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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 29, pp. 11782 - 11787
Recombinant immunotoxins (RITs) are hybrid proteins used to treat cancer. These proteins are composed of an Fv that reacts with cancer cells joined to a... 
Bacteriophages | Immunotoxins | Reactivity | Immune response | Antibodies | B lymphocyte epitopes | Amino acids | Toxins | Epitopes | Tumors | Protein engineering | Mesothelioma | Cancer treatment | Immunotherapy | Leukemia | H-CHAIN | cancer treatment | leukemia | ANIMAL TOXICITY | MOXETUMOMAB PASUDOTOX | MULTIDISCIPLINARY SCIENCES | RFB4(DSFV)-PE38 | INFUSION | protein engineering | PHASE-I TRIAL | immunotherapy | ANTIBODY-BINDING REGIONS | ANTITOXIN ANTIBODIES | MICE | mesothelioma | HEMATOLOGIC MALIGNANCIES | Immunotherapy - methods | Protein Engineering - methods | Humans | Molecular Sequence Data | Recombinant Proteins - pharmacokinetics | Epitopes, B-Lymphocyte - immunology | Peptide Library | Statistics, Nonparametric | Immunotoxins - chemistry | Amino Acid Sequence | Immunotoxins - immunology | Enzyme-Linked Immunosorbent Assay | Antineoplastic Agents - immunology | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Neoplasms - drug therapy | Immunotoxins - genetics | Animals | Mutagenesis | Recombinant Proteins - immunology | Neoplasms - immunology | Immunotoxins - pharmacokinetics | Mice | Single-Chain Antibodies - immunology | Care and treatment | B cells | Research | Antibody-toxin conjugates | Antigenic determinants | Cancer | Proteins | Antigens | Bacteria | Mutation | Cells | Index Medicus | Biological Sciences
Journal Article
2002, 1, Cellular and molecular mechanisms of toxin action, ISBN 6610102252, Volume 4, 288
Bacteria and plants produce powerful toxins that can cause a variety of diseases, some of which are lethal for many animal species. The mechanisms of action... 
Immunotoxins | Antitoxins | Toxins | Chimeric Proteins | Therapeutic use | pharmacology | Toxicology | Pharmacology | Cell Biology
eBook
Journal of Biological Chemistry, ISSN 0021-9258, 02/2011, Volume 286, Issue 6, pp. 4165 - 4172
Gelonin-based immunotoxins vary widely in their cytotoxic potency as a function of antigen density, target cell internalization and trafficking kinetics, and... 
COLORECTAL-CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNTHESIS INHIBITION | CARCINOEMBRYONIC ANTIGEN | MONOCLONAL-ANTIBODIES | RIBOSOME-INACTIVATING PROTEINS | PSEUDOMONAS EXOTOXIN | QUANTITATIVE-ANALYSIS | CYTOTOXIC ACTIVITY | DIPHTHERIA-TOXIN | SINGLE-CHAIN IMMUNOTOXIN | Protein Structure, Tertiary | Recombinant Fusion Proteins - immunology | Ribosome Inactivating Proteins, Type 1 - genetics | Receptor, Epidermal Growth Factor - immunology | Fibronectins - pharmacology | Immunotoxins - immunology | Drug Screening Assays, Antitumor - methods | Fibronectins - immunology | Recombinant Fusion Proteins - pharmacology | Single-Chain Antibodies - pharmacology | Carcinoembryonic Antigen - immunology | Humans | Ribosome Inactivating Proteins, Type 1 - immunology | Immunotoxins - pharmacology | Ribosome Inactivating Proteins, Type 1 - pharmacology | Immunotoxins - genetics | Single-Chain Antibodies - genetics | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Fibronectins - genetics | Single-Chain Antibodies - immunology | Index Medicus | Flow cytometry | Antibodies | Fluorescence | Cytotoxicity | Data processing | Pinocytosis | Fibronectin | Carcinoembryonic antigen | Immunotoxins | Endocytosis | Epidermal growth factor | scaffolds | Antigen (tumor-associated) | Toxins | Kinetics | Tumors | Protein Translocation | Immunotoxin | Drug Transport | Fusion Protein | Tumor Therapy | Membrane Biology | Intracellular Trafficking | Gelonin | Anticancer Drug
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 04/2010, Volume 28, Issue 12, pp. 2085 - 2093
Journal Article
Journal Article
Applied Microbiology and Biotechnology, ISSN 0175-7598, 4/2017, Volume 101, Issue 7, pp. 2747 - 2766
D2C7-(scdsFv)-PE38KDEL (D2C7-IT) is a novel recombinant Pseudomonas exotoxin A-based immunotoxin (IT), targeting both wild-type epidermal growth factor... 
Life Sciences | Malignant glioma | Biotechnology | Recombinant immunotoxin | Microbiology | Microbial Genetics and Genomics | Mutant EGFR variant III | Good laboratory practice | Epidermal growth factor receptor | GROWTH-FACTOR-RECEPTOR | PROGNOSTIC VALUE | CANCER | HUMAN-BRAIN-TUMORS | HAIRY-CELL LEUKEMIA | AMPLIFICATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PSEUDOMONAS EXOTOXIN | EXPRESSION | STABILIZED FV-IMMUNOTOXINS | EGF RECEPTOR | Receptor, Epidermal Growth Factor - genetics | Virulence Factors - genetics | Drug Stability | Electrophoresis, Polyacrylamide Gel | Humans | Fermentation | ADP Ribose Transferases - genetics | Immunotoxins - genetics | Receptor, Epidermal Growth Factor - metabolism | Immunotoxins - therapeutic use | Escherichia coli - genetics | Exotoxins - genetics | Immunotoxins - metabolism | Cell Line, Tumor | Adult | Bacterial Toxins - genetics | Immunotoxins - chemistry | Glioblastoma - drug therapy | Clinical Trials, Phase I as Topic | Clinical Trials, Phase II as Topic | Quality Control | Clinical trials | Product development | Medical centers | Brain tumors | Quality control | Studies | Epidermal growth factor | Brain cancer | Analysis | Protein expression | Toxins | Genetic recombination | Index Medicus | recombinant immunotoxin | good laboratory practice | malignant glioma | epidermal growth factor receptor | mutant EGFR variant III
Journal Article
1994, 2nd ed., Target organ toxicology series, ISBN 0781702194, xxi, 761
Book
Immunopharmacology and immunotoxicology, ISSN 0892-3973, 1987
Journal
International Journal of Cancer, ISSN 0020-7136, 09/2014, Volume 135, Issue 6, pp. 1497 - 1508
Journal Article
The Journal of Immunology, ISSN 0022-1767, 10/2007, Volume 179, Issue 7, pp. 4919 - 4928
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2011, Volume 29, Issue 4, pp. 398 - 405
Journal Article
2001, Methods in Molecular Biology, ISBN 0896037754, Volume 166., xi, 302
More potent and selective for killing cancer cells than chemotherapy, immunotoxins constitute a new class of human therapeutics that have widespread... 
Antibody-toxin conjugates | Antibody-drug conjugates | Immunology | Biomedicine
Book
Cancer, ISSN 0008-543X, 12/2012, Volume 118, Issue 23, pp. 5733 - 5740
Journal Article
Applied Microbiology and Biotechnology, ISSN 0175-7598, 11/2018, Volume 102, Issue 22, pp. 9585 - 9594
The specific targeting of immunotoxins enables their wide application in cancer therapy. The A-chain of the ricin protein (RTA) is an N-glycosidase that... 
Life Sciences | Biotechnology | Ricin A | Localization peptide | Microbiology | Recombinant immunotoxin | Microbial Genetics and Genomics | Cancer cell | HER2 | Specific targeting | ABRIN | ESCHERICHIA-COLI | TOXIC LECTINS | INCREASES | RICIN-A-CHAIN | GLUCOSE-REGULATED PROTEIN | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PHASE-I | EXPRESSION | CYTOTOXICITY | Lung Neoplasms - drug therapy | Receptor, ErbB-2 - genetics | Recombinant Fusion Proteins - pharmacology | Humans | Lung Neoplasms - metabolism | Receptor, ErbB-2 - metabolism | Endoplasmic Reticulum - metabolism | Immunotoxins - pharmacology | Recombinant Fusion Proteins - metabolism | Ovarian Neoplasms - genetics | Single-Chain Antibodies - metabolism | Single-Chain Antibodies - genetics | HEK293 Cells | Immunotoxins - metabolism | Female | Ovarian Neoplasms - metabolism | Receptor, ErbB-2 - antagonists & inhibitors | Ovarian Neoplasms - drug therapy | Lung Neoplasms - genetics | Endoplasmic Reticulum - genetics | Single-Chain Antibodies - pharmacology | Oligopeptides - genetics | Oligopeptides - metabolism | Amino Acid Motifs | Protein Transport | Ricin - pharmacology | Immunotoxins - genetics | Protein Sorting Signals - genetics | Ricin - metabolism | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Ricin - genetics | Single-Chain Antibodies - chemistry | Prevention | Antibody-toxin conjugates | Endoplasmic reticulum | Health aspects | Production processes | Cancer cells | rRNA 28S | Ovarian carcinoma | Toxicity | Ricin | Lung cancer | Adenine | Chains | ErbB-2 protein | Ovarian cancer | Anticancer properties | Proteins | Fv | Immunotoxins | Cell death | N-glycosidase | Immunofluorescence | Cytoplasm | Cancer | Recombinant | Index Medicus
Journal Article