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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 02/2014, Volume 22, Issue 3, pp. 1008 - 1015
Journal Article
Nature Genetics, ISSN 1061-4036, 10/2014, Volume 46, Issue 10, pp. 1131 - 1134
Pancreatitis occurs in approximately 4% of patients treated with the thiopurines azathioprine or mercaptopurine. Its development is unpredictable and almost... 
AZATHIOPRINE | THERAPY | COMPLICATION | GENOTYPE | DISEASE | GENETICS & HEREDITY | Haplotypes | Humans | HLA-DQ alpha-Chains - chemistry | HLA-DQ alpha-Chains - genetics | Mercaptopurine - chemistry | Pancreatitis - genetics | Mercaptopurine - metabolism | Immunosuppressive Agents - metabolism | Molecular Structure | HLA-DRB1 Chains - metabolism | Inflammatory Bowel Diseases - drug therapy | Protein Structure, Tertiary | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Azathioprine - metabolism | HLA-DRB1 Chains - genetics | Gene Frequency | Risk Factors | Mercaptopurine - adverse effects | Models, Molecular | Genotype | Pancreatitis - chemically induced | Azathioprine - chemistry | Protein Binding | Immunosuppressive Agents - adverse effects | Polymorphism, Single Nucleotide | HLA-DRB1 Chains - chemistry | Azathioprine - adverse effects | HLA-DQ alpha-Chains - metabolism | Immunosuppressive Agents - chemistry | Complications and side effects | Pancreatitis | Genetic aspects | Histocompatibility | Health aspects | Risk factors | Immunosuppressive agents | Studies | Inflammatory bowel disease | Medical research | Genomes | Drug therapy | Methods | Crohns disease | Index Medicus | Genetik | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Genetics
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2013, Volume 191, Issue 12, pp. 5785 - 5791
Calcineurin inhibitors (CNIs) revolutionized the field of organ transplantation and remain the standard of care 40 years after the discovery of cyclosporine.... 
COSTIMULATION BLOCKADE | ANTILYMPHOCYTIC AGENT | RHEUMATOID-ARTHRITIS | CYCLOSPORINE-A | GLOMERULAR-DISEASES | REGULATORY T-CELLS | RANDOMIZED-TRIAL | MEMBRANOUS NEPHROPATHY | GRAFT-SURVIVAL | IMMUNOLOGY | RENAL-TRANSPLANT RECIPIENTS | Meta-Analysis as Topic | History, 21st Century | Cyclosporine - pharmacology | Humans | Immunosuppressive Agents - therapeutic use | Tacrolimus - history | Calcineurin Inhibitors | Multicenter Studies as Topic | Immunosuppressive Agents - history | T-Lymphocytes - drug effects | Kidney Diseases - chemically induced | Tacrolimus - pharmacology | Drug Evaluation, Preclinical | Drug Therapy, Combination | Immunosuppressive Agents - pharmacology | Autoimmune Diseases - drug therapy | Cyclosporine - history | Kidney Transplantation - history | Graft Rejection - prevention & control | History, 20th Century | Tacrolimus - chemistry | Kidney Diseases - drug therapy | Clinical Trials as Topic | Tacrolimus - adverse effects | Forecasting | Randomized Controlled Trials as Topic | Calcineurin - physiology | Kidney Diseases - immunology | Cyclosporine - therapeutic use | Tacrolimus - therapeutic use | Animals | Cyclosporine - chemistry | Lymphocyte Activation - drug effects | Cyclosporine - adverse effects | Immunosuppressive Agents - adverse effects | T-Lymphocytes - immunology | Diabetes Mellitus, Type 2 - chemically induced | Immunosuppressive Agents - chemistry | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2013, Volume 110, Issue 24, pp. 9704 - 9709
Multidrug resistance is a serious barrier to successful treatment of many human diseases, including cancer, wherein chemotherapeutics are exported from target... 
ATP binding cassette transporters | Molecules | Vapor phases | Micelles | Lipids | Mass spectroscopy | Ligands | Nucleotides | Detergents | Membrane proteins | Real time substrate monitoring | Mass spectrometry from native state | ABC TRANSPORTER | ATPASE ACTIVITY | MEMBRANE | MULTIDISCIPLINARY SCIENCES | COMPLEXES | mass spectrometry from native state | CONFORMATIONS | RECONSTITUTED P-GLYCOPROTEIN | GAS-PHASE | real time substrate monitoring | MACROMOLECULAR ASSEMBLIES | PROTEINS | MOLECULAR-BASIS | Detergents - chemistry | Drug Resistance, Multiple | Humans | Molecular Conformation | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Pharmaceutical Preparations - classification | Nucleotides - chemistry | Lipids - chemistry | Biological Transport | Immunosuppressive Agents - metabolism | Lipids - classification | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Cyclosporine - metabolism | Binding, Competitive | Detergents - metabolism | Models, Molecular | Cardiolipins - metabolism | Nucleotides - metabolism | Cardiolipins - chemistry | Pharmaceutical Preparations - metabolism | Cyclosporine - chemistry | Pharmaceutical Preparations - chemistry | Protein Binding | Protein Conformation | Kinetics | Mass Spectrometry - methods | Immunosuppressive Agents - chemistry | Cluster Analysis | Physiological aspects | Research | Drug resistance | Mass spectrometry | Methods | Binding sites (Biochemistry) | ABC transporters | Glycoproteins | Index Medicus | Biological Sciences | Physical Sciences
Journal Article
Environmental Pollution, ISSN 0269-7491, 01/2016, Volume 208, Issue Pt B, pp. 467 - 476
Journal Article
Nanoscale, ISSN 2040-3364, 02/2014, Volume 6, Issue 4, pp. 2321 - 2327
Journal Article
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 04/2011, Volume 133, Issue 15, pp. 5931 - 5940
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 06/2016, Volume 22, Issue 24, pp. 8158 - 8166
A new dimeric macrolide xylopyranoside, cocosolide ( 1 ), was isolated from the marine cyanobacterium preliminarily identified as Symploca sp. from Guam. The... 
macrolides | marine natural products | structure elucidation | total synthesis | glycosides | LYNGBYA-MAJUSCULA | ACID | CONVERSION | (-)-POLYCAVERNOSIDE | NATURAL-PRODUCT (-)-CLAVOSOLIDE-A | SPONGE MYRIASTRA-CLAVOSA | CHEMISTRY, MULTIDISCIPLINARY | ABSOLUTE-CONFIGURATION | CYANOLIDE | METABOLITE | Stereoisomerism | Cyanobacteria - chemistry | Humans | Molecular Conformation | Cyanobacteria - metabolism | Crystallography, X-Ray | Immunosuppressive Agents - chemical synthesis | Mycobacterium tuberculosis - drug effects | Macrolides - chemistry | Anti-Bacterial Agents - chemistry | Glycosides - chemical synthesis | Bacillus cereus - drug effects | Macrolides - pharmacology | Drug Evaluation, Preclinical | Dimerization | Glycosides - chemistry | Immunosuppressive Agents - pharmacology | Interleukin-2 - metabolism | Cell Survival - drug effects | Lipopolysaccharides - toxicity | Magnetic Resonance Spectroscopy | Jurkat Cells | HCT116 Cells | Glycosylation | Macrophages - cytology | Pseudomonas aeruginosa - drug effects | Anti-Bacterial Agents - chemical synthesis | Macrophages - metabolism | Animals | Macrolides - chemical synthesis | Macrophages - drug effects | RAW 264.7 Cells | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Mice | Nitric Oxide - metabolism | Immunosuppressive Agents - chemistry | Hydrolysis | Synthesis | Analysis | Cyclopropane compounds | Nuclear magnetic resonance spectroscopy | T cells | Organic compounds | T cell receptors | Index Medicus | Organic chemistry | Synthesis (chemistry) | Marine | Cyanobacteria | Carbon | Sugars | structure determination
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2019, Volume 161, pp. 239 - 251
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2014, Volume 22, Issue 21, pp. 5776 - 5782
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 09/2017, Volume 13, Issue 9, pp. 943 - 943
Journal Article