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Immunity, ISSN 1074-7613, 10/2017, Volume 47, Issue 4, pp. 776 - 788.e5
Antiretroviral therapy (ART) suppresses viral replication in HIV-infected individuals but does not eliminate the reservoir of latently infected cells. Recent... 
SIV | animal models | HIV | latent viral reservoir | regulatory T cells | co-inhibitory receptors | CTLA-4 | T follicular helper cells | PD-1 | regulatory T cells | TGF-BETA | REPLICATION | RESERVOIR | REGULATORY CELLS | IMMUNE ACTIVATION | GENE-EXPRESSION | IMMUNODEFICIENCY VIRUS-INFECTION | IMMUNOLOGY | CHRONIC HIV-INFECTION | FOLLICULAR HELPER-CELLS | Humans | Host-Pathogen Interactions - drug effects | Macaca mulatta | Immunologic Memory - drug effects | Host-Pathogen Interactions - immunology | T-Lymphocytes, Helper-Inducer - virology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | T-Lymphocytes, Helper-Inducer - drug effects | HIV Infections - immunology | Simian Acquired Immunodeficiency Syndrome - virology | HIV-1 - physiology | In Situ Hybridization | T-Lymphocytes, Helper-Inducer - immunology | Lymph Nodes - drug effects | CD4-Positive T-Lymphocytes - virology | Immunologic Memory - immunology | Simian Immunodeficiency Virus - immunology | Anti-Retroviral Agents - therapeutic use | HIV-1 - drug effects | HIV Infections - virology | CTLA-4 Antigen - metabolism | Programmed Cell Death 1 Receptor - metabolism | Lymph Nodes - virology | Lymph Nodes - immunology | CTLA-4 Antigen - immunology | Simian Immunodeficiency Virus - physiology | Microscopy, Confocal | HIV-1 - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Simian Acquired Immunodeficiency Syndrome - drug therapy | Simian Acquired Immunodeficiency Syndrome - immunology | HIV Infections - drug therapy | Programmed Cell Death 1 Receptor - immunology | Simian Immunodeficiency Virus - drug effects | CD4-Positive T-Lymphocytes - drug effects | T-Lymphocytes, Regulatory - virology | Therapy | PD-1 protein | Memory | Viruses | Infections | Lymphocytes T | Lymph nodes | CTLA-4 protein | Lymphocytes | Antiretroviral agents | Immunotherapy | Human immunodeficiency virus--HIV | Drug therapy | Deoxyribonucleic acid--DNA | Spleen | Antiretroviral drugs | Immunological memory | Memory cells | Immunoregulation | Latent infection | Monkeys & apes | Antiretroviral therapy | CD4 antigen | Lymphocytes B | Replication | Reservoirs | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 06/2017, Volume 214, Issue 6, pp. 1593 - 1606
Antigen-independent homeostasis of memory CD8 T cells is vital for sustaining long-lived T cell-mediated immunity. In this study, we report that maintenance of... 
BISULFITE SEQUENCING DATA | MEDICINE, RESEARCH & EXPERIMENTAL | LINEAGE RELATIONSHIP | DNA METHYLATION | TRANSCRIPTION FACTOR EOMESODERMIN | SUBSETS | PROLIFERATION | DIFFERENTIATION | IMMUNOLOGY | EXPRESSION | CUTTING EDGE | ANTIGEN | Humans | Adoptive Transfer | Genetic Loci | Hepatocyte Nuclear Factor 1-alpha - metabolism | Immunologic Memory - drug effects | Lymphocyte Subsets - immunology | Receptors, CCR7 - metabolism | Epigenesis, Genetic - drug effects | Homeostasis - drug effects | Cellular Reprogramming - genetics | Immunologic Memory - genetics | Lymphocyte Subsets - drug effects | Hematopoietic Stem Cell Transplantation | Homeostasis - immunology | DNA Methylation - genetics | Cellular Reprogramming - drug effects | Cell Differentiation - immunology | Phenotype | Cell Differentiation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Cell Proliferation - drug effects | Immunocompromised Host | Tissue Donors | CD8-Positive T-Lymphocytes - immunology | Genome, Human | DNA Methylation - drug effects | Cytokines - pharmacology | Homeostasis - genetics | Cell proliferation | CC chemokine receptors | Bisulfite | CD8 antigen | Homeostasis | Effector cells | Genomes | Lymphocytes T | Immunity | Gene sequencing | Interleukin 7 | Demethylation | Lymphocytes | DNA methylation | Deoxyribonucleic acid--DNA | Immunological memory | Memory cells | Cytokines | Preservation | Data acquisition | CCR7 protein | T cell receptors | Interleukin 15 | Loci | Computer memory | Stem cells | Methylation | DNA sequencing | Index Medicus | 312
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2017, Volume 198, Issue 8, pp. 3069 - 3080
Dimethyl fumarate (DMF; trade name Tecfidera) is an oral formulation of the fumaric acid ester that is Food and Drug Administration approved for treatment of... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | OXIDATIVE STRESS | PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY | PLACEBO-CONTROLLED PHASE-3 | SUBSETS | CENTRAL-NERVOUS-SYSTEM | IMMUNOLOGY | BLOOD-BRAIN-BARRIER | ORAL BG-12 | ACID ESTERS | TH17 CELLS | T-Lymphocyte Subsets - immunology | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Male | Th2 Cells - immunology | Immunologic Memory - drug effects | Th1 Cells - immunology | Th2 Cells - drug effects | Lymphocyte Activation - immunology | Th17 Cells - drug effects | Flow Cytometry | T-Lymphocyte Subsets - drug effects | Adult | Female | Immunologic Memory - immunology | Cell Survival - drug effects | Th1 Cells - drug effects | Multiple Sclerosis, Relapsing-Remitting - immunology | Cross-Sectional Studies | Multiple Sclerosis, Relapsing-Remitting - drug therapy | Immunophenotyping | Dimethyl Fumarate - therapeutic use | Lymphocyte Activation - drug effects | Th17 Cells - immunology | Cell Proliferation - drug effects | Longitudinal Studies | Dimethyl | CC chemokine receptors | Flow cytometry | Reactive oxygen species | Multiple sclerosis | CD8 antigen | Helper cells | Effector cells | Activation | Lymphocytes T | Leukoencephalopathy | Progressive multifocal leukoencephalopathy | Interleukin 4 | Cell activation | Lymphocytes | Longitudinal studies | Immunological memory | Memory cells | Cell survival | CCR7 protein | Inflammation | CXCR3 protein | FDA approval | Patients | Interleukin 17 | CCR6 protein | CD4 antigen | Cytometry | Side effects | Fumaric acid | Correlation analysis | γ-Interferon | Interferon | Apoptosis | Index Medicus | Abridged Index Medicus | RRMS | Effector memory T cells | T helper cells | Dimethyl Fumarate | PBMC
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2009, Volume 4, Issue 2, pp. e4384 - e4384
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2005, Volume 175, Issue 3, pp. 1551 - 1557
TLRs are involved in innate cell activation by conserved structures expressed by microorganisms. Human T cells express the mRNA encoding most of TLRs.... 
SIGNALING PATHWAYS | ACTIVATION | DENDRITIC CELLS | RECOGNITION | TOLL-LIKE RECEPTORS | INNATE IMMUNE-RESPONSE | BACTERIAL FLAGELLIN | KAPPA-B | IMMUNOLOGY | LYMPHOCYTES | RESIQUIMOD | T-Lymphocyte Subsets - immunology | Toll-Like Receptor 3 | Toll-Like Receptor 4 | Membrane Glycoproteins - metabolism | Humans | Membrane Glycoproteins - biosynthesis | Leukocyte Common Antigens - biosynthesis | Immunologic Memory - drug effects | Toll-Like Receptor 5 | Toll-Like Receptor 7 | CD4-Positive T-Lymphocytes - immunology | Flagellin - pharmacology | RNA, Messenger - biosynthesis | Toll-Like Receptors | Lymphocyte Activation - immunology | Membrane Glycoproteins - physiology | T-Lymphocyte Subsets - drug effects | Flagellin - metabolism | Receptors, Cell Surface - biosynthesis | Receptors, Cell Surface - physiology | Imidazoles - metabolism | Interleukin-8 - biosynthesis | Receptors, CCR7 | Receptors, Chemokine - metabolism | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Receptors, Cell Surface - metabolism | Imidazoles - pharmacology | Membrane Glycoproteins - genetics | Up-Regulation - drug effects | Up-Regulation - immunology | Lymphocyte Activation - drug effects | T-Lymphocyte Subsets - metabolism | Interleukin-10 - biosynthesis | Ligands | Cell Proliferation - drug effects | Interleukin-2 - biosynthesis | CD4-Positive T-Lymphocytes - drug effects | Interferon-gamma - biosynthesis | Receptors, Cell Surface - genetics | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 36, pp. 13139 - 13144
T-cell receptor (TCR) diversity, a prerequisite for immune system recognition of the universe of foreign antigens, is generated in the first two decades of... 
T lymphocytes | Memory | Analytical estimating | Cultured cells | Libraries | Older adults | Sequencing | Blood | Age | T cell antigen receptors | Aging | Immunosenescence | T-cell homeostasis | Adaptive immune responses | RHEUMATOID-ARTHRITIS | VIRUS | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | adaptive immune responses | NAIVE | OLD PRIMATES | MAINTENANCE | immunosenescence | RECEPTOR DIVERSITY | AUTOIMMUNITY | THYMIC FUNCTION | aging | AGE | CD8-Positive T-Lymphocytes - cytology | CD4-Positive T-Lymphocytes - cytology | Humans | Gene Rearrangement, beta-Chain T-Cell Antigen Receptor | Immunologic Memory - drug effects | CD4-Positive T-Lymphocytes - immunology | Aging - immunology | T-Lymphocytes - cytology | T-Lymphocytes - drug effects | Base Sequence | CD8-Positive T-Lymphocytes - drug effects | Cell Compartmentation - drug effects | Complementarity Determining Regions - immunology | Adult | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Aged | Cell Proliferation - drug effects | Clone Cells | CD8-Positive T-Lymphocytes - immunology | Cell Compartmentation - immunology | CD4-Positive T-Lymphocytes - drug effects | Cytokines - pharmacology | Cell research | Cloning | Genetic research | Genetic aspects | Research | T cells | Biological diversity | Homeostasis | Antigens | Genotype & phenotype | T cell receptors | Older people | Index Medicus | Biological Sciences
Journal Article