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1. Full Text Clinical Relevance of Thyroid-Stimulating Autoantibodies in Pediatric Graves' Disease—A Multicenter Study
by Diana, T and Brown, R. S and Bossowski, A and Segni, M and Niedziela, M and König, J and Bossowska, A and Ziora, K and Hale, A and Smith, J and Pitz, S and Kanitz, M and Kahaly, G. J
The journal of clinical endocrinology and metabolism, ISSN 0021-972X, 05/2014, Volume 99, Issue 5, pp. 1648 - 1655
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Graves Disease - blood | Humans | Autoimmune Diseases - immunology | Male | Immunoglobulins, Thyroid-Stimulating - immunology | Autoimmune Diseases - blood | Young Adult | Immunoglobulins, Thyroid-Stimulating - blood | Graves Disease - immunology | Thyroid Hormones - blood | Sensitivity and Specificity | Adolescent | Female | Retrospective Studies | Child | Index Medicus | Abridged Index Medicus
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2. Full Text Novel chimeric thyroid‐stimulating hormone‐receptor bioassay for thyroid‐stimulating immunoglobulins
by Lytton, S. D and Li, Y and Olivo, P. D and Kohn, L. D and Kahaly, G. J
Clinical and experimental immunology, ISSN 0009-9104, 12/2010, Volume 162, Issue 3, pp. 438 - 446
chimeric TSH receptor | thyroid‐stimulating immunoglobulins | biomarker | luciferase reporter | cell‐based assay | Life Sciences & Biomedicine | Immunology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Analytical, structural and metabolic biochemistry | Graves Disease - diagnosis | Graves Disease - blood | Cricetinae | Protein Binding - genetics | Receptors, Thyrotropin - genetics | Reproducibility of Results | Cricetulus | Receptors, Thyrotropin - metabolism | Humans | Transgenes - genetics | Recombinant Fusion Proteins - metabolism | Immunoglobulins, Thyroid-Stimulating - blood | Animals | Graves Disease - immunology | Sensitivity and Specificity | Protein Engineering | Recombinant Fusion Proteins - genetics | Biological Assay | Graves Disease - physiopathology | CHO Cells | Autoimmunity | Immunoglobulins | Autoantibodies | Analysis | Luciferase | Thyroid diseases | Hemoglobin | Lipids | Bilirubin | Adenylic acid | Index Medicus | thyroid diseases | Graves' disease | biomarkers | Cyclic AMP | Data processing | Hormones | Hashimoto's thyroiditis | Nodules | Thyroid-stimulating hormone | Reporter gene | thyroid-stimulating hormone receptors | Standard deviation | Autoimmune diseases | Translational Studies | thyroid-stimulating immunoglobulins | cell-based assay
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3. Full Text A Novel Thyroid Stimulating Immunoglobulin Bioassay Is a Functional Indicator of Activity and Severity of Graves’ Orbitopathy
by Lytton, S. D and Ponto, K. A and Kanitz, M and Matheis, N and Kohn, L. D and Kahaly, G. J
The journal of clinical endocrinology and metabolism, ISSN 0021-972X, 05/2010, Volume 95, Issue 5, pp. 2123 - 2131
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Fundamental and applied biological sciences. Psychology | Feeding. Feeding behavior | Non tumoral diseases. Target tissue resistance. Benign neoplasms | Vertebrates: anatomy and physiology, studies on body, several organs or systems | Vertebrates: endocrinology | Thyroid. Thyroid axis (diseases) | Biological and medical sciences | Endocrinopathies | Medical sciences | Graves Disease - blood | Graves Ophthalmopathy - surgery | Humans | Middle Aged | Graves Disease - drug therapy | Male | Reference Values | Young Adult | Immunoglobulins, Thyroid-Stimulating - blood | Iodine Radioisotopes - therapeutic use | Methimazole - therapeutic use | Aged, 80 and over | Adult | Female | Graves Ophthalmopathy - drug therapy | Severity of Illness Index | Graves Disease - surgery | Hyperthyroidism - blood | Receptors, Thyrotropin - metabolism | Antithyroid Agents - therapeutic use | Rats | Hyperthyroidism - drug therapy | Graves Ophthalmopathy - genetics | Graves Ophthalmopathy - radiotherapy | Thyroidectomy | Graves Disease - radiotherapy | Animals | Adolescent | Graves Ophthalmopathy - blood | Aged | Index Medicus | Abridged Index Medicus
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4. Full Text Thyroid Stimulating Antibodies Are Highly Prevalent in Hashimoto's Thyroiditis and Associated Orbitopathy
by Kahaly, George J and Diana, Tanja and Glang, Jennifer and Kanitz, Michael and Pitz, Susanne and König, Jochem
The journal of clinical endocrinology and metabolism, ISSN 0021-972X, 05/2016, Volume 101, Issue 5, pp. 1998 - 2004
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Cricetinae | Cricetulus | Humans | Middle Aged | Hashimoto Disease - blood | Male | Receptors, Thyrotropin - immunology | Graves Ophthalmopathy - immunology | Young Adult | Immunoglobulins, Thyroid-Stimulating - blood | Hashimoto Disease - immunology | Animals | Adolescent | Graves Ophthalmopathy - blood | Adult | Female | CHO Cells | Index Medicus | Abridged Index Medicus
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5. Full Text Measurement of thyroid stimulating immunoglobulins using a novel thyroid stimulating hormone receptor–guanine nucleotide‐binding protein, (GNAS) fusion bioassay
by Pierce, M and Sandrock, R and Gillespie, G and Meikle, A. W
Clinical and experimental immunology, ISSN 0009-9104, 11/2012, Volume 170, Issue 2, pp. 115 - 121
Graves' disease | bioassay | thyroid stimulating immunoglobulins | Thyroid stimulating immunoglobulins | Bioassay | Life Sciences & Biomedicine | Immunology | Science & Technology | Fundamental and applied biological sciences. Psychology | Non tumoral diseases. Target tissue resistance. Benign neoplasms | Analytical, structural and metabolic biochemistry | Thyroid. Thyroid axis (diseases) | Biological and medical sciences | Endocrinopathies | Medical sciences | Graves Disease - blood | Receptors, Thyrotropin - genetics | Receptors, G-Protein-Coupled - metabolism | Humans | Hyperthyroidism - metabolism | Polyethylene Glycols - chemistry | GTP-Binding Proteins - genetics | Immunoglobulins, Thyroid-Stimulating - chemistry | Graves Disease - genetics | Immunoglobulins, Thyroid-Stimulating - blood | Sensitivity and Specificity | Immunoglobulins, Thyroid-Stimulating - metabolism | Cyclic AMP - genetics | Receptors, Thyrotropin - chemistry | Cyclic AMP - metabolism | CHO Cells | Graves Disease - metabolism | Cricetinae | GTP-Binding Proteins - chemistry | Hyperthyroidism - blood | Receptors, Thyrotropin - metabolism | Cells, Cultured | Biological Assay - methods | Animals | Hyperthyroidism - genetics | Receptors, G-Protein-Coupled - genetics | Thyroid Gland - metabolism | Receptors, G-Protein-Coupled - chemistry | GTP-Binding Proteins - metabolism | Measurement | Purines | Immunoglobulins | Polyethylene glycol | Analysis | Thyroid diseases | Glycoproteins | Thyroid hormones | Polyols | Index Medicus | Original
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6. Full Text Clinical Relevance of Thyroid-Stimulating Immunoglobulins in Graves' Ophthalmopathy
by Ponto, Katharina A., MD and Kanitz, Michael and Olivo, Paul D., MD, PhD and Pitz, Susanne, MD, PhD and Pfeiffer, Norbert, MD, PhD and Kahaly, George J., MD, PhD
Ophthalmology (Rochester, Minn.), ISSN 0161-6420, 2011, Volume 118, Issue 11, pp. 2279 - 2285
Ophthalmology | Life Sciences & Biomedicine | Science & Technology | Miscellaneous | Non tumoral diseases. Target tissue resistance. Benign neoplasms | Thyroid. Thyroid axis (diseases) | Biological and medical sciences | Endocrinopathies | Medical sciences | Severity of Illness Index | Prevalence | Cross-Sectional Studies | Humans | Middle Aged | Male | Biomarkers - blood | Diplopia - physiopathology | Graves Ophthalmopathy - immunology | Young Adult | Immunoglobulins, Thyroid-Stimulating - blood | Sensitivity and Specificity | Adolescent | Aged, 80 and over | Adult | Biological Assay | Female | Aged | Diplopia - blood | Graves Ophthalmopathy - physiopathology | Autoimmunity | Immunoglobulins | Autoantibodies | Thyroid eye disease | Index Medicus
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7. Full Text Prevalence and clinical relevance of thyroid stimulating hormone receptor‐blocking antibodies in autoimmune thyroid disease
by Diana, T and Krause, J and Olivo, P. D and König, J and Kanitz, M and Decallonne, B and Kahaly, G. J
Clinical and experimental immunology, ISSN 0009-9104, 09/2017, Volume 189, Issue 3, pp. 304 - 309
bioassay | TSH‐receptor blocking antibodies | TSH‐receptor stimulating antibodies | Graves' disease | Hashimoto's thyroiditis | TSH-receptor blocking antibodies | TSH-receptor stimulating antibodies | Life Sciences & Biomedicine | Immunology | Science & Technology | Graves Disease - blood | Prevalence | Thyroiditis, Autoimmune - immunology | Cricetulus | Autoantibodies - blood | Humans | Middle Aged | Hashimoto Disease - blood | Male | Young Adult | Hashimoto Disease - immunology | Graves Disease - immunology | Adult | Biological Assay | Female | Thyroid Gland - immunology | CHO Cells | Cricetinae | Receptors, Thyrotropin - blood | Receptors, Thyrotropin - immunology | Autoantibodies - immunology | Animals | Thyroid Gland - pathology | Adolescent | Thyroiditis, Autoimmune - blood | Viral antibodies | Antibodies | Glycoproteins | Pituitary hormones | Thyroid hormones | Hypothyroidism | Thyroiditis | Immunoglobulins | Bioassays | Hyperthyroidism | Thyroid diseases | Patients | Thyroid-stimulating hormone receptors | Thyroid-stimulating hormone | Reporter gene | Inhibition | Thyroid | Index Medicus | Original
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8. Full Text Human monoclonal thyroid stimulating autoantibody
by Sanders, J and Evans, M and Premawardhana, LDKE and Depraetere, H and Jeffreys, J and Richards, T and Furmaniak, J and Smith, B Rees
The Lancet (British edition), ISSN 0140-6736, 07/2003, Volume 362, Issue 9378, pp. 126 - 128
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Autoantibodies - immunology | Immunoglobulin Fab Fragments - immunology | Receptors, Thyrotropin - immunology | Immunoglobulin G - immunology | Humans | Antibodies, Monoclonal - immunology | Monoclonal antibodies | Physiological aspects | Graves' disease | Hormone receptors | Thyrotropin | Autoantibodies | Research | Health aspects | Medical disorders | Lymphatic system | Hormones | Binding | Immunoglobulins | Blood & organ donations | Pathogenesis | Cloning | Hyperthyroidism | Cyclic AMP | Thyroid gland | Studies | Thyroid-stimulating hormone receptors | Thyroid-stimulating hormone | Lymphocytes | Deoxyribonucleic acid--DNA | Thyroid | Index Medicus | Abridged Index Medicus
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9. Full Text An immunoglobulin G complexed form of thyroid-stimulating hormone (macro thyroid-stimulating hormone) is a cause of elevated serum thyroid-stimulating hormone concentration
by Mills, Francesca and Jeffery, Jinny and Mackenzie, Paul and Cranfield, Alex and Ayling, Ruth M
Annals of clinical biochemistry, ISSN 0004-5632, 9/2013, Volume 50, Issue 5, pp. 416 - 420
Life Sciences & Biomedicine | Medical Laboratory Technology | Science & Technology | Thyrotropin - chemistry | Immunoglobulin G - blood | Thyroid Function Tests | Congenital Hypothyroidism - blood | Humans | Immunoglobulin G - chemistry | Polyethylene Glycols - chemistry | Antigen-Antibody Complex - blood | False Positive Reactions | Antigen-Antibody Complex - chemistry | Congenital Hypothyroidism - diagnosis | Protein Binding | Congenital Hypothyroidism - immunology | Chromatography, Gel | Thyrotropin - blood | Index Medicus
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10. Full Text Graves Disease in Children: Thyroid-Stimulating Hormone Receptor Antibodies as Remission Markers
by Gastaldi, Roberto, MD and Poggi, Elena, MD and Mussa, Alessandro, MD and Weber, Giovanna, MD and Vigone, Maria Cristina, MD and Salerno, Mariacarolina, MD and Delvecchio, Maurizio, MD and Peroni, Elena, MD and Pistorio, Angela, MD and Corrias, Andrea, MD
The Journal of pediatrics, ISSN 0022-3476, 2014, Volume 164, Issue 5, pp. 1189 - 1194.e1
Pediatrics | fT3 | Receiver operating curve | fT4 | ROC | TSH | Antithyroid drug | Free triiodothyronine | ATD | Body mass index | Thyroid-stimulating hormone | Thyroid-stimulating hormone receptor antibody | TRAb | Free thyroxine | BMI | Life Sciences & Biomedicine | Science & Technology | Graves Disease - blood | Recurrence | Drug Administration Schedule | Follow-Up Studies | Humans | Antithyroid Agents - therapeutic use | Graves Disease - drug therapy | Logistic Models | Male | Treatment Outcome | Biomarkers - blood | Remission Induction | Immunoglobulins, Thyroid-Stimulating - blood | Methimazole - therapeutic use | Graves Disease - immunology | Radioimmunoassay | Adolescent | Female | Retrospective Studies | Drug Monitoring | Child | Viral antibodies | Antibodies | Thyrotropin | Children | Graves' disease | Diseases | Index Medicus | Abridged Index Medicus
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11. Full Text Monoclonal Pathogenic Antibodies to the Thyroid-Stimulating Hormone Receptor in Graves' Disease with Potent Thyroid-Stimulating Activity but Differential Blocking Activity Activate Multiple Signaling Pathways
by Gilbert, Jacqueline A and Gianoukakis, Andrew G and Salehi, Siamak and Moorhead, Jane and Rao, Prakash V and Khan, M. Zareen and McGregor, Alan M and Smith, Terry J and Banga, J. Paul
The Journal of immunology (1950), ISSN 0022-1767, 04/2006, Volume 176, Issue 8, pp. 5084 - 5092
Life Sciences & Biomedicine | Immunology | Science & Technology | Binding, Competitive | Signal Transduction | Autoantibodies - blood | Humans | Receptors, Thyrotropin - blood | Antibody Affinity | Receptors, Thyrotropin - immunology | MAP Kinase Signaling System | Antibodies, Monoclonal - blood | Immunoglobulins, Thyroid-Stimulating | Animals | Graves Disease - immunology | Thyroid Gland - pathology | Hybridomas - immunology | Immunization, Passive | Female | Mice | Mice, Inbred BALB C | Thyroid Gland - immunology | Graves Disease - pathology | Disease Models, Animal | Index Medicus | Abridged Index Medicus
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