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Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2011, Volume 54, Issue 24, pp. 8251 - 8270
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2017, Volume 139, pp. 3 - 14
Marine sponges have consistently been the richest source of new marine natural products with unprecedented chemical scaffolds and potent biological activities... 
Porifera | Marine natural products | Drug discovery | ANDROGEN RECEPTOR | INOSITOL 5-PHOSPHATASE | MAST-CELLS | PAPUA-NEW-GUINEA | STRUCTURE ELUCIDATION | MARINE SPONGE | SHIP1 ACTIVATOR AQX-1125 | IN-VIVO | PHARMACOLOGY & PHARMACY | CYSTITIS/BLADDER PAIN SYNDROME | RESISTANT PROSTATE-CANCER | Indans - adverse effects | Anti-Asthmatic Agents - therapeutic use | Humans | Drugs, Investigational - therapeutic use | Antineoplastic Agents - therapeutic use | Prodrugs - chemistry | Nonsteroidal Anti-Androgens - chemistry | Oligopeptides - therapeutic use | Nonsteroidal Anti-Androgens - therapeutic use | Sterols - adverse effects | Glycerol - analogs & derivatives | Porifera - chemistry | Benzhydryl Compounds - therapeutic use | Oligopeptides - chemistry | Anti-Asthmatic Agents - chemistry | Glycerol - therapeutic use | Indans - chemistry | Anti-Asthmatic Agents - pharmacology | Pyrrolidinones - adverse effects | Antimitotic Agents - adverse effects | Pyrrolidinones - therapeutic use | Antimitotic Agents - therapeutic use | Biological Products - isolation & purification | Biological Products - chemistry | Pyrrolidinones - isolation & purification | Cyclohexanols - therapeutic use | Oligopeptides - pharmacology | Anti-Asthmatic Agents - adverse effects | Cyclohexanols - adverse effects | Drugs, Investigational - adverse effects | Drugs, Investigational - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Oligopeptides - adverse effects | Indans - therapeutic use | Benzhydryl Compounds - chemistry | Drugs, Investigational - chemistry | Sterols - therapeutic use | Benzhydryl Compounds - adverse effects | Antineoplastic Agents - adverse effects | Cyclohexanols - chemistry | Nonsteroidal Anti-Androgens - adverse effects | Drug Design | Antineoplastic Agents - pharmacology | Glycerol - pharmacology | Aquatic Organisms - chemistry | Nonsteroidal Anti-Androgens - pharmacology | Sterols - pharmacology | Sterols - chemistry | Antineoplastic Agents - chemistry | Drug Discovery | Pyrrolidinones - chemistry | Prodrugs - adverse effects | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Antimitotic Agents - pharmacology | Benzhydryl Compounds - pharmacology | Prodrugs - therapeutic use | Prodrugs - pharmacology | Antimitotic Agents - chemistry | Chemical oceanography | Index Medicus
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2008, Volume 16, Issue 17, pp. 7894 - 7899
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2016, Volume 121, pp. 864 - 879
Currently available drugs against Alzheimer's disease (AD) are only able to ameliorate the disease symptoms resulting in a moderate improvement in memory and... 
Human acetylcholinesterase | MAO-A | Molecular modeling | Human butyrylcholinesterase | Metal chelating properties | ADME+T properties | Antioxidant properties | MAO-B | Alzheimer's disease | Molecular docking | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | CHOLINESTERASE-INHIBITORS | SEROTONIN 5-HT1A | DRUGS | POTENTIAL TREATMENT | NITRIC-OXIDE | FORCE-FIELD | OXIDASE-INHIBITORS | ADME plus T properties | RATIONAL DESIGN | HYBRIDS | Antioxidants - chemistry | Antioxidants - metabolism | Humans | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Monoamine Oxidase - chemistry | Piperidines - pharmacology | Drug Design | Indans - chemistry | Monoamine Oxidase Inhibitors - pharmacology | Piperidines - chemistry | Chemistry Techniques, Synthetic | Piperidines - metabolism | Chelating Agents - chemistry | Indans - metabolism | Acetylcholinesterase - chemistry | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Chelating Agents - pharmacology | Piperidines - chemical synthesis | Monoamine Oxidase Inhibitors - metabolism | Indans - chemical synthesis | Protein Conformation | Molecular Docking Simulation | Monoamine Oxidase Inhibitors - chemistry | Chelating Agents - chemical synthesis | Chelating Agents - metabolism | Acetylcholinesterase - metabolism | Indans - pharmacology | Monoamine Oxidase - metabolism | Antioxidants | Enzymes | Monoamine oxidase | Analysis | Models | Drug discovery | Target marketing
Journal Article
Journal Article
ChemMedChem, ISSN 1860-7179, 2016, Volume 11, Issue 12, pp. 1284 - 1295
We discovered a small series of hit compounds that show multitargeting activities against key targets in Alzheimer's disease (AD). The compounds were designed... 
Antioxidants | Chelation | Inhibitors | Alzheimer's disease | Cholinesterases | β-amyloid | inhibitors | TARGET-DIRECTED LIGANDS | CHEMISTRY, MEDICINAL | antioxidants | NEURODEGENERATIVE DISEASES | ZINC | beta-amyloid | AMYLOID-BETA PEPTIDE | IN-VITRO | ACETYLCHOLINESTERASE | cholinesterases | CHELATION-THERAPY | chelation | A-BETA | PHARMACOLOGY & PHARMACY | POLYAMINE BACKBONE | TRANSGENIC MICE | Human Umbilical Vein Endothelial Cells | Cholinesterase Inhibitors - toxicity | Antioxidants - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Structure-Activity Relationship | Zinc - chemistry | Indans - therapeutic use | Clioquinol - chemistry | Butyrylcholinesterase - chemistry | Copper - chemistry | Butyrylcholinesterase - metabolism | Amyloid beta-Peptides - metabolism | Drug Design | Oxyquinoline - toxicity | Clioquinol - toxicity | Indans - chemistry | Cell Survival - drug effects | Piperidines - toxicity | Piperidines - chemistry | Clioquinol - therapeutic use | Chelating Agents - chemistry | Alzheimer Disease - drug therapy | Oxyquinoline - therapeutic use | Blood-Brain Barrier - metabolism | Antioxidants - toxicity | Amyloid beta-Peptides - antagonists & inhibitors | Antioxidants - therapeutic use | Piperidines - therapeutic use | Cell Line, Tumor | Indans - toxicity | Cholinesterase Inhibitors - therapeutic use | Oxyquinoline - chemistry | Copper compounds | Permeability | Drug therapy | Target marketing | Alzheimers disease
Journal Article