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The Plant Cell, ISSN 1040-4651, 10/2014, Volume 26, Issue 10, pp. 3964 - 3983
Jasmonic acid and its derivatives Gasmonates [JAs]) play central roles in floral development and maturation. The binding of jasmonoyl-l-isoleucine (JA-IIe) to... 
Transcriptional regulatory elements | RESEARCH ARTICLES | Flowering | Nectaries | Gene expression regulation | Biosynthesis | Plants | Flowers | Corolla | Genotypes | Plant cells | BHLH TRANSCRIPTION FACTOR | ARABIDOPSIS-THALIANA | DEFENSE RESPONSES | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALLENE OXIDE CYCLASE | POLLINATOR ATTRACTION | ACID BIOSYNTHESIS | PLANT SCIENCES | CELL BIOLOGY | FLOWER DEVELOPMENT | CHALCONE SYNTHASE | GENE-EXPRESSION | PLANT-METABOLISM | Oligonucleotide Array Sequence Analysis | Flowers - metabolism | Methyltransferases - metabolism | Indenes - metabolism | Methyltransferases - genetics | Gene Expression Profiling | Amino Acids - pharmacology | Arabidopsis Proteins - metabolism | Amino Acids - metabolism | Isoleucine - pharmacology | RNA Interference | Plant Nectar - metabolism | Plants, Genetically Modified | Abscisic Acid - metabolism | Plant Proteins - metabolism | Manduca - physiology | Indenes - pharmacology | Acetone - analogs & derivatives | Arabidopsis Proteins - genetics | Tobacco - metabolism | Acetates - metabolism | Tobacco - drug effects | Esterases - metabolism | Acetone - metabolism | Cyclopentanes - pharmacology | Esterases - genetics | Reverse Transcriptase Polymerase Chain Reaction | Isoleucine - metabolism | Pollination | Abscisic Acid - pharmacology | Oxylipins - metabolism | Plant Proteins - genetics | Gene Expression Regulation, Plant - drug effects | Animals | Metabolic Networks and Pathways | Isoleucine - analogs & derivatives | Models, Biological | Tobacco - genetics | Oxylipins - pharmacology | Cyclopentanes - metabolism | Acetates - pharmacology | Flowers - drug effects | Plant Growth Regulators - metabolism | Flowers - genetics | Plant Growth Regulators - pharmacology | Physiological aspects | Amino acids | Genetic engineering | Instrument industry
Journal Article
The Plant Journal, ISSN 0960-7412, 09/2008, Volume 55, Issue 6, pp. 979 - 988
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 02/2019, Volume 131, pp. 345 - 355
Traumatic brain injury (TBI) is a principal cause of death and disability worldwide. Melatonin, a hormone made by the pineal gland, is known to have... 
Oxidative stress | Chronotherapy | Inflammation | Ramelteon | Traumatic brain injury | NF-E2-related factor | SLEEP | POSSIBLE INVOLVEMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | RAT MODEL | NEUROPROTECTION | RAMELTEON TAK-375 | NEUROINFLAMMATION | MONONUCLEAR-CELL TRANSPLANTATION | ENDOCRINOLOGY & METABOLISM | INTRACEREBRAL HEMORRHAGE | UP-REGULATION | AGONIST | Receptor, Melatonin, MT2 - genetics | Microglia - metabolism | Superoxide Dismutase - genetics | Tumor Necrosis Factor-alpha - genetics | Astrocytes - pathology | Cerebral Cortex - pathology | Male | Interleukin-1beta - genetics | Kelch-Like ECH-Associated Protein 1 - genetics | Interleukin-1beta - metabolism | Microglia - pathology | Cerebral Cortex - drug effects | Disease Models, Animal | Glutathione Peroxidase - metabolism | Brain Injuries, Traumatic - drug therapy | Signal Transduction | Kelch-Like ECH-Associated Protein 1 - metabolism | Receptor, Melatonin, MT1 - genetics | Glutathione Peroxidase - genetics | Mice, Knockout | Brain Injuries, Traumatic - pathology | Interleukin-10 - genetics | NF-E2-Related Factor 2 - metabolism | Mice | Oxidative Stress - drug effects | Receptor, Melatonin, MT2 - metabolism | Astrocytes - metabolism | Receptor, Melatonin, MT1 - metabolism | Receptor, Melatonin, MT2 - agonists | Tumor Necrosis Factor-alpha - metabolism | Brain Injuries, Traumatic - genetics | Cerebral Cortex - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Brain Edema - genetics | Interleukin-10 - metabolism | NF-E2-Related Factor 2 - genetics | Interleukin-4 - genetics | Superoxide Dismutase - metabolism | Astrocytes - drug effects | Indenes - pharmacology | Brain Edema - metabolism | Microglia - drug effects | Brain Edema - pathology | Interleukin-4 - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Antioxidants - pharmacology | Receptor, Melatonin, MT1 - agonists | Animals | Brain Injuries, Traumatic - metabolism | Brain Edema - drug therapy | rat model | p6412 | sleep | Biochemistry & Molecular Biology | Endokrinologi och diabetes | neuroinflammation | Traumatic brain | ramelteon tak-375 | Endocrinology and Diabetes | ates of america | Neurologi | mononuclear-cell transplantation | agonist | intracerebral hemorrhage | up-regulation | Neurology | possible involvement | v107 | neuroprotection | Endocrinology & Metabolism
Journal Article
Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 431 - 435
Activating mutations in KRAS and BRAF are found in more than 30% of all human tumours and 40% of melanoma, respectively, thus targeting this pathway could have... 
SELECTIVE INHIBITOR | POTENT | EFFICACY | MECHANISM | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | KINASE | C-RAF | B-RAF | MUTATIONS | PROTEINS | Neoplasms - metabolism | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Diphenylamine - pharmacology | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | ras Proteins - metabolism | Protein Transport - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Diphenylamine - analogs & derivatives | Mitogen-Activated Protein Kinase Kinases - metabolism | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Benzamides - pharmacology | Cell Membrane - metabolism | raf Kinases - genetics | Cell Membrane - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Pyrazoles - pharmacology | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Indenes - pharmacology | raf Kinases - chemistry | Proto-Oncogene Proteins c-raf - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Neoplasms - enzymology | Proto-Oncogene Proteins - genetics | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins c-raf - deficiency | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Ras genes | Growth | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Mitogen-activated protein kinases | Competition | Clinical trials | Enzymes | Kinases | Proteins | Cellular | Inhibitors | Pathways | Tumours | Signalling | Dimerization
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2014, Volume 10, Issue 8, pp. 671 - 676
(+)-7-iso-Jasmonoyl-L-isoleucine (JA-Ile) regulates developmental and stress responses in plants. Its perception involves the formation of a ternary complex... 
SIGNAL-TRANSDUCTION | PLANT STRESS-RESPONSE | DOMAIN PROTEINS INTERACT | PATHOGEN | AUXIN PERCEPTION | BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | JAZ REPRESSORS | ARABIDOPSIS | BHLH TRANSCRIPTION FACTORS | REGULATED DEFENSE | Indenes - metabolism | Amino Acids - chemistry | Indenes - chemistry | Amino Acids - pharmacology | Pseudomonas syringae - pathogenicity | Arabidopsis Proteins - metabolism | Botrytis - pathogenicity | DNA-Binding Proteins - metabolism | Amino Acids - metabolism | Isoleucine - pharmacology | Plants, Genetically Modified | Drug Design | Gene Expression Regulation, Plant | Plant Roots - growth & development | Repressor Proteins - metabolism | Amino Acids, Neutral - pharmacology | Indenes - pharmacology | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | DNA-Binding Proteins - antagonists & inhibitors | Plant Roots - metabolism | Repressor Proteins - genetics | Transcription Factors - antagonists & inhibitors | Cyclopentanes - pharmacology | Anthocyanins - metabolism | Arabidopsis - metabolism | Isoleucine - metabolism | Transcription Factors - metabolism | Arabidopsis - microbiology | Oxylipins - metabolism | Isoleucine - analogs & derivatives | Oximes - pharmacology | Cyclopentanes - metabolism | Ligands | Arabidopsis Proteins - antagonists & inhibitors | Plant diseases | Plant pathology | Sustainable agriculture | Agricultural biotechnology | Plant resistance | Hormones
Journal Article
The Plant Cell, ISSN 1040-4651, 8/2004, Volume 16, Issue 8, pp. 2117 - 2127
Despite its importance in a variety of plant defense responses, our understanding of how jasmonic acid (JA) functions at the biochemical level is limited.... 
Enzymes | Plant growth regulators | Root growth | Amino acids | Esters | Biosynthesis | Plants | Genotypes | Plant cells | Seedlings | FLOWER ORGANS | TRANSGENIC TOBACCO | DEFENSE RESPONSES | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALLENE OXIDE CYCLASE | ETHYLENE BIOSYNTHESIS | PLANT SCIENCES | CELL BIOLOGY | PHYTOTOXIN CORONATINE | METHYL JASMONATE | LIQUID-CHROMATOGRAPHY | PLANT-RESPONSES | MALE-STERILE | Seedlings - chemistry | Amino Acids - chemistry | Cyclopentanes - chemistry | Indenes - chemistry | Recombinant Fusion Proteins - metabolism | Oxylipins | Arabidopsis Proteins - metabolism | Plant Growth Regulators - chemistry | Isoleucine - chemistry | Plants, Genetically Modified | Nucleotidyltransferases - metabolism | Plant Roots - growth & development | Plant Leaves - chemistry | Arabidopsis Proteins - genetics | Plant Roots - metabolism | Isotopes - metabolism | Amino Acid Motifs | Arabidopsis - metabolism | Isoleucine - metabolism | Arabidopsis - genetics | Plant Leaves - metabolism | Amino Acids, Cyclic - metabolism | Arabidopsis - anatomy & histology | Nucleotidyltransferases - genetics | Recombinant Fusion Proteins - genetics | Cyclopentanes - metabolism | Signal Transduction - physiology | Mutation | Plant Growth Regulators - metabolism | Seedlings - metabolism | Plant cells and tissues | Genetic aspects | Research | Arabidopsis
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 2015, Volume 172, Issue 1, pp. 24 - 37
Background and Purpose N-docosahexaenoylethanolamine (DHEA) is the ethanolamine conjugate of the long-chain polyunsaturated n-3 fatty acid docosahexaenoic... 
arrive guidelines | pharmacology | fatty-acids | cannabinoid receptor | prostaglandin e-2 | nitric-oxide synthase | anandamide | fish-oil | concise guide | kappa-b | PLASMA | CONCISE GUIDE | NITRIC-OXIDE SYNTHASE | INFLAMMATION | OXYGENATION | ANANDAMIDE | PHARMACOLOGY & PHARMACY | FATTY-ACIDS | FISH-OIL | KAPPA-B | ETHANOLAMIDE | Endocannabinoids - metabolism | Bornanes - pharmacology | Male | NF-kappa B - metabolism | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | PPAR gamma - metabolism | Piperidines - pharmacology | Thiazolidinediones - pharmacology | Pyrazoles - pharmacology | Cell Line | Indenes - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Dehydroepiandrosterone - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 4 - metabolism | Arachidonic Acids - pharmacology | Mice, Knockout | Dinoprostone - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Macrophages - metabolism | Animals | PPAR gamma - antagonists & inhibitors | Interferon-beta - metabolism | Anilides - pharmacology | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Nitric Oxide - metabolism | Myeloid Differentiation Factor 88 - metabolism | Androgens | Dehydroepiandrosterone | DNA microarrays | Anti-inflammatory drugs | RNA | Ethanolamines | Macrophages | Gene expression | Fatty acids | Medical research | Rodents | Research Papers
Journal Article
The Plant Cell, ISSN 1040-4651, 11/2012, Volume 24, Issue 11, pp. 4763 - 4774
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