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Clinical Chemistry, ISSN 0009-9147, 11/2011, Volume 57, Issue 11, pp. 1574 - 1583
Journal Article
Journal Article
Journal Article
Pharmacogenetics and Genomics, ISSN 1744-6872, 05/2013, Volume 23, Issue 5, pp. 251 - 261
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 6/2014, Volume 70, Issue 6, pp. 685 - 693
Tacrolimus (Tac) and cyclosporine (CsA) are mainly metabolized by CYP3A4 and CYP3A5. Several studies have demonstrated an association between the CYP3A5... 
CYP3A | POR | Biomedicine | Calcineurin inhibitors | Kidney recipients | Pharmacology/Toxicology | Pharmacokinetics | PPARA | CYP3A4-ASTERISK-22 | GENOTYPE | POLYMORPHISM | CLINICAL PHARMACOKINETICS | DOSE REQUIREMENTS | CYTOCHROME-P450 OXIDOREDUCTASE | IN-VITRO | P450 OXIDOREDUCTASE | IMPACT | PHARMACOLOGY & PHARMACY | MIDAZOLAM | NADPH-Ferrihemoprotein Reductase - genetics | Humans | Immunosuppressive Agents - pharmacokinetics | Immunosuppressive Agents - therapeutic use | Middle Aged | Male | Cyclosporine - blood | Dose-Response Relationship, Drug | Young Adult | Immunosuppressive Agents - blood | Cytochrome P-450 CYP3A - genetics | Cyclosporine - pharmacokinetics | Adult | Female | Retrospective Studies | Real-Time Polymerase Chain Reaction | Immunosuppressive Agents - administration & dosage | Tacrolimus - administration & dosage | Tacrolimus - blood | Gene Frequency | Genotype | PPAR alpha - genetics | Kidney Transplantation | Tacrolimus - pharmacokinetics | Cyclosporine - therapeutic use | Tacrolimus - therapeutic use | Analysis of Variance | Polymorphism, Restriction Fragment Length | Cyclosporine - administration & dosage | Aged | Kidneys | Tacrolimus | Cytochrome P-450 | Genetic research | Physiological aspects | Drugstores | Organ transplant recipients | Transplantation | Cyclosporine | Genetics | Pharmacology | Transplants & implants | Index Medicus | Pharmacogenetics
Journal Article
Gastroenterology, ISSN 0016-5085, 2015, Volume 148, Issue 1, pp. 108 - 117
Background & Aims Interferon alfa–based regimens used to treat recurrent hepatitis C virus (HCV) infection after liver transplantation are poorly tolerated,... 
Gastroenterology and Hepatology | Antiviral Agent | Clinical Trial | DAA | NS5B Polymerase Inhibitor | PLUS RIBAVIRIN | ANTIVIRAL THERAPY | EFFICACY | HCV GENOTYPE 1 | MULTICENTER EXPERIENCE | COMBINATION | RECIPIENTS | PEGYLATED INTERFERON | GRAFT-SURVIVAL | GASTROENTEROLOGY & HEPATOLOGY | DRUG-DRUG INTERACTIONS | Recurrence | Prospective Studies | Antiviral Agents - pharmacokinetics | Hepatitis C - drug therapy | Liver Transplantation - adverse effects | United States | Humans | Drug Resistance, Viral | Hepacivirus - genetics | Hepacivirus - pathogenicity | Male | RNA, Viral - blood | Viral Load | Time Factors | Ribavirin - pharmacokinetics | Female | Hepatitis C - complications | Uridine Monophosphate - adverse effects | Drug Therapy, Combination | Uridine Monophosphate - therapeutic use | Hepacivirus - drug effects | Liver Neoplasms - virology | Liver Cirrhosis - diagnosis | Antiviral Agents - therapeutic use | Carcinoma, Hepatocellular - diagnosis | Ribavirin - therapeutic use | Carcinoma, Hepatocellular - surgery | Genotype | Liver Neoplasms - surgery | Treatment Outcome | Carcinoma, Hepatocellular - virology | Biomarkers - blood | Spain | New Zealand | Hepatitis C - diagnosis | Pilot Projects | Liver Cirrhosis - virology | Liver Neoplasms - diagnosis | Ribavirin - adverse effects | Antiviral Agents - adverse effects | Uridine Monophosphate - analogs & derivatives | Liver Cirrhosis - surgery | Uridine Monophosphate - pharmacokinetics | Sofosbuvir | Virus diseases | Relapse | Liver | Transplantation | Biological response modifiers | Drug therapy | Hepatitis C virus | Health aspects | Immunosuppressive agents | Ribavirin | Diseases | Index Medicus | Abridged Index Medicus
Journal Article
Therapeutic Drug Monitoring, ISSN 0163-4356, 12/2012, Volume 34, Issue 6, pp. 660 - 670
Journal Article
American Journal of Transplantation, ISSN 1600-6135, 12/2007, Volume 7, Issue 12, pp. 2816 - 2820
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 05/2018, Volume 58, Issue 5, pp. 666 - 673
Elbasvir (EBR)/grazoprevir (GZR) may be coadministered with immunosuppressant drugs in posttransplant people who are infected with hepatitis C virus. The aim... 
cyclosporine | drug‐drug interactions | tacrolimus | pharmacokinetics | grazoprevir | mycophenolate mofetil | prednisone | elbasvir | drug-drug interactions | EFFICACY | GRAZOPREVIR MK-5172 | SAFETY | COMBINATION THERAPY | LABEL PHASE-2 TRIAL | RIBAVIRIN | HEPATITIS-C VIRUS | GENOTYPE 1 INFECTION | PHARMACOLOGY & PHARMACY | ELBASVIR MK-8742 | TREATMENT-NAIVE PATIENTS | Quinoxalines - adverse effects | Antiviral Agents - pharmacokinetics | Area Under Curve | Humans | Immunosuppressive Agents - pharmacokinetics | Middle Aged | Imidazoles - administration & dosage | Benzofurans - administration & dosage | Male | Imidazoles - pharmacokinetics | Benzofurans - pharmacokinetics | Young Adult | Drug Interactions | Cyclosporine - pharmacokinetics | Adult | Female | Mycophenolic Acid - administration & dosage | Immunosuppressive Agents - administration & dosage | Tacrolimus - administration & dosage | Prednisone - administration & dosage | Quinoxalines - pharmacokinetics | Prednisone - adverse effects | Quinoxalines - administration & dosage | Administration, Oral | Imidazoles - adverse effects | Mycophenolic Acid - pharmacokinetics | Tacrolimus - pharmacokinetics | Tacrolimus - adverse effects | Antiviral Agents - administration & dosage | Benzofurans - adverse effects | Mycophenolic Acid - adverse effects | Antiviral Agents - adverse effects | Cyclosporine - adverse effects | Cyclosporine - administration & dosage | Prednisone - pharmacokinetics | Immunosuppressive Agents - adverse effects | Drug Combinations | Drugs | Mycophenolic acid | Cyclosporins | Transaminase | Viruses | Prednisone | Pharmacology | Hepatitis | Tacrolimus | Mycophenolate mofetil | Hepatitis C virus | Pharmacokinetics | Hepatitis C | Drug dosages | Prednisolone | Index Medicus
Journal Article
Drug metabolism and disposition: the biological fate of chemicals, ISSN 0090-9556, 03/2019, Volume 47, Issue 3, pp. 257 - 268
Cyclophosphamide (CP), a prodrug that is enzymatically converted to the cytotoxic 4-hydroxycyclophosphamide (4OHCP) by hepatic enzymes, is commonly used in... 
CLEARANCE | IN-VITRO | ACTIVATION | PROTEIN | CYP2B6 | SCALING FACTORS | 4-HYDROXYCYCLOPHOSPHAMIDE | PHARMACOLOGY & PHARMACY | HUMAN-LIVER-MICROSOMES | CHEMOTHERAPY | DRUG-METABOLISM | Cytochrome P-450 Enzyme Inhibitors | Humans | Immunosuppressive Agents - pharmacokinetics | Immunosuppressive Agents - therapeutic use | Cytochrome P-450 Enzyme System - metabolism | Cat Diseases - drug therapy | Male | Cyclophosphamide - therapeutic use | Prodrugs - metabolism | Dog Diseases - drug therapy | Dog Diseases - immunology | Oxidation-Reduction - drug effects | Immunosuppressive Agents - metabolism | Female | Cats | Cyclophosphamide - metabolism | Antineoplastic Agents, Alkylating - pharmacokinetics | Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Animals | Prodrugs - pharmacokinetics | Models, Biological | Dogs | Cell Line, Tumor | Cat Diseases - immunology | Cyclophosphamide - pharmacokinetics | Mice | Prodrugs - therapeutic use | Cytochrome P-450 Enzyme System - pharmacology | Microsomes, Liver | Antineoplastic Agents, Alkylating - metabolism | Cytochrome | Parameter estimation | Toxicity | Liver | Immune clearance | Cytotoxicity | Veterinary medicine | Reaction kinetics | Biocompatibility | Inhibition | Species | Immune system | Computer simulation | Breast cancer | Pharmacology | Metabolism | Microsomes | Biological activity | Cyclophosphamide | Cytochromes | Kinetics | Pharmacokinetics | Cancer
Journal Article