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1. Full Text Somatostatin receptor-based imaging and therapy of gastroenteropancreatic neuroendocrine tumors
by Kwekkeboom, Dik J and Kam, Boen L and van Essen, Martijn and Teunissen, Jaap J M and van Eijck, Casper H J and Valkema, Roelf and de Jong, Marion and de Herder, Wouter W and Krenning, Eric P
Endocrine-related cancer, ISSN 1351-0088, 3/2010, Volume 17, Issue 1, pp. R53 - R73
Review | Oncology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Humans | Digestive System Neoplasms - radiotherapy | Antineoplastic Agents - therapeutic use | Yttrium Radioisotopes - pharmacokinetics | Octreotide - pharmacokinetics | Digestive System Neoplasms - drug therapy | Gallium Radioisotopes - therapeutic use | Digestive System Neoplasms - diagnostic imaging | Neuroendocrine Tumors - diagnostic imaging | Receptors, Somatostatin - analysis | Organometallic Compounds - therapeutic use | Yttrium Radioisotopes - therapeutic use | Somatostatin - analogs & derivatives | Radiopharmaceuticals - pharmacokinetics | Octreotide - analogs & derivatives | Organometallic Compounds - pharmacokinetics | Treatment Outcome | Clinical Trials as Topic | Combined Modality Therapy | Indium Radioisotopes - pharmacokinetics | Positron-Emission Tomography - methods | Octreotide - therapeutic use | Somatostatin - pharmacokinetics | Peptides, Cyclic - pharmacokinetics | Neuroendocrine Tumors - radiotherapy | Animals | Organotechnetium Compounds - pharmacokinetics | Positron-Emission Tomography - standards | Receptors, Somatostatin - drug effects | Gallium Radioisotopes - pharmacokinetics | Neuroendocrine Tumors - drug therapy | Peptides, Cyclic - therapeutic use | Quality of Life | Indium Radioisotopes - therapeutic use | Somatostatin - therapeutic use | Radiopharmaceuticals - therapeutic use | Index Medicus
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2. Full Text Evaluation of a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated bombesin-based radioantagonist for the labeling with single-photon emission computed tomography, positron emission tomography, and therapeutic radionuclides
by Mansi, Rosalba and Wang, Xuejuan and Forrer, Flavio and Kneifel, Stefan and Tamma, Maria-Luisa and Waser, Beatrice and Cescato, Renzo and Reubi, Jean Claude and Maecke, Helmut R
Clinical cancer research, ISSN 1078-0432, 08/2009, Volume 15, Issue 16, pp. 5240 - 5249
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Neoplasms - metabolism | Receptors, Bombesin - agonists | Radioisotopes - pharmacokinetics | Tomography, Emission-Computed, Single-Photon - methods | Receptors, G-Protein-Coupled - metabolism | Humans | Transplantation, Heterologous | Receptors, G-Protein-Coupled - agonists | Gallium Radioisotopes - therapeutic use | Heterocyclic Compounds, 1-Ring - chemistry | Female | Bombesin - chemistry | Oligopeptides - chemistry | Radioisotopes - therapeutic use | Oligopeptides - pharmacokinetics | Cells, Cultured | Indium Radioisotopes - chemistry | Gallium Radioisotopes - chemistry | Indium Radioisotopes - pharmacokinetics | Positron-Emission Tomography - methods | Neoplasms - diagnostic imaging | Receptors, Bombesin - antagonists & inhibitors | Receptors, Bombesin - metabolism | Animals | Mice, Nude | Models, Biological | Receptors, G-Protein-Coupled - antagonists & inhibitors | Gallium Radioisotopes - pharmacokinetics | Indium Radioisotopes - therapeutic use | Mice | Drug Delivery Systems - methods | Radioisotopes - chemistry | Index Medicus
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3. Full Text Pharmacokinetics and Biodistribution of 111In- and 177Lu-Labeled J591 Antibody Specific for Prostate-Specific Membrane Antigen: Prediction of 90Y-J591 Radiation Dosimetry Based on 111In or 177Lu?
by Vallabhajosula, Shankar and Kuji, Ichei and Hamacher, Klaus A and Konishi, Shota and Kostakoglu, Lale and Kothari, Paresh A and Milowski, Mathew I and Nanus, David M and Bander, Neil H and Goldsmith, Stanley J
The Journal of nuclear medicine (1978), ISSN 0161-5505, 04/2005, Volume 46, Issue 4, pp. 634 - 641
Lu-labeled J591 monoclonal antibody | Y dosimetry | Antiprostate-specific membrane antigen antibody | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - radiotherapy | Radioisotopes - pharmacokinetics | Humans | Middle Aged | Half-Life | Antibodies, Monoclonal - therapeutic use | Male | Metabolic Clearance Rate | Yttrium Radioisotopes - pharmacokinetics | Tissue Distribution | Aged, 80 and over | Lutetium - therapeutic use | Radiometry - methods | Yttrium Radioisotopes - therapeutic use | Lutetium - pharmacokinetics | Radiotherapy Dosage | Radioisotopes - therapeutic use | Radiopharmaceuticals - pharmacokinetics | Antibodies, Monoclonal - pharmacokinetics | Body Burden | Indium Radioisotopes - pharmacokinetics | Organ Specificity | Indium Radioisotopes - therapeutic use | Aged | Prostate-Specific Antigen - immunology | Relative Biological Effectiveness | Radiopharmaceuticals - therapeutic use | Index Medicus
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4. Full Text Dual-receptor-targeted radioimmunotherapy of human breast cancer xenografts in athymic mice coexpressing HER2 and EGFR using 177Lu-or 111In-labeled bispecific radioimmunoconjugates
by Razumienko, Eva J and Chen, Jason C and Cai, Zhongli and Chan, Conrad and Reilly, Raymond M
Journal of Nuclear Medicine, ISSN 0161-5505, 03/2016, Volume 57, Issue 3, pp. 444 - 452
HER2 | EGFR | Bispecific radioimmunoconjugates | Neoplasm Transplantation | Receptor, Epidermal Growth Factor - genetics | Receptor, ErbB-2 - genetics | Humans | Breast Neoplasms - therapy | Tissue Distribution | Immunoconjugates - therapeutic use | Radioimmunotherapy - methods | Radiometry | Lutetium - therapeutic use | Lutetium - adverse effects | Immunoconjugates - adverse effects | Receptor, Epidermal Growth Factor - biosynthesis | Receptor, ErbB-2 - biosynthesis | Radioisotopes - therapeutic use | Radioisotopes - adverse effects | Xenograft Model Antitumor Assays | Breast Neoplasms - radiotherapy | Animals | Breast Neoplasms - genetics | Indium Radioisotopes - adverse effects | Mice, Nude | Indium Radioisotopes - therapeutic use | Mice | Mice, Inbred BALB C | Radiopharmaceuticals - adverse effects | Radiopharmaceuticals - therapeutic use | Index Medicus
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5. Full Text Preclinical animal research on therapy dosimetry with dual isotopes
by Konijnenberg, Mark and Jong, Marion
European journal of nuclear medicine and molecular imaging, ISSN 1619-7070, 05/2011, Volume 38, Issue SUPPL. 1, pp. 19 - 27
Radionuclide therapy | Dose-effect models | Radiation dosimetry | Medicine & Public Health | Orthopedics | Oncology | Nuclear Medicine | Imaging / Radiology | Cardiology | Dose–effect models | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Lutetium - pharmacokinetics | Radiotherapy Dosage | Drug Evaluation, Preclinical - methods | Radioisotopes - pharmacokinetics | Radioisotopes - therapeutic use | Rats | Yttrium Radioisotopes - pharmacokinetics | Indium Radioisotopes - pharmacokinetics | Radiation Dosage | Lutetium - administration & dosage | Yttrium Radioisotopes - administration & dosage | Animals | Indium Radioisotopes - administration & dosage | Radioisotopes - administration & dosage | Indium Radioisotopes - therapeutic use | Neoplasms - radiotherapy | Lutetium - therapeutic use | Radiometry - methods | Dose-Response Relationship, Radiation | Yttrium Radioisotopes - therapeutic use | Radiopharmaceuticals - therapeutic use | Peptides | Radiation | Tumors | Nuclear medicine | Radiation therapy | Laboratory animals | Isotopes | Index Medicus | Review
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6. Full Text High-Dose Radioimmunotherapy Combined with Fixed, Low-Dose Paclitaxel in Metastatic Prostate and Breast Cancer by Using a MUC-1 Monoclonal Antibody, m170, Linked to Indium-111/Yttrium-90 via a Cathepsin Cleavable Linker with Cyclosporine to Prevent Human Anti-mouse Antibody
by Carol M. Richman and Sally J. DeNardo and Robert T. O'Donnell and Aina Yuan and Sui Shen and Desiree S. Goldstein and Joseph M. Tuscano and Ted Wun and Helen K. Chew and Primo N. Lara and David L. Kukis and Arutselvan Natarajan and Claude F. Meares and Kathleen R. Lamborn and Gerald L. DeNardo
Clinical cancer research, ISSN 1078-0432, 08/2005, Volume 11, Issue 16, pp. 5920 - 5927
Fractionated radioimmunotherapy | Breast cancer | Peripheral blood stem cell support | Combined modality radioimmunotherapy | Prostate cancer | Life Sciences & Biomedicine | Oncology | Science & Technology | Prostatic Neoplasms - radiotherapy | Humans | Middle Aged | Bone Neoplasms - secondary | Antibodies, Monoclonal - therapeutic use | Male | Yttrium Radioisotopes - pharmacokinetics | Dose-Response Relationship, Drug | Neutropenia - etiology | Heterocyclic Compounds, 1-Ring - chemistry | Aged, 80 and over | Radioimmunotherapy - methods | Adult | Female | Antineoplastic Agents, Phytogenic - therapeutic use | Cyclosporine - metabolism | Yttrium Radioisotopes - therapeutic use | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Prostatic Neoplasms - drug therapy | Antineoplastic Agents, Phytogenic - adverse effects | Prostatic Neoplasms - pathology | Soft Tissue Neoplasms - secondary | Heterocyclic Compounds, 1-Ring - pharmacokinetics | Indium Radioisotopes - chemistry | Paclitaxel - adverse effects | Treatment Outcome | Combined Modality Therapy | Indium Radioisotopes - pharmacokinetics | Breast Neoplasms - drug therapy | Paclitaxel - therapeutic use | Cyclosporine - therapeutic use | Breast Neoplasms - radiotherapy | Animals | Bone Neoplasms - prevention & control | Breast Neoplasms - pathology | Cathepsins - metabolism | Soft Tissue Neoplasms - prevention & control | Indium Radioisotopes - therapeutic use | Aged | Mice | Dose-Response Relationship, Radiation | Radioimmunotherapy - adverse effects | Yttrium Radioisotopes - chemistry | Index Medicus
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7. Full Text Comprehensive evaluation of a somatostatin-based radiolabelled antagonist for diagnostic imaging and radionuclide therapy
by Wang, Xuejuan and Fani, Melpomeni and Schulz, Stefan and Rivier, Jean and Reubi, Jean Claude and Maecke, Helmut R
European journal of nuclear medicine and molecular imaging, ISSN 1619-7070, 12/2012, Volume 39, Issue 12, pp. 1876 - 1885
Medicine & Public Health | Orthopedics | Imaging | Oncology | Radionuclide therapy | Nuclear Medicine | Somatostatin | Antagonist | Imaging / Radiology | Cardiology | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Neoplasm Transplantation | Humans | Octreotide - pharmacokinetics | Tissue Distribution | Radiopharmaceuticals - metabolism | HEK293 Cells | Organometallic Compounds - therapeutic use | Female | Neoplasms - radiotherapy | Receptors, Somatostatin - antagonists & inhibitors | Receptors, Somatostatin - metabolism | Indium Radioisotopes - metabolism | Lutetium - therapeutic use | Lutetium - pharmacokinetics | Radiopharmaceuticals - pharmacokinetics | Organometallic Compounds - pharmacokinetics | Indium Radioisotopes - pharmacokinetics | Neoplasms - diagnostic imaging | Octreotide - therapeutic use | Octreotide - metabolism | Animals | Organometallic Compounds - metabolism | Mice, Nude | Radionuclide Imaging | Indium Radioisotopes - therapeutic use | Mice | Radiopharmaceuticals - therapeutic use | Lutetium - metabolism | Nuclear medicine | Pharmacology | Medical imaging | Radiation therapy | Peptides | Cancer | Index Medicus | Cell culture | Animal models | Sucrose | Radioisotopes | Data processing | imaging | Kidney | Lysine | Xenografts | Pharmacokinetics | Somatostatin receptors | Tumors
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8. Full Text NODAGATOC, a New Chelator-Coupled Somatostatin Analogue Labeled with [67/68Ga] and [111In] for SPECT, PET, and Targeted Therapeutic Applications of Somatostatin Receptor (hsst2) Expressing Tumors
by Eisenwiener, Klaus-Peter and Prata, M. I. M and Buschmann, I and Zhang, Han-Wen and Santos, A. C and Wenger, Sandra and Reubi, Jean Claude and Mäcke, Helmut R
Bioconjugate chemistry, ISSN 1043-1802, 05/2002, Volume 13, Issue 3, pp. 530 - 541
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Multidisciplinary | Science & Technology | Pancreatic Neoplasms - metabolism | Tomography, Emission-Computed, Single-Photon | Cells, Cultured - diagnostic imaging | Octreotide - pharmacokinetics | Tissue Distribution | Gallium Radioisotopes - therapeutic use | Heterocyclic Compounds - chemistry | Female | Receptors, Somatostatin - metabolism | Peptide Fragments - metabolism | Radiopharmaceuticals - pharmacokinetics | Octreotide - analogs & derivatives | Drug Stability | Liver - metabolism | Pancreatic Neoplasms - radiotherapy | Rats | Heterocyclic Compounds - metabolism | Indium Radioisotopes - pharmacokinetics | Octreotide - therapeutic use | Peptide Fragments - chemistry | Animals | Mice, Nude | Gallium Radioisotopes - pharmacokinetics | Protein Binding | Indium Radioisotopes - therapeutic use | Ligands | Cells, Cultured - metabolism | Mice | Tomography, Emission-Computed | In Vitro Techniques | Radiopharmaceuticals - therapeutic use | Index Medicus
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9. Full Text Application of single-vial ready-for-use formulation of 111In- or 177Lu-labelled somatostatin analogs
by de Blois, Erik and Chan, Ho Sze and de Zanger, Rory and Konijnenberg, Mark and Breeman, Wouter A.P
Applied radiation and isotopes, ISSN 0969-8043, 02/2014, Volume 85, pp. 28 - 33
Quenchers | Ascorbic acid | Somatostatin | Ethanol | Gentisic acid | Radiochemical purity | Somatostatin - analogs & derivatives | Radioisotopes - therapeutic use | Drug Stability | Humans | Chromatography, High Pressure Liquid | Lutetium - administration & dosage | Chemistry, Pharmaceutical | Gentisates | Radiopharmaceuticals - administration & dosage | Ascorbic Acid | Drug Storage | Solutions | Indium Radioisotopes - administration & dosage | Radioisotopes - administration & dosage | Indium Radioisotopes - therapeutic use | Lutetium - therapeutic use | Somatostatin - therapeutic use | Radiopharmaceuticals - therapeutic use | Index Medicus
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10. Somatostatin Receptor-Targeted Radionuclide Therapy in Patients with Gastroenteropancreatic Neuroendocrine Tumors
by Kwekkeboom, Dik J and de Herder, Wouter W and Krenning, Eric P
Endocrinology and metabolism clinics of North America, ISSN 0889-8529, 03/2011, Volume 40, Issue 1, pp. 173 - 185
Targeted radionuclide therapy | Gastroenteropancreatic neuroendocrine tumor | Somatostatin receptor | Peptide receptor radionuclide therapy | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Gastrointestinal Neoplasms - mortality | Pancreatic Neoplasms - diagnosis | Humans | Antineoplastic Agents - therapeutic use | Neuroendocrine Tumors - diagnosis | Neuroendocrine Tumors - diagnostic imaging | Receptors, Somatostatin - antagonists & inhibitors | Pancreatic Neoplasms - mortality | Lutetium - therapeutic use | Yttrium Radioisotopes - therapeutic use | Molecular Targeted Therapy - methods | Radioisotopes - therapeutic use | Octreotide - analogs & derivatives | Pancreatic Neoplasms - radiotherapy | Gastrointestinal Neoplasms - diagnosis | Octreotide - therapeutic use | Neuroendocrine Tumors - radiotherapy | Animals | Gastrointestinal Neoplasms - diagnostic imaging | Gastrointestinal Neoplasms - radiotherapy | Neuroendocrine Tumors - mortality | Radionuclide Imaging | Indium Radioisotopes - therapeutic use | Pancreatic Neoplasms - diagnostic imaging | Radiopharmaceuticals - therapeutic use
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11. Full Text A first-in-human study investigating biodistribution, safety and recommended dose of a new radiolabeled MAb targeting FZD10 in metastatic synovial sarcoma patients
by Giraudet, Anne-Laure and Cassier, Philippe Alexandre and Iwao-Fukukawa, Chicaco and Garin, Gwenaelle and Badel, Jean-Noël and Kryza, David and Chabaud, Sylvie and Gilles-Afchain, Laurence and Clapisson, Gilles and Desuzinges, Claude and Sarrut, David and Halty, Adrien and Italiano, Antoine and Mori, Masaharu and Tsunoda, Takuya and Katagiri, Toyomasa and Nakamura, Yusuke and Alberti, Laurent and Cropet, Claire and Baconnier, Simon and Berge-Montamat, Sandrine and Pérol, David and Blay, Jean-Yves
BMC cancer, ISSN 1471-2407, 06/2018, Volume 18, Issue 1, pp. 646 - 646
First-in-human trial | Synovial sarcoma | Theranostic | Radioimmunotherapy | Life Sciences & Biomedicine | Oncology | Science & Technology | Frizzled Receptors - antagonists & inhibitors | Antibodies, Monoclonal - pharmacology | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | Antineoplastic Agents, Immunological - pharmacology | Dose-Response Relationship, Drug | Tissue Distribution | Young Adult | Sarcoma, Synovial - radiotherapy | Antineoplastic Agents, Immunological - therapeutic use | Radioimmunotherapy - methods | Adult | Female | Yttrium Radioisotopes - pharmacology | Aged | Yttrium Radioisotopes - therapeutic use | Usage | Care and treatment | Sarcoma | Analysis | Clinical trials | Diagnosis | Research | Index Medicus | Life Sciences | Medical Physics | Physics | Cancer
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12. Full Text Brachytherapy with intratumoral injections of radiometal-labeled polymers that thermoresponsively self-aggregate in tumor tissues
by Sano, Kohei and Kanada, Yuko and Kanazaki, Kengo and Ding, Ning and Ono, Masahiro and Saji, Hideo
Journal of Nuclear Medicine, ISSN 0161-5505, 09/2017, Volume 58, Issue 9, pp. 1380 - 1385
Brachytherapy | Polyoxazoline | Thermoresponsive polymer | Radiotherapy | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Prostatic Neoplasms - radiotherapy | Temperature | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Brachytherapy - methods | Polymerization | Male | Oxazoles - chemistry | Radiopharmaceuticals - administration & dosage | Tissue Distribution | Animals | Injections, Intralesional | Mice, Nude | Cell Line, Tumor | Indium Radioisotopes - therapeutic use | Mice | Mice, Inbred BALB C | Yttrium Radioisotopes - therapeutic use | Radiopharmaceuticals - therapeutic use | Surgical implants | Seeds | Radioisotopes | Oncology | Retention | Tissues | Mouse devices | Animal tissues | Anesthesia | Biocompatibility | Localization | Polymers | Radioactivity | Transition temperature | Organs | Implantation | Radiation therapy | Injection | Derivatives | Survival | Radiation dosage | Autoradiography | Transition temperatures | Prostate cancer | Prostate | Tumors | Index Medicus
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13. Full Text Predictive patient-specific dosimetry and individualized dosing of pretargeted radioimmunotherapy in patients with advanced colorectal cancer
by Schoffelen, R and Weg, W. van de and Visser, E.P and Goldenberg, D.M and Sharkey, R.M and McBride, W.J and Chang, C.-H and Rossi, E.A and Graaf, W.T.A. van der and Oyen, W.J.G and Boerman, O.C
European journal of nuclear medicine and molecular imaging, ISSN 1619-7070, 2014, Volume 41, Issue 8, pp. 1593 - 1602
Carcinoembryonic antigen | Medicine & Public Health | Orthopedics | Oncology | Nuclear Medicine | Dosimetry | Red bone marrow | Imaging / Radiology | Cardiology | Pretargeted radioimmunotherapy (PRIT) | Bispecific antibodies | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Humans | Middle Aged | Colorectal Neoplasms - radiotherapy | Tomography, Emission-Computed, Single-Photon | Antibodies, Bispecific - pharmacokinetics | Male | Lutetium - administration & dosage | Haptens - immunology | Oligopeptides - therapeutic use | Heterocyclic Compounds, 1-Ring - administration & dosage | Antibodies, Bispecific - administration & dosage | Adult | Female | Lutetium - therapeutic use | Radiometry - methods | Lutetium - pharmacokinetics | Carcinoembryonic Antigen - immunology | Heterocyclic Compounds, 1-Ring - pharmacokinetics | Oligopeptides - pharmacokinetics | Radioimmunotherapy | Colorectal Neoplasms - diagnostic imaging | Indium Radioisotopes - pharmacokinetics | Radiation Dosage | Antibodies, Bispecific - therapeutic use | Indium Radioisotopes - administration & dosage | Heterocyclic Compounds, 1-Ring - therapeutic use | Indium Radioisotopes - therapeutic use | Aged | Oligopeptides - administration & dosage | Precision Medicine - methods | Cancer patients | Care and treatment | Peptides | Analysis | Colorectal cancer | Nuclear medicine | Radiation therapy | Immunotherapy | Index Medicus
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