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Journal Article
Molecular Cell, ISSN 1097-2765, 01/2019, Volume 73, Issue 1, pp. 48 - 60.e5
Journal Article
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 06/2015, Volume 43, Issue 6, pp. 803 - 811
PF-05231023, a long-acting fibroblast growth factor 21 (FGF21) analog, was generated by covalently conjugating two engineered [des-His1, Ala129Cys]FGF21... 
PBPK MODEL | NEONATAL FC-RECEPTOR | PLASMA | LYMPHATIC TRANSPORT | THERAPEUTIC PROTEINS | IN-VIVO | PHARMACOLOGY & PHARMACY | MONOCLONAL-ANTIBODIES | BINDING | FGF21 | PREDICTION | Mutant Proteins - pharmacokinetics | Immunoglobulin G - blood | Humans | Fibroblast Growth Factors - genetics | Half-Life | Macaca fascicularis | Male | Metabolic Clearance Rate | Drugs, Investigational - analysis | Fibroblast Growth Factors - chemistry | Fibroblast Growth Factors - metabolism | Hypolipidemic Agents - blood | Hypoglycemic Agents - administration & dosage | Proteolysis | Injections, Subcutaneous | Hypolipidemic Agents - chemistry | Hypoglycemic Agents - pharmacokinetics | Immunoglobulin G - chemistry | Rats | Recombinant Proteins - chemistry | Fibroblast Growth Factors - pharmacology | Immunoglobulin G - genetics | Models, Biological | Hypolipidemic Agents - pharmacokinetics | Immunoglobulin G - metabolism | Injections, Intravenous | Drugs, Investigational - pharmacokinetics | Recombinant Proteins - pharmacokinetics | Mutant Proteins - blood | Drugs, Investigational - chemistry | Hypoglycemic Agents - blood | Antibodies, Monoclonal, Humanized - administration & dosage | Fibroblast Growth Factors - administration & dosage | Antibodies, Monoclonal, Humanized - blood | Antibodies, Monoclonal, Humanized - pharmacology | Peptide Fragments - blood | Drug Evaluation, Preclinical | Immunoglobulin kappa-Chains - blood | Hypoglycemic Agents - chemistry | Immunoglobulin kappa-Chains - metabolism | Recombinant Proteins - administration & dosage | Mutant Proteins - administration & dosage | Recombinant Proteins - blood | Immunoglobulin kappa-Chains - genetics | Animals | Fibroblast Growth Factors - blood | Mutant Proteins - chemistry | Hypolipidemic Agents - administration & dosage | Drugs, Investigational - administration & dosage | Immunoglobulin kappa-Chains - chemistry | Amino Acid Substitution | Antibodies, Monoclonal, Humanized - chemistry
Journal Article
Journal of Immunological Methods, ISSN 0022-1759, 12/2017, Volume 451, pp. 11 - 19
The production of antibodies is accompanied by a slight excess of synthesis of κ and λ immunoglobulin light chains; small amounts of them are released in the... 
Rituximab | Free light chains | Multiple sclerosis | Autoimmune diseases | Immediate hypersensitivity | Viral infections | RHEUMATOID-ARTHRITIS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | BIOCHEMICAL RESEARCH METHODS | IMMUNOLOGY | CEREBROSPINAL-FLUID | BENCE-JONES PROTEINS | MULTIPLE-SCLEROSIS | N LATEX FLC | NON-HODGKIN-LYMPHOMA | IMMUNOGLOBULIN-SYNTHESIS | CHRONIC KIDNEY-DISEASE | LYMPHOPROLIFERATIVE DISORDERS | Predictive Value of Tests | Multiple Sclerosis - diagnosis | Prognosis | Humans | Structure-Activity Relationship | Drug Monitoring - methods | Immunoglobulin Light Chains - chemistry | Renal Insufficiency, Chronic - metabolism | Rituximab - therapeutic use | Immunoglobulin kappa-Chains - immunology | Hypersensitivity, Immediate - immunology | Renal Insufficiency, Chronic - diagnosis | Autoimmune Diseases - metabolism | Hypersensitivity, Immediate - diagnosis | Multiple Sclerosis - metabolism | Biomarkers - metabolism | Immunoglobulin Light Chains - immunology | Immunoglobulin lambda-Chains - chemistry | Immunoglobulin lambda-Chains - immunology | Renal Insufficiency, Chronic - immunology | Virus Diseases - immunology | Autoimmune Diseases - immunology | Virus Diseases - metabolism | Autoimmune Diseases - diagnosis | Immunoglobulin kappa-Chains - metabolism | Immunoglobulin Light Chains - metabolism | Immunoglobulin lambda-Chains - metabolism | Animals | Hypersensitivity, Immediate - metabolism | Virus Diseases - diagnosis | Multiple Sclerosis - immunology | Protein Conformation | Immunoglobulin kappa-Chains - chemistry | Immunologic Factors - therapeutic use | Lupus | Rheumatoid factor | Systemic lupus erythematosus | Chronic kidney failure | Multiple myeloma | Hepatitis C | HIV (Viruses) | Health aspects
Journal Article