Synthesis, ISSN 0039-7881, 07/2015, Volume 47, Issue 13, pp. 1827 - 1837
Abstract Bis(indolyl)methane (BIM) alkaloids are an important group of bioactive natural products predominantly found in marine organisms. Thus, compounds like...
short review | synthesis | natural products | isolation | bioactive metabolites | bis(indolyl)methanes | STREPTINDOLE | VIBRINDOLE-A | NATURAL-PRODUCTS | AQUEOUS-MEDIUM | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | VIBRIO-PARAHAEMOLYTICUS | BACTERIUM | ARSINDOLINE B | INDOLE ALKALOIDS
short review | synthesis | natural products | isolation | bioactive metabolites | bis(indolyl)methanes | STREPTINDOLE | VIBRINDOLE-A | NATURAL-PRODUCTS | AQUEOUS-MEDIUM | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | VIBRIO-PARAHAEMOLYTICUS | BACTERIUM | ARSINDOLINE B | INDOLE ALKALOIDS
Journal Article
Drug Discovery Today, ISSN 1359-6446, 11/2014, Volume 19, Issue 11, pp. 1781 - 1791
The infectious disease Malaria is caused by different species of the genus Resistance to quinoline antimalarial drugs and decreased susceptibility to...
Carbazoles - isolation & purification | Carbazoles - chemistry | Humans | Indole Alkaloids - therapeutic use | Antimalarials - therapeutic use | Plasmodium - drug effects | Structure-Activity Relationship | Antimalarials - pharmacology | Antimalarials - isolation & purification | Animals | Indole Alkaloids - isolation & purification | Indole Alkaloids - pharmacology | Antimalarials - chemistry | Carbazoles - therapeutic use | Carbazoles - pharmacology | Indole Alkaloids - chemistry | Quinoline | Antimalarials | Alkaloids | Communicable diseases
Carbazoles - isolation & purification | Carbazoles - chemistry | Humans | Indole Alkaloids - therapeutic use | Antimalarials - therapeutic use | Plasmodium - drug effects | Structure-Activity Relationship | Antimalarials - pharmacology | Antimalarials - isolation & purification | Animals | Indole Alkaloids - isolation & purification | Indole Alkaloids - pharmacology | Antimalarials - chemistry | Carbazoles - therapeutic use | Carbazoles - pharmacology | Indole Alkaloids - chemistry | Quinoline | Antimalarials | Alkaloids | Communicable diseases
Journal Article
Alkaloids: Chemistry and Biology, ISSN 1099-4831, 01/2019, Volume 81, pp. 115 - 150
The alstoscholarisines are a small family of biologically and structurally interesting polycyclic monoterpenoid indole alkaloids isolated from the leaf...
Stem cell proliferation | Isolation | Biogenesis | Enantioselective synthesis | Indole alkaloids | Total synthesis
Stem cell proliferation | Isolation | Biogenesis | Enantioselective synthesis | Indole alkaloids | Total synthesis
Conference Proceeding
Nature, ISSN 0028-0836, 2014, Volume 509, Issue 7500, pp. 318 - 324
Many natural products that contain basic nitrogen atoms-for example alkaloids like morphine and quinine-have the potential to treat a broad range of human...
OXIDATION | REVISION | METABOLITES | STEPHACIDIN | MULTIDISCIPLINARY SCIENCES | CHEMISTRY | SECONDARY | MARINE-DERIVED FUNGUS | ENANTIOSELECTIVE TOTAL-SYNTHESIS | DERIVATIVES | ALKALOIDS | Indolizidines - chemical synthesis | Chemistry Techniques, Synthetic | Oxidation-Reduction | Stereoisomerism | Alkaloids - isolation & purification | Indolizidines - chemistry | Alkaloids - chemical synthesis | Indolizidines - metabolism | Oxygen - metabolism | Biological Products - chemical synthesis | Biological Products - chemistry | Indole Alkaloids - chemical synthesis | Indole Alkaloids - isolation & purification | Nitrogen - chemistry | Indolizidines - isolation & purification | Molecular Structure | Alkaloids - biosynthesis | Indole Alkaloids - chemistry | Indole Alkaloids - metabolism | Alkaloids - chemistry | Studies | Biosynthesis | Metabolites | Nitrogen
OXIDATION | REVISION | METABOLITES | STEPHACIDIN | MULTIDISCIPLINARY SCIENCES | CHEMISTRY | SECONDARY | MARINE-DERIVED FUNGUS | ENANTIOSELECTIVE TOTAL-SYNTHESIS | DERIVATIVES | ALKALOIDS | Indolizidines - chemical synthesis | Chemistry Techniques, Synthetic | Oxidation-Reduction | Stereoisomerism | Alkaloids - isolation & purification | Indolizidines - chemistry | Alkaloids - chemical synthesis | Indolizidines - metabolism | Oxygen - metabolism | Biological Products - chemical synthesis | Biological Products - chemistry | Indole Alkaloids - chemical synthesis | Indole Alkaloids - isolation & purification | Nitrogen - chemistry | Indolizidines - isolation & purification | Molecular Structure | Alkaloids - biosynthesis | Indole Alkaloids - chemistry | Indole Alkaloids - metabolism | Alkaloids - chemistry | Studies | Biosynthesis | Metabolites | Nitrogen
Journal Article
Chemical Reviews, ISSN 0009-2665, 07/2009, Volume 109, Issue 7, pp. 3080 - 3098
Scott R. Walker, Erin J. Carter, Belinda C. Huff, and Jonathan C. Morris
CYCLIN-DEPENDENT KINASES | TOSYLMETHYL ISOCYANIDE | TUNICATE APLIDIUM-MERIDIANUM | HYRTINADINE-A | TRANSFER-RNA SYNTHETASE | COUPLING REACTIONS | ANTARCTIC SPONGE | SPONGE KIRKPATRICKIA-VARIALOSA | DEOXYVARIOLIN-B | BRUGIA-MALAYI | CHEMISTRY, MULTIDISCIPLINARY | Aza Compounds - isolation & purification | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Aza Compounds - chemical synthesis | Aza Compounds - pharmacology | Pyrimidines - pharmacology | Pyrimidines - isolation & purification | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Indole Alkaloids - chemical synthesis | Indole Alkaloids - isolation & purification | Antineoplastic Agents - isolation & purification | Indole Alkaloids - pharmacology | Antineoplastic Agents - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - isolation & purification | Cyclin-Dependent Kinases - antagonists & inhibitors | Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis | Enzyme inhibitors | Chemical properties | Structure | Heterocyclic compounds
CYCLIN-DEPENDENT KINASES | TOSYLMETHYL ISOCYANIDE | TUNICATE APLIDIUM-MERIDIANUM | HYRTINADINE-A | TRANSFER-RNA SYNTHETASE | COUPLING REACTIONS | ANTARCTIC SPONGE | SPONGE KIRKPATRICKIA-VARIALOSA | DEOXYVARIOLIN-B | BRUGIA-MALAYI | CHEMISTRY, MULTIDISCIPLINARY | Aza Compounds - isolation & purification | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Aza Compounds - chemical synthesis | Aza Compounds - pharmacology | Pyrimidines - pharmacology | Pyrimidines - isolation & purification | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Indole Alkaloids - chemical synthesis | Indole Alkaloids - isolation & purification | Antineoplastic Agents - isolation & purification | Indole Alkaloids - pharmacology | Antineoplastic Agents - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - isolation & purification | Cyclin-Dependent Kinases - antagonists & inhibitors | Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis | Enzyme inhibitors | Chemical properties | Structure | Heterocyclic compounds
Journal Article
Journal of Natural Products, ISSN 0163-3864, 07/2017, Volume 80, Issue 7, pp. 2178 - 2187
Mushrooms are known to produce over 140 natural products bearing an indole heterocycle. In this review, the isolation of these mushroom-derived indole...
BIOLOGICALLY-ACTIVE COMPONENTS | CHEMISTRY, MEDICINAL | BIOACTIVE COMPOUNDS | ALPHA-AMANITIN | FRUITING BODIES | PLANT SCIENCES | BETA-CARBOLINE ALKALOIDS | ABSOLUTE-CONFIGURATION | A-C | MEDICINAL MUSHROOM | PHARMACOLOGY & PHARMACY | CORTINARIUS-SPECIOSISSIMUS | PYRROLOQUINOLINE ALKALOIDS | Biological Products - chemistry | Indole Alkaloids - isolation & purification | Indole Alkaloids - pharmacology | Biological Products - pharmacology | Molecular Structure | Indole Alkaloids - chemistry | Biological Products - isolation & purification | Agaricales - chemistry
BIOLOGICALLY-ACTIVE COMPONENTS | CHEMISTRY, MEDICINAL | BIOACTIVE COMPOUNDS | ALPHA-AMANITIN | FRUITING BODIES | PLANT SCIENCES | BETA-CARBOLINE ALKALOIDS | ABSOLUTE-CONFIGURATION | A-C | MEDICINAL MUSHROOM | PHARMACOLOGY & PHARMACY | CORTINARIUS-SPECIOSISSIMUS | PYRROLOQUINOLINE ALKALOIDS | Biological Products - chemistry | Indole Alkaloids - isolation & purification | Indole Alkaloids - pharmacology | Biological Products - pharmacology | Molecular Structure | Indole Alkaloids - chemistry | Biological Products - isolation & purification | Agaricales - chemistry
Journal Article
Chemical Reviews, ISSN 0009-2665, 06/2012, Volume 112, Issue 6, pp. 3193 - 3328
PROTEIN-KINASE-C | TRANSITION-METAL-COMPLEXES | ONE-POT SYNTHESIS | DOUBLE N-ARYLATION | PALLADIUM-CATALYZED SYNTHESIS | 1ST TOTAL-SYNTHESIS | FREE-RADICAL SCAVENGER | CELL-PROTECTING SUBSTANCE | ENANTIOSELECTIVE TOTAL-SYNTHESIS | IRON-MEDIATED SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | Carbazoles - chemistry | Alkaloids - pharmacology | Quinones - chemical synthesis | Alkaloids - isolation & purification | Organic Chemistry Phenomena | Alkaloids - chemical synthesis | Carbazoles - chemical synthesis | Pyrroles - chemical synthesis | Indole Alkaloids - chemical synthesis | Ellipticines - chemical synthesis | Benzoquinones - chemical synthesis | Molecular Structure | Furans - chemical synthesis | Carbazoles - pharmacology | Alkaloids - chemistry | Palladium catalysts | Alkaloids | Usage | Analysis | Heterocyclic aromatic compounds | Chemical bonds | Chemical properties | Ring formation (Chemistry)
Journal Article
Natural product reports, ISSN 0265-0568, 4/2013, Volume 3, Issue 5, pp. 694 - 752
Covering: 2010-2011. Previous review: Nat. Prod. Rep. 2010, 27 , 1630-1680 This review covers the literature on simple indole alkaloids and those with a...
DIKETOPIPERAZINE ALKALOIDS | CHEMISTRY, MEDICINAL | CONCISE TOTAL-SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | STREPTOMYCES SP | RING-CLOSING METATHESIS | ABSOLUTE-CONFIGURATION | 1ST TOTAL-SYNTHESIS | A-D | SEDIMENT-DERIVED FUNGUS | ENANTIOSELECTIVE TOTAL-SYNTHESIS | ASYMMETRIC TOTAL-SYNTHESIS | Monoterpenes - chemistry | Molecular Structure | Monoterpenes - isolation & purification | Indole Alkaloids - isolation & purification | Indole Alkaloids - chemistry
DIKETOPIPERAZINE ALKALOIDS | CHEMISTRY, MEDICINAL | CONCISE TOTAL-SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | STREPTOMYCES SP | RING-CLOSING METATHESIS | ABSOLUTE-CONFIGURATION | 1ST TOTAL-SYNTHESIS | A-D | SEDIMENT-DERIVED FUNGUS | ENANTIOSELECTIVE TOTAL-SYNTHESIS | ASYMMETRIC TOTAL-SYNTHESIS | Monoterpenes - chemistry | Molecular Structure | Monoterpenes - isolation & purification | Indole Alkaloids - isolation & purification | Indole Alkaloids - chemistry
Journal Article
Natural Product Reports, ISSN 0265-0568, 10/2015, Volume 32, Issue 10, pp. 1389 - 1471
This review covers the literature on simple indole alkaloids and those with a nonrearranged monoterpenoid unit from the beginning of 2012 up to the end of...
CHEMISTRY, MEDICINAL | CATALYZED DECARBOXYLATIVE ALLYLATION | CONCISE TOTAL-SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARBON QUATERNARY STEREOCENTERS | CHEMISTRY, ORGANIC | MARINE-DERIVED FUNGUS | ENANTIOSPECIFIC TOTAL-SYNTHESIS | TETRAHYDRO-BETA-CARBOLINES | BIOMIMETIC TOTAL-SYNTHESIS | 1ST TOTAL-SYNTHESIS | ENANTIOSELECTIVE TOTAL-SYNTHESIS | ASYMMETRIC TOTAL-SYNTHESIS | Monoterpenes - pharmacology | Monoterpenes - isolation & purification | Indole Alkaloids - chemical synthesis | Indole Alkaloids - isolation & purification | Indole Alkaloids - pharmacology | Monoterpenes - chemistry | Molecular Structure | Indole Alkaloids - chemistry | Monoterpenes - chemical synthesis
CHEMISTRY, MEDICINAL | CATALYZED DECARBOXYLATIVE ALLYLATION | CONCISE TOTAL-SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARBON QUATERNARY STEREOCENTERS | CHEMISTRY, ORGANIC | MARINE-DERIVED FUNGUS | ENANTIOSPECIFIC TOTAL-SYNTHESIS | TETRAHYDRO-BETA-CARBOLINES | BIOMIMETIC TOTAL-SYNTHESIS | 1ST TOTAL-SYNTHESIS | ENANTIOSELECTIVE TOTAL-SYNTHESIS | ASYMMETRIC TOTAL-SYNTHESIS | Monoterpenes - pharmacology | Monoterpenes - isolation & purification | Indole Alkaloids - chemical synthesis | Indole Alkaloids - isolation & purification | Indole Alkaloids - pharmacology | Monoterpenes - chemistry | Molecular Structure | Indole Alkaloids - chemistry | Monoterpenes - chemical synthesis
Journal Article
Chemical Communications, ISSN 1359-7345, 2017, Volume 53, Issue 72, pp. 10066 - 10069
Three pairs of new enantiomeric alkaloids with an unprecedented spiro indolinone-naphthofuran skeleton were isolated from a marine Streptomyces sp. The pure...
CHEMISTRY, MULTIDISCIPLINARY | ENANTIOMERIZATION BARRIERS | Models, Chemical | Stereoisomerism | Streptomyces - chemistry | Furans - pharmacology | Humans | Antineoplastic Agents - chemistry | Indole Alkaloids - isolation & purification | Antineoplastic Agents - isolation & purification | Furans - chemistry | Furans - isolation & purification | Indole Alkaloids - pharmacology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Indole Alkaloids - chemistry
CHEMISTRY, MULTIDISCIPLINARY | ENANTIOMERIZATION BARRIERS | Models, Chemical | Stereoisomerism | Streptomyces - chemistry | Furans - pharmacology | Humans | Antineoplastic Agents - chemistry | Indole Alkaloids - isolation & purification | Antineoplastic Agents - isolation & purification | Furans - chemistry | Furans - isolation & purification | Indole Alkaloids - pharmacology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Indole Alkaloids - chemistry
Journal Article
Journal of Natural Products, ISSN 0163-3864, 05/2016, Volume 79, Issue 5, pp. 1388 - 1399
Ten new indole alkaloids (1–10) comprising five ibogan, two aspidosperman, one vincamine, and two bisindole alkaloids, in addition to 32 known alkaloids, were...
REVISION | CHEMISTRY, MEDICINAL | MOIETY | DIVARICATA | PRECURSOR | ABSOLUTE-CONFIGURATION | PHARMACOLOGY & PHARMACY | TACAMAN | INDOLE ALKALOIDS | DERIVATIVES | JERANTININE | PLANT SCIENCES | Plant Leaves - chemistry | Vincristine - pharmacology | Stereoisomerism | Humans | KB Cells | Molecular Conformation | Antineoplastic Agents, Phytogenic - chemistry | Crystallography, X-Ray | Vincamine - pharmacology | Structure-Activity Relationship | Plant Bark - chemistry | Vincamine - chemistry | Indole Alkaloids - isolation & purification | Ibogaine - analogs & derivatives | Tabernaemontana - chemistry | Molecular Structure | Indole Alkaloids - chemistry | Drug Screening Assays, Antitumor | Vincamine - isolation & purification
REVISION | CHEMISTRY, MEDICINAL | MOIETY | DIVARICATA | PRECURSOR | ABSOLUTE-CONFIGURATION | PHARMACOLOGY & PHARMACY | TACAMAN | INDOLE ALKALOIDS | DERIVATIVES | JERANTININE | PLANT SCIENCES | Plant Leaves - chemistry | Vincristine - pharmacology | Stereoisomerism | Humans | KB Cells | Molecular Conformation | Antineoplastic Agents, Phytogenic - chemistry | Crystallography, X-Ray | Vincamine - pharmacology | Structure-Activity Relationship | Plant Bark - chemistry | Vincamine - chemistry | Indole Alkaloids - isolation & purification | Ibogaine - analogs & derivatives | Tabernaemontana - chemistry | Molecular Structure | Indole Alkaloids - chemistry | Drug Screening Assays, Antitumor | Vincamine - isolation & purification
Journal Article
Natural Product Reports, ISSN 0265-0568, 10/2010, Volume 27, Issue 11, pp. 163 - 168
Covering: 2008 to 2009 This review covers the literature on simple indole alkaloids and those with a nonrearranged monoterpenoid unit, and includes newly...
EFFICIENT TOTAL-SYNTHESIS | CHEMISTRY, MEDICINAL | CONCISE TOTAL-SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | MARINE-DERIVED FUNGUS | FORMAL TOTAL-SYNTHESIS | CARBAZOLE ALKALOIDS | BIOMIMETIC TOTAL-SYNTHESIS | A-C | 1ST TOTAL-SYNTHESIS | ASYMMETRIC TOTAL-SYNTHESIS | ENANTIOSELECTIVE TOTAL-SYNTHESIS | Monoterpenes - pharmacology | Monoterpenes - isolation & purification | Indole Alkaloids - isolation & purification | Indole Alkaloids - pharmacology | Monoterpenes - chemistry | Molecular Structure | Indole Alkaloids - chemistry
EFFICIENT TOTAL-SYNTHESIS | CHEMISTRY, MEDICINAL | CONCISE TOTAL-SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | MARINE-DERIVED FUNGUS | FORMAL TOTAL-SYNTHESIS | CARBAZOLE ALKALOIDS | BIOMIMETIC TOTAL-SYNTHESIS | A-C | 1ST TOTAL-SYNTHESIS | ASYMMETRIC TOTAL-SYNTHESIS | ENANTIOSELECTIVE TOTAL-SYNTHESIS | Monoterpenes - pharmacology | Monoterpenes - isolation & purification | Indole Alkaloids - isolation & purification | Indole Alkaloids - pharmacology | Monoterpenes - chemistry | Molecular Structure | Indole Alkaloids - chemistry
Journal Article