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Journal Article
Biochemistry, ISSN 0006-2960, 05/2017, Volume 56, Issue 17, pp. 2294 - 2303
The toxicities of azole pollutants that have widespread agricultural and industrial uses are either poorly understood or unknown, particularly with respect to... 
DEHALOPEROXIDASE-HEMOGLOBIN | PEROXIDASE | SUBSTRATE-BINDING | INHIBITION | GLOBIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | CYTOCHROME P450BM3 | RESONANCE RAMAN | MARINE | DISTAL HISTIDINE | Benzimidazoles - toxicity | Triazoles - chemistry | Imidazoles - chemistry | Fungicides, Industrial - toxicity | Isoenzymes - chemistry | Environmental Pollutants - metabolism | Benzimidazoles - chemistry | Recombinant Fusion Proteins - metabolism | Fungicides, Industrial - metabolism | Peroxidases - antagonists & inhibitors | Triazoles - toxicity | Isoenzymes - metabolism | Peroxidases - chemistry | Enzyme Inhibitors - chemistry | Enzyme Inhibitors - toxicity | Peroxidases - metabolism | Imidazoles - toxicity | Environmental Pollutants - toxicity | Pesticides - metabolism | Polychaeta - enzymology | Imidazoles - metabolism | Recombinant Proteins - metabolism | Catalytic Domain | Indazoles - chemistry | Enzyme Inhibitors - metabolism | Computational Biology | Hemoglobins - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Indazoles - metabolism | Recombinant Fusion Proteins - chemistry | Fungicides, Industrial - chemistry | Amino Acid Motifs | Triazoles - metabolism | Hemoglobins - antagonists & inhibitors | Hemoglobins - chemistry | Animals | Environmental Pollutants - chemistry | Hydrogen Bonding | Pesticides - toxicity | Benzimidazoles - metabolism | Indazoles - toxicity | Hydrophobic and Hydrophilic Interactions | Pesticides - chemistry | Ligands | Kinetics | Isoenzymes - antagonists & inhibitors | Azoles (Class of compounds) | Computational chemistry | Usage | Chemical properties | X-ray spectroscopy | Research | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2017, Volume 474, Issue 11, pp. 1867 - 1877
Until recently, one of the major limitations of hydrogen/deuterium exchange mass spectrometry (HDX-MS) was the peptide-level resolution afforded by proteolytic... 
ACTIVATION | AMIDE HYDROGENS | PROTEIN | HDX-MS | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRAMOLECULAR MIGRATION | KINASE | IDENTIFICATION | CAPTURE DISSOCIATION | BINDING | Oligonucleotides - genetics | Oligonucleotides - chemistry | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Electron Transport | Molecular Weight | Humans | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Oligonucleotides - antagonists & inhibitors | Signal Processing, Computer-Assisted | Binding Sites | Peptide Fragments - genetics | Drug Evaluation, Preclinical - methods | Triazines - metabolism | Triazines - pharmacology | Indazoles - chemistry | Enzyme Inhibitors - metabolism | Purines - metabolism | Enzyme Inhibitors - pharmacology | Models, Molecular | Indazoles - metabolism | Recombinant Fusion Proteins - chemistry | Sulfonamides - pharmacology | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Indazoles - pharmacology | Oligonucleotides - metabolism | Peptide Fragments - chemistry | Class I Phosphatidylinositol 3-Kinases | Purines - chemistry | Peptide Fragments - antagonists & inhibitors | Protein Conformation | Quinazolinones - chemistry | Quinazolinones - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Recombinant Fusion Proteins - metabolism | Quinolines - pharmacology | Antineoplastic Agents - metabolism | Tandem Mass Spectrometry | Class Ia Phosphatidylinositol 3-Kinase - chemistry | Deuterium Exchange Measurement | Triazines - chemistry | Antineoplastic Agents - pharmacology | Class Ia Phosphatidylinositol 3-Kinase - genetics | Quinazolinones - pharmacology | Peptide Fragments - metabolism | Reproducibility of Results | Sulfonamides - chemistry | Purines - pharmacology | Quinolines - chemistry | Phosphatidylinositol 3-Kinases - chemistry | Antineoplastic Agents - chemistry | Phosphatidylinositol 3-Kinases - genetics | Quinolines - metabolism | Sulfonamides - metabolism | ETD | PI3K
Journal Article
Nature chemical biology, ISSN 1552-4450, 10/2014, Volume 10, Issue 10, pp. 853 - 860
Activation of the ERK pathway is a hallmark of cancer, and targeting of upstream signaling partners led to the development of approved drugs. Recently,... 
POLY(ADP-RIBOSE) POLYMERASE | RAF INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ACQUIRED-RESISTANCE | MAP KINASE ERK2 | BRAF | CONFORMATION | MEK INHIBITORS | SELECTIVITY | DISCOVERY | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - metabolism | Piperazines - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Enzyme Inhibitors - chemistry | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | Antineoplastic Agents - pharmacology | Mitogen-Activated Protein Kinase 3 - chemistry | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Gene Expression | Indazoles - chemistry | Mitogen-Activated Protein Kinase 3 - genetics | Protein Structure, Secondary | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - chemistry | Mitogen-Activated Protein Kinase 8 - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Piperazines - pharmacology | Indazoles - pharmacology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Cell Line, Tumor | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Kinetics | Mitogen-Activated Protein Kinase 1 - metabolism | Signal transduction | Binding sites | Pharmaceutical sciences | Cancer
Journal Article
Journal Article
Organic Letters, ISSN 1523-7060, 01/2016, Volume 18, Issue 2, pp. 232 - 235
The rhodium(III)-catalyzed direct C-H functionalization of azobenzenes with ethyl glyoxalate and aryl glyoxals is described. This protocol provides the facile... 
FUNCTIONALIZATION | AMIDATION | INDAZOLES | CHEMISTRY, ORGANIC | OLEFINS | N BOND FORMATION | ARYL | 1H-INDAZOLES | CLEAVAGE | ALKENYLATION | Azo Compounds - chemistry | Glyoxal - chemistry | Indazoles - chemistry | Cyclization | Indazoles - chemical synthesis | Ketones - chemistry | Molecular Structure | Catalysis | Glyoxal - analogs & derivatives | Rhodium - chemistry | Aldehydes - chemistry
Journal Article
Organic Letters, ISSN 1523-7060, 09/2014, Volume 16, Issue 18, pp. 4702 - 4705
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 09/2016, Volume 7, Issue 9, pp. 1241 - 1254
Journal Article
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 07/2016, Volume 160, pp. 180 - 188
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 08/2010, Volume 12, Issue 15, pp. 3368 - 3371
A new synthesis of 1-substitued-1H-indazoles via 1,3-dipolar cycloaddition of nitrile imines to benzyne is described. The reaction is completed within 5 min,... 
1-ARYL-1H-INDAZOLES | INTRAMOLECULAR AMINATION | CLICK CHEMISTRY | EFFICIENT SYNTHESIS | INDAZOLES | CHEMISTRY, ORGANIC | CYCLIZATION | Combinatorial Chemistry Techniques | Indazoles - chemistry | Cyclization | Indazoles - chemical synthesis | Imines - chemistry | Nitriles - chemistry | Molecular Structure | Benzene Derivatives - chemistry
Journal Article
Journal Article