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immunoglobulin j recombination signal sequence-binding protein - metabolism (316) 316
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immunoglobulin j recombination signal sequence-binding protein - genetics (211) 211
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notch (128) 128
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transcription (59) 59
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basic helix-loop-helix transcription factors - metabolism (56) 56
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homeodomain proteins - genetics (55) 55
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multidisciplinary sciences (54) 54
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Cell, ISSN 0092-8674, 06/2012, Volume 149, Issue 6, pp. 1207 - 1220
Journal Article
Nature Cell Biology, ISSN 1465-7392, 09/2015, Volume 17, Issue 9, pp. 1193 - 1204
Journal Article
Nature, ISSN 0028-0836, 11/2009, Volume 462, Issue 7270, pp. 182 - 188
Direct inhibition of transcription factor complexes remains a central challenge in the discipline of ligand discovery. In general, these proteins lack surface... 
PROGENITOR CELLS | ACTIVATION | GENE | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | T-CELL LEUKEMIA | C-MYC | GAMMA-SECRETASE INHIBITORS | MUTATIONS | HUMAN HOMOLOG | MASTERMIND | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Transcription Factors - chemistry | Humans | Transcriptional Activation - drug effects | Genome - genetics | Receptor, Notch1 - chemistry | Cell Membrane Permeability | Substrate Specificity | DNA-Binding Proteins - metabolism | Peptides - chemical synthesis | Peptides - metabolism | Protein Binding - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Disease Models, Animal | Binding, Competitive | Protein Structure, Tertiary | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Peptides - chemistry | Protein Structure, Secondary | Models, Molecular | Drosophila Proteins - chemistry | Receptor, Notch1 - metabolism | Genome - drug effects | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Peptides - pharmacology | Transcription Factors - metabolism | Animals | Signal Transduction - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Receptor, Notch1 - antagonists & inhibitors | Transcription factors | Research | Ligands (Biochemistry) | Peptide bonds | Index Medicus
Journal Article
Cell Stem Cell, ISSN 1934-5909, 07/2014, Volume 15, Issue 1, pp. 51 - 65
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 5, pp. 1875 - 1880
Here we examined the involvement of Notch signaling in the endochondral ossification process, which is crucial for osteoarthritis (OA) development.... 
Cartilage | Knee joint | Articular cartilage | Chondrocytes | Ligands | Bones | Mice | Skeletal development | Gene expression regulation | Osteoarthritis | Cartilage degradation | CELLS | OSTEOBLAST DIFFERENTIATION | MULTIDISCIPLINARY SCIENCES | skeletal development | BONE-DEVELOPMENT | KNEE-JOINT INSTABILITY | LIGANDS | ARTICULAR-CARTILAGE | PATHWAY | GROWTH | cartilage degradation | EXPERIMENTAL MOUSE MODELS | EXPRESSION | Cartilage - pathology | Homeodomain Proteins - metabolism | Humans | Cartilage - drug effects | Collagen Type II - metabolism | Knee Joint - pathology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Serrate-Jagged Proteins | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Jagged-1 Protein | SOX9 Transcription Factor - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Membrane Proteins - genetics | Osteoarthritis - metabolism | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Cell Line, Tumor | HeLa Cells | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Calcium-Binding Proteins - genetics | Transcription Factor HES-1 | Receptor, Notch2 - antagonists & inhibitors | Receptor, Notch2 - genetics | Chondrocytes - drug effects | Intercellular Signaling Peptides and Proteins - metabolism | Membrane Proteins - metabolism | Chondrocytes - metabolism | Calcium-Binding Proteins - metabolism | Knee Joint - metabolism | Cell Line | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Osteoarthritis - prevention & control | Dipeptides - pharmacology | Knee Joint - drug effects | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch2 - metabolism | Receptor, Notch1 - metabolism | Cartilage - metabolism | Collagen Type II - genetics | Homeodomain Proteins - genetics | Osteoarthritis - genetics | Animals | Fluorescent Antibody Technique | SOX9 Transcription Factor - genetics | Osteogenesis | Endochondral ossification | Physiological aspects | Development and progression | Cellular signal transduction | Health aspects | Membrane proteins | Proteins | Knee | Tissue | Rodents | Arthritis | Cells | Index Medicus | Biological Sciences
Journal Article