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Journal of Neuroscience Methods, ISSN 0165-0270, 01/2019, Volume 311, pp. 295 - 306
Gene delivery within the central nervous system at postnatal age is one of the most challenging tasks in neuroscience and currently only a few effective... 
In vivo | Gene delivery | Transfection | Non viral gene therapy | KCC2 | Rattus norvegicus | Postnatal brain | CHLORIDE HOMEOSTASIS | BIOCHEMICAL RESEARCH METHODS | ENDOCYTOSIS | ADENOVIRUS | NEUROSCIENCES | CORTEX | COTRANSPORTER KCC2 | Neurosciences | Neurons | Analysis | Genetically modified organisms | Genetic engineering | Polymers | Biosafety | Life Sciences | Neurons and Cognition
Journal Article
Oncogene, ISSN 0950-9232, 06/2017, Volume 36, Issue 25, pp. 3618 - 3628
Despite decades of research in the epidermal growth factor receptor (EGFR) signalling field, and many targeted anti-cancer drugs that have been tested... 
GENE DELIVERY | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PEPTIDE LIGAND | CELL MIGRATION | NEGATIVE BREAST-CANCER | CELL BIOLOGY | GROWTH-FACTOR RECEPTOR | PHASE-II TRIAL | MAMMARY-TUMORS | ONCOLOGY | COLORECTAL-CANCER | GENETICS & HEREDITY | TUMOR-ASSOCIATED MACROPHAGES | Receptor, Epidermal Growth Factor - genetics | Humans | Fluorescence | Tumor Microenvironment | Mammary Neoplasms, Experimental - metabolism | Neoplasm Proteins - metabolism | Mammary Neoplasms, Experimental - genetics | Breast Neoplasms - metabolism | Receptor, Epidermal Growth Factor - metabolism | Animals | Breast Neoplasms - genetics | Transfection - methods | Nitric Oxide Synthase Type II - genetics | Breast Neoplasms - pathology | Mammary Neoplasms, Experimental - pathology | Cell Line, Tumor | Biosensing Techniques - methods | Female | Mice | Liposomes | Neoplasm Proteins - genetics | Nitric Oxide Synthase Type II - metabolism | Phosphorylation | Genetic aspects | Cellular signal transduction | Health aspects | Carcinogenesis | Tyrosine | Animal models | Epidermal growth factor receptors | Lung | Colorectal carcinoma | Media | Non-small cell lung carcinoma | Breast cancer | Macrophages | Survival | Cancer therapies | Immunosuppressive agents | Nitric-oxide synthase | Cell activation | Epidermal growth factor | Transfection | Allografts | Xenografts | Biosensors | Cancer | Tumors | Index Medicus | Original
Journal Article
Journal Article
Radiology, ISSN 0033-8419, 08/2015, Volume 276, Issue 2, pp. 518 - 525
Purpose: To determine whether (a) stem cells loaded with DNA-carrying microbubbles (MBs) can be transfected in vivo, (b) the cells remain alive to express the... 
DESTRUCTION | NEUTRAL MICROBUBBLES | THERAPY | ULTRASOUND | CONTRAST AGENTS | MICE | MODEL | CANCER | EFFICIENCY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | DELIVERY | Stem Cells | Gene Expression | Animals | Transfection - methods | Mice, Nude | Cells, Cultured | DNA - administration & dosage | Microbubbles | Mice | Transfection - instrumentation | Index Medicus | Abridged Index Medicus | Original Research
Journal Article
Biomaterials, ISSN 0142-9612, 03/2019, Volume 197, pp. 255 - 267
There has been a progressive interest in the molecular design of polymers and lipids as synthetic carriers for targeting therapeutic mRNA with the ability to... 
Messenger RNA | Cholesterol | Polyplex micelle | RNA oligonucleotide | THERAPEUTICS | SYSTEMIC DELIVERY | MATERIALS SCIENCE, BIOMATERIALS | RECOGNITION | ENGINEERING, BIOMEDICAL | NANOPARTICLES | POLYION COMPLEX MICELLES | INDUCIBLE GENE-I | PLASMID DNA | BLOCK-COPOLYMER | EXPRESSION | VECTORS | Medical colleges | Lipids | Block copolymers
Journal Article
The Journal of Gene Medicine, ISSN 1099-498X, 01/2017, Volume 19, Issue 1-2, pp. e2940 - n/a
Background Hydrodynamic tail vein injection (HTVI) of transposon-based integration vectors is an established system for stably transfecting mouse hepatocytes... 
transposon | hydrodynamic tail vein injection | inducible gene expression | HTVI | Tet‐ON system | sleeping beauty | Tet-ON system | sleeping beauty transposon | MEDICINE, RESEARCH & EXPERIMENTAL | RNAI | PROTEIN | MOUSE-LIVER | LIVER-CANCER | INACTIVATION | SOMATIC INTEGRATION | TRANSGENE EXPRESSION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DNA | GENETICS & HEREDITY | MICE | HEPATOCELLULAR CARCINOMAS | Promoter Regions, Genetic | RNA, Small Interfering - genetics | Gene Expression | Genetic Vectors - administration & dosage | Gene Silencing | Homologous Recombination | Hepatocytes - metabolism | Gene Knockout Techniques | DNA Transposable Elements | Genetic Vectors - genetics | Gene Expression Regulation - drug effects | Animals | Transfection - methods | Doxycycline - pharmacology | Mice | Transgenes | Gene Order | Genes, Reporter | Transposons | Gene mutations | Analysis | Liver | Genes | Genetically modified organisms | Genetic research | Genetic engineering | Gene expression | Protein binding | Rodents | Animal models | Recombination | Recombinase | Genetic screening | Liver cancer | Transfection | Expression vectors | Integration | Cyclic AMP response element-binding protein | Tamoxifen | Transposase | Ribonucleic acid--RNA | Cre recombinase | Membrane proteins | Gene silencing | Hepatocytes | Doxycycline | Green fluorescent protein | Point mutation | Immunofluorescence | Cancer | Index Medicus
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2019, Volume 42, Issue 2, pp. 299 - 302
While the use of in vitro-transcribed mRNA (IVT-mRNA) in therapeutics is a rapidly expanding area, the transfection of the exogenous IVT-mRNA is accompanied by... 
dexamethasone | lipid nanoparticle | mRNA delivery | inflammation | integrated stress response | PHARMACOLOGY & PHARMACY | Drug delivery systems | Dexamethasone | Intravenous administration | Immune response | Lipids | mRNA | Embryo fibroblasts | Inflammation | Nanoparticles | Transfection | Immunology | Protein folding | In vivo methods and tests | Index Medicus
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 04/2012, Volume 425, Issue 1-2, pp. 35 - 43
The aim of present work is to evaluate the transfection capacity of a new multicomponent system based on dextran (Dex), protamine (Prot), and solid lipid... 
Endocytosis | Non-viral vectors | Gene therapy | Solid lipid nanoparticles | Intracellular trafficking | In vivo transfection | LOCALIZATION | TRANSCRIPTION | PEPTIDE | DELIVERY | CELL TRANSFECTION | PLASMID DNA | NASAL EPITHELIUM | PHARMACOLOGY & PHARMACY | CYSTIC-FIBROSIS | EXPRESSION | LIPOSOMES | Hemolysis - drug effects | Injections, Intravenous | Genetic Vectors - administration & dosage | Nanoparticles - chemistry | Humans | Dextrans - chemistry | Green Fluorescent Proteins - genetics | Transfection | HEK293 Cells | Erythrocytes - pathology | Protamines - administration & dosage | Female | Diglycerides - administration & dosage | Cell Line | Protamines - chemistry | Genetic Vectors - chemistry | Endocytosis - drug effects | DNA - administration & dosage | Erythrocytes - drug effects | DNA - chemistry | Animals | Mice, Nude | Diglycerides - chemistry | Hemagglutination - drug effects | Plasmids - chemistry | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Nanoparticles - administration & dosage | Dextrans - administration & dosage | Plasmids - administration & dosage | Genetic Therapy - methods | Nanoparticles | Genetic vectors | Genes | Genetic aspects | Universities and colleges | Virus diseases | Dextran | Drugstores | Index Medicus | Spleen | Clathrin | Particle size | Surface charge | Intravenous administration | Caveolae | Gene transfer | Liver | Lung | Erythrocytes | Lipids | protamine | nanoparticles | Plasmids | Green fluorescent protein | Agglutination | Expression vectors
Journal Article
Frontiers in immunology, ISSN 1664-3224, 2018, Volume 9, pp. 2477 - 2477
Fish red blood cells (RBCs), are integral in several biologic processes relevant to immunity, such as pathogen recognition, pathogen binding and clearance, and... 
DNA vaccine | red blood cells | VHSV glycoprotein G | erythrocytes | rainbow trout | immune response | transcriptome | proteome | HEMORRHAGIC SEPTICEMIA VIRUS | CELLS | PROTEIN | ONCORHYNCHUS-MYKISS | IMMUNOLOGY | IDENTIFICATION | CARRIER | I INTERFERON | FISH | EXPRESSION | ATLANTIC SALMON | Usage | Immune response | Rainbow trout | Erythrocytes | DNA vaccines | Glycoproteins | Genetic aspects | Research
Journal Article