-MICROSCOPY | MICROBIOLOGY | CONFORMATIONAL EPITOPE | VIROLOGY | IMMUNODEFICIENCY-VIRUS TYPE-1 | INFLUENZA-A VIRUSES | PARASITOLOGY | HIV Envelope Protein gp120 - genetics | Humans | Immunoglobulin Heavy Chains - chemistry | Crystallography, X-Ray | Epitopes - immunology | HIV Envelope Protein gp120 - immunology | Allosteric Regulation - immunology | Antibodies, Neutralizing - immunology | HEK293 Cells | Protein Structure, Quaternary | HIV Envelope Protein gp120 - chemistry | Glycoproteins - chemistry | Immunoglobulin Heavy Chains - immunology | CD4 Antigens - genetics | Glycoproteins - genetics | CD4 Antigens - immunology | Allosteric Regulation - genetics | Antibodies, Neutralizing - genetics | Epitopes - genetics | HIV-1 - genetics | Glycoproteins - immunology | HIV-1 - immunology | CD4 Antigens - chemistry | Antibodies, Neutralizing - chemistry | Antibodies, Viral - chemistry | Antibodies, Viral - immunology | Epitopes - chemistry | Binding Sites, Antibody | Antibodies, Viral - genetics | Immunoglobulin Heavy Chains - genetics | Immune response | HIV antibodies | Analysis | Crystals | Research | Structure | Identification and classification | Index Medicus | Competition | Medical research | Acquired immune deficiency syndrome | HIV | AIDS | Human immunodeficiency virus | Binding sites
Journal Article
Nature, ISSN 0028-0836, 09/2010, Volume 467, Issue 7315, pp. 591 - 595
Journal Article
Cell, ISSN 0092-8674, 09/2016, Volume 166, Issue 6, pp. 1471 - 1484.e18
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 10/2012, Volume 209, Issue 11, pp. 2079 - 2097
One component of memory in the antibody system is long-lived memory B cells selected for the expression of somatically mutated, high-affinity antibodies in the... 
B-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | CLONAL SELECTION | GERMINAL-CENTER FORMATION | MURINE MEMORY | AFFINITY MATURATION | LIVED PLASMA-CELLS | PRIMARY IMMUNIZATION | GENE-EXPRESSION | IMMUNOLOGY | T-CELLS | PRIMARY IMMUNE-RESPONSE | Antibodies - metabolism | Oligonucleotide Array Sequence Analysis | Germinal Center - immunology | Immunoglobulin Variable Region - metabolism | Molecular Sequence Data | Male | Gene Expression Profiling | Immunoglobulin Variable Region - immunology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Flow Cytometry | Immunoglobulin G - immunology | Antibodies - immunology | Female | Germ Cells - metabolism | Immunoglobulin Heavy Chains - immunology | B-Lymphocytes - metabolism | Immunologic Memory - immunology | DNA-Binding Proteins - immunology | Mice, Inbred C57BL | Mice, Transgenic | Signal Transduction - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Sequence Analysis, DNA | Mice, Knockout | Animals | B-Lymphocytes - immunology | Germinal Center - metabolism | Immunoglobulin G - genetics | Immunoglobulin Heavy Chains - metabolism | Antibodies - genetics | Immunoglobulin Variable Region - genetics | Mice | Mice, Inbred BALB C | Germ Cells - immunology | Immunoglobulin Heavy Chains - genetics | Immunoglobulin G - metabolism | Proto-Oncogene Proteins c-bcl-6 | Index Medicus
Journal Article