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Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 2007, Volume 43, Issue 4, pp. 1562 - 1567
An accurate, sensitive and simple reverse-phase (RP) high-performance liquid chromatography (HPLC) assay has been developed and validated for the simultaneous... 
Therapeutic drug monitoring | High-performance liquid chromatography (HPLC) | Tipranavir | Antiretroviral drug | Protease inhibitor | CHEMISTRY, ANALYTICAL | antiretroviral drug | protease inhibitor | REVERSE-TRANSCRIPTASE INHIBITORS | tipranavir | QUANTIFICATION | PHARMACOLOGY & PHARMACY | ATAZANAVIR | high-performance liquid chromatography (HPLC) | therapeutic drug monitoring | RITONAVIR | Saquinavir - blood | Nelfinavir - chemistry | Chromatography, High Pressure Liquid - methods | Pyridines - chemistry | Humans | Benzoxazines | Carbamates - chemistry | Pyrimidinones - chemistry | Indinavir - chemistry | Pyrones - blood | Nevirapine - blood | Sulfonamides - blood | Indinavir - blood | Pyrones - chemistry | Time Factors | Sensitivity and Specificity | Atazanavir Sulfate | Molecular Structure | Anti-HIV Agents - blood | Oligopeptides - chemistry | HIV Protease Inhibitors - blood | Reproducibility of Results | Saquinavir - chemistry | Oligopeptides - blood | Sulfonamides - chemistry | Ritonavir - blood | Drug Stability | Lopinavir | Carbamates - blood | HIV Protease Inhibitors - chemistry | Spectrophotometry, Ultraviolet | Nelfinavir - blood | Ritonavir - chemistry | Anti-HIV Agents - chemistry | Pyridines - blood | Nevirapine - chemistry | Pyrimidinones - blood | Oxazines - chemistry | Oxazines - blood | Antiviral agents | Highly active antiretroviral therapy | Liquid chromatography | Anti-HIV agents
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 2004, Volume 4, Issue 10, pp. 1079 - 1095
There are currently (July, 2002) six protease inhibitors approved for the treatment of HIV infection, each of which can be classified as peptidomimetic in... 
CHEMISTRY, MEDICINAL | REVERSE-TRANSCRIPTASE INHIBITORS | ORALLY BIOAVAILABLE INHIBITOR | BIOLOGICAL EVALUATION | ANTIVIRAL ACTIVITY | SOCIETY-USA PANEL | ANTIRETROVIRAL THERAPY | INFECTED PATIENTS | HUMAN-IMMUNODEFICIENCY-VIRUS | TYPE-1 PROTEASE | STRUCTURE-BASED DESIGN | Anti-HIV Agents - pharmacology | Pyridines - chemistry | Humans | Saquinavir - therapeutic use | Urethane - chemistry | Pyrimidinones - chemistry | Oligopeptides - therapeutic use | HIV Protease Inhibitors - pharmacology | Saquinavir - pharmacology | Urethane - therapeutic use | Atazanavir Sulfate | Phenylbutyrates - pharmacology | Ritonavir - therapeutic use | Oligopeptides - chemistry | Saquinavir - chemistry | Lopinavir | Pyrimidinones - therapeutic use | Models, Molecular | Sulfonamides - pharmacology | HIV Protease Inhibitors - therapeutic use | Nelfinavir - pharmacology | Anti-HIV Agents - chemistry | Carbamates | Urethane - pharmacology | Oligopeptides - pharmacology | Organophosphates - therapeutic use | Indinavir - pharmacology | Urethane - analogs & derivatives | HIV - drug effects | Molecular Mimicry | Phenylbutyrates - chemistry | Anti-HIV Agents - therapeutic use | Pyrimidinones - pharmacology | Ritonavir - pharmacology | Molecular Structure | Pyridines - therapeutic use | Nelfinavir - therapeutic use | Peptides - chemistry | Sulfonamides - chemistry | Dipeptides - pharmacology | HIV Protease Inhibitors - chemistry | Clinical Trials as Topic | Dipeptides - chemistry | Ritonavir - chemistry | Peptides - pharmacology | Organophosphates - pharmacology | Sulfonamides - therapeutic use | HIV Infections - drug therapy | Organophosphates - chemistry | Pyridines - pharmacology | Peptides - therapeutic use | Indinavir - therapeutic use
Journal Article
Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 05/2009, Volume 75, Issue 3, pp. 556 - 568
The importance of the active site region aspartyl residues 25 and 29 of the mature HIV‐1 protease (PR) for the binding of five clinical and three experimental... 
retroviral protease | protein structure | calorimetry | kinetics | aspartic protease | Aspartic protease | Calorimetry | Kinetics | Retroviral protease | Protein structure | PROTEINASE-INHIBITORS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG-RESISTANCE | VIRUS TYPE-1 PROTEASE | IN-VITRO | CANDIDA-ALBICANS | BIOPHYSICS | THERMODYNAMIC BASIS | PLASMODIUM-FALCIPARUM | HUMAN-IMMUNODEFICIENCY | MOLECULAR-BASIS | Nelfinavir - chemistry | Darunavir | Pyridines - chemistry | Humans | HIV Protease - genetics | HIV Protease Inhibitors - metabolism | Crystallography, X-Ray | Saquinavir - metabolism | Pyrimidinones - metabolism | Carbamates - chemistry | Pepsin A - chemistry | Pyrimidinones - chemistry | Indinavir - chemistry | Carbamates - metabolism | Pyrones - chemistry | Atazanavir Sulfate | Molecular Structure | Nelfinavir - metabolism | Oligopeptides - chemistry | Indinavir - metabolism | Binding, Competitive | Protein Structure, Tertiary | Saquinavir - chemistry | Sulfonamides - chemistry | Lopinavir | Models, Molecular | HIV Protease Inhibitors - chemistry | Binding Sites - genetics | Oligopeptides - metabolism | Pepsin A - metabolism | Ritonavir - chemistry | Pyridines - metabolism | Ritonavir - metabolism | Sulfonamides - metabolism | Protein Binding | Calorimetry, Differential Scanning | HIV Protease - chemistry | Mutation | Pyrones - metabolism | HIV Protease - metabolism
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 10/2018, Volume 107, Issue 10, pp. 2731 - 2734
Journal Article
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 08/2014, Volume 103, Issue 8, pp. 2520 - 2529
We evaluated two human immunodeficiency virus (HIV) protease inhibitors, atazanavir (ATV) and darunavir (DRV), for pH-dependent solubility, lipid binding, and... 
primate | physical characterization | HIV | stabilization | nanotechnology | pharmacokinetics | targeted drug delivery | lipid-drug interactions | long acting | lipid‐drug interactions | INDINAVIR | CHEMISTRY, MEDICINAL | LYMPHOID-TISSUES | FLUORESCENCE DEPOLARIZATION | IMMUNODEFICIENCY-VIRUS-INFECTION | PHASE-TRANSITIONS | ANTIRETROVIRAL THERAPY | HIV-1-INFECTED PATIENTS | CHEMISTRY, MULTIDISCIPLINARY | PHOSPHOLIPID BILAYERS | PHOSPHATIDYLCHOLINE LIPOSOMES | PHARMACOLOGY & PHARMACY | LOPINAVIR/RITONAVIR | Darunavir | Pyridines - chemistry | Humans | Delayed-Action Preparations - chemistry | Adenine - chemistry | Drug Delivery Systems | Adenine - blood | Anti-HIV Agents - administration & dosage | Tenofovir | Sulfonamides - blood | Lipids - chemistry | Atazanavir Sulfate | Organophosphonates - blood | Anti-HIV Agents - blood | Oligopeptides - chemistry | Macaca nemestrina | Adenine - analogs & derivatives | Pyridines - administration & dosage | Oligopeptides - blood | Sulfonamides - chemistry | Adenine - administration & dosage | Organophosphonates - administration & dosage | Anti-HIV Agents - chemistry | Pyridines - blood | Animals | Organophosphonates - chemistry | Oligopeptides - administration & dosage | Drug Combinations | Sulfonamides - administration & dosage | Hydrogen-Ion Concentration | Nanoparticles | Highly active antiretroviral therapy | Antiviral agents | Analysis | Lipids | HIV (Viruses) | Drug therapy | Hydrogen-ion concentration | Anti-HIV agents | nanoparticles | anti-HIV | atazanavir | tenofovir | drug combination | pH-dependent release | darunavir | long-acting
Journal Article
International journal of nanomedicine, ISSN 1178-2013, 2011, Volume 6, pp. 3393 - 3404
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, pp. e0146529 - e0146529
Cytochrome P450 3A4 (CYP3A4) is the major drug metabolic enzyme, and is involved in the metabolism of antiretroviral drugs, especially protease inhibitors... 
SITE | ANTIRETROVIRAL DRUGS | CYTOCHROMES P450 | ENZYMES | MULTIDISCIPLINARY SCIENCES | FLEXIBILITY | INFECTION | PROTEASE INHIBITORS | Inactivation, Metabolic | Nelfinavir - chemistry | Pyridines - chemistry | Humans | Lopinavir - chemistry | Atazanavir Sulfate - metabolism | Methamphetamine - chemistry | Pyrones - pharmacology | HIV Protease Inhibitors - pharmacology | Pyrones - chemistry | Drug Interactions | Cytochrome P-450 CYP3A - chemistry | Microsomes, Liver - enzymology | Nelfinavir - metabolism | Atazanavir Sulfate - chemistry | Methamphetamine - pharmacology | Catalytic Domain | Lopinavir - pharmacology | HIV Protease Inhibitors - chemistry | Lopinavir - metabolism | Nelfinavir - pharmacology | Amphetamine-Related Disorders - enzymology | Pyridines - metabolism | Cytochrome P-450 CYP3A - metabolism | Protein Binding | Atazanavir Sulfate - pharmacology | HIV Infections - drug therapy | Molecular Docking Simulation | Pyridines - pharmacology | Pyrones - metabolism | Antiviral agents | Ligand binding (Biochemistry) | Protease inhibitors | Methamphetamine | Dosage and administration | Research | Anti-HIV agents | Cytochrome | Ecstasy | Drugs | Drug abuse | Laboratories | Ritonavir | Pathogenesis | Liver | Design | Demethylation | Toxicology | E coli | Antiretroviral agents | Human immunodeficiency virus--HIV | Heme | Nelfinavir | Drug metabolism | Docking | Indinavir | Pharmaceutical sciences | Binding | Antiretroviral drugs | Enzymes | Solvents | Lopinavir | Cytochrome P450 | Proteinase inhibitors | Pharmacology | Spectra | Metabolism | Antiretroviral therapy | Microsomes | Studies | Pharmacy | Ligands | Index Medicus | HIV | Human immunodeficiency virus
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Journal Article
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