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Journal of Neuroscience, ISSN 0270-6474, 07/2012, Volume 32, Issue 28, pp. 9677 - 9689
Passive immunization against beta-amyloid (A beta) has become an increasingly desirable strategy as a therapeutic treatment for Alzheimer's disease (AD).... 
APP TRANSGENIC MICE | NATURAL OLIGOMERS | HUMAN IGG1 | ALZHEIMERS-DISEASE | PROTEIN-KINASE | LONG-TERM POTENTIATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | PASSIVE-IMMUNIZATION | SECRETED OLIGOMERS | P38 MAP KINASE | Microglia - metabolism | Humans | Middle Aged | Male | Green Fluorescent Proteins - genetics | Neuroprotective Agents - metabolism | Alzheimer Disease - pathology | Neuroprotective Agents - pharmacology | Time Factors | Protein Binding - drug effects | Amyloid beta-Peptides - metabolism | Statistics, Nonparametric | Aged, 80 and over | Neurons - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Alzheimer Disease - immunology | Receptors, Chemokine - genetics | Plaque, Amyloid - immunology | Disease Models, Animal | Animals, Newborn | Rats | Mice, Transgenic | Mutation - genetics | Rats, Sprague-Dawley | Microscopy, Confocal | Plaque, Amyloid - metabolism | Mice | CX3C Chemokine Receptor 1 | Alzheimer Disease - blood | Immunoglobulin G - metabolism | Tumor Necrosis Factor-alpha - metabolism | Dose-Response Relationship, Immunologic | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Immunoglobulin G - pharmacology | Female | Neurons - drug effects | Peptide Fragments - metabolism | Double-Blind Method | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Plaque, Amyloid - pathology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Alzheimer Disease - therapy | Cells, Cultured | Presenilin-1 - genetics | Hippocampus - cytology | Gene Expression Regulation - drug effects | Amyloid beta-Protein Precursor - genetics | Animals | Amyloid beta-Peptides - immunology | Aged | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 06/2012, Volume 149, Issue 6, pp. 1207 - 1220
Journal Article
Neuron, ISSN 0896-6273, 03/2012, Volume 73, Issue 6, pp. 1116 - 1126
The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that establish these connections are... 
SYNAPTIC SPECIFICITY | ADULT BRAIN | SIGNALING PATHWAY | IN-VIVO | BOC | GROWTH | MECHANISMS | AXON-GUIDANCE | MEMBRANE-PROTEINS | NEUROSCIENCES | CEREBRAL-CORTEX | Silver Staining - methods | RNA, Small Interfering - genetics | Furans - metabolism | Electric Stimulation | gamma-Aminobutyric Acid - metabolism | Channelrhodopsins | Hedgehog Proteins - metabolism | Dendritic Spines - metabolism | Functional Laterality - genetics | Nerve Net - cytology | Synaptophysin - genetics | Neurons - ultrastructure | Neurons - metabolism | Repressor Proteins - metabolism | Gene Expression Regulation, Developmental - physiology | Synaptophysin - metabolism | Animals, Newborn | Fluorobenzenes - metabolism | Tumor Suppressor Proteins - metabolism | Matrix Attachment Region Binding Proteins - metabolism | Dendritic Spines - physiology | Mice, Transgenic | Synapses - ultrastructure | Electroporation - methods | Mutation - genetics | Corpus Callosum - cytology | Patch-Clamp Techniques | Immunoglobulin G - genetics | Cerebral Cortex - growth & development | Luminescent Proteins - genetics | Corpus Callosum - growth & development | Mice | Immunoglobulin G - metabolism | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Membrane Potentials - genetics | Age Factors | Gene Expression Regulation, Developmental - genetics | Phosphopyruvate Hydratase - metabolism | Cerebral Cortex - cytology | DNA-Binding Proteins - metabolism | Synapses - metabolism | Hedgehog Proteins - genetics | Pyramidal Tracts - physiology | Stilbamidines - metabolism | Receptors, Cell Surface - metabolism | Nuclear Proteins - metabolism | Transcription Factors - metabolism | Animals | Nerve Net - metabolism | In Vitro Techniques | Luminescent Proteins - metabolism | Stem cell research | Neurosciences | Nervous system diseases | Neurons | Stem cells | Collateralized debt obligations | Physiological aspects | Cells | Proteins | Transcription factors | Software | Sucrose | Synaptogenesis | Circuits | Hedgehog protein | Neural networks | Pyramidal cells | Cortex | Synapses | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 2005, Volume 47, Issue 2, pp. 215 - 229
Accumulation of Na channels at the nodes of Ranvier is a prerequisite for saltatory conduction. In peripheral nerves, clustering of these channels along the... 
MYELINATED AXONS | PROTEIN | INITIAL SEGMENTS | PERIPHERAL NERVOUS-SYSTEM | BETA-IV-SPECTRIN | ADHESION MOLECULES | ANKYRIN-BINDING | IDENTIFICATION | NEUROSCIENCES | SODIUM-CHANNEL DISTRIBUTION | K+ CHANNELS | Cytoskeletal Proteins | Age Factors | Humans | Myelin-Associated Glycoprotein - metabolism | Cercopithecus aethiops | Sciatic Nerve - growth & development | Cell Adhesion Molecules - immunology | Phosphoproteins - metabolism | Ranvier's Nodes - metabolism | Ranvier's Nodes - ultrastructure | Cell Compartmentation | Sciatic Nerve - metabolism | Transfection - methods | Gene Expression Regulation, Developmental | Cloning, Molecular - methods | Sodium Channels - metabolism | Macromolecular Substances - immunology | Cell Adhesion Molecules, Neuronal - metabolism | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | Spectrin - metabolism | Microscopy, Immunoelectron - methods | Protein Structure, Tertiary | Amino Acid Sequence | Blotting, Western - methods | Myelin Basic Protein - metabolism | Fluorescent Antibody Technique - methods | Cells, Cultured | Axons - metabolism | Rats | S100 Proteins - metabolism | Schwann Cells - metabolism | Cell Adhesion Molecules - metabolism | Claudins | Animals | Schwann Cells - ultrastructure | Ankyrins - metabolism | Blotting, Northern - methods | Neurofilament Proteins - metabolism | Macromolecular Substances - metabolism | Ganglia, Spinal - metabolism | Protein Binding - physiology | Receptors, Peptide - metabolism | Immunoglobulins | Proteins | Microscopy | Plasmids | Rodents | Ligands | Experiments | Binding sites | Index Medicus
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 02/2003, Volume 23, Issue 4, pp. 1428 - 1440
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 02/2016, Volume 75, Issue 2, pp. 422 - 429
ObjectiveTo investigate the effects of BET bromodomain protein inhibition on inflammatory activation and functional properties of rheumatoid arthritis synovial... 
TRIAL | KNEE | EPIGENETICS | ACTIVATION | SECUKINUMAB | CHROMATIN | TISSUE | DOUBLE-BLIND | ANTI-INTERLEUKIN-17A MONOCLONAL-ANTIBODY | RHEUMATOLOGY | BET PROTEIN | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Gene Expression - drug effects | Humans | Lipopolysaccharides - metabolism | Arthritis, Rheumatoid - enzymology | Matrix Metalloproteinase 3 - metabolism | Nuclear Proteins - metabolism | RNA, Messenger - metabolism | Synovial Membrane - metabolism | Heterocyclic Compounds, 4 or More Rings - pharmacology | Osteoarthritis - genetics | Osteoarthritis - enzymology | Transcription Factors - metabolism | Arthritis, Rheumatoid - genetics | Interleukin-1beta - metabolism | Interleukin-8 - metabolism | Toll-Like Receptors - metabolism | Matrix Metalloproteinase 1 - metabolism | Interleukin-6 - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - metabolism | Fibroblasts - metabolism | Epigenetic inheritance | Care and treatment | Interleukins | Tumor necrosis factor | Rheumatoid arthritis | Dosage and administration | Research | Enzymes | Immunoglobulins | Statistical analysis | Disease | Cytokines | Laboratories | Gene expression | Variance analysis | Bone surgery | Studies | Proteins | Pathology | Rodents | DNA methylation | Epigenetics | Fibroblasts | Tumor necrosis factor-TNF | Chemokines | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, pp. e35905 - e35905
Hematopoietic progenitor CD133(+)/c-kit(+) cells have been shown to be involved in myocardial healing following myocardial infarction (MI). Previously we... 
CD31(+) CELLS | ENDOTHELIAL PROGENITOR CELLS | ISCHEMIA/REPERFUSION INJURY | ACTIVATION | ISCHEMIC VASCULAR-DISEASE | ANGIOGENIC ACTIVITY | BONE-MARROW | BIOLOGY | RECEPTOR | TOPCARE-AMI | EXPRESSION | Up-Regulation | Capillaries - pathology | Receptors, Notch - metabolism | Cardiomegaly - pathology | Angiopoietin-1 - metabolism | Antigens, CD - metabolism | Peptides - metabolism | Serrate-Jagged Proteins | Bone Marrow - metabolism | Myocardium - metabolism | Endomyocardial Fibrosis - complications | Myocardial Infarction - physiopathology | Capillaries - metabolism | Apelin | Jagged-1 Protein | Capillaries - physiopathology | Signal Transduction | Cardiomegaly - physiopathology | Myocardial Infarction - metabolism | Receptors, CXCR4 - metabolism | Chemokine CXCL12 - metabolism | Hematopoietic Stem Cells - cytology | Endomyocardial Fibrosis - metabolism | Mice | Diabetes Mellitus, Type 2 - pathology | Cardiomegaly - metabolism | Cell Movement | Actins - metabolism | Glycoproteins - metabolism | Diabetes Mellitus, Type 2 - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Myocardial Infarction - pathology | Endomyocardial Fibrosis - pathology | Membrane Proteins - metabolism | Heart Function Tests | Diabetes Mellitus, Type 2 - complications | Calcium-Binding Proteins - metabolism | Myocardium - pathology | Adipokines | AC133 Antigen | Cardiomegaly - complications | Myocardial Infarction - complications | Animals | Diabetes Mellitus, Type 2 - physiopathology | Bone Marrow - pathology | Receptor, Notch3 | Endomyocardial Fibrosis - physiopathology | Apoptosis | Advertising executives | Vascular endothelial growth factor | Adenoviruses | Heart attack | Myocardial infarction | Heart | Diabetic retinopathy | Heart attacks | Angiopoietin | Recovery of function | Smooth muscle | Cardiovascular disease | Recruitment | Angiogenesis | Toxicology | Cell growth | Ischemia | Data recovery | Rodents | Bone marrow | Repair | Heart diseases | Immunoglobulins | Diabetes mellitus | Coronary artery | Muscles | Pharmacology | c-Kit protein | Hemopoiesis | Studies | Ostomy | Coronary vessels | Fibrosis | Stem cells | Myocardium | Infarction | Diabetes | Laboratory animals | Index Medicus
Journal Article
Science, ISSN 0036-8075, 05/2018, Volume 360, Issue 6388, pp. 558 - 563
Journal Article
Blood, ISSN 0006-4971, 02/2017, Volume 129, Issue 6, pp. 759 - 770
Kinases downstream of B-cell antigen receptor (BCR) represent attractive targets for therapy in non-Hodgkin lymphoma (NHL). As clinical responses vary,... 
SURFACE IGM | BCR | CHRONIC-LYMPHOCYTIC-LEUKEMIA | BRUTONS TYROSINE KINASE | HUMAN FOLLICULAR LYMPHOMA | GENE-EXPRESSION | KINASE INHIBITOR IBRUTINIB | MUTATIONS | TARGETING BTK | HEMATOLOGY | NF-KAPPA-B | Lymphoma, Follicular - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Lymphoma, Mantle-Cell - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Receptors, Antigen, B-Cell - metabolism | STAT1 Transcription Factor - metabolism | Lymphoma, Follicular - genetics | Mitogen-Activated Protein Kinase 1 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Single-Cell Analysis | Immunoglobulin M - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | STAT1 Transcription Factor - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Lymphoma, Large B-Cell, Diffuse - diagnosis | Mitogen-Activated Protein Kinase 3 - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Receptors, Antigen, B-Cell - genetics | CD79 Antigens - genetics | src-Family Kinases - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Phosphorylation | Gene Expression Regulation, Neoplastic | Lymphoma, Follicular - diagnosis | Lymphoma, Large B-Cell, Diffuse - metabolism | Phosphoproteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Lymphoma, Mantle-Cell - diagnosis | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Protein-Tyrosine Kinases - genetics | Flow Cytometry | Syk Kinase - genetics | Phospholipase C gamma - genetics | src-Family Kinases - metabolism | Lymphoma, Mantle-Cell - genetics | Lymphoma, Mantle-Cell - metabolism | Diagnosis, Differential | Phospholipase C gamma - metabolism | Lymphoma, Large B-Cell, Diffuse - pathology | Lymphoma, Follicular - pathology | p38 Mitogen-Activated Protein Kinases - genetics | Phosphoproteins - genetics | CD79 Antigens - metabolism | Syk Kinase - metabolism | Lymphoma, Large B-Cell, Diffuse - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis | Index Medicus | Abridged Index Medicus | Life Sciences | Human health and pathology | Hematology | Cancer | Lymphoid Neoplasia
Journal Article
Gastroenterology, ISSN 0016-5085, 2011, Volume 141, Issue 2, pp. 621 - 632
Background & Aims Epithelial cells that cover the intestinal mucosal surface maintain immune homeostasis and tolerance in the gastrointestinal tract. However,... 
Gastroenterology and Hepatology | IgA | Inflammatory Bowel Disease | T Cell | Immune Response | CELLS | COMPLEX | ACTIVATION | POLYMERIC IMMUNOGLOBULIN RECEPTOR | INTESTINAL EPITHELIUM | TRANSPORT | INFLAMMATORY-BOWEL-DISEASE | ADAPTER | HOST-DEFENSE | INFECTION | GASTROENTEROLOGY & HEPATOLOGY | Tumor Necrosis Factor-alpha - metabolism | Intestinal Mucosa - metabolism | Adaptor Protein Complex mu Subunits - metabolism | Epithelial Cells - metabolism | Adaptor Protein Complex beta Subunits - deficiency | Humans | Cell Membrane Permeability | Crohn Disease - metabolism | Cell Membrane - physiology | Ribonucleases - metabolism | Adaptor Protein Complex 1 - metabolism | Th17 Cells - metabolism | Intestinal Mucosa - immunology | alpha-Defensins - metabolism | Adaptor Protein Complex beta Subunits - immunology | Cell Membrane - metabolism | beta-Defensins - metabolism | Colon | Receptors, Cytokine - metabolism | Colitis - immunology | Adaptor Protein Complex 1 - deficiency | Lipocalins - metabolism | Adaptor Protein Complex 1 - immunology | Immunoglobulin A - metabolism | Signal Transduction | Acute-Phase Proteins - metabolism | Down-Regulation | Oncogene Proteins - metabolism | Homeostasis - immunology | Epithelial Cells - pathology | S100 Proteins - metabolism | Muramidase - metabolism | Intestinal Mucosa - microbiology | Mice, Knockout | Interleukin-17 - metabolism | Adaptor Protein Complex beta Subunits - metabolism | Animals | Colitis - microbiology | Proteins - metabolism | Ribonuclease, Pancreatic - metabolism | Lipocalin-2 | Cathelicidins - metabolism | Epithelial Cells - immunology | Receptors, Cytokine - immunology | Mice | Intestinal Mucosa - pathology | Medical colleges | Fc receptors | Gastrointestinal diseases | Homeostasis | Biological response modifiers | Immunoglobulin A | T cells | Index Medicus | Abridged Index Medicus
Journal Article