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Dyes and Pigments, ISSN 0143-7208, 02/2020, Volume 173, p. 107882
This work was aimed at expanding the diversity of indigoid compounds with novel characteristics by employing biological catalysts. A total of 16 novel indigoid... 
Indirubin | Indigo | Bacterial flavin-dependent monooxygenases
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2016, Volume 39, Issue 6, pp. 993 - 999
Indirubin inhibits cyclin-dependent kinases by binding to their ATP-binding site, thereby exerting potent cytotoxicity on some tumor cells. We examined the... 
Journal Article
Industrial Crops & Products, ISSN 0926-6690, 12/2019, Volume 141, p. 111783
The harvest time of a plant usually affects the yield of its metabolites. ( Ait., ) is an important cultivated plant that produces the natural blue dye indigo... 
Polygonum tinctorium | Transcriptome analysis | Indirubin | Indigo | High-performance liquid chromatography
Journal Article
Journal Article
Molecular Immunology, ISSN 0161-5890, 09/2018, Volume 101, pp. 386 - 395
Indirubin (IR) is a bisindole compound extracted from the leaves of Chinese herb . has been widely used in traditional Chinese medicine to treat inflammatory... 
Jak3/Stat3 | γδT cell | IL-17A | Indirubin | Psoriasis
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2018, Volume 496, Issue 1, pp. 7 - 11
Hepatocellular carcinoma (HCC) is a disease with poor prognosis. Nuclear accumulation of YB-1 is closely related to the malignancy of HCC. Treatment with... 
HepG2 | Inhibitor | Indirubin 3′-oxime | YB-1 | Nuclear translocation | LOCALIZATION | MARKER | BOX-BINDING PROTEIN-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | Indirubin 3 '-oxime | CANCER | THERAPY | BIOPHYSICS | MDR1 GENE-EXPRESSION | DISEASE
Journal Article
Biomolecules & Therapeutics(구 응용약물학회지), ISSN 1976-9148, 2019, Volume 27, Issue 2, pp. 216 - 221
The c-Met protein is a receptor tyrosine kinase involved in cell growth, proliferation, survival, and angiogenesis of several human tumors. Overexpression of... 
c-Met | Indirubin | Gastric cancer | LDD-1937
Journal Article
Experimental Cell Research, ISSN 0014-4827, 09/2018, Volume 370, Issue 2, pp. 454 - 460
YB-1 nuclear translocation/accumulation caused by anticancer agents leads to malignant transformation. Nuclear import of YB-1 requires a nuclear localization... 
Hepatocellular carcinoma cells | Inhibitor | Indirubin 3′-oxime | YB-1 | Nuclear translocation | TARGET | LOCALIZATION | Indirubin 3'-oxime | DRUG-RESISTANCE | P53 | CELL BIOLOGY | IMPORT | BINDING-PROTEIN YB-1 | INTERACT | THERAPY | GENE | ONCOLOGY | PROGNOSTIC MARKER | Antimitotic agents | Care and treatment | RNA | Hepatoma | Binding proteins | Antineoplastic agents | Cancer | Protein binding
Journal Article
IUBMB Life, ISSN 1521-6543, 10/2019, Volume 71, Issue 10, pp. 1465 - 1474
Indirubin is widely used as the active component of “Dangui Luhui Wan” in ancient China. However, its effects against the osteosarcoma (OS), the most common... 
migration | indirubin | apoptosis | invasion | cell cycle | osteosarcoma | ACTIVATION | INDIRUBIN DERIVATIVES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-CYCLE ARREST | PROLIFERATION | MEDICINE | NEUROTOXICITY | PACLITAXEL | CELL BIOLOGY | THERAPY | Osteosarcoma | Analysis
Journal Article
SYMMETRY-BASEL, ISSN 2073-8994, 08/2019, Volume 11, Issue 8, p. 980
Indirubin derivatives and analogues are a large group of compounds which are widely and successfully used in treatment of many cancer diseases. In particular,... 
CHRONIC MYELOGENOUS LEUKEMIA | rhombellanes | FULLERENES C-60 | CELLS | MULTIDISCIPLINARY SCIENCES | TUMOR | fullerenes | MODEL | ChEMBL474807 | docking | NANOPARTICLES | INHIBITION | carbon nanotubes | indirubin analogs | C-60 | DERIVATIVES | INDIRUBIN | C60
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 08/2019, Volume 476, pp. 2371 - 2391
Saturated free fatty acid-induced adipocyte inflammation plays a pivotal role in implementing insulin resistance and type 2 diabetes. Recent reports suggest... 
OBESITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | TNF-ALPHA | LIGAND | INHIBITORS | TLR4 | DERIVATIVES | SELECTIVITY | INDIRUBIN | ADIPOSE-TISSUE
Journal Article
Postgraduate Medical Journal, ISSN 0032-5473, 08/2019, Volume 95, Issue 1126, pp. 453 - 453
Journal Article
RSC Advances, ISSN 2046-2069, 2017, Volume 7, Issue 2, pp. 606 - 610
A combinative C2-selective arylation, and C3-selective carbonylation of free indole derivatives, by means of TEMPO catalysis and a silver oxidant under... 
CHRONIC MYELOGENOUS LEUKEMIA | FUNCTIONALIZATION | APOPTOSIS | INHIBITION | EN-ROUTE | DERIVATIVES | EFFICIENT | CHEMISTRY, MULTIDISCIPLINARY | INDOLES | INDIRUBIN | TRIMERIZATION
Journal Article
Cancer Letters, ISSN 0304-3835, 2017, Volume 397, pp. 72 - 82
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a poor prognosis. To identify potential effective therapeutic drugs for PDAC, we... 
Hematology, Oncology and Palliative Medicine | Epithelial–stromal interaction | Microenvironment | Indirubin 3′-oximes | Pancreatic ductal adenocarcinoma | APOPTOSIS | Epithelial-stromal interaction | ACTIVATION | CHINESE ANTILEUKEMIA MEDICINE | Indirubin 3 '-oximes | HUMAN CANCER-CELLS | INHIBITS TUMOR-GROWTH | HUMAN NEUROBLASTOMA | CYCLIN-DEPENDENT KINASES | LUNG-CANCER | ONCOLOGY | ENDOTHELIAL-CELL | DERIVATIVES | CDC2 Protein Kinase | Phosphorylation | Cyclin-Dependent Kinases - metabolism | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Humans | Carcinoma, Pancreatic Ductal - metabolism | Male | Cyclin B1 - metabolism | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | G2 Phase Cell Cycle Checkpoints - drug effects | Time Factors | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Pancreatic Neoplasms - pathology | Carcinoma, Pancreatic Ductal - pathology | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Oximes - pharmacology | Mice, Inbred BALB C | Adenocarcinoma | Medical colleges | Microbiology | Cell death | Analysis | Pancreatic cancer | Biochemistry | Biotechnology | Immunoglobulins | Toxicity | Lung cancer | Leukemia | Xenotransplantation | Kinases | Cancer therapies | Anticancer properties | Studies | Cell growth | Chemotherapy | Medical prognosis | Rodents | Cell cycle | Fibroblasts | Biocompatibility | Software | Inhibition | Apoptosis | Cancer
Journal Article
Drug Discovery Today, ISSN 1359-6446, 07/2016, Volume 21, Issue 7, pp. 1139 - 1146
Despite the numerous methods available for predicting the location and affinity of water molecules, there is still a degree of scepticism and reluctance... 
MONTE-CARLO | LIGAND-BINDING-SITES | THERMODYNAMICS | INDIRUBIN DERIVATIVES | DRUG DESIGN | PHARMACOLOGY & PHARMACY | FREE-ENERGIES | INHIBITORS | SOLVATION | HYDRATION | MOLECULES | Drug Discovery | Monte Carlo Method | Water - chemistry | Case studies | Analysis | Drug discovery
Journal Article
Oncogene, ISSN 0950-9232, 10/2006, Volume 25, Issue 47, pp. 6304 - 6318
Indirubin, an isomer of indigo, is a reported inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) as well as an agonist of the... 
Caspase | Indirubin | Cell death | Protein kinase | Autophagy | Cancer | CANCER-CELLS | autophagy | cell death | INDIRUBIN DERIVATIVES | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEPATOMA-CELLS | NEUROBLASTOMA-CELLS | protein kinase | PROTEIN-KINASES | caspase | CELL BIOLOGY | CYCLIN-DEPENDENT KINASES | indirubin | CDK INHIBITORY DRUGS | ONCOLOGY | ARYL-HYDROCARBON RECEPTOR | GENETICS & HEREDITY | SELECTIVE INHIBITORS | cancer | Caspases - physiology | Phosphorylation | Proto-Oncogene Proteins c-bcl-2 - physiology | Humans | Indoles - chemical synthesis | Male | Cell Line, Tumor - drug effects | Structure-Activity Relationship | Quinolines - pharmacology | Spodoptera | Tumor Suppressor Protein p53 - physiology | Recombinant Fusion Proteins - antagonists & inhibitors | Amino Acid Chloromethyl Ketones - pharmacology | Swine | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Indoles - pharmacology | Starfish | Cell Death - drug effects | Cyclin-Dependent Kinases - antagonists & inhibitors | STAT3 Transcription Factor - metabolism | Cell Line | CDC2 Protein Kinase - antagonists & inhibitors | Cell Line, Tumor - enzymology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Oximes - chemical synthesis | Cell Nucleus - ultrastructure | Oximes - chemistry | Animals | Cysteine Proteinase Inhibitors - pharmacology | bcl-X Protein - physiology | Oximes - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Protein Processing, Post-Translational | Cell Cycle - drug effects | Indoles - chemistry | Proteins | Inhibitor drugs | Kinases | Leukemia | Apoptosis | Oximes | Quinolines | CDC2 Protein Kinase | Glycogen Synthase Kinase 3 | Recombinant Fusion Proteins | Life Sciences | Cell Death | Cyclin-Dependent Kinases | Indoles | bcl-X Protein | Cyclin-Dependent Kinase Inhibitor p21 | Biochemistry, Molecular Biology | Protein Kinase Inhibitors | Tumor Suppressor Protein p53 | Cell Cycle | Cysteine Proteinase Inhibitors | Amino Acid Chloromethyl Ketones | Cell Line, Tumor | STAT3 Transcription Factor | Proto-Oncogene Proteins c-bcl-2 | Caspases | Cell Nucleus
Journal Article