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Nature Medicine, ISSN 1078-8956, 06/2016, Volume 22, Issue 6, pp. 586 - 597
Astrocytes have important roles in the central nervous system (CNS) during health and disease. Through genome-wide analyses we detected a transcriptional... 
MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYELOID CELLS | BLOOD-BRAIN-BARRIER | BETA | CELL BIOLOGY | RESPONSES | MULTIPLE-SCLEROSIS | REGULATORY T-CELLS | DIFFERENTIATION | NF-KAPPA-B | EXPRESSION | Optical Imaging | Cell Proliferation | Central Nervous System - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Immunoblotting | Gene Expression Profiling | Chromatography, High Pressure Liquid | Glial Fibrillary Acidic Protein - metabolism | Interferon Type I - immunology | Suppressor of Cytokine Signaling Proteins | Tryptophan - metabolism | Case-Control Studies | Central Nervous System - immunology | Tryptophanase - metabolism | Gene Knockdown Techniques | Indoles - metabolism | STAT1 Transcription Factor - metabolism | Lactobacillus reuteri | Astrocytes - immunology | Chromatin Immunoprecipitation | Polymerase Chain Reaction | Receptors, Aryl Hydrocarbon - metabolism | Chemokine CCL2 - metabolism | Receptor, Interferon alpha-beta - genetics | Multiple Sclerosis - metabolism | Indican - urine | Serotonin | Gastrointestinal Microbiome | Inflammation | Mice, Knockout | Animals | Interferon-beta - pharmacology | Fluorescent Antibody Technique | Multiple Sclerosis - immunology | T-Lymphocytes - immunology | Mice | Myxovirus Resistance Proteins - metabolism | Receptors, Aryl Hydrocarbon - immunology | Nitric Oxide Synthase Type II - metabolism | Microbiota (Symbiotic organisms) | Astrocytes | Physiological aspects | Tryptophan | Interferon | Genetic aspects | Research | Autoimmunity | Multiple sclerosis | Care and treatment | Encephalomyelitis | Central nervous system | Prevention | Metabolites | Analysis | Dosage and administration | Diagnosis | Health aspects | Nervous system | Microorganisms | Immune system
Journal Article
BMC Nephrology, ISSN 1471-2369, 01/2017, Volume 18, Issue 1, p. 35
Background: During chronic kidney disease progression, kidney-specific risk factors for cardiovascular disease come into play. The present study investigated... 
Prothrombotic state | Hemostatic disorder | Indoxyl sulfate | von Willebrand factor | Tissue factor | Tryptophan derivatives | Uremic toxin | Cardiovascular disease | Chronic kidney disease | Monocytes activation | MORTALITY | KAPPA-B ACTIVATION | OXIDATIVE STRESS | RISK-FACTORS | KYNURENINE PATHWAY | ARYL-HYDROCARBON RECEPTOR | INFLAMMATION | ENDOTHELIAL-CELLS | UROLOGY & NEPHROLOGY | CARDIORENAL SYNDROME | EXPRESSION | Prevalence | C-Reactive Protein | Oxidative Stress | Tissue Plasminogen Activator - metabolism | Humans | Middle Aged | Male | Case-Control Studies | Renal Insufficiency, Chronic - epidemiology | Renal Insufficiency, Chronic - metabolism | Plasminogen Activator Inhibitor 1 - metabolism | Hemostasis | Lipoproteins - metabolism | Cardiovascular Diseases - epidemiology | Adult | Female | Prothrombin - metabolism | von Willebrand Factor - metabolism | Peptide Fragments - metabolism | Cardiovascular Diseases - metabolism | Inflammation | Hydrogen Peroxide - metabolism | Intercellular Adhesion Molecule-1 - metabolism | Urokinase-Type Plasminogen Activator - metabolism | Indican - metabolism | Aged | Thrombin - metabolism | Thromboplastin - metabolism | Neopterin - metabolism | Vascular Cell Adhesion Molecule-1 - metabolism | Physiological aspects | Toxins | Chronic kidney failure | Cardiovascular diseases | Health aspects
Journal Article
Archives of Medical Research, ISSN 0188-4409, 2014, Volume 45, Issue 4, pp. 309 - 317
Journal Article
Seminars in Nephrology, ISSN 0270-9295, 05/2018, Volume 38, Issue 3, pp. 233 - 250
In chronic kidney disease (CKD), the progressive decrease in renal function leads to disturbances of mineral metabolism that generally cause secondary... 
inhibitors | Chronic kidney disease | promoters | treatments | vascular calcification | CHRONIC-HEMODIALYSIS PATIENTS | MATRIX GLA PROTEIN | CORONARY-ARTERY CALCIFICATION | INDUCED VASCULAR CALCIFICATION | CALCIUM-SENSING RECEPTOR | GROWTH-FACTOR 23 | UROLOGY & NEPHROLOGY | SMOOTH-MUSCLE-CELLS | E-DEFICIENT MICE | STAGE RENAL-DISEASE | GLYCATION END-PRODUCTS | Tunica Media - pathology | Zinc Finger Protein GLI1 - metabolism | Calcium - metabolism | Cardiovascular Diseases - prevention & control | Humans | Glucuronidase - metabolism | Renal Insufficiency, Chronic - complications | Renal Insufficiency, Chronic - metabolism | Fibroblast Growth Factors - metabolism | Inflammation - complications | Vascular Calcification - metabolism | Inflammation - drug therapy | Anti-Inflammatory Agents - therapeutic use | Chelating Agents - therapeutic use | Mesenchymal Stem Cells - metabolism | Vitamin K 2 - therapeutic use | Cardiovascular Diseases - metabolism | Vascular Calcification - prevention & control | Vascular Calcification - drug therapy | Vascular Calcification - pathology | Calcimimetic Agents - therapeutic use | Magnesium - therapeutic use | Mesenchymal Stem Cells - pathology | Phosphates - metabolism | Animals | Tunica Intima - pathology | Glycation End Products, Advanced - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Indican - metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 3, p. e91517
Renin-angiotensin system (RAS) plays a pivotal role in chronic kidney disease (CKD). Angiotensin converting enzyme-related carboxypeptidase 2... 
CONVERTING ENZYME 2 | ACE2 | ARYL-HYDROCARBON RECEPTOR | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | NITRIC-OXIDE | ANGIOTENSIN-II | SENESCENCE | DYSFUNCTION | KIDNEY | PROGRESSION | Immunohistochemistry | Reactive Oxygen Species - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Transforming Growth Factor beta1 - metabolism | Angiotensins - pharmacology | Male | Renal Insufficiency, Chronic - metabolism | Time Factors | Organic Anion Transporters, Sodium-Independent - metabolism | Indican - administration & dosage | Receptors, Aryl Hydrocarbon - metabolism | Rats, Inbred Dahl | Nitric Oxide Synthase Type III - metabolism | Phosphorylation - drug effects | STAT3 Transcription Factor - metabolism | Proto-Oncogene Proteins - metabolism | Kidney Tubules, Proximal - cytology | Down-Regulation - drug effects | Rats, Sprague-Dawley | Animals | Signal Transduction - drug effects | Indican - pharmacology | Models, Biological | Acetylcysteine - pharmacology | Kidney Tubules, Proximal - metabolism | Kidney Tubules, Proximal - drug effects | RNA, Small Interfering - metabolism | Hypertension | Chronic kidney failure | Nitric oxide | Angiotensin converting enzyme | Angiotensin | Acetylcysteine | Bone morphogenetic proteins | Transforming growth factors | Sulfates | Endothelium | Phosphorylation | Syngeneic grafts | Transforming growth factor | Immunoblotting | Carboxypeptidase | Kinases | Antioxidants | Renin | Aromatic compounds | Peptidyl-dipeptidase A | Inhibition | Angiotensin II | Kidneys | Stat3 protein | Nitric-oxide synthase | Sulfate | Laboratory animals | Transporter | Kidney transplantation | Veins & arteries
Journal Article
Nephrology Dialysis Transplantation, ISSN 0931-0509, 06/2012, Volume 27, Issue 6, pp. 2176 - 2181
Journal Article
Kidney International, ISSN 0085-2538, 10/2013, Volume 84, Issue 4, pp. 733 - 744
In chronic kidney disease (CKD), uremic solutes accumulate in blood and tissues. These compounds probably contribute to the marked increase in cardiovascular... 
tissue factor | uremic solutes | aryl hydrocarbon receptor | OXIDATIVE STRESS | ACTIVATION | FACTOR EXPRESSION | RESPONSE ELEMENT | INFLAMMATION | HEMODIALYSIS-PATIENTS | GENE-EXPRESSION | UROLOGY & NEPHROLOGY | CARDIOVASCULAR-DISEASES | CHRONIC KIDNEY-DISEASE | FACTOR UP-REGULATION | Endothelium, Vascular - cytology | Leukocytes, Mononuclear - metabolism | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | Tissue Array Analysis | Humans | Middle Aged | Dioxins - pharmacology | Endothelium, Vascular - drug effects | Male | Case-Control Studies | Renal Insufficiency, Chronic - metabolism | Umbilical Veins - drug effects | Up-Regulation - physiology | Polymerase Chain Reaction | Aged, 80 and over | Receptors, Aryl Hydrocarbon - metabolism | Adult | Female | Umbilical Veins - cytology | Leukocytes, Mononuclear - drug effects | Indoleacetic Acids - metabolism | RNA, Small Interfering - pharmacology | Cells, Cultured | Receptors, Aryl Hydrocarbon - drug effects | Lactams, Macrocyclic - pharmacology | Benzoquinones - pharmacology | Up-Regulation - drug effects | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Indican - pharmacology | Indoleacetic Acids - pharmacology | Indican - metabolism | Leukocytes, Mononuclear - cytology | Signal Transduction - physiology | Aged | Thromboplastin - metabolism | In Vitro Techniques | Umbilical Veins - metabolism | Index Medicus | Life Sciences | Human health and pathology | Urology and Nephrology | Cardiology and cardiovascular system
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, p. e0149276
Objective The uremic toxin Indoxyl-3-sulphate (IS), a ligand of Aryl hydrocarbon Receptor (AhR), raises in blood during early renal dysfunction as a... 
ACTIVATION | UREMIC TOXIN | AORTIC-ANEURYSMS | ARYL-HYDROCARBON RECEPTOR | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | CARDIOVASCULAR-DISEASE | SUBSETS | DIFFERENTIATION | EXPRESSION | ARTERY-DISEASE | Cell Proliferation | Reactive Oxygen Species - metabolism | Monocytes - cytology | Humans | Monocytes - metabolism | Cell Transdifferentiation - genetics | Monocytes - immunology | Indican - blood | Aortic Aneurysm, Abdominal - blood | Case-Control Studies | Antigens, CD - metabolism | Aortic Aneurysm, Abdominal - metabolism | Receptors, Aryl Hydrocarbon - metabolism | Macrophages - immunology | Cell Line | Gene Expression | Glomerular Filtration Rate | Indican - urine | Receptors, Cell Surface - metabolism | Immunophenotyping | Macrophages - cytology | Macrophages - metabolism | Phenotype | Antigens, Differentiation, Myelomonocytic - metabolism | Indican - metabolism | Biomarkers | Chemotaxis, Leukocyte - immunology | Apoptosis | Physiological aspects | Monocytes | Genetic aspects | Research | Macrophages | Cell differentiation | Renal function | Laboratories | Cardiovascular disease | Activation | Biology | Tissue inhibitor of metalloproteinase 1 | CD14 antigen | Blood | Interleukin 6 | Proteins | Cell activation | Aromatic compounds | Cell cycle | Aorta | Cardiology | Vascular surgery | Internal medicine | Epidermal growth factor receptors | Mortality | Cloning | Inflammation | Metabolism | Disease control | Patients | Medicine | CD163 antigen | CD16 antigen | Correlation analysis | Interleukin 10 | Plasma levels | Kidney diseases | Cyclooxygenase-2 | Sulfate | Differentiation | Monocyte chemoattractant protein 1 | Plasmas (physics) | Kidney transplantation
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 2013, Volume 24, Issue 12, pp. 1981 - 1994
Journal Article