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Cell (Cambridge), ISSN 0092-8674, 06/2012, Volume 149, Issue 6, pp. 1207 - 1220
Journal Article
Structure (London), ISSN 0969-2126, 01/2014, Volume 22, Issue 1, pp. 70 - 81
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 01/2013, Volume 110, Issue 5, pp. 1875 - 1880
.... A tissue-specific inactivation of the Notch transcriptional effector recombination signal binding protein for Ig kappa J (RBPjκ... 
Cartilage | Knee joint | Articular cartilage | Chondrocytes | Ligands | Bones | Mice | Skeletal development | Gene expression regulation | Osteoarthritis | Cartilage degradation | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cartilage - pathology | Homeodomain Proteins - metabolism | Humans | Cartilage - drug effects | Collagen Type II - metabolism | Knee Joint - pathology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Serrate-Jagged Proteins | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Jagged-1 Protein | SOX9 Transcription Factor - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Membrane Proteins - genetics | Osteoarthritis - metabolism | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Cell Line, Tumor | HeLa Cells | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Calcium-Binding Proteins - genetics | Transcription Factor HES-1 | Receptor, Notch2 - antagonists & inhibitors | Receptor, Notch2 - genetics | Chondrocytes - drug effects | Intercellular Signaling Peptides and Proteins - metabolism | Membrane Proteins - metabolism | Chondrocytes - metabolism | Calcium-Binding Proteins - metabolism | Knee Joint - metabolism | Cell Line | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Osteoarthritis - prevention & control | Dipeptides - pharmacology | Knee Joint - drug effects | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch2 - metabolism | Receptor, Notch1 - metabolism | Cartilage - metabolism | Collagen Type II - genetics | Homeodomain Proteins - genetics | Osteoarthritis - genetics | Animals | Fluorescent Antibody Technique | SOX9 Transcription Factor - genetics | Osteogenesis | Endochondral ossification | Physiological aspects | Development and progression | Cellular signal transduction | Health aspects | Membrane proteins | Proteins | Knee | Tissue | Rodents | Arthritis | Cells | Index Medicus | cartilage degradation | Biological Sciences | skeletal development
Journal Article
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 11/2014, Volume 211, Issue 12, pp. 2411 - 2423
Hematopoietic stem cell (HSC) specification occurs in the embryonic aorta and requires Notch activation; however, most of the Notch-regulated elements... 
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Humans | Embryo, Nonmammalian - metabolism | Embryo, Nonmammalian - embryology | Aorta - metabolism | Zebrafish - embryology | Embryo, Mammalian - metabolism | Cell Differentiation - genetics | Intercellular Signaling Peptides and Proteins - metabolism | In Situ Hybridization | Gene Expression Regulation, Developmental | Serrate-Jagged Proteins | HEK293 Cells | Transcription, Genetic | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Calcium-Binding Proteins - metabolism | Cell Line | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Membrane Proteins - genetics | Mice, Inbred C57BL | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Aorta - embryology | Nuclear Proteins - metabolism | Hematopoietic Stem Cells - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Zebrafish - genetics | Mice, Knockout | Animals | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Hematopoietic Stem Cells - cytology | Protein Binding | Receptor, Notch1 - genetics | Calcium-Binding Proteins - genetics | Index Medicus | Peixos zebra (Animals de laboratori) | Cultius cel·lulars
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 7/2012, Volume 109, Issue 27, pp. 10921 - 10926
.... Mutation of Axin2, the negative regulator of canonical Wnt signaling, enhances Wnt and Bmp4 signals and suffices to rescue the arrest of cardiac differentiation caused by loss of RBPJ... 
Heart | Transcription factors | Genes | Stem cells | Cellular immunity | Embryonic stem cells | In situ hybridization | Progenitor cells | Embryos | Cellular differentiation | Mesoderm patterning | Progenitor differentiation in culture | MesP1-cre | Canonical Wnt | Cardiogenesis | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Axin Protein - genetics | LIM-Homeodomain Proteins - metabolism | Receptors, Notch - metabolism | Homeodomain Proteins - metabolism | Wnt Signaling Pathway - physiology | Male | Bone Morphogenetic Protein 4 - metabolism | Axin Protein - metabolism | Flow Cytometry | Mice, Mutant Strains | Muscle Proteins - metabolism | Female | Cell Differentiation - physiology | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | GATA4 Transcription Factor - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Myocytes, Cardiac - cytology | GATA4 Transcription Factor - genetics | Transcription Factors - genetics | beta Catenin - metabolism | Homeodomain Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Muscle Proteins - genetics | Pregnancy | Transcription Factors - metabolism | Homeobox Protein Nkx-2.5 | LIM-Homeodomain Proteins - genetics | Animals | Mice | Lac Operon | Index Medicus | Biological Sciences | cardiogenesis | canonical Wnt | progenitor differentiation in culture | mesoderm patterning
Journal Article
PloS one, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, pp. e78439 - e78439
Neuroinflammation mediated by the activated microglia is suggested to play a pivotal role in the pathogenesis of hypoxic brain injury; however, the underlying... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Amyloid Precursor Protein Secretases - genetics | Microglia - metabolism | Transcription Factor HES-1 | Homeodomain Proteins - metabolism | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Hypoxia - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Microglia - pathology | Membrane Proteins - metabolism | TNF Receptor-Associated Factor 6 - genetics | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Animals, Newborn | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Membrane Proteins - genetics | Dipeptides - pharmacology | Enzyme Inhibitors - pharmacology | Myeloid Differentiation Factor 88 - genetics | Rats | Toll-Like Receptor 4 - genetics | Receptor, Notch1 - metabolism | Toll-Like Receptor 4 - metabolism | Homeodomain Proteins - genetics | Amyloid Precursor Protein Secretases - metabolism | Hypoxia - genetics | Animals | NF-kappa B - genetics | Hypoxia - pathology | TNF Receptor-Associated Factor 6 - metabolism | Cell Line, Tumor | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Receptor, Notch1 - antagonists & inhibitors | Cell Hypoxia - genetics | Receptor, Notch1 - genetics | Myeloid Differentiation Factor 88 - metabolism | Brain | Mental disorders | Laboratories | Pathogenesis | Crosstalk | Activation | Neurogenesis | Signal transduction | Embryology | Head injuries | Pathways | Rodents | Cerebrum | Toll-like receptors | Microglial cells | Inhibition | Pretreatment | Casualties | Translocation | NF-κB protein | Adenosine | TRAF6 protein | Cytokines | Histology | Exposure | Inflammation | TLR4 protein | Gene expression | Microglia | Medicine | Studies | Signaling | Brain research | DELTA protein | Stem cells | MyD88 protein | Hypoxia | Ligands | Brain damage | Notch protein | Brain injury | Secretase | Index Medicus
Journal Article