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Journal Article
Cancer Cell, ISSN 1535-6108, 03/2013, Volume 23, Issue 3, pp. 406 - 420
Oncogenic Kras activates a plethora of signaling pathways, but our understanding of critical Ras effectors is still very limited. We show that cell-autonomous... 
RAS ONCOGENE | PI3K | ONCOLOGY | DUCTAL ADENOCARCINOMA | MOUSE MODEL | IN-VIVO | C-RAF | TUMOR-SUPPRESSOR | MICE | TUMORIGENESIS | EGF RECEPTOR | CELL BIOLOGY | Neoplasm Transplantation | Proto-Oncogene Proteins p21(ras) | Adenocarcinoma - pathology | Cell Proliferation | Pancreatic Neoplasms - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | ras Proteins - metabolism | Transplantation, Heterologous | Phosphatidylinositol 3-Kinases - metabolism | Carcinoma, Pancreatic Ductal - genetics | Lithostathine - metabolism | Adenocarcinoma - metabolism | Cell Transformation, Neoplastic - genetics | Adenocarcinoma - genetics | Tumor Cells, Cultured | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Signal Transduction | Pancreatic Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Pancreatic Neoplasms - genetics | TNF Receptor-Associated Factor 3 - metabolism | Sulfonamides - pharmacology | Carcinoma, Pancreatic Ductal - pathology | Cell Transformation, Neoplastic - metabolism | Indazoles - pharmacology | Metaplasia | Animals | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Mice, Inbred NOD | Mice | Enzyme Activation | Analysis | Genomics | Genetic research | Genetic aspects | Livestock | Lung cancer, Non-small cell | Health aspects | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2016, Volume 291, Issue 1, pp. 42 - 57
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2006, Volume 116, Issue 10, pp. 2610 - 2621
Inhibitors of VEGF signaling can block angiogenesis and reduce tumor vascularity, but little is known about the reversibility of these changes after treatment... 
MEDICINE, RESEARCH & EXPERIMENTAL | NERVE REGENERATION | BASAL LAMINA | ANGIOGENESIS INHIBITORS | BLOOD-VESSELS | EXTRACELLULAR-MATRIX | MUSCLE ACTIN EXPRESSION | ENDOTHELIAL SPROUTS | BASEMENT-MEMBRANES | GROWTH IN-VIVO | ESTABLISHED TUMORS | Basement Membrane - drug effects | Pericytes - drug effects | Blood Vessels - metabolism | Blood Vessels - pathology | Actins - metabolism | Endothelium, Vascular - drug effects | Vascular Endothelial Growth Factor A - metabolism | Basement Membrane - pathology | Carcinoma, Lewis Lung - blood supply | Neovascularization, Pathologic - pathology | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Insulinoma - blood supply | Pericytes - pathology | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Organic Chemicals - pharmacology | Angiogenesis Inhibitors - therapeutic use | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Imidazoles - therapeutic use | Collagen Type IV - immunology | Receptor, Platelet-Derived Growth Factor beta - metabolism | Collagen Type IV - metabolism | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Pericytes - metabolism | Insulinoma - drug therapy | Angiogenesis Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Mice, Transgenic | Neoplasms - blood supply | Treatment Outcome | Imidazoles - pharmacology | Basement Membrane - metabolism | Carcinoma, Lewis Lung - drug therapy | Neoplasms - drug therapy | Indazoles - pharmacology | Animals | Endothelium, Vascular - metabolism | Neovascularization, Pathologic - drug therapy | Blood Vessels - drug effects | Carcinoma, Lewis Lung - pathology | Matrix Metalloproteinase Inhibitors | Endothelium, Vascular - pathology | Insulinoma - pathology | Mice | Neovascularization, Pathologic - metabolism | Neoplasms - pathology | Indazoles - therapeutic use | Care and treatment | Research | Vascular endothelial growth factor | Cancer
Journal Article
Biochemistry, ISSN 0006-2960, 05/2017, Volume 56, Issue 17, pp. 2294 - 2303
The toxicities of azole pollutants that have widespread agricultural and industrial uses are either poorly understood or unknown, particularly with respect to... 
DEHALOPEROXIDASE-HEMOGLOBIN | PEROXIDASE | SUBSTRATE-BINDING | INHIBITION | GLOBIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | CYTOCHROME P450BM3 | RESONANCE RAMAN | MARINE | DISTAL HISTIDINE | Benzimidazoles - toxicity | Triazoles - chemistry | Imidazoles - chemistry | Fungicides, Industrial - toxicity | Isoenzymes - chemistry | Environmental Pollutants - metabolism | Benzimidazoles - chemistry | Recombinant Fusion Proteins - metabolism | Fungicides, Industrial - metabolism | Peroxidases - antagonists & inhibitors | Triazoles - toxicity | Isoenzymes - metabolism | Peroxidases - chemistry | Enzyme Inhibitors - chemistry | Enzyme Inhibitors - toxicity | Peroxidases - metabolism | Imidazoles - toxicity | Environmental Pollutants - toxicity | Pesticides - metabolism | Polychaeta - enzymology | Imidazoles - metabolism | Recombinant Proteins - metabolism | Catalytic Domain | Indazoles - chemistry | Enzyme Inhibitors - metabolism | Computational Biology | Hemoglobins - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Indazoles - metabolism | Recombinant Fusion Proteins - chemistry | Fungicides, Industrial - chemistry | Amino Acid Motifs | Triazoles - metabolism | Hemoglobins - antagonists & inhibitors | Hemoglobins - chemistry | Animals | Environmental Pollutants - chemistry | Hydrogen Bonding | Pesticides - toxicity | Benzimidazoles - metabolism | Indazoles - toxicity | Hydrophobic and Hydrophilic Interactions | Pesticides - chemistry | Ligands | Kinetics | Isoenzymes - antagonists & inhibitors | Azoles (Class of compounds) | Computational chemistry | Usage | Chemical properties | X-ray spectroscopy | Research | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2017, Volume 474, Issue 11, pp. 1867 - 1877
Until recently, one of the major limitations of hydrogen/deuterium exchange mass spectrometry (HDX-MS) was the peptide-level resolution afforded by proteolytic... 
ACTIVATION | AMIDE HYDROGENS | PROTEIN | HDX-MS | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRAMOLECULAR MIGRATION | KINASE | IDENTIFICATION | CAPTURE DISSOCIATION | BINDING | Oligonucleotides - genetics | Oligonucleotides - chemistry | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Electron Transport | Molecular Weight | Humans | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Oligonucleotides - antagonists & inhibitors | Signal Processing, Computer-Assisted | Binding Sites | Peptide Fragments - genetics | Drug Evaluation, Preclinical - methods | Triazines - metabolism | Triazines - pharmacology | Indazoles - chemistry | Enzyme Inhibitors - metabolism | Purines - metabolism | Enzyme Inhibitors - pharmacology | Models, Molecular | Indazoles - metabolism | Recombinant Fusion Proteins - chemistry | Sulfonamides - pharmacology | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Indazoles - pharmacology | Oligonucleotides - metabolism | Peptide Fragments - chemistry | Class I Phosphatidylinositol 3-Kinases | Purines - chemistry | Peptide Fragments - antagonists & inhibitors | Protein Conformation | Quinazolinones - chemistry | Quinazolinones - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Recombinant Fusion Proteins - metabolism | Quinolines - pharmacology | Antineoplastic Agents - metabolism | Tandem Mass Spectrometry | Class Ia Phosphatidylinositol 3-Kinase - chemistry | Deuterium Exchange Measurement | Triazines - chemistry | Antineoplastic Agents - pharmacology | Class Ia Phosphatidylinositol 3-Kinase - genetics | Quinazolinones - pharmacology | Peptide Fragments - metabolism | Reproducibility of Results | Sulfonamides - chemistry | Purines - pharmacology | Quinolines - chemistry | Phosphatidylinositol 3-Kinases - chemistry | Antineoplastic Agents - chemistry | Phosphatidylinositol 3-Kinases - genetics | Quinolines - metabolism | Sulfonamides - metabolism | ETD | PI3K
Journal Article
Nuclear Medicine and Biology, ISSN 0969-8051, 2016, Volume 43, Issue 10, pp. 612 - 624
Journal Article
Endocrinology, ISSN 0013-7227, 12/2017, Volume 158, Issue 12, pp. 4300 - 4316
Journal Article
Cell Reports, ISSN 2211-1247, 05/2016, Volume 15, Issue 6, pp. 1144 - 1160
Journal Article
Journal Article
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