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Bioconjugate Chemistry, ISSN 1043-1802, 12/2014, Volume 25, Issue 12, pp. 2144 - 2156
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0131177
Antibody drug conjugates (ADCs) have recently been proven to be highly potent anti-tumor drugs, typically exceeding the efficacy of conventional monoclonal... 
RECOMBINANT IMMUNOTOXIN | IMMUNOGENICITY | MULTIDISCIPLINARY SCIENCES | PURIFICATION | SURFACE-PROTEINS | STAPHYLOCOCCUS-AUREUS | ANTITUMOR-ACTIVITY | MONOCLONAL-ANTIBODIES | FRAGMENTATION | CANCER-THERAPY | PROTEIN LIGATION | Cysteine Endopeptidases - chemistry | Staphylococcus aureus - enzymology | Aminoacyltransferases - immunology | Receptor, ErbB-2 - genetics | Humans | Bacterial Proteins - chemistry | Ovarian Neoplasms - pathology | Ki-1 Antigen - immunology | Maytansine - pharmacology | Immunoconjugates - immunology | Immunoconjugates - pharmacology | Antibodies, Monoclonal, Humanized - pharmacology | Protein Engineering | Maytansine - chemistry | Female | Antineoplastic Agents - pharmacology | Bacterial Proteins - immunology | Receptor, ErbB-2 - antagonists & inhibitors | Receptor, ErbB-2 - immunology | Oligopeptides - chemistry | Ovarian Neoplasms - drug therapy | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Aminoacyltransferases - chemistry | Antineoplastic Agents - immunology | Maytansine - analogs & derivatives | Antibodies, Monoclonal - pharmacology | Oligopeptides - immunology | Antineoplastic Agents - chemistry | Immunoconjugates - chemistry | Staphylococcus aureus - chemistry | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Ki-1 Antigen - antagonists & inhibitors | Mice | Antibodies, Monoclonal, Humanized - immunology | Cysteine Endopeptidases - immunology | Maytansine - immunology | Trastuzumab | Antibodies, Monoclonal, Humanized - chemistry | Ki-1 Antigen - genetics | Ovarian Neoplasms - immunology | Monoclonal antibodies | Enzymes | Cysteine | Peptides | Biopharmaceutics | Drugs | Conjugates | Addition polymerization | Ovarian carcinoma | Clinical trials | Pentaglycine | Cancer therapies | Molecular weight | Ovarian cancer | Proteins | Tubulin | CD30 antigen | Xenografts | Medical research | Immunoglobulins | Polypeptides | Cloning | Polymerization | Breast cancer | ErbB-2 protein | Substrates | Chemotherapy | Lysine | Heavy chains | Toxins | Conjugation | Sortase | Tumors
Journal Article
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 06/2015, Volume 26, Issue 6, pp. 1120 - 1128
Journal Article
Journal Article
The FEBS Journal, ISSN 1742-464X, 12/2011, Volume 278, Issue 23, pp. 4683 - 4700
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 2008, Volume 128, Issue 3, pp. 209 - 216
The clinical use of immunotoxins is severely limited by nonspecific toxicity. To overcome this limitation, PE38KDEL was used as a model protein toxin to... 
Nanoparticles | rhuMAbHER2 | Immunotoxins | PLGA | Targeted delivery | VASCULAR LEAK SYNDROME | L-ASPARAGINASE | CELLS | MEMBRANE ANTIGEN | targeted delivery | MONOCLONAL-ANTIBODY | CHEMISTRY, MULTIDISCIPLINARY | CELLULAR UPTAKE | IN-VITRO | nanoparticles | IMMUNOLIPOSOMES | PROSTATE-CANCER | PHARMACOLOGY & PHARMACY | immunotoxins | ANTICANCER DRUGS | ADP Ribose Transferases - toxicity | Antibody Specificity | Breast Neoplasms - immunology | Humans | Immunotoxins - pharmacology | Glycolates - chemistry | Endocytosis | Time Factors | Surface Properties | Receptor, ErbB-2 - immunology | Immunoglobulin Fab Fragments | Antibodies, Monoclonal - chemistry | ADP Ribose Transferases - metabolism | Virulence Factors - toxicity | Cell Survival - drug effects | Exotoxins - chemistry | Antibodies, Monoclonal - pharmacology | Polyglycolic Acid | Recombinant Proteins - chemistry | Breast Neoplasms - drug therapy | Bacterial Toxins - chemistry | Particle Size | Mice, Nude | Cell Line, Tumor | Exotoxins - toxicity | Virulence Factors - metabolism | Mice | Mice, Inbred BALB C | Antibodies, Monoclonal - metabolism | Bacterial Toxins - toxicity | Exotoxins - metabolism | Drug Carriers | Antineoplastic Agents - metabolism | Dose-Response Relationship, Drug | Immunotoxins - metabolism | Inhibitory Concentration 50 | Female | Immunotoxins - chemistry | Antineoplastic Agents - pharmacology | ADP Ribose Transferases - chemistry | Lactic Acid | Virulence Factors - chemistry | Recombinant Proteins - pharmacology | Antineoplastic Agents - chemistry | Xenograft Model Antitumor Assays | Bacterial Toxins - metabolism | Animals | Breast Neoplasms - pathology | Medical colleges | Care and treatment | Transmission electron microscopes | Drugstores | Antineoplastic agents | Antimitotic agents | Analysis | Monoclonal antibodies | Chemical properties | Antibody-toxin conjugates | Health aspects | Cancer | Index Medicus
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 02/2014, Volume 13, Issue 2, pp. 375 - 385
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 23, pp. 8577 - 8582
Immune responses can make protein therapeutics ineffective or even dangerous. We describe a general computational protein design method for reducing... 
T lymphocytes | Immune response | Immunodominant epitopes | Exotoxins | Medical treatment | Alleles | T lymphocyte epitopes | Epitopes | Genetic mutation | Epics | Biotherapeutics | Immunotoxin | Deimmunization | Machine learning | Rosetta | biotherapeutics | MULTIDISCIPLINARY SCIENCES | ANTIBODY | deimmunization | ALGORITHMS | machine learning | IDENTIFICATION | GREEN FLUORESCENT PROTEIN | REDUCED IMMUNOGENICITY | THERAPEUTIC PROTEINS | immunotoxin | OPTIMIZATION | PHASE-I | Virulence Factors - genetics | Protein Engineering - methods | Humans | Molecular Sequence Data | Epitopes, T-Lymphocyte - genetics | Green Fluorescent Proteins - genetics | Virulence Factors - immunology | HLA Antigens - genetics | Support Vector Machine | Flow Cytometry | Bacterial Toxins - genetics | Immunotoxins - chemistry | Epitopes, T-Lymphocyte - immunology | Green Fluorescent Proteins - chemistry | ADP Ribose Transferases - chemistry | Protein Structure, Tertiary | ADP Ribose Transferases - immunology | Immunization | Immunotoxins - immunology | Exotoxins - chemistry | Bacterial Toxins - immunology | Exotoxins - immunology | Mice, Inbred C57BL | HLA Antigens - immunology | Models, Molecular | Spectrometry, Fluorescence | Virulence Factors - chemistry | Bacterial Toxins - chemistry | Proteins - immunology | Proteins - genetics | Sequence Homology, Amino Acid | ADP Ribose Transferases - genetics | Immunotoxins - genetics | Animals | Green Fluorescent Proteins - immunology | Exotoxins - genetics | Cell Line, Tumor | Mice | Computer-Aided Design | Proteins - chemistry | Microbiological research | Protein research | Peptides | Research | Pseudomonas | T cells | Health aspects | Index Medicus | Biological Sciences | Physical Sciences
Journal Article