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1. Full Text Clinical responses with T lymphocytes targeting malignancy-associated κ light chains
by Ramos, Carlos A and Savoldo, Barbara and Torrano, Vicky and Ballard, Brandon and Zhang, Huimin and Dakhova, Olga and Liu, Enli and Carrum, George and Kamble, Rammurti T and Gee, Adrian P and Mei, Zhuyong and Wu, Meng-Fen and Liu, Hao and Grilley, Bambi and Rooney, Cliona M and Brenner, Malcolm K and Heslop, Helen E and Dotti, Gianpietro
The Journal of clinical investigation, ISSN 0021-9738, 07/2016, Volume 126, Issue 7, pp. 2588 - 2596
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Lymphoma, Non-Hodgkin - immunology | Enzyme-Linked Immunosorbent Assay | Humans | Middle Aged | Immunophenotyping | Male | Treatment Outcome | Adoptive Transfer | Remission Induction | Feasibility Studies | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | Immunoglobulin kappa-Chains - immunology | Retroviridae - metabolism | Lymphoma, Non-Hodgkin - therapy | Adult | Female | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Antigens, CD19 - immunology | Index Medicus | Abridged Index Medicus
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2. Full Text Free light chains: Eclectic multipurpose biomarker
by Basile, Umberto and Gulli, Francesca and Gragnani, Laura and Napodano, Cecilia and Pocino, Krizia and Rapaccini, Gian Ludovico and Mussap, Michele and Zignego, Anna Linda
Journal of immunological methods, ISSN 0022-1759, 12/2017, Volume 451, pp. 11 - 19
Rituximab | Free light chains | Multiple sclerosis | Autoimmune diseases | Immediate hypersensitivity | Viral infections | Biochemistry & Molecular Biology | Immunology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Predictive Value of Tests | Multiple Sclerosis - diagnosis | Prognosis | Humans | Structure-Activity Relationship | Drug Monitoring - methods | Immunoglobulin Light Chains - chemistry | Renal Insufficiency, Chronic - metabolism | Rituximab - therapeutic use | Immunoglobulin kappa-Chains - immunology | Hypersensitivity, Immediate - immunology | Renal Insufficiency, Chronic - diagnosis | Autoimmune Diseases - metabolism | Hypersensitivity, Immediate - diagnosis | Multiple Sclerosis - metabolism | Biomarkers - metabolism | Immunoglobulin Light Chains - immunology | Immunoglobulin lambda-Chains - chemistry | Immunoglobulin lambda-Chains - immunology | Renal Insufficiency, Chronic - immunology | Virus Diseases - immunology | Autoimmune Diseases - immunology | Virus Diseases - metabolism | Autoimmune Diseases - diagnosis | Immunoglobulin kappa-Chains - metabolism | Immunoglobulin Light Chains - metabolism | Immunoglobulin lambda-Chains - metabolism | Animals | Hypersensitivity, Immediate - metabolism | Virus Diseases - diagnosis | Multiple Sclerosis - immunology | Protein Conformation | Immunoglobulin kappa-Chains - chemistry | Immunologic Factors - therapeutic use | Lupus | Rheumatoid factor | Systemic lupus erythematosus | Chronic kidney failure | Multiple myeloma | Hepatitis C | HIV (Viruses) | Health aspects | Index Medicus
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3. Full Text In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire
by DeKosky, Brandon J and Kojima, Takaaki and Rodin, Alexa and Charab, Wissam and Ippolito, Gregory C and Ellington, Andrew D and Georgiou, George
Nature medicine, ISSN 1078-8956, 01/2015, Volume 21, Issue 1, pp. 86 - 91
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Adaptive Immunity | Immunoglobulin Light Chains - immunology | RNA, Messenger - immunology | Humans | RNA, Messenger - genetics | HIV-1 - genetics | Immunoglobulin Light Chains - genetics | Autoantibodies - immunology | HIV-1 - immunology | B-Lymphocytes - immunology | Autoantibodies - isolation & purification | Antibodies - immunology | Antibodies - genetics | Immunoglobulin Variable Region - genetics | High-Throughput Nucleotide Sequencing | Autoantibodies - genetics | Antibodies - isolation & purification | Immunoglobulin Heavy Chains - immunology | Immunoglobulin Heavy Chains - genetics | Viral antibodies | Autoimmunity | Usage | Vaccination | Antibodies | Physiological aspects | Genetic aspects | Research | Nucleotide sequencing | DNA sequencing | Immunoglobulins | Immune system | Index Medicus
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4. Full Text Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing
by Xueling Wu and Tongqing Zhou and Jiang Zhu and Baoshan Zhang and Ivelin Georgiev and Charlene Wang and Xuejun Chen and Nancy S. Longo and Mark Louder and Krisha McKee and Sijy O'Dell and Stephen Perfetto and Stephen D. Schmidt and Wei Shi and Lan Wu and Yongping Yang and Zhi-Yong Yang and Zhongjia Yang and Zhenhai Zhang and Mattia Bonsignori and John A. Crump and Saidi H. Kapiga and Noel E. Sam and Barton F. Haynes and Melissa Simek and Dennis R. Burton and Wayne C. Koff and Nicole A. Doria-Rose and Mark Connors and James C. Mullikin and Gary J. Nabel and Mario Roederer and Lawrence Shapiro and Peter D. Kwong and John R. Mascola and NISC Comparative Sequencing Progra and NISC Comparative Sequencing Program and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Science (American Association for the Advancement of Science), ISSN 0036-8075, 9/2011, Volume 333, Issue 6049, pp. 1593 - 1602
Germ cells | Neutralizing antibodies | B lymphocytes | RESEARCH ARTICLES | Genomics | Alleles | Antibodies | Phylogenetics | Epitopes | HIV 1 | High throughput nucleotide sequencing | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Fundamental immunology | Structure in molecular biology | Genetics of the immune response | Molecular biophysics | Biological and medical sciences | Immunobiology | Crystalline structure | Antibody Specificity | Complementarity Determining Regions - genetics | Humans | Immunoglobulin Heavy Chains - chemistry | Molecular Sequence Data | Crystallography, X-Ray | HIV Antibodies - isolation & purification | HIV Envelope Protein gp120 - metabolism | Genes, Immunoglobulin Heavy Chain | HIV Envelope Protein gp120 - immunology | Immunoglobulin Light Chains - chemistry | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV Antibodies - immunology | HIV-1 - chemistry | Immunoglobulin J-Chains - genetics | Base Sequence | HIV Envelope Protein gp120 - chemistry | Binding Sites | Immunoglobulin Heavy Chains - immunology | Immunoglobulin Light Chains - immunology | Amino Acid Sequence | Models, Molecular | Antibody Affinity | Antibodies, Neutralizing - genetics | HIV Antibodies - chemistry | Sequence Analysis, DNA | Antibodies, Neutralizing - isolation & purification | HIV-1 - immunology | Antibodies, Neutralizing - chemistry | Immunoglobulin Fab Fragments - chemistry | AIDS Vaccines | High-Throughput Nucleotide Sequencing | HIV Antibodies - genetics | Immunoglobulin Fab Fragments - immunology | Mutation | Binding Sites, Antibody | CD4 Antigens - metabolism | Evolution, Molecular | Viral antibodies | X-ray crystallography | Immunoglobulins | Physiological aspects | Genetic aspects | HIV (Viruses) | Health aspects | Methods | Index Medicus | ANTIBODIES | IMMUNITY | BASIC BIOLOGICAL SCIENCES | GENETICS | IMMUNOGLOBULINS | CRYSTAL STRUCTURE | CRYSTALLOGRAPHY | CHAINS | 60 APPLIED LIFE SCIENCES | FUNCTIONALS
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5. Full Text T lymphocytes redirected against the κ light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells
by Vera, Juan and Savoldo, Barbara and Vigouroux, Stephane and Biagi, Ettore and Pule, Martin and Rossig, Claudia and Wu, Jessie and Heslop, Helen E and Rooney, Cliona M and Brenner, Malcolm K and Dotti, Gianpietro
Blood, ISSN 0006-4971, 12/2006, Volume 108, Issue 12, pp. 3890 - 3897
Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Biological and medical sciences | Medical sciences | Recombinant Fusion Proteins - immunology | Cell Proliferation | Humans | Lymphoma, B-Cell - therapy | Neoplasm Proteins - immunology | Antigens, CD19 - genetics | Lymphoma, B-Cell - genetics | Immunoglobulin kappa-Chains - immunology | CD28 Antigens - genetics | Lymphoma, B-Cell - immunology | Antigens, CD19 - immunology | T-Lymphocytes, Cytotoxic - immunology | Antigens, CD20 - immunology | Antibody Formation - immunology | Immunoglobulin lambda-Chains - immunology | CD28 Antigens - immunology | Protein Structure, Tertiary - genetics | Mice, SCID | Antigens, CD20 - genetics | Animals | Adoptive Transfer - methods | K562 Cells | Recombinant Fusion Proteins - genetics | Mice | Gene Expression Regulation, Leukemic - immunology | Index Medicus | Abridged Index Medicus | Neoplasia
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6. Full Text AL amyloidosis with a localized B cell neoplasia
by Stuhlmann-Laeisz, Christiane and Schönland, Stefan O and Hegenbart, Ute and Oschlies, Ilske and Baumgart, Julius-Valentin and Krüger, Sandra and Röcken, Christoph
Virchows Archiv : an international journal of pathology, ISSN 0945-6317, 2019, Volume 474, Issue 3, pp. 353 - 363
Amyloid | Congo red | B cell lymphoma | Light chain | Life Sciences & Biomedicine | Pathology | Science & Technology | Immunohistochemistry | Prospective Studies | Humans | Middle Aged | Male | Lymphoma, B-Cell - genetics | Plasma Cells - pathology | Waldenstrom Macroglobulinemia - pathology | Immunoglobulin kappa-Chains - immunology | DNA Mutational Analysis | Immunoglobulin lambda-Chains - genetics | Lymphoma, B-Cell - immunology | Myeloid Differentiation Factor 88 - immunology | Aged, 80 and over | Adult | Female | Gene Rearrangement, B-Lymphocyte, Light Chain | B-Lymphocytes - pathology | Immunoglobulin Heavy Chains - immunology | Immunoglobulin Light-chain Amyloidosis - immunology | Immunoglobulin lambda-Chains - immunology | Immunoglobulin Light-chain Amyloidosis - genetics | Myeloid Differentiation Factor 88 - genetics | Waldenstrom Macroglobulinemia - immunology | Immunoglobulin kappa-Chains - genetics | Phenotype | B-Lymphocytes - immunology | Gene Rearrangement, B-Lymphocyte, Heavy Chain | Lymphoma, B-Cell - pathology | Immunoglobulin Light-chain Amyloidosis - pathology | Aged | Biomarkers, Tumor - genetics | Mutation | Immunoglobulin Heavy Chains - genetics | Waldenstrom Macroglobulinemia - genetics | Plasma Cells - immunology | Lymphomas | Amyloidosis | B cells | Histochemistry | Plasma | Immunoglobulins | Chains | Hybridization | Lymphoma | Patients | Histopathology | Lymphocytes B | Light | Gene rearrangement | Plasma cells | Index Medicus
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7. Full Text High-throughput sequencing of natively paired antibody chains provides evidence for original antigenic sin shaping the antibody response to influenza vaccination
by Tan, Yann-Chong and Blum, Lisa K and Kongpachith, Sarah and Ju, Chia-Hsin and Cai, Xiaoyong and Lindstrom, Tamsin M and Sokolove, Jeremy and Robinson, William H
Clinical immunology (Orlando, Fla.), ISSN 1521-6616, 2014, Volume 151, Issue 1, pp. 55 - 65
Allergy and Immunology | B cell | Antibody | Influenza | Life Sciences & Biomedicine | Immunology | Science & Technology | Immunoglobulin Heavy Chains - biosynthesis | Humans | Vaccination | Molecular Sequence Data | Molecular Typing | Antibodies, Neutralizing - immunology | Immunoglobulin G - biosynthesis | Immunoglobulin G - immunology | Immunoglobulin Heavy Chains - immunology | Antibodies, Viral - biosynthesis | Immunoglobulin Light Chains - immunology | Amino Acid Sequence | Vaccines, Subunit | Influenza A Virus, H1N2 Subtype - immunology | Influenza A Virus, H3N2 Subtype - immunology | Hemagglutinins, Viral - immunology | Immunoglobulin Light Chains - biosynthesis | Antigens, Viral - immunology | B-Lymphocytes - immunology | Influenza Vaccines - immunology | Antibodies, Neutralizing - biosynthesis | Antibodies, Viral - immunology | Immunologic Memory | High-Throughput Nucleotide Sequencing | Influenza, Human - prevention & control | Influenza, Human - immunology | Influenza vaccines | Index Medicus
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8. Full Text Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development
by Ochiai, Kyoko and Mandal, Malay and Georgopoulos, Katia and Singh, Harinder and Clark, Marcus R and Powers, Sarah E and Kee, Barbara L
Nature immunology, ISSN 1529-2908, 10/2009, Volume 10, Issue 10, pp. 1110 - 1117
Life Sciences & Biomedicine | Immunology | Science & Technology | Cell Cycle - genetics | ras Proteins - genetics | Cyclins - immunology | Oligonucleotide Array Sequence Analysis | STAT5 Transcription Factor - immunology | ras Proteins - metabolism | Immunoblotting | ras Proteins - immunology | Cyclin D3 | Extracellular Signal-Regulated MAP Kinases - immunology | Immunoglobulin Light Chains - genetics | STAT5 Transcription Factor - metabolism | Signal Transduction - immunology | Flow Cytometry | Basic Helix-Loop-Helix Transcription Factors - metabolism | Cyclins - metabolism | Recombination, Genetic | Cell Cycle - immunology | Electrophoretic Mobility Shift Assay | Receptors, Interleukin-7 - immunology | B-Lymphocytes - cytology | Receptors, Interleukin-7 - metabolism | Gene Expression Regulation - immunology | Gene Silencing - immunology | Reverse Transcriptase Polymerase Chain Reaction | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Cell Differentiation - immunology | Animals | B-Lymphocytes - immunology | Basic Helix-Loop-Helix Transcription Factors - immunology | Mice | Physiological aspects | Immunoglobulins | Research | B cells | Cell cycle | Index Medicus
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